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Hep C Discussion Forum -> General Discussion -> Cirrhosis in HepC - ( more, on grading) "testing"
Post Info TOPIC: Cirrhosis in HepC - ( more, on grading) "testing"
Canuck


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RE: Cirrhosis in HepC - ( more, on grading) "testing"
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LM,

In the abstract article I shared, these were some of the "tools" they were assessing:

... "Sixteen tests [13 blood tests, LSM (Fibroscan), 2 combined: FibroMeters] were evaluated" ... 

They further listed them, referred to in "categories", and/or, were specifically named:  ,,,"Fibrometer(s), Fibrotest(s), Cirrhometer(s), and then LSM (fibroscan), Hepascore and AST/Platelet Ratio Index (Apri)" ...

Sigh, there ARE so many "tools"!  

I wouldn't try to go too deep into the learning, unless you want to, there is just so much! - just be glad if they do further offer you, additionally, ultrasounds and fibroscans.

The "conclusion" (in that abstract): ..."Some tests developed in CHC outperformed other tests in their specific etiologies. Tests combining blood markers and LSM outperformed single tests, validating recent guidelines and extending them to main etiologies. Noninvasive fibrosis evaluation can thus be simplified in the main etiologies by using a unique test: either LSM alone, especially in ALD, or preferably combined to blood markers" ...

I only posted the abstract article, in re-iteration of many previous  "like" posts and past articles where everyone hashes over what is "best", simply to highlight that a variety of tests (combined) offers more information.

See Mallani's post: (you will see many of these tests listed there too) -  Cirrhosis in HepC. Do we need a better Grading system?

 

 



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 64 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)
Tig


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Hi Lindsay,

Here is a link to some additional information that will help. You may have to register if asked, but it's free and we refer to Healio articles all the time. It will be helpful going forward.

Fibrosis



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Tig

68yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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Lindsmatt52


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C-Can you decipher this and put it into layman's terms for those of us not as enlightened in Hep C speak as you and Tig are?  I'm not sure I understand which tests they're referring to?



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64 y/o female, no idea how HEP C contracted

diag. 6/2017, GT 1a, VL 7.64 mil

Fibrotest-.41 (F1-F2) ; Actitest/Metavir 0.18; Apri: 0.266

Mutations detected: Q30H/Y, H58Q

Alt-33;  Ast-28

4 week:  VL<15; ALT-7 AST-11: 8 week: VL-UND, ALT-9, AST- 9

 Epclusa SOT 8-31-17; EOT 11-22-17

Lindsay
Tig


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We coulda told them that a long time ago and saved them a bunch of research money! They could've got us all on that cruise ship and we would've had a short seminar the first day and had the rest of the week to party. 

If they would only check with us first.... >>>Shrugs<<<   wink



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Tig

68yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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Canuck


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Published in Gastroenterology - Journal Scan / Research · August 21, 2017

 

A Combined Blood Marker and Elastography Test Found to Be More Accurate Than Other Tests for Fibrosis

 

TAKE-HOME MESSAGE

·    Because of a recent recommendation to combine a blood test and liver stiffness measurement to gauge liver fibrosis in patients with chronic HCV and nonalcoholic fatty liver disease (NAFLD), the accuracy of 16 tests (13 blood tests, a liver stiffness test, and 2 combined tests) were compared. Patients with chronic HCV (n = 698), HBV (n = 152), HIV and HCV (n = 628), NAFLD (n = 225), and alcoholic liver disease (ALD; n = 265) were assessed. For ALD, liver stiffness measurement was the most accurate; but, for most etiologies, excluding ALD, combined FibroMeters outperformed.

·     Tests that combined blood marker and liver stiffness measurement were more accurate than single tests and should be performed per recent recommendations.

 

 



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 64 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)
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