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Post Info TOPIC: ALL ABOARD THE VOSEVI TRAIN


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RE: ALL ABOARD THE VOSEVI TRAIN
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RC-   I didn't totally follow all of Canuck's reasonings, but I do agree with her and Tig that you have an UNDETECTED and that is fabulous news!  Keep on doing what you're doing and I hope this will all be behind you soon!  You have a lot of people rooting for you and sending you positive vibes and prayers!



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64 y/o female, no idea how HEP C contracted

diag. 6/2017, GT 1a, VL 7.64 mil

Fibrotest-.41 (F1-F2) ; Actitest/Metavir 0.18; Apri: 0.266

Mutations detected: Q30H/Y, H58Q

Alt-33;  Ast-28

4 week:  VL<15; ALT-7 AST-11: 8 week: VL-UND, ALT-9, AST- 9

 Epclusa SOT 8-31-17; EOT 11-22-17

Lindsay

Tig


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That’s the thing with procuring the Indian generics, all you need is a prescription from your doctor. Insurance wouldn’t reimburse anyway and the cost, comparatively mind you, is negligible for the extra weeks. If required, I would certainly ask your doctors impression and approval. If they don’t think it’s wise, follow their sound advice. I’m with Canuck, you’re in mop up stage and this is perhaps completely unnecessary. We’ll work on that premise for now!



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Tig

67yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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I'm with Tig - you will get there, I am sure of this. (You already have, you are already und now!). 

 

As sure as the sun will rise, the earth will spin, and the stars come out at night! - your first und has happened!

http://49.media.tumblr.com/8cb9cf74762d03261ef29abd96e6c692/tumblr_nzt8u5weQe1u7gnm9o1_500.gif

 

I am glad YOU are going to bat for YOU (just as you have always done), keep doing it, and I am glad that your doc's are going to bat for you!

You certainly deserve the insurance and reassurance of another 4 weeks of vosevi. 

I somehow thought your extra 4 weeks (12 + 4 extra) 16 weeks of vosevi WAS already approved? So the first, and second, and now this current "peer to peer" third appeal by your doc is to get you a total of 16 weeks? Can you clarify that? If this is how it is, then I am betting your doc will get approval, with the peer to peer, to add 4 weeks to your 12.

It was unfortunate you had to add riba to your regime, if it could have been avoided, but every bit helps (for insurance, into all you have invested).

The current black and white "paper" recs do say riba is to be added to vosevi in some cases, they do not speak to lengthening vosevi beyond 12 weeks. I do understand your wish for 16 weeks of treatment, even though the 12 plus riba is what they offer, and, for all intents and purposes the 12 weeks of vosevi has already cured you (even before the riba was added).

But I like your plan thus far.

a) wise to add the riba at the 8th week (out of 12), just because.

b) continue with the docs appeal's to add 4 more weeks of vosevi to the 12 (16 weeks) until this avenue is exhausted

c) meanwhile, pre-arrange procuring (on your own) via Gileads assistance program, to make your course 16 weeks. IF THIS IS a viable option that you can make happen (as your back-up plan) - then I would pre-arrange for the 7000.00 option, if possible. That's the price you would have to pay  in order the gain this extra insurance and reassurance. You should not be having to pay out of pocket for this, but, if this is all there is, then ...

d) next best back-up plan would be the good idea indian epclusa (to make it 16 weeks) and add whatever 3/4A your doc dictates/approves of, but this would be time sensitive and approval sensitive also.

e) and, of course, now that you are on riba, you and your docs would also likely have to pre-arrange for you to continue being on riba (for when you succeed in getting the additional 4 weeks) - over the remaining balance of the 16 weeks.

You're on it RC, keep digging and pulling (as you always do) - you will fret regardless of the facts that you are showing every good positive indication that the vosevi has already done the job, very well, for you. 

What a wonderful relief it is to see your first UND RC! C.

 



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 64 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)

Tig


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First of all, DID YOU SAY, “UNDETECTED”?? We’ve got WOO-HOO’S happening all over this morning!! Big congratulations on this very good news, RC! Finally...

All of the denials and your constant battle to get what’s necessary is damn aggravating. You shouldn’t have to keep dealing with these issues, but I also know you’re not the type to take no for an answer. Just look how far you’ve gotten and you’re not done yet. Keep your head up and eyes on the prize. Just like always my friend!

I’ve got some people looking into your Vosevi supply chain, too. The Indian Pharmaceutical Machine is working steadily on its generic equivalent and getting close, but not close enough to meet your deadline. I have a question though. Ask your doctor if you could use Epclusa, there is a generic available for that. If the NS3/4a is required, could you substitute another, off label? There are others readily available. Now that you’re undetected and on that effectively evil drug, Ribavirin, Epclusa alone might be enough. You’re not cirrhotic now, that’s another consideration. Non cirrhotic GT 3’s don’t necessarily require Ribavirin. We all know your case is unique though. I’m just throwing things out there, maybe something will stick!

