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Post Info TOPIC: ALL ABOARD THE VOSEVI TRAIN


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RE: ALL ABOARD THE VOSEVI TRAIN
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Stop it macmaklin!  You're going to be cured.

Please do so under medical care.  This is exact,  long term, and sophisticated science, so please don't self diagnose or self medicate.  I wan't you to get well and really don't think you should second guess it until after SRV12.  Although, EOT UND is a fantastic sign, the docs like to see that no stragglers found their way through after taking the meds.

There are very few cases UND at SVR12 these days.  Consider yourself a success rather than a failure.  

I don't mean to be harsh, just clear.  I do understand how worrisome this process can be and I'm sorry you have to got through it.  But, go through it anyway.  It's the way out.

Best to you, mcmaklin.

Cheddy



__________________

GT2a, VL 681,500, Less than F1, Treatment Naive

12 wks Sovaldi/Ribavirin, SOT 2/25/16, EOT 5/17/16

UND at 2,4,8 and 12 wks during treatment but ribavirin crazy.

ALT/AST normal EOT

SVR12 8/13/2016!!!!!!!!!  I WON!!

EOT 6 Months 11/12/2016  CURED

 



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hello, thank you - this was just recommandation to test the virus again in later time. I was talking to the person who operates machine for those tests. She told me that before if they write it is 12 it was just 12, if they write less it is less than 12 but when the machine shows UND they double check a curve again the next day.Maybe they wrote recommendation because I was talkin before they gave me those result I would not worry here. Another lab test not another laboratory.

if I cannot do things officially I am slowly thinking- I hope to be UND soon, if it will be a late UND I am thinking about buying myself Velpatasvir + sofosbuvir from India and make my treatment longer. 

how many cases there were who were not UND till the end of treatment and what would it mean? 



-- Edited by mcmaklin on Saturday 27th of October 2018 05:41:34 AM



-- Edited by mcmaklin on Saturday 27th of October 2018 05:42:26 AM



-- Edited by mcmaklin on Saturday 27th of October 2018 05:44:43 AM

__________________

2nd Vosevi12wks- SOT Sept 12,2018 to EOTDec 5, 2018. Pre-trtmnt - VL 1.4 mil, ALT 45, AST __, ALP 69, GGT 90. 2 week - VL 49, ALT 26, AST __, GGT 53. 4 week-VL <15, GGT42 other normal, 5week: ALT 17,AST 27, Bili 11.8, ALP 68,GGT 36,15X VL12., 6week ALT 19,AST 26,Bili 16,20,GGT35, VL<12,8W UND



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Canuck, Might the mean another lab test and not another laboratory?

mcmaklin,  Those labs look pretty good to me.  Again, the purpose of these labs is to see if the treatment is working right now and to make sure you are going in the right direction. It does not tell you what it will say in the future.  EOT and SVR 12 results come later

Moving from 12,00 to <12 is does mean that it is going down. Again, you simply don't have all the information yet.  It's too early.  Take the encouragement. Make sure your medical team answers what they can, and keep asking questions.  You'll find lots of answers here.

Look up. Peace out. And wait.  Gruelling, isn't it?



__________________

GT2a, VL 681,500, Less than F1, Treatment Naive

12 wks Sovaldi/Ribavirin, SOT 2/25/16, EOT 5/17/16

UND at 2,4,8 and 12 wks during treatment but ribavirin crazy.

ALT/AST normal EOT

SVR12 8/13/2016!!!!!!!!!  I WON!!

EOT 6 Months 11/12/2016  CURED

 



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Ah, good. Thanks for doing that (writing it out "in full") ...

You wrote ... 

      "22 Oct 2018: HCV method PCR, quantitative  <12 IU/ml

     (found presence of target RNA sequencies of hepC virus. Range of method 12-100 000 000 IU/ml)

     Recommanded another lab from a different sample to confirm or exclude the presence of the virus" ...

 

The words (in red above,) "found presence", I would interpret "found presence" to mean the same as "Detected". Too low to measure/count any VL and this is why they would be saying "less than 12", but still, the evidence/presence of virus can still be detected.

I am guessing you are still not UND yet, going by this language in your report, but being detected into your 6th week is not critical - did you not read the posts we sent to you in the past 4 or 5 days about how people can remain detected long into their treatment and still end up perfectly cured?? You do not comment on this old post info to you.

That is an odd comment the lab added to your Oct 22 test - that you should go to another lab?? That's weird, I've never seen that written on a lab report before, and there are the spelling errors, unless those are just yours.

Your 8 week VL will soon be done. All still looks excellent. Nice crashed VL and LFT's. You are on target, even if you would wish to be UND earlier. C.

