Hep C Discussion Forum

Congratulations, Mac! You went through a lot during that period of time and we’re all thrilled that you were finally able to kill that Dragon. After the first relapse, you were justly concerned about the effectiveness of future regimens, but we knew you’d be successful when you got your hands on Vosevi. Enjoy all that SVR will bring!

I would like to say thank you for all who were helping me to be healthy especially when I was in doubt. Whrn I had to take one more longer the Vosevi as I was not completely clear on week eight while on treatment. 

Here my results: 18June 2019 AST 27.1, ALT 19.5, bili 11.9, phosphatase 68, GGT 24. UND

It is 23 weeks after the end of treatment - I was not waiting the week longer as I wanted to have holidays. Your help especially Cannuck and Tig was great, And I would like to thank you with all my heart for this and I wish you all the good health.

Finally I drunk a small glass of wine. By the way is there any alcohol that is healthy?

The Vosevi is incredible.

Hey Mak!  

Happy SVR

Huge Congrats.

Nice to finally see you here at this Happy Day.  : )

Sincere congratulations, Mak.  You DID make it!

I’m loving what I’m reading, Mak! Congrats my friend, I know you had doubts along the way, but for me, it was never in doubt. You struggled and so did we, trying to get your fears quelled. It was quite a long ordeal for you, including all of the travel to accomplish this goal, but you did it! 

Time to do the Happy Dance! SVR12 it is

Mcmakin - whoo hoo!! Who would've thought the word UNDETECTED would mean so much?

mcmaklin wrote:

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Hello dear Friends , news from today: 

12 march 2019 which is day 70 after EOT, UNDETECTED, ALT 22, AST 31, Phosphatase 65, GGT 29, Bili 16.9

I hope I am cured.

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  right on mak!! you did it! 

The reference I used compared the rates of success between SVR4 and SVR12. As an example of what I’m trying to relay, if a patient achieved SVR4, the chance that they wouldn’t achieve the same result at week 12, was separated by one or two tenths of a percent. They have essentially proven that if you’re going to relapse after treatment, it’s going to happen during the first 4 weeks following EOT. You’re well beyond that at 10 weeks. Relax and enjoy the sun shining on your success!

Congrats again! While 70 days only amounts to 10 weeks, you should know, the probability of SVR12 (rate of success) after an undetected EOT+4 viral load, is essentially equal. You’re cured, enjoy the good things to come. Starting with a Hep C free liver...

Hey Mak,

Congratulations! I’ll go out on an educated limb and tell you, I have not heard of anyone relapsing after an undetected EOT+4 viral load. Every single one has gone on to SVR! To make it official, you need to have the +12 week testing, but I already know what it’ll be, 0. It has been a long journey for you. What do you plan to do with all your free time? I suggest enjoying your new Hep C free life! Good luck...

Congrats Mak on your lovely UND at EOT+7weeks.  : )

Your question? (... about the timing of your next VL according to your UK doctor? ... he says you are to have your last VL in March? ... and you are questioning this ...) - I am surmising that if your "standard" 12 week vosevi treatment had ended the first week of Dec (as it normally would have, if you had been like everyone else who was on a standard 12 week vosevi treatment), then your SVR12 VL date (in that case) would have been due around Feb 27.

But being that you elected to extend your treatment to 16 weeks (you added 4 weeks of vosevi) then your EOT date was about Jan 5, in that case, your SVR12 date would be due around the end of March.  

So, if your UK doc wants a SVR12 VL and LFT's at end of March - good!

Ask him about ongoing LFT and VL testing, perhaps at the EOT+6 month mark (SVR24), and ask what they plan on doing for you as far as imaging and follow-up going forward.

I am going to be looking forward to your (soon!) next SVR12 UND at the end of March! : ) 

Yes, i couls not wait so long so I dis the test. My official test will be at the ene of March, they could offer only one, they were calling me. So it seems that there will be no more official- should it be?

Hi Mak,

Glad to hear from you.

Gee whiz, seems like you just finished having bloods done (for EOT+4 weeks on Feb 5) and then these labs are only 20 days later? ... so, that makes this draw for aprox EOT+7 weeks?

Tig is right about LFT fluctuations, we can all do that (have fluctuations). Some people never seem to get to see any fluctuations as they don't get their bloods drawn much, others seem to always test out at about the same levels with not much variation, for others levels will vary a little, from draw to draw.

Your bili's have always bounced back and forth between 11/12 and 16's and 20's - so for you it seems it simply doesn't mean much for your bili to vary this small amount - now, had your bili skyrocketed to very high levels, way above normal limits and stayed that way, that might be more indicative of maybe something going on with your gall bladder function.