Greg Jeffreys has some info on the Epclusa generic. I’m waiting to hear back from Nirav on options as well. Don’t worry Brother, I know we (you) will get this figured out and we’ll all share a collective sigh of relief!

The Vosevi Train continues down the track, each day is one closer to the prize! You’ll get there, I have no doubt...

 

 



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Tig

67yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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Good morning all, Its Monday morning 5:00 am. I had to set another alarm for 5am&5pm to take my ribaviren, yep thats right I said Ribavirin. 1200mg a day split into two doses of 600mg each. This will be my third time treating with RIBA, but It will only be for 8 weeks. Dr said because of my past slow response to attain UND it is necessary.(still detected at week 6-7) It looks like 24 weeks of treatment aint gonna happen. Im having to fight my insurance company for the extra 4 weeks as it is! My Dr sent in the RX for the extra 4 weeks of Vosevi and they denied it,  He then appealed that denial and was denied again. So today he has a scheduled peer to peer phone call with insurance companys Doctor. My Dr will plead my case and we will see where it goes from there. The next level of action is a written appeal that goes to arbitration and that will be the final decision. This third level appeal takes some time and I may run out of it? As you all know I cant skip a day of my Vosevi. I have contacted Gileads patient assist program and with there help the 4 weeks of Vosevi will cost me $7000.00. I guess thats better than $29,000.00 for 4 more weeks!! I looked into the prospect of buying the drug from India  but was told by a reputable source that Vosevi is not available yet. It will be 7-8 months before it is manufactured over there in India. I should know in a day or two how the peer to peer turns out.

The trip over to Seattle a week before last was pretty uneventful. All my numbers look good for now. Lfts both low normal 12 and 23 . They ordered a ultrasound of abdomen and liver (done last week). It all looks ok to me however I havent discussed the results with my Dr. The tech who did the U/S said I have nothing to worry about. No liquid in abdomen . Turns out that the pressure im feeling is a result of belly fat! I have been sitting around for the last year and a half and developed what I want to call Thick skin!!!

So last week I had my 8 week blood draw and got the results Saturday. All the numbers look good, the white blood cells and neutrophils are low normal.They did a viral load and it came back undetected.(finally).  I really need the extra 4 weeks of treatment.That would give me 8 weeks of treatment  being in the undetectable Range. Thats the good news bad news of the last two weeks. Sorry I havent posted in a few days, I just dident have all the test results. Back soonRC



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 M-64) 3 Treatments)( SOF-RIBA 2014)(SOF-RIBA-PEG 2016)(HCC 2016) (LIVER TRANSPLANT 8-2017)(VOSEVI-RIBA 2017)   SVR-12. 3-13-18   

Tig


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I’m going to set off a flare and find out why the Vosevi Train is idling on the track! We seem to have lost our favorite passenger. Time for you check in Bro! Your fan club awaits... smile



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Tig

67yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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Hey RC-I miss your updates.  How are things going?



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64 y/o female, no idea how HEP C contracted

diag. 6/2017, GT 1a, VL 7.64 mil

Fibrotest-.41 (F1-F2) ; Actitest/Metavir 0.18; Apri: 0.266

Mutations detected: Q30H/Y, H58Q

Alt-33;  Ast-28

4 week:  VL<15; ALT-7 AST-11: 8 week: VL-UND, ALT-9, AST- 9

 Epclusa SOT 8-31-17; EOT 11-22-17

Lindsay



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RC,

All is quiet on the Western Washington front (at least it seems that way) ... how are you doing bro? smile C.



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HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 64 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



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Hey bro,

How did the long haul to the wet emerald green city go?

How did the visit/checkup with docs go? Do they do a basic physcial exam everytime? Weigh you. Disrobe you into one of those paper outfits, only to lie down in another nice crinkley sheet of paper, palpate your adb., call their co-horts in for shared lookie-loos, make you stand on one leg, I bet one of the few things that might NOT have changed since you have been going there is your height! But ya never know!

Do you drive over the day before, for doc appoint and stay overnight and then go back home the next day after your appointment?