 

 



-- Edited by Canuck on Friday 26th of October 2018 11:12:08 PM

__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 64 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



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Additional labs are because I am doing it privately in a different EU country, not in English. I did it at week 5 and 6.  But they are of course up to highest standards.  So I can only translate it word by word. My next  official Labs are at week 8.

SO here it is:

15 Oct 2018: HCV method PCR, quantitative:  12,00 IU/ml

(found presence of target RNA sequencies of hepC virus. Range of method 12-100 000 000 IU/ml)

Made REAL-Time PCR method on m2000rt manufactured by Abbott.

Snesivity of the method around 95% in the range of method.

Made accroding do precedure IB/LAB/905 (vesrion V from 2016-10-21)

 

then

22 Oct 2018: HCV method PCR, quantitative  <12 IU/ml

(found presence of target RNA sequencies of hepC virus. Range of method 12-100 000 000 IU/ml)

Recommanded another lab from a different sample to confirm or exclude the presence of the virus

 

I am not saying what is my doctor saying because they do not say anything until my official 8 week labs



-- Edited by mcmaklin on Friday 26th of October 2018 08:50:03 AM

__________________

2nd Vosevi12wks- SOT Sept 12,2018 to EOTDec 5, 2018. Pre-trtmnt - VL 1.4 mil, ALT 45, AST __, ALP 69, GGT 90. 2 week - VL 49, ALT 26, AST __, GGT 53. 4 week-VL <15, GGT42 other normal, 5week: ALT 17,AST 27, Bili 11.8, ALP 68,GGT 36,15X VL12., 6week ALT 19,AST 26,Bili 16,20,GGT35, VL<12,8W UND



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Mac,

If you will please, (if you have the actual PCR lab report - in print - right there in front of you?) can you please type out (in full) what it says on your lab report "word for word" - and copy that to here so we can read the WHOLE of your lab report for ourselves with NO words left out. 

It is important to know these details, and, like we mentioned before, it is significant if the labs wording says "detected" or "not detected". 

Seeing the lab report in it's totality is better, so that we know that any important words are not being left out. C.

PS - I thought your next VL and LFT's was planned to be done at eight weeks? Why at 6 weeks? Without knowing exactly what "words" are on your VL report, I would only be guessing that this last lab was a similar result to the one you had last week. A VL number that is showing you have had a profoundly positive response to the Vosevi.



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 64 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



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Hello, I did another test this Monday 22 of Oct. Which is week 6. This Tuesday was a middle of my treatment. Is it normal?

Here are the results  <12 Iu/ml

Other results: 

phosphatase 65,

Bilirubin total 16,20

AST 26

ALT 19

GTP 35

 

By the way after taking Vitamin D level of vitamin was 16,20 ng/ml which is still low but better



__________________

2nd Vosevi12wks- SOT Sept 12,2018 to EOTDec 5, 2018. Pre-trtmnt - VL 1.4 mil, ALT 45, AST __, ALP 69, GGT 90. 2 week - VL 49, ALT 26, AST __, GGT 53. 4 week-VL <15, GGT42 other normal, 5week: ALT 17,AST 27, Bili 11.8, ALP 68,GGT 36,15X VL12., 6week ALT 19,AST 26,Bili 16,20,GGT35, VL<12,8W UND



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Sorry Mak, that this is so worrisome.  I understand.  It's quite difficult not to worry, but listen to the information below.  If and when you can stop the "what ifs" our minds seem to like to generate, you will have an easier time slugging through all of this.

There is room for great optimism.  We have cures these days!  Wow! That means you can get better all around with this virus out of your system  It seems like such a long haul, but you will be looking back on this.  It gets increasingly shorter looking at it in the rear view mirror.  

Try not to overthink it if you can.  You simply don't have enough information yet.  It's too early!!!  You'll see.

 



__________________

GT2a, VL 681,500, Less than F1, Treatment Naive

12 wks Sovaldi/Ribavirin, SOT 2/25/16, EOT 5/17/16

UND at 2,4,8 and 12 wks during treatment but ribavirin crazy.

ALT/AST normal EOT

SVR12 8/13/2016!!!!!!!!!  I WON!!

EOT 6 Months 11/12/2016  CURED

 



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Mak,

The other important bit to take note of is "early crashing", which is exactly just what you and me and everyone mostly do on these new DAA's.

Early crashing - a pronounced drop in LFT's and VL, often by week 4 of treatment - is a notable indicator of a successful/robust response to the DAA's, and you have already done this, shown a robust response. 

Less important is what particular day you go UND - that alone does not spell success. What is important about UND is that you sustain it, thus why SVR 12 is the official milestone.

