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Post Info TOPIC: post treatment blood test


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RE: post treatment blood test
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Yes, I am getting an ultrasound every six months.  I had one in September and  all was well.



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John   non-responder  

Undetected at week 2 on solvaldi/rib/interferon:  stayed through week 12 but virus came back as soon as I stopped.  on   Harvoni and ribravirin 24 weeks undetected after two. 8/2/15  12 week EOT  UNDETECTED!  SVR

1991-2015 RIP

 

Tig


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Hey John,

I'm curious about your fibroscan score and your previous results. You stated your last registered an 18, is that correct? Cirrhosis (F4) begins at 12.5. If you are cirrhotic, you need to know for sure. There are guidelines established for continued monitoring the fibrosis stage and the increased potential for HCC development. Your hepatologist will be able to inform you of this if you aren't already on top of it. All of us high flying fibrotics need to keep a watch on it, just for safety's sake. Standard guidelines indicate 6 month ultrasounds. I'm adding a graphic of the current fibroscan scoring system.

 



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Tig

66 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 8+ years!

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Hi John,

So, from what I can piece together you must be more than EOT+24 weeks now, and that you went UND early (by week 2? of your 24 weeks of your re-treatment with harvoni and riba)!  

 

YESSSS!

I did begin a low dose statin (10 mg), but other than that no new prescriptions.  

 

 

I was actually interested in the little lab blip you had early in your treatment, must have been in the first few weeks, maybe when your VL was crashing to und?, where your first ALP was only noted at 24?, but then your ALP actually increased, up to 163 and 154 and then nicely/ slowly came down and never increased upward again. Your bili was up a teeny bit too, for a wee while. That was interesting to me! But then everyone knows ... I'm weird, what catches my attention, and that i get interested in many things that end up not being of any grand consequence or significance!!!!

 

Yes, but now they are both normal.  

 

Tig was asking about your F level, you said you were "3 - 4". Did you mean you were deemed to be F3 or 4 by means of a "Fibroscan", or by biopsy, or by what mode of measurement?? Just wondering how fibrotic/cirrhotic you are and how they decided that.

I did have a fibroscan and it came back 18.  They also did biopsies and some showed more scarring than others.  

Thanks for all the wisdom! 



__________________

John   non-responder  

Undetected at week 2 on solvaldi/rib/interferon:  stayed through week 12 but virus came back as soon as I stopped.  on   Harvoni and ribravirin 24 weeks undetected after two. 8/2/15  12 week EOT  UNDETECTED!  SVR

1991-2015 RIP

 



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Hi John,

So, from what I can piece together you must be more than EOT+24 weeks now, and that you went UND early (by week 2? of your 24 weeks of your re-treatment with harvoni and riba)!

Big congrats!!!, well deserved, after your prior unsuccesful attempt, and then having to do the long re-treatment with riba!

Hard work, but you did so well! You got that golden und!!

You labs are a "bit" of curiousity, and tig is right, to keep discussing them with your doc for his feedback. You are on their follow-up radar now, so it should not be hard to keep tabs on all going forward.

I won't be able to shed any light on why you have (or have had) some flucuations, but, you ARE und, you have no other major oddities going on?, and the bloods are NOT wildly fluctuating or increasing in a dramatic fashion, so then, it is just wise for you and your doc to keep watching and conversing about them just for your own piece of mind. (I know, I too would be wanting some kind of explanation from my doc, for any increase in my labs, even if they were small and he just said, forget about it/don't sweat it, just so i could rest easier about it). There are other organs and systems that all work with your liver that may affect your LFT labs, gallbladder (for one) comes to mind. So, it is very hard to guess into what any small increase may mean. 

Your doc should be able to rule out any other conditions you might have had in the past still affecting you, or even conditions you may currently have, or are being treated for, that could account for slight rises in your ALT or other LFT's ... for instance, have you been given or have you been taking any presciption meds for some other condition you are being treated for?? Some prescription meds too, might "possibly" cause some minor flucs in your labs. 

