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Post Info TOPIC: EOT + 12 partial results


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RE: EOT + 12 partial results
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Shadowfax wrote:

Hi Lisa,

Remember that it seems I have cleared B but of course there was a trace in the DNA so they needed to ensure it did not flair up. I believe it is a non-issue but we are watching. When the C comes in, that should also be a non issue but there are many people that also need a B cure.

 

Hi, Canuck,

How are you? It's been too long. To try and answer, I don't believe they will do another Fibroscan for about a year but I am unsure and yes, there is the new clinic that should be open now by my NP who can do them so we shall see. There is no MRI or endoscopy ordered at this point. The deal is an Ultra sound every six months so May and Oct/Nov I will be seeing my specialist.  They will watch me that way. Regarding my BP, it is much improved and almost normal really. I am not concerned so I will say that it was the Harvoni that raised it since I started to have good readings during the weeks after I was finished. I still monitor it a few times a week and it seems fine. I am unsure about my lipids.

How did your EOT + 12 appointment go? You have probably had it by now since you posted approx 12 hours ago and you are three hours behind me, so that would have made it 1 AM Thursday ... or maybe your appointment is Friday.

SF

 

 

 

 

 

 

 

 


 Oh, I thought you still had both active, my bad. I am glad though that the focus is changing as we seem to be all set up fine for cures now. I wish you a lovely day. Sometimes I read at past 1 am in the morning half asleep. x



__________________

Genotype: 3b

VL.�over 15, 000 000

Failed TX 2014: Interferon/Riba.

Cured using Sof/Dak combination.

I can eat cake again! <3 



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JimmyK wrote:
Loopy Lisa wrote:

Thanks for the info....I too am wondering why they are not researching a cure.


 Hi Loop!

Actually this is what Gilead claims to be moving towards now. They say they are moving from Hep C cure (been there done that sort of thing) to a cure for Hep B.

JimmyK


 Per Canuck, overheard at the water cooler ... Heb B now becoming the main focus for Gilead

Linux



__________________

63yy,HCV,2b,F3-A1, Sof/Riba,12wks Tx   SOT: 1/20/16, HCV-RNA 9,816,581, ALT 56, Hb 14.6

4wk: HCV-RNA <15 Detected, ALT 15, AST 17, Hb 13.6 EOT: 4/12/16, ALT 18 , Hb 12.9176a2f85d05d9c965eafe199f2ba9ba5.jpg SVR Achieved 7/8/16

 



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Hi Lisa,

Remember that it seems I have cleared B but of course there was a trace in the DNA so they needed to ensure it did not flair up. I believe it is a non-issue but we are watching. When the C comes in, that should also be a non issue but there are many people that also need a B cure.

 

Hi, Canuck,

How are you? It's been too long. To try and answer, I don't believe they will do another Fibroscan for about a year but I am unsure and yes, there is the new clinic that should be open now by my NP who can do them so we shall see. There is no MRI or endoscopy ordered at this point. The deal is an Ultra sound every six months so May and Oct/Nov I will be seeing my specialist.  They will watch me that way. Regarding my BP, it is much improved and almost normal really. I am not concerned so I will say that it was the Harvoni that raised it since I started to have good readings during the weeks after I was finished. I still monitor it a few times a week and it seems fine. I am unsure about my lipids.

How did your EOT + 12 appointment go? You have probably had it by now since you posted approx 12 hours ago and you are three hours behind me, so that would have made it 1 AM Thursday ... or maybe your appointment is Friday.

SF

 

 

 

 

 

 

 

 



__________________

65 yo, GT1A, , Cirrhosis, F-Scan F4 33.5, TX Naive Harvoni 12 wks

SOT 2/9/16 / ALT 187 AST 114 VL 2.3M.    POSTS

EOT 5/2/16  ALT 35/ AST/25  platlets 126 C/B VL UND

EOT +12 7/26/16  ALT 25 /AST 22/ ALP 83  platlets 129 C/B VL UND

EOT + 24 10/18/16 ALT 27/ AST 20/ ALP 71 platlets 153 C UND

 * SVR *



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I am happy for you folk, about time too. Its terrible it took so long though considering the statistics. Yay for science. :D x



__________________

Genotype: 3b

VL.�over 15, 000 000

Failed TX 2014: Interferon/Riba.