I wondered if you were going to have more blood tests done (between EOT+4 weeks and your SVR12), now we know, that you decided to get yourself a EOT+7 week draw done - and I am positive we are going to get to see another lovely UND to go along with these LFT's for you.

For the moment (since EOT) of course your main interest has centered around on seeing good labs and witnessing your lovely UNDs, but after SVR12, what do your doc(s) have planned for you - will you be getting follow-up U/S imaging - when?

Tell us what all you have been up to, how you are feeling, what your Mom and Sis have to say about your cure. I bet you are all happy to be seeing these long awaited good and better days! C.

, im sure the news will be good mak. it is tough waiting for the results tho.

Mak,

Hey, good! Now we are doubly sure you are indeed UND and your labs are to the good at EOT+4 weeks!  : )

Glad your hurt back didn't require anything more than some TLC and some over the counter pain control - hope it gets better/stays better fast.

While you recover from all this stress of being on the meds and getting yourself cured, please do still try to take very good care of yourself, eat well, sleep well, keep drinking lots of water, get some gentle exercise and fresh air, I like the idea that your doc gave you a dose of vitamin B (obviously he thought that would be good for you). 

It won't be long now and you'll fairly soon have your SVR12!

So between these labs, at EOT+4 weeks and SVR12, are you going to have any more labs drawn, while you are waiting until the SVR12 ones get done?

I bet your Mom and Sis are happy for you. Are you feeling some more relief now with these EOT+4 week lab results? Less worry? C.

Oh dear. Too bad about your hurt/sore back Mak.

It's hard to say what the doc might want to suggest to do for it.

Maybe he will just recommend some over the counter medicine for discomfort or for inflammation, depending on what the problem is with your back.

Maybe you just pulled or strained something??

As long as he know how well your liver is functioning, then he would know if he would have to avoid any drugs for you - I highly doubt (with your good Fscores and LFT's that any doc would be worried that you could not be treated with drugs for something as simple as a back strain? 

I hope your back thing is not serious and is short-lived.  C.  

Hello - what is safe to do after treatment? Yesterday I bent to pick up things and something ached in my back. Unfortunately probably there will be an injection at a doctor. Is there anything he should not inject or medicines that could interfere with waiting for the SVR? Urgent. Thank you.

If you had a viral load test, 4 weeks following the End of Treatment and it was undetected, that’s great! It means you’re on your way to success. An EOT +4 week undetected viral load is a sign of good things to come. Hang in there!

Mac,

If you’re undetected following a week +4 PCR, you should start dancing! The rate of success is comparable to week +12. I‘m confident you’ll continue on to SVR.

Yes, thank you I was very stressed. How big are my chances to achieve the VSR? Are the growing up now?

28 days after EOT (I do labs on Tuesday to not wait all weekend) HCV RNA sequence not found 

Hello,

I did a VL test today (today because they need up to 3 days for the result). And the liver panel.

For now I have: AST 30, ALT 23,6, Bilirubin 16,40   Phosphatase 74,  GGT 30

It is 28 days after EOT

Mak, 

That was just one quite small study, a good one, but not too many participants really - but still ... I found it informative then (and now). Also their data showing how quickly people dropped logs, and the division of participants who were CC CT or a TT, was all good info. All these studies are good learning, but do you really need to know that particular riba data once you are cured? Don't you recall us talking about the vosevi/riba study results before?

So, what did you think about my other queries to you (like what your sister had to say, and what you think you will end up doing with the epclusa)? C.

I wouldn't be wasting my time trying to think about riba (yuck), when you are already well-cured. I would instead be trying to devote some time and effort in rebuilding the rest of my health and recover from all this time of having hepc harming me, now being free of it!  But, to each his own - you do have the rest of your hepcfree life to study riba or RAV's if you wish.

Here is a link to an old phase 2 study that had "with and without" riba arms for TE GT1's (I am positive we have run this riba data by you before!), but you can read the whole of the study results for yourself to see what effect riba had when it was added to 12 weeks of vosevi or not, and whether this data answers your question for you. If you do not read the answer you seek in this data, then i would not know the answer either. 

NCT02536313  (open, then click on/see all of the "Study Results")

PS - You mentioned your Mom's reaction to your treatment results - does your sister know as well that you have finished your vosevi treatment? They must be very happy for you?

Later, C. (hm, just noted the data above does not show up here properly, so you WILL have to open it and read it all for yourself Mak. Also, my bad, in my prior post I MEANT to say TE (not cirrhotics).