I got a fill-in doctor my last "follow-up" appointment, nice guy, but same very quick appointment MO style, I gotta be clear, concise, prioritized with my burning questions and requests memorized (impossible for me!) I tend to prattle on whilst he just carries on doing his abbreviated version of a full physical exam which only distracts me further from trying to convey what I want to convey to him! It wasn't 'til hours and hours later, after my visit with him, that i twigged to something he did ... while I was prattling on and he was trying to get his "physical done", he asked me to extend my arms straight out and rotate my hands and wrists upward/skyward and then downward. I was thinking later, now, that's odd, to be doing that kind of neurological assessement on me, no nose touching, hand grip or eyeball/tongue movement components involved, no quizes on my tinnitus/double vision/fugue states, just the wrist rotation thing .... then, Duh!, it hit me ... dummy, it had nothing to do with any kind of neurological assessment, he was simply looking for needle tracks up and down my arms!!! How insulting - but true, this was the first time he had had me as a patient. They get lots of folk through their office where it would be wise, perhaps "standard" to be looking for needle tracks. But, really?!, bro-ther!! How dissappointing, when I had so many other things I wished to be addressed. Oh well, they have their wiley ways of ensuring they ARE doing their due diligence.

Did you get any relief or satisafction with this last visit? Hope so. C.



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 64 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)

Tig


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Yah, I don’t think I’d bet against that either! I have a feeling that Gilead and your doctors will be ahead of this before such a decision has to be made. None of you want anything but the right outcome and I’m confident that’s what you’ll get.

In the meantime, I’m putting a stamp or two on this and mailing it today. You can keep it for your trips to the Emerald madhouse!

BC14160D-15E4-4685-A10E-33A59E3A12E8.jpeg



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Tig

67yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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Hm, the 24 weeks vs 16 week bet isn't really one I am wanting to wager on, I figure my wager is ... on you going UND (right SOON)! That's a sure-fire better bet for me - saaaaaay, like ... how about a million bucks on that one, OK?

So ... IF you get an 8 week VL, and IF it is UND, and IF they say NO to 24 weeks in their infinite wisdom ... how are you going to feel about that?

UND is UND! - especially now that we are talking new DAA triples like vosevi (not the old stuff!), we are not talking peg or sof/riba/dacla here. Vosevi IS your magic.

Prior failures "set you up", and trials (such as like ALL you have been through) are unnerving. You are raw nerves - stay the course my man, you ARE doing it. I Know that these nerves are (really) nerves of steel that you possess. Jubilent days of relief are coming. 

You are doing a great job, it IS going the right way, this stuff IS unerving, but all your army is back on-line, and vosevi will NOT fail you. winkbiggrin C.



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 64 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



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Hellow All, I have blood draw tomorrow (wed) morning, then going over to Seattle on Thursday for clinic. Just the usual blood work this week, no V/L.  Tomorrow will be 7-1/4 weeks on Vosevi. Almost 1/2 through treatment. I think they will ask for a week 8 load test so next weeks bloods will be Interesting and important, and did I mention I will be asking for 8 more weeks of treatment, extending it out to 24 weeks. Im too far into this thing to just stop at 16 weeks then cross my fingers and hope it goes away! The POLARIS 5 TRIAL must be successful. I want to see 100% SVR ( 99% aint gonna do it!! )  Back in the day- (Just last year that is) relapses were recommended 24 weeks of re-treatment no matter what they used to treat. Seeing how this is my trial, I get to make the decisions around hear, so 24 it is!!! Ok everyone start placing your bets on weather or not I get my 24!!LoL!!  I havent driven my car in 10 weeks, we did not take it over to Seattle for the L/T. I would have been a complete mess worrying about door dings and city traffic. Over there you need a YUGO to get around in, smaller is better in this case,the parking is terrible, the streets ar soo narro. Even with a handicap permit you half to drive around looking for a spot. If I lived in the big city I wouldent even use a car.Thank god for UBER and LYFT. You could spend 20.00 bucks a day and get anyware you wanted to go in the city. Parking at the hotel is 30 bucks a night, what a rip off. as if the 300.00 nightly room charge isn't enough. Im starting to ramble so its time to check out.   RC



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 M-64) 3 Treatments)( SOF-RIBA 2014)(SOF-RIBA-PEG 2016)(HCC 2016) (LIVER TRANSPLANT 8-2017)(VOSEVI-RIBA 2017)   SVR-12. 3-13-18   

Tig


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Those are good responses from one injection! I took two per week for six months and my results were just above acceptable. I do believe you touched on why it's taking a while longer to achieve your first undetected VL. All of those anti rejection drugs attacking your immune system are most certainly responsible. Hence the reason for adding four more weeks of the good stuff. You will see the Dragon vanquished, but the response times had to be altered to compensate for everything else you've been going after. You'll get there, we all know it and I know you won't be satisfied until you're dancing on it's grave.

In the words of Capt Picard, "Make it So, Number One"... wink



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Tig

67yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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Hoping your tracks will be clear all the way to A Cure!



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Lamont Cranston "Only the Shadow knows."

70 years old, retired IT Network support 33 years continuous sobriety in AA, ,DX'd in '99 with MS, DX'd with HCV 2, 2b , F0-F1 3/17/2017 VL 5.7m Started EPCLUSA 7/28/17

No Virus Detected on November 20, 2017 3 months after EOT



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Nice to see how fast you are responding to the shot as well as the meds. Great progress!



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Wendy 53 y/o, DX 1994, geno 1A F1

1999 TX 1 - Inter -non responder 2001 TX 2 - Peg + Riba - viral load tripled and taken off

T3:  Harvoni 12 weeks Sept. 19, 2015 ALT 41 AST 30 VL 541800 UND at EOT and SVR 24 ALT 18 AST 26 platelets 223

 



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Good morning Canuck.    My one and only Nuprogen shot was Last Tuesday, so the results you comment on are 3 days after the shot. I was expecting several shots to get the numbers up, but it only took one!! The third bottle of VOSEVI arrives Monday via UPS. The pharmacy (BriovaRX)calls me and sets up the shipment about 12 days before I run out.I should be EOT mid December (16 weeks) Plenty of time to eradicate the foreign invaders. Yes im fireing  on all 8 cylinders, just having a little turbo lag at the start!! We will see what week 8 has to offer.  RC



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 M-64) 3 Treatments)( SOF-RIBA 2014)(SOF-RIBA-PEG 2016)(HCC 2016) (LIVER TRANSPLANT 8-2017)(VOSEVI-RIBA 2017)   SVR-12. 3-13-18   



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Well bro, looks like good news to me! I had to go through your posted labs with a fine tooth comb, and I am still confused, but things look pretty good to me. confuse

Obvious (easy) things to see, were glucose and BUN a tad up, HGB/HCT a tad down (but all of these were only by tads).

The other important bits, that are harder for me to suss, are what appear to be, within normal ranges WCB and neutrophils!

 

The lab report you posted below has the date of Friday, Oct 13 on it, and (if I have the timeline right), you only started your first sub q of neuprogen 4 days agao - so then, did it go like this??:

Day 1 of neuprogen - Weds Oct 11?  - you reported your neutrophils prior to starting neuprogen had been clocked at only .33? 

Day 2? of neuprogen - ?                   - you mentioned neutrophils had increased to still being too low at 1.26?

Day 3 of neuprogen - Friday, Oct 13? - shows (on your posted lab) neutrophils have already increased to be (technically) within normal limits at 2.46?

(If I have this right), then ... that's a very good and fast rebound, isn't it?

 

As far as I can see, you are back on-line, firing on all cylinders again, no?

Things should speed up again in the VL dept - only 70 to go! 

Kill, KILL. KIIIILLLL bro! smile C.

 



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 64 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



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Hi All. Well I have the results of week 5 and week 6 viral loads. I?m still not where I wanted to be by now. However on the bright side of things the Neupogen shot I got last week is working, my WBC is solidly in the middle and the Neutrophils are now in the low(very low) normals.  Week 5 V/L= 87 & Week 6 V/L= 70  (for anyone new to this) The VOSEVI stops the reproduction of the HCV VIRUS (several billion a day) so that your Immune systen can kill the virus. Thats a good scenario if your immune system is up and working. Mine is NOT working very well because of all the anti-rejection medicine I take post liver transplant. Im hoping that with the higher white blood cell count and the Neutrophils count coming up I can fight a little harder and get to UND soon. There for a couple weeks I really dident have a immune system to kill the virus. They have added 4 weeks to my treatment-  so 16 weeks total instead od 12 weeks. I am going to ask for 24 weeks and see what they say. I really expected to be undetected by now, but I dident take into consideration all the anti-everything meds I would be on, and how they would adversely effect my immune system. Im going to ask for a week 8 V/L and go from there.    RC



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Tig


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Yah Buddy! Time for a Polaris 5 update? We think so anyway! I trust you’ve got this under control. Everything has really improved, so I have to believe things have turned the corner. You have a persistent Dragon, always have, but we know this time is the end of the line for it. Whatever it takes...

You got this wink



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Tig

67yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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Hey RC,

So, 'bout 5 days ago, you were reporting the result of your 5 week VL being at "about" 87, and good you also said you will get a 6 week VL done as well, which is great, I don't have the exact timelines what these exact dates are, but ... when IS your 6 week VL to be drawn and when do you think you will get those results back?? You do seem to get these results back so fast!

I know you are having to go to the lab SO much, drat, so much jabbing being required, it is a lot, and tough, but all to the right end. Them, keeping tabs on ALL aspects of your army, and counting the inevitable viral casualities. And now, extra sub q drugs to boost your bloods! Fingers crossed, that all the good things we all want to see go up in your bloods, go up quick!, and that we see an ever-lowering VL for your 6 week VL result - it will happen, it's just a matter of when ... that und IS coming! Nice if would come now, but, it looks like you got a whole other 10 weeks to kill off a measely 80-some varmits. You are doing it!!! and we can all bet that UND IS gonna happen right soon! Oh that und is going to feel so good, after all this time, NO ONE deserves those 3 little letters more than you (and Chris) my dear.

You, on your first-ever "one-of-a-kind" (made-just-for-you) official/un-official Polaris "5" trial, ARE lucky to be getting so many VL's done - talk about a small number of subjects for a trial!!

I felt lucky too when Gilead followed me so closely during my trial. NOT counting pre-trial VL's or any of the many after EOT ones, I got 4 VL's during my 8 weeks of Vosevi - week 1, week 2, week 4 and week 8 (EOT).

Your bloods are on a whole dif scale tho, emcompassing your many more miracles happening! Worth every poke to see them blossom. biggrin C.

Sometimes being a pincushion is a goood look!

Image result for porcupine pin cushion

 



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HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 64 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)

Tig


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BIG WOOT!!

That's what I wanted to see this morning, yeah buddy! That has to be the largest Log reduction I've ever witnessed in my young (cough) life. It must be that fiber free, miracle liver saying the same thing, "Die Dragon, Die". If you have another VL at week 6, I already know the results will be a big fat zero. What a special day that will be, Brother! Nothing but success in your future....



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Tig

67yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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"100,000,000 to only 469 in 4 weeks"  That is amazing RC!    You've got this!  You are truly an inspiration to all of us!



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64 y/o female, no idea how HEP C contracted

diag. 6/2017, GT 1a, VL 7.64 mil

Fibrotest-.41 (F1-F2) ; Actitest/Metavir 0.18; Apri: 0.266

Mutations detected: Q30H/Y, H58Q

Alt-33;  Ast-28

4 week:  VL<15; ALT-7 AST-11: 8 week: VL-UND, ALT-9, AST- 9

 Epclusa SOT 8-31-17; EOT 11-22-17

Lindsay



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Now that`s what I call a GREAT result, RC!! 

Congrats on such a huge drop in vl in such a short space of time!  Especially after what your body and new liver have been through recently and are still adjusting to.  Really brilliant! 

You`re well on track and the tx is working its magic!  A super hero, yes, I second that!!  biggrin

 

 

 



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Jill 

(71 yo, lives in UK)

Was Gen 3a, 

24wks Peg Ifn/Riba, Sep 2010 - Mch 2011

UND @ Wk.4, UND @ EOT, 

SVR Nov 2011 --> Still UND @ EOT + 4 yrs.

 

 



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Jealous as RC's ALT/AST are lower than mine! I think we have a new super hero amongst us



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Wendy 53 y/o, DX 1994, geno 1A F1

1999 TX 1 - Inter -non responder 2001 TX 2 - Peg + Riba - viral load tripled and taken off

T3:  Harvoni 12 weeks Sept. 19, 2015 ALT 41 AST 30 VL 541800 UND at EOT and SVR 24 ALT 18 AST 26 platelets 223

 



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Huh, did I mis-read the memo?? SOUNDS like VERY GOOD news to me!! biggrin 

eh hem ... over a 100 millionVL? ... (might as well say a zillion!), ripped to shat to a mere 2580 maimed and wounded with 14 pills?, then only 469 left in their final death throes with 28 pills?, um, donja kinda think another 56 pills is gunna kinda be a bit "over"-kill? Your troops will have nothing left to do, right shortly. 

ppphhtt, you had 'er made with your first ALT/AST crashes!

Just remember bro, this IS magic stardust we are talkin' about here, and Gilead made it just for me and you.

hee hee "me!, stalking you!", hahahaha --- ya, OK, I admit it!, I am! I remember fondly when we first started chatting back and forth here ... (seems so long ago, AND yet, it feels just like yesterday! - there goes that weird time-warp thing again I guess!) ... you initially felt to need to assure me that you were not one of those "stalking" guys, I chuckled at the time ... touched that you felt the need to reassure me on that point. Gals can always tell when people are nice anyway - don't you guys know that? - just ask Chris - she'll have to explain it to you! I will also never forget how you stuck on your bravery badge and did not just "say", but PROMISED me, that everything was going to be OK, and I will never forget that, and I will always treasure you putting yourself on the line like that just to reassure and comfort me. (This is where I get to use up your thread thanking you and EVERYBODY who have become my good friends here and helped me in immeasurable ways. Indebted to you all forever!) Now, back to you, speeding along past the mileposts.

I am sure we all wish for everyone to be safe and well, how we wanted you to be well, and how you and chris wish the same for everyone else - but as far as you finally getting your GT3a absentee-card, and pulling the lucky new liver straw, it's too late, it's already a done deal! - you and "buddy" and Chris have already started your "new" lives!, and nothing that the rest of your friends here can take any credit for, except for our well wishes, prayers, freindship and every positive vibe we could muster up to send your way. It was all you and Chris, all the way, winning this race, and what an astounding job of it you have done. 

I made a promise to you too, a while back, that I would see you cured in my life-time - thank you for helping me to keep that promise and for allowing me to see this happen so soon!   

You remind me of this commercial. You and chris buckled up in those special rocket-type X across the cross the chest seat belts, replete with astronaut type helmets and ear protection, engine screaming, seeing the finish. Part of the beauty of this machine is that it can go from 100 to 0 mph in about 3 seconds flat, which is about the same amount of time you two will be needing to get that UND. biggrin C. (Gilead really should make better commercials!) Just pretend that's you and buddy and chris and vosevi in the red machine and that dumb ball is the last virus so easily outperformed. 

https://www.youtube.com/watch?v=EAUG6E1nVO0 

 

 

 



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 64 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



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496 after only 28 pills is really rather amazing RC.

Of course you'd wish for und but those low LFTs are holding steady and man oh man your body is going through a lot of readjustments and with all your anti rejection meds it's just a matter of time.  I'm glad the Drs are going to do a 6 week test.

Stay strong, keep your positive attitude smile

A



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61 y/o, Infected via transfusion Oct'83, GT-1a, F-4 cirrhotic,
tx Holkira pak/moderiba 12 weeks

4 years.... successful dragon slayer 



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Hi all, well I got the news on my Viral Load. at 4 weeks I'm at 469  It's a bummer but they said that was not out of the ordinary for a post transplant patient. I need to remember that I'm taking tons of anti-rejection medicine and thats knocked my immune system way down. Basically all of my virus fighting soldiers (immune system) have been cought off guard by the anti-rejection meds and are too weak to put up a good fight!!   HOWEVER  I can't discount the fact that I have gone from 100,0000000 to only 469 in 4 weeks, after 28 VOSEVI !!!     My sick soldiers won't quit, they will never give up.Kill,Kill,Kill. I'm digging in and prepared to take this as far as I need to.  The doctors are talking about doing a V/L at the 6 week mark. Does anyone remember the lesson we all have learned in the process of fighting HCV?  It's all about being patient.  It's a hurry up and wait game. LFT's are just about the same as the last blood draw, they are AST-15 & ALT-28    With LFT's like this and a low viral count~It's working,It's just going to take a little longer to get to UND   It was disappointing but I'm over it now.   RC



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Tig


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That's a great idea, Mike! I'll hold him down, you know where we have to stick that thruster, right? If RC gets the results before we can get set up, we might not catch him and Chris in that red hot rod of theirs! They'll be flying high and doing 175. We might need the turbo to catch them, ha, ha!! 

I hope you get those results today, RC. I need something to brighten my weekend. We're all keeping our fingers and toes crossed buddy! You got this, I just feel it....



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Tig

67yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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robertsamx wrote:

 Take a look at these LFT"s.     AST-12    ALT-19


 Time to inject you with some N2O and strap a turbo to your butt and break that new liver in the right way. LOL biggrin

Looking good RC!!!



__________________

60 yo, geno 1a, Dx 1994 HCV-HIV co-inf, Dx 2013 decompensated cirrhosis
Tx #1 - 24wks Sov+Riba /SOT 7-24-2014/UND@EOT/DETECTED@EOT+16 wks
Tx #2 - 24wks Harvoni /SOT 7-25-2015/UND@EOT,+12,+24,+52 = SVR

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I may get the V/L results today, if not it will be Monday.  Makes for a long weekend waiting!

Rc



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Tig


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That does look pretty good! I’m waiting for that great big UND to finish off that beautiful picture! 



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67yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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Hi C.   That all looks right.  I will go back and take a look and post what I Have but I think you have done a great job in grafting my numbers.   They look so good the way you have it grafted! Thank you for doing that.  It looks like you may have a peachey folder on me with all my stats. Do I need to worry? Are you stalking me :)  Some how and some day Ragdoll and I are going to jump into our little red hot rod and pay a visit to Canada, down to Florida, and we are stoping by Texas too!!  That is truley on my bucket list.    Rbertsamx.  RC



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So, your 12 weeks of Vosevi is:  SOT Aug 29, 2017 EOT Nov 11, 2017 (lest we forget!)