Cured using Sof/Dak combination.

I can eat cake again! <3 



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What Jimmy said! biggrin and Viread is also a Gilead product.

 



-- Edited by Shadowfax on Thursday 28th of July 2016 03:36:36 PM

__________________

65 yo, GT1A, , Cirrhosis, F-Scan F4 33.5, TX Naive Harvoni 12 wks

SOT 2/9/16 / ALT 187 AST 114 VL 2.3M.    POSTS

EOT 5/2/16  ALT 35/ AST/25  platlets 126 C/B VL UND

EOT +12 7/26/16  ALT 25 /AST 22/ ALP 83  platlets 129 C/B VL UND

EOT + 24 10/18/16 ALT 27/ AST 20/ ALP 71 platlets 153 C UND

 * SVR *



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Loopy Lisa wrote:

Thanks for the info....I too am wondering why they are not researching a cure.


 Hi Loop!

Actually this is what Gilead claims to be moving towards now. They say they are moving from Hep C cure (been there done that sort of thing) to a cure for Hep B.

JimmyK



__________________

Harvoni TX 2 12 weeks. UND weeks 4, 12 and now EOT + 4 Weeks. SVR-12 09/29/16. All Glory, Honor and Thanks be to God.

"I go to war with the brothers I trust."



Guru

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Thanks for the info....I too am wondering why they are not researching a cure. I suspect that will be next now Hep C is being controlled. It is unusual to meet a chronic Hep B, so I had to ask. Getting rid of Hep C is a blessing though, It is a fast moving in research, they are doing amazing stuff!

I am happy for you both though to get through this battle, dual infections are much more essential to treat. x



__________________

Genotype: 3b

VL.�over 15, 000 000

Failed TX 2014: Interferon/Riba.

Cured using Sof/Dak combination.

I can eat cake again! <3 



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hurray hurray 

those numbers look simply fantastic! 

Congrats, and bravo.

 

Alison



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61 y/o, Infected via transfusion Oct'83, GT-1a, F-4 cirrhotic,
tx Holkira pak/moderiba 12 weeks

4 years.... successful dragon slayer 



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Hey SF!!

ALT, AST, Alk. Phos beauties!! Can't wait to see your VL ZERO results (again) when your labs are ready! I've never been able to do math, but late in life, i find I have suddenly developed a distinct interest in numbers, especial zero.

I've not been able to post much lately, been absolutely swamped.

I am sitting in my motel room tonight, waiting for my EOT+12 weeks appointment tomorrow. Also saw a ENT guy today, uneventful, a technical ho-hum lookie-loo.

On our trek back home tomorrow night, I'll see if I can't find a DQ, and I 'll have one on you, to celebrate your lab lovelies! I'll be sure to ask them for one of those healthy slurries tho (OK Linux).

Forgot what you said ... about when they might do another fibroscan/MRI/US on you! That nice gal you know, said she would, (I recall), when she is set up with a fibroscan, but when will that be? And do you get any other imaging of liver done to keep tabs on changes/improvement to the good? How are your lipids?? BP is OK now?

When I am able, I will try to keep posting things I have stumbled across, re: B/C people and research (I for one find the relationships between B/C interesting)! Ya, you and me both, remember fondly how it felt contracting both B and C at the same time in the good ole days! - NOT!

Really nice to see all your recent labs look so good now. You feel ... "optimistic"??!!! - surely you mean ... i am feeling smug, proud, relieved, gloating, exhausted, happy and invigorated all at the same time ... like a brave warrior who as just won his best battle??    biggrin C.



-- Edited by Canuck on Thursday 28th of July 2016 02:54:24 AM

__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 64 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



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That is my understanding as well Gracie but having said that and the fact it is more easily contracted than Hep C, these are the current statistics.

2 Billion people have been infected with it worldwide.

It is estimated that there are more than 250 million carriers of the hepatitis B virus in the world, with over 500,000 dying annually from hepatitis B-related liver disease.

They need to find a cure



__________________

65 yo, GT1A, , Cirrhosis, F-Scan F4 33.5, TX Naive Harvoni 12 wks

SOT 2/9/16 / ALT 187 AST 114 VL 2.3M.    POSTS

EOT 5/2/16  ALT 35/ AST/25  platlets 126 C/B VL UND

EOT +12 7/26/16  ALT 25 /AST 22/ ALP 83  platlets 129 C/B VL UND

EOT + 24 10/18/16 ALT 27/ AST 20/ ALP 71 platlets 153 C UND

 * SVR *



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somebody can correct me if I'm wrong, but hep b is cleared in most cases, only 10% become chronic .... 

  • In 90% of persons who become infected as adults with hepatitis B, the immune system successfully fights off the infection during the acute phase -- the virus is cleared from the body within 6 months, the liver heals completely, and the person becomes immune to hepatitis B infection for the rest of their life. In the other 10%, the immune system cannot clear the virus and hepatitis B infection persists past 6 months, usually for the rest of the person's life. This persistent state is known as chronic hepatitis B infection.


__________________
  1. Gracie

1A. Previously treated non responder Rebetron in 2000 And Incevik in 2014 with a breakthrough at week 12. Fibroscan 15.5. VL 6,000,000. Finished 24 weeks harvoni on Dec. 19, 2015. SVR. Latest Fibroscan 8.8.



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Thank you everyone and I am feeling optimistic

Those blizzards are looking mighty fine Tig and yes Wendy, the sprig was a nice thought but never going to happen.

Lisa, Hep B is not curable but is preventable by inoculation. It is indeed a chronic virus. In my case, I had B and C and the big problem was would the B rush back in once the C was cleared or being cleared since it was more aggressive and seems to hold B at bay. Based on that, my B VL was done all through treatment to ensure it was being nice. It did seem that I had cleared it but if it reared it's ugly head it would have had to be taken care of with antivirals such as Viread. There are newer and better ones soon to be approved.  This is a site about the drug in the even you or anybody else would like to view it. I am not the only one who had both. Our friend Canuck was also lucky enough to have both B and C. I was very sick when I first contracted them and in bed for 7 weeks. Not fun times.

http://www.viread.com/

My C VL was never done during TX. It was done before, at EOT and yesterday EOT+12.

 

I will of course post my final results when I get them in a few weeks. More waiting but hey, that's what we do.

 

SF



__________________

65 yo, GT1A, , Cirrhosis, F-Scan F4 33.5, TX Naive Harvoni 12 wks

SOT 2/9/16 / ALT 187 AST 114 VL 2.3M.    POSTS

EOT 5/2/16  ALT 35/ AST/25  platlets 126 C/B VL UND

EOT +12 7/26/16  ALT 25 /AST 22/ ALP 83  platlets 129 C/B VL UND

EOT + 24 10/18/16 ALT 27/ AST 20/ ALP 71 platlets 153 C UND

 * SVR *



Guru

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Great news Shadowfax. Since you are in the normal ranges it is looking very good! I know I am too curious at time, sorry if it seems rude, but is Hep B curable? I read yes and no. I know someone who caught it and their immune system dealt with it. I've never met anyone with chronic Hep B. 



__________________

Genotype: 3b

VL.�over 15, 000 000

Failed TX 2014: Interferon/Riba.

Cured using Sof/Dak combination.

I can eat cake again! <3 

Tig


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Good results SF! The ALT dropped again at week +5, that's a good sign of further reduction in inflammation. I hope you have your party planning underway! 

While you're waiting for the festivities to begin, I'm sending you something to quiet the sweet tooth. I'll take the caramel one if you can't finish them all smile

 



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Tig

64 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 7+ years!

Hep C FAQ   Lab Ref. Ranges  HCV Resistance

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Guru

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Great news even if partial SF! Very happy for you. 

You can have a mint chocolate chip blizzard and screw the sprig of kale or pistachio. (to get the green in for Dave) Just this time. 



__________________

Wendy 53 y/o, DX 1994, geno 1A F1

1999 TX 1 - Inter -non responder 2001 TX 2 - Peg + Riba - viral load tripled and taken off

T3:  Harvoni 12 weeks Sept. 19, 2015 ALT 41 AST 30 VL 541800 UND at EOT and SVR 24 ALT 18 AST 26 platelets 223

 



Guru

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ALP then still well within range ...

You've been right there for all of us on this journey Shadowfax, (After all, you saw me through the whole screenplay of "Linuxter Unhinged"), we're all glad to hear that you're not going anywhere. smile

 

Dave

 



__________________

63yy,HCV,2b,F3-A1, Sof/Riba,12wks Tx   SOT: 1/20/16, HCV-RNA 9,816,581, ALT 56, Hb 14.6

4wk: HCV-RNA <15 Detected, ALT 15, AST 17, Hb 13.6 EOT: 4/12/16, ALT 18 , Hb 12.9176a2f85d05d9c965eafe199f2ba9ba5.jpg SVR Achieved 7/8/16

 



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Thank you Dave,

I feel confident but of course need to know those numbers.

Yes the ALP is in range. It is a bit different in the USA, your units are not the same but for us it's 30 - 110 U/L

It has been an interesting journey as you know and it was an extreme pleasure to be on it with friends like you and Jimmy and Canuck to mention just a few.

I really don't know what I would have done without this forum to help with my questions and concerns. I applaud you for taking on a moderator role (Something I foresaw when we first got here) I am not going anywhere. There are people who need to hear from people like us. 

Cheers

SF



__________________

65 yo, GT1A, , Cirrhosis, F-Scan F4 33.5, TX Naive Harvoni 12 wks

SOT 2/9/16 / ALT 187 AST 114 VL 2.3M.    POSTS

EOT 5/2/16  ALT 35/ AST/25  platlets 126 C/B VL UND

EOT +12 7/26/16  ALT 25 /AST 22/ ALP 83  platlets 129 C/B VL UND

EOT + 24 10/18/16 ALT 27/ AST 20/ ALP 71 platlets 153 C UND

 * SVR *



Guru

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Hi SF,

Had to look up the ALP but from what I can tell The normal range is 44 to 147 IU/L ...

So you're well within range and looking extremely good with ALT and AST.

I'd say this is all VERY good news SF!

Sorry you have to wait for the RNA test, you'll know the good news soon though.

The Oreo Ice Cream Blizzard is well deserved ... Do Enjoy!

Glad to see these numbers SF, thanks for keeping us posted!!

 

Dave

 



__________________

63yy,HCV,2b,F3-A1, Sof/Riba,12wks Tx   SOT: 1/20/16, HCV-RNA 9,816,581, ALT 56, Hb 14.6

4wk: HCV-RNA <15 Detected, ALT 15, AST 17, Hb 13.6 EOT: 4/12/16, ALT 18 , Hb 12.9176a2f85d05d9c965eafe199f2ba9ba5.jpg SVR Achieved 7/8/16

 



Guru

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Well yesterday I had my lab work done and got some partial results that make me feel positive. It will take at least 2 weeks to know my C and B Status but my general numbers are good. I have referenced my last two draws as well. 

EOT       5/2/16     ALT 35/ AST/25 ALP 68

EOT +5  6/7/16     ALT 28/AST/21  ALP 80

July 26th blood draw verdict.

EOT +12 7/26/16
ALP 83
ALT 25
AST 22

Platlets 129 * Cirrhosis 

Based on these numbers I feel confident that nothing is messing with my liver right now but I need to see the real McCoy.  Fingers, eyes, toes and everything else possible are crossed right now. I do not see my specialist until August 30th but I will do my best to get my results via telephone after 10 days. I as the rest of you have waited long enough.

** Time for an Oreo Ice Cream Blizzard (with a sprig of Kale for Dave) to make it green smile



__________________

65 yo, GT1A, , Cirrhosis, F-Scan F4 33.5, TX Naive Harvoni 12 wks

SOT 2/9/16 / ALT 187 AST 114 VL 2.3M.    POSTS

EOT 5/2/16  ALT 35/ AST/25  platlets 126 C/B VL UND

EOT +12 7/26/16  ALT 25 /AST 22/ ALP 83  platlets 129 C/B VL UND

EOT + 24 10/18/16 ALT 27/ AST 20/ ALP 71 platlets 153 C UND

 * SVR *

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