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Hep C Discussion Forum -> On Treatment -> Platelets - high/low?
Post Info TOPIC: Platelets - high/low?
singsong


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RE: Platelets - high/low?
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Thanks, Tig for the explanation re platelets.  It does make sense.  Someone else can answer on the AFP.  I looked through last few years of test results and haven't seen them post that one.



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Age 66. 1988? Dx 1996. G1a.  Biopsies 1996/1998.  Mild inflam. Tx naive.12/2015-Fibro F3/10.5 kPa. VL 1.1m Harvoni 8 wks. 5/9 VL was 69.  EOT 6-13-16. ALT/AST 13/16. Platelets 325. UND.  9/4/16 EOT+12 UND & 1-10-17 EOT+30 UND!
humbled


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Thanks for the detailed and very reassuring response Tig. I've been studying my blood work really closely, so I tend to obsess over details.

Does anybody know anything about the AFP score in blood work? 



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GT 1a, VL 3.7ml Fibroscan 13.6 Diagnosed: April 2016

SOT: 9 / 17 / 2016 (12 weeks Harvoni)

4-Week Bloods: AST (22) ALT (15)

EOT: 12 / 9 / 2016 - UNDETECTED!!

EOT + 12 weeks - 4 / 6 / 2017 - UNDETECTED!!!
Tig


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I agree, that's nothing to worry about at all. We routinely see them sub 100, without intervention. Not so much with the new DAA's however. When the count gets that low, there certainly has to be attention given to it, particularly to find out why. Cirrhotics and other immunocompromised patients commonly see them much lower. If a crisis is determined, packed cells can be administered to give immediate relief. I believe our Moderator Mike, is currently holding steady about 75 and has been less in the past. Those on Ribavirin can see their platelet count fall as a result of the accompanying anemia. Once treatment is over, if the platelet reduction was treatment induced, it will recover rather quickly.



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Tig

67yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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humbled


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Thanks JimmyK - I'm a worrier :)



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GT 1a, VL 3.7ml Fibroscan 13.6 Diagnosed: April 2016

SOT: 9 / 17 / 2016 (12 weeks Harvoni)

4-Week Bloods: AST (22) ALT (15)

EOT: 12 / 9 / 2016 - UNDETECTED!!

EOT + 12 weeks - 4 / 6 / 2017 - UNDETECTED!!!
JimmyK


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176 is fine.

120 and below needs some attention.

JimmyK



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Harvoni TX 2 12 weeks. UND weeks 4, 12 and now EOT + 4 Weeks. SVR-12 09/29/16. All Glory, Honor and Thanks be to God.

"I go to war with the brothers I trust."
humbled


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What is considered a low platelet count? Does this mean one has varices? Mine is currently 176



__________________

GT 1a, VL 3.7ml Fibroscan 13.6 Diagnosed: April 2016

SOT: 9 / 17 / 2016 (12 weeks Harvoni)

4-Week Bloods: AST (22) ALT (15)

EOT: 12 / 9 / 2016 - UNDETECTED!!

EOT + 12 weeks - 4 / 6 / 2017 - UNDETECTED!!!
Tig


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As fibrosis increases, particularly in cirrhosis (F4+) the blood perfusion through the liver decreases. That can result in portal hypertension and subsequent splenomegaly (spleen enlargement). As the spleen gets enlarged, it can (and does) cause a reduction in circulating red blood cells. Blood pools or collects in the spleen when it can't flow through the liver properly. Hemolytic anemia can cause platelets to drop, which is a  adverse reaction to Ribavirin. It's very common in cirrhotics to see a lower platelet count, sometimes significant.



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Tig

67yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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singsong


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When I read the bio of folks, it seems like the closer to F4 or cirrhotic, the lower the platelets?  I'm trying to figure the correlation. 



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Age 66. 1988? Dx 1996. G1a.  Biopsies 1996/1998.  Mild inflam. Tx naive.12/2015-Fibro F3/10.5 kPa. VL 1.1m Harvoni 8 wks. 5/9 VL was 69.  EOT 6-13-16. ALT/AST 13/16. Platelets 325. UND.  9/4/16 EOT+12 UND & 1-10-17 EOT+30 UND!
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