Week 4 was Sep 26?

Pre-treatment: VL - Over 100 million!  ALT - 348  AST - 151

 ?                                                      ALT - 160  AST -  19

Week 2?:         VL - 2580                    ALT -   31  AST -  16

?                                                       ALT -   28  AST -  15

Week 4?:         VL -                            ALT -   19   AST -  12

 

AS-TOUND-ING!!!!

 

 



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 64 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)

Tig


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Hey RC,

Brother! Those are fabulous LFT's! You can be completely proud of those and you know, it tells me everything I need to conclude that Vosevi is the magical silver bullet you've been waiting for. Of course that shiny new liver has helped some too, lol! With numbers like that, you should be well aware of the good things going on throughout the Kingdom of Dead Dragons. Treatment is clearly working, congratulations my friend. I fully anticipate the undetected viral load you have been waiting for. We are all excited and look forward to the good news.

One more thing. I'm glad your Sentinel Tree wasn't in my yard two weeks ago. Had it been, you'd be warming up to it in your wood stove this winter! Glad to hear you're back home and things are getting back on track. Nothing better than the comfort of your own recliner. Something about your own Gluteus Maximus returning to it's rightful place on your own throne makes all things better.... Welcome home Bro!

Hi Chris 



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Tig

67yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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Wow!  That is wonderful news, RC!  Those LFT's are phenomenal.  Congrats!!biggrin



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64 y/o female, no idea how HEP C contracted

diag. 6/2017, GT 1a, VL 7.64 mil

Fibrotest-.41 (F1-F2) ; Actitest/Metavir 0.18; Apri: 0.266

Mutations detected: Q30H/Y, H58Q

Alt-33;  Ast-28

4 week:  VL<15; ALT-7 AST-11: 8 week: VL-UND, ALT-9, AST- 9

 Epclusa SOT 8-31-17; EOT 11-22-17

Lindsay



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Hi all-  Just got the results from the 9-20-17 blood work. Everything is in order!! Take a look at these LFT"s.     AST-12    ALT-19    I had blood draw this morning to check VIRAL LOAD- I expect it to come back UND. I will know on Friday.  Can't wait.     RC



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Such good news, RC, it must feel wonderful for you both to be back in your own home at last!!

Sounds like everything`s going so well for you now, just take it easy and let your body heal.  Once you`re through this you`ll be able to do all the heavy lifting you want!  Lol

Good luck with your results, I`m expecting a big fat UND too!!  smile



__________________

Jill 

(71 yo, lives in UK)

Was Gen 3a, 

24wks Peg Ifn/Riba, Sep 2010 - Mch 2011

UND @ Wk.4, UND @ EOT, 

SVR Nov 2011 --> Still UND @ EOT + 4 yrs.

 

 



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Robert,

i am so very happy to hear that you, your beloved and your shiny new liver are all home.

thank you for sharing your amazing journey with us.

A



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61 y/o, Infected via transfusion Oct'83, GT-1a, F-4 cirrhotic,
tx Holkira pak/moderiba 12 weeks

4 years.... successful dragon slayer 



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Hee hee (your wish for a 6 pak, unadultered or other wise), never mind, you have PLENTY of time to work on the 6 pak again in FUTURE!!!!!!!

aw, kitty sure must have missed you guys, don't they have a way of making us feel soooo guilty, playing with our heartstrings so.

The tree stood in silent heroic salute to you, as you passed by.

Oh good, pics in full Arlo style glossy 8x10 techni-color? I hope so - I am still miffed you edited out the best of the gory foot ones, and, I really wanted to see your GB and sludge in a jar too! Oh well, steady hands, don't send us any weenie selfies tho eh.

Oh contraire Mister, you are NOT just sittin' around, YOU have thee most important jobs to perform right now, you are supposed to getting rest, obeying, recovering, and killing them varmit viruses. 

Do as Arlo inspired - kill!  ; ) C.  https://www.youtube.com/watch?v=m57gzA2JCcM

 



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 64 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



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RE: ALL ABOARD THE VOSEVI TRAINRC
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Thanks C.  And yes we did pass the tree. Its a old tree and looks like it has taken a lighting strike or two but its still standing! Rocky slept on the bed all knight and wouldent leave us alone. He slept at the top of the bed on Chris's pillow.He kept a paw on her the hole night! It is nice to be home. Its hard just sitting around,I cant lift anything over 5 pound,cant risk a abdominal hernia. They cut through your six pak to get to your liver. (Like I had a six pak)-I could put up a picture of the incision , i will try to crop a pic that just shows the incision. RC



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Nice. Did you pass by your sentinal tree homeward bound? You both must be so happy to be back now, and Rocky will be so happy to have you two back again.