It would be impossibly time-consuming for me to sift through every member hx to find you people who did not go UND exactly at 4 weeks! But they are there, and like I say, when you go UND is not critical, it is the sustaining of your UND (sustaining your virological response -  your SVR) is what most constitutes success

Tig has already mentioned to you someone who was detected at EOT and still became cured. RC was slow to become UND, I think he was not UND until his 9th week. "RainyJ" on Epclusa was detected at week 4, then was UND at week 5. "Lindsmatt52" on Epclusa was detected at week 4, became UND at week 8. "coolheat" on Harvoni was detected at EOT and then was UND at EOT+12 weeks. "Sydhanrhan" on sof/dac/riba was slow to go UND until week 9. And there ARE more folk than these. But, like I say the "particular day" you go UND is not as important as showing a good early robust response to the DAA's (as evidenced by early LFT and/or VL's drops).

You have already shown a very excellent robust successful response to Vosevi.

Which day you go UND is not as important as showing a good response to the DAA.

I know you won't stop worrying, but do try - focus on all the irrefutably positive signs you are showing! C.

PS - you never did say what your docs are saying to you, what they think or say to you, how they think you are doing?

 



-- Edited by Canuck on Monday 22nd of October 2018 12:26:59 AM

__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 64 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



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mc, that's why we are on the meds for 8-16 weeks, to catch the hiders who are trying to replicate... they don't stand a chance tho cos the daa's are like birthcontrol for the replicating the virus... they have lost the ability to produce more virus even if they did survive or showed up during early tx.

 



-- Edited by 5-1-18 on Sunday 21st of October 2018 06:11:19 AM

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Gt:1a-36yrs .Started Intron-A in 96' for 2.5mo-VL still too high.taken off. Labs on 3.6.18:. A1 activity.  f3@60: fibrosur bloodtst. AFP=norm. enz=mostly norm.VL=3.9 million.sot=5.1.18>Harvoni>[8wks]: 4WEEKS=UND. Eot 6/25=L.J*13weeks=UND * 6 m =UND: CLUB ZERO.1yr.=0



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Thank you, just one think - i read many bios here of people taking Harvoni or Epclusa. Where there anyone who was not UND at week 4 and 5?



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2nd Vosevi12wks- SOT Sept 12,2018 to EOTDec 5, 2018. Pre-trtmnt - VL 1.4 mil, ALT 45, AST __, ALP 69, GGT 90. 2 week - VL 49, ALT 26, AST __, GGT 53. 4 week-VL <15, GGT42 other normal, 5week: ALT 17,AST 27, Bili 11.8, ALP 68,GGT 36,15X VL12., 6week ALT 19,AST 26,Bili 16,20,GGT35, VL<12,8W UND



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Mak,

The most important part of this to understand  - is whether you are "detected" or "undetected". Don't worry - you will soon be "undetected". 

All of your labs (from ALTs to VLs) are indicating you are responding beautifully to the Vosevi. Just wait - it will not be long before you are undetected.

Your "Abbott" PCR was only telling you they detected their lowest level (12 IU), similar to the other test (maybe a Roche-Tagman PCR) which was also telling you they could only detect their lowest level (less than 15). 2 different testing systems you have had done, one operates by only being able to go as low as 12 in detection, and the other operates by only being able to go as low as 15 IU.

Undetected is undetected, and it would not matter which test system you have it done by next (by the one with 15 as their lower limit, or the one using 12 as their lower limit ...  by either system ... UN-detected will be UN-detected. C.

 



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 64 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



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Thank you for all your heart. My question: why they have told me it was 12 Units not just impossible to count and less than 12? So were they able to count exactly 12 units? And before they told me it is was less then 15 and they were not able to count. Is it just the same?



-- Edited by mcmaklin on Saturday 20th of October 2018 11:59:58 AM

__________________

2nd Vosevi12wks- SOT Sept 12,2018 to EOTDec 5, 2018. Pre-trtmnt - VL 1.4 mil, ALT 45, AST __, ALP 69, GGT 90. 2 week - VL 49, ALT 26, AST __, GGT 53. 4 week-VL <15, GGT42 other normal, 5week: ALT 17,AST 27, Bili 11.8, ALP 68,GGT 36,15X VL12., 6week ALT 19,AST 26,Bili 16,20,GGT35, VL<12,8W UND



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Mak,

Regarding whether you are <15 or 12 (at either lab) ... this was what I had said to you about it earlier ....