Just to keep us confused (it seems), internationally, I have found quite a few dif "reference ranges" of what dif labs and dif countries consider "normal" for ALT's and other bloods. I have read all these dif ref. ranges for:

ALT ... 3 to 36 U/L, 7 to 55, 7 to 56, 17 to 63 (as Tig mentioned, the latest revision adopted, now shows at  29 to 33 - for men) 

AST ... 0 to 35, 18 to 40, 8 to 48

ALP ... 35 to 100, 45 to 118, 36 to 126, 38 to 126

Brother!

Until otherwise stated by your doc, or by your lab, go by the ref ranges your lab uses:

ALT ...  17 to 63, AST high normal limit is 35, ALP  high normal limit is 125

I was actually interested in the little lab blip you had early in your treatment, must have been in the first few weeks, maybe when your VL was crashing to und?, where your first ALP was only noted at 24?, but then your ALP actually increased, up to 163 and 154 and then nicely/ slowly came down and never increased upward again. Your bili was up a teeny bit too, for a wee while. That was interesting to me! But then everyone knows ... I'm weird, what catches my attention, and that i get interested in many things that end up not being of any grand consequence or significance!!!!

I don't think you have anything to worry about (now that your have so well proven yourself cured of HCV), but, wise to keep tabs on all things just for all-round reassurance.

Tig was asking about your F level, you said you were "3 - 4". Did you mean you were deemed to be F3 or 4 by means of a "Fibroscan", or by biopsy, or by what mode of measurement?? Just wondering how fibrotic/cirrhotic you are and how they decided that.

Congrats again, don't fret, just keep checking, keep on top of things and keep taking good care of yourself, just like you are doing. biggrin C.



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HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 64 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)

Tig


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Hi John,

They have revised the enzyme parameters a little. I included the link to the post left by our own Canuck. We had a short discussion on it. Your level of fibrosis could be responsible for that increase. I would do some additional checking with your doc to find out why. As EX HCV patients, we can still have a few issues that linger on. Best to know exactly where you stand.

Liver Tests

Revised ALT levels

 



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Tig

66 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 8+ years!

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Greetings,

 

Hard to say what your normal numbers would be. The 31 you mentioned if while on Harvoni I believe the numbers go down during treatment. Mine did and then settled higher after EOT. 51 is still within the normal range.

 

JimmyK



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Harvoni TX 2 12 weeks. UND weeks 4, 12 and now EOT + 4 Weeks. SVR-12 09/29/16. All Glory, Honor and Thanks be to God.

"I go to war with the brothers I trust."



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Hi Tig

I am 3-4 scarring - the alt had risen from 31 to 48 to 51, but is still under the range of the test. This is after a year. Do you know if these number fluctuate even though they stay under the high range what does it indicate? Glad you are doing well too.



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John   non-responder  

Undetected at week 2 on solvaldi/rib/interferon:  stayed through week 12 but virus came back as soon as I stopped.  on   Harvoni and ribravirin 24 weeks undetected after two. 8/2/15  12 week EOT  UNDETECTED!  SVR

1991-2015 RIP

 

Tig


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Hey John,

Good to hear you're doing well. I think the ALT is one of the most telling liver tests. It will indicate whether there is any inflammatory processes occuring. Without going back and looking through your posts, can you tell me what your most recent fibrosis stage was? Those with higher levels of fibrosis will often have fluctuations in their enzymes and platelets. An ever increasing set of enzymes is cause for attention. Killing the beast does wonders for turning the entire inflammatory process around and allows the healing to begin. None of these improvements happens overnight, but steady progress is what we strive to achieve!



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Tig

66 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 8+ years!

Hep C FAQ   Lab Ref. Ranges  HCV Resistance

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Hello my old friends - I am still negative after Harvoni. smile My alt and ast have been rising a little, but at still within range (alt 51  ast 35) . Bilirubin normal.  What is the most telling test for the liver?  I forget......  been a while.  I hope everyone is fine



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John   non-responder  

Undetected at week 2 on solvaldi/rib/interferon:  stayed through week 12 but virus came back as soon as I stopped.  on   Harvoni and ribravirin 24 weeks undetected after two. 8/2/15  12 week EOT  UNDETECTED!  SVR

1991-2015 RIP

 

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