What a momentous day (of the many momentous days you are having) - home again! : ) C.

Ya, I keep hoping we wll hear some good news from "Dax" soon, somebody to keep you company (aside from all us in the crowd) and for us to be able to have someone else to compare our Vosevi notes with!

Just rest comfy there in your chair for a bit dear.



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HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 64 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



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We made it home today. Rolled in at 7:00 P.M.     Its nice to be home.    My recliner feels soooo Good! Nothing new to report. I will have blood work done locally, on the 26th I do a V/L and should get the results by next Friday . I'm expecting UND!!

I hope someone else jumps on this train pretty soon.          RC



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we have talked about the poppy field in one thread and RC with his new liver, we could rewrite The Wizard of Oz! But for RC right now...

 



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Wendy 53 y/o, DX 1994, geno 1A F1

1999 TX 1 - Inter -non responder 2001 TX 2 - Peg + Riba - viral load tripled and taken off

T3:  Harvoni 12 weeks Sept. 19, 2015 ALT 41 AST 30 VL 541800 UND at EOT and SVR 24 ALT 18 AST 26 platelets 223

 



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Home! No sweeter sounding words.

I love your re-view back back (AND forward)!, 37 years is a lonnnng time, dealt with SO well and bravely (and you still are), we all know this is not easy. If anyone deserved this successful second chance, it was you RC. You will carry/own/adopt this lovely gift from your young man so well, and with the utmost love/respect he and you both so deserve. We can all relate to your need to reach out to his family.

Can't wait to hear your next 4 week VL, no matter what the number, we know it is all good.

SO MUCH good news - that, in itself, must be just boggling for you and Ragdoll to fathom, handle and sort. : ) C.



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 64 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



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OMG! I am speechless...5 weeks! You are the bar I have to shoot for.. I am so glad to hear all the positive comments about your experience. I know (not really) it is not a walk in the park but you have made it real and doable. I hope you keep us posted on your progress and glad you have such a dedicated support person to see you thru this.

Boxers



__________________

65 yo female

dx. 1996

TX with interferon/riba 2001..failed

Uncompromised 2015

TX with Harvoni  2015..virus undet.

Meld 14 7/2017  TIPS 1/2017

 

TP 5/12/18 



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What spectacular news, RC!  Those results are splendiferous!!!  And you get to go home!  Congratulations!



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64 y/o female, no idea how HEP C contracted

diag. 6/2017, GT 1a, VL 7.64 mil

Fibrotest-.41 (F1-F2) ; Actitest/Metavir 0.18; Apri: 0.266

Mutations detected: Q30H/Y, H58Q

Alt-33;  Ast-28

4 week:  VL<15; ALT-7 AST-11: 8 week: VL-UND, ALT-9, AST- 9

 Epclusa SOT 8-31-17; EOT 11-22-17

Lindsay



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OK-Nothing but good things to report!!    My LFT"s.  AST-15.    ALT-28.  The Doctor said those were the numbers of a 15 year old kid!!!!!!!      My doner was between 14 and 24-Thats all they would telll me about the new liver, however they slipped and mentioned it was from Alaska and male.  I will write the doner family soon. All my labs are great,and they are cutting me loose- We get to go home. I will have lab work done at home and come back to Seattle at the two month's post for clinic, then at the three month post,  V/L next week on the 26th,then who knows?

I'm feeling stronger every day. What an experience this has been. Life changing for sure!

IM GOING HOME !!     RC



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robertsamx wrote:

The future looks bright to me!!    RC


 Me too RC. I'm looking for my sunglasses reading this. And I'm so happy for you. You certainly deserve it after the fight you've fought to get here. Enjoy - life is good!!! 



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60 yo, geno 1a, Dx 1994 HCV-HIV co-inf, Dx 2013 decompensated cirrhosis
Tx #1 - 24wks Sov+Riba /SOT 7-24-2014/UND@EOT/DETECTED@EOT+16 wks
Tx #2 - 24wks Harvoni /SOT 7-25-2015/UND@EOT,+12,+24,+52 = SVR

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A new man! : )  C.



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HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 64 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



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you have been reborn! That is amazing RC. 



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Wendy 53 y/o, DX 1994, geno 1A F1

1999 TX 1 - Inter -non responder 2001 TX 2 - Peg + Riba - viral load tripled and taken off

T3:  Harvoni 12 weeks Sept. 19, 2015 ALT 41 AST 30 VL 541800 UND at EOT and SVR 24 ALT 18 AST 26 platelets 223

 

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