One lab says <15, the other similarly says 12 detected - I am not surprised at this similarity between the two results, given that both these VL tests were done so close together.  15 may be the lowest level of detection (at the first lab) using their particular PCR equipment, and 12 may happen to be the lowest level of detection (at the other lab you used), because of the particular type of PCR equip they happen to use.

Because you have failed a prior treatment you are pre-primed with "fear of failure", thus no matter how pleased we are and no matter how pleased your docs must be with your very obvious stellar response to the Vosevi, you will likely continue to struggle with this fear. Accept it that you will just naturally have this fear, fears cannot always be conquered for convenience, or to help yourself get through things more easily. Often we just have to bite the bullet and do only what we are capable of doing, mustering all the courage and hope we can - I think you are doing a VERY good job in holding up - you are trying very hard, to be accurate and to comply with every nuance of your treatment, and you are going to succeed (this time)! You will have to just take our word for it, that we feel so confident FOR YOU, maybe a little of our sureness has rubbed off on you just a tiny bit - i think you are truly waaaaaay more hopeful than you are fearful. There is nothing to fear really (except for the fear itself), what you are doing right now (going through everything you are going through, good and bad) is an extremely positive and hopeful act, we cannot ask anything more of you and nor can you ask more of yourself - you ARE performing the ultimate act of positive action here - be proud of this work and struggle you are going through.

You had already clarified, quite a while back, that your doc had already planned on doing (additionally) an 8 week VL?, as well as a EOT VL? - so that will be a lot of VL's you will have had done through treatment!

Becoming und at 2 weeks, or 4 weeks or at 2 months is good, but it is not counting as an official cure, just very good news - like Tig points out, your "sustained" virological response is what officially counts ... your SVR12 (your und 12 weeks after treatment has finished is what counts). I suspect you would STILL worry about failure all throughout treatment until you see your und at SVR12! 

I hope you do not have to wait that long to be be feeling more confident that things ARE (indeed) going well! C.



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 64 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



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I am taking only D3 with K2 as I was indeed low on D vitamin. I will take for a week and test. I have asked my other doctor as I am not  that close from home, I have asked the one from clinical trials and on my previous treatment. Also I noticed that there ar no interactions between those vitamins and my drugs In the hepc interactions chart
by the way the one from Abott m200rt machine -counted 12 IU (the range of the method is 12-100 000 000 IU/ml)
Tig wrote:

You can still be <15 IU/ml and be detected. I know it's odd, but the PCR has a lowest level of quantification of 15. If there is still a few stragglers around, the test isn't sensitive enough to quantify them, but will still pick up the few stragglers remaining and categorize it as "<15 IU/ml - Detected" That's not uncommon, especially when they do the viral load early on. Many doctors don't test the viral load until the end of treatment, some even wait until EOT +12.

Mak, don't worry about it. Your viral load dropped to almost nothing and did it fast. You're responding exactly as you should be. I'm sure by now, you're undetected, considering how close the last test results were. You don't need to do these weekly or biweekly viral loads, they can be deceiving. You're doing fine. Wait until the end of treatment and 12 weeks after that. The EOT + 12 is the money shot, all the rest are just to confirm something is happening and it is. You don't need to be taking a bunch of supplements during treatment either. Some of them aren't recommended, so be sure you get permission from your doctor before taking anything while on treatment. If they said to take a bunch of vitamins, then follow their instructions. Don't just add stuff without checking first.

You're doing fine, don't overthink all of this.


 



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2nd Vosevi12wks- SOT Sept 12,2018 to EOTDec 5, 2018. Pre-trtmnt - VL 1.4 mil, ALT 45, AST __, ALP 69, GGT 90. 2 week - VL 49, ALT 26, AST __, GGT 53. 4 week-VL <15, GGT42 other normal, 5week: ALT 17,AST 27, Bili 11.8, ALP 68,GGT 36,15X VL12., 6week ALT 19,AST 26,Bili 16,20,GGT35, VL<12,8W UND



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I have 50 more pills to take  since Monday.



-- Edited by mcmaklin on Wednesday 17th of October 2018 03:37:53 PM

__________________

2nd Vosevi12wks- SOT Sept 12,2018 to EOTDec 5, 2018. Pre-trtmnt - VL 1.4 mil, ALT 45, AST __, ALP 69, GGT 90. 2 week - VL 49, ALT 26, AST __, GGT 53. 4 week-VL <15, GGT42 other normal, 5week: ALT 17,AST 27, Bili 11.8, ALP 68,GGT 36,15X VL12., 6week ALT 19,AST 26,Bili 16,20,GGT35, VL<12,8W UND

Tig


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You can still be <15 IU/ml and be detected. I know it's odd, but the PCR has a lowest level of quantification of 15. If there is still a few stragglers around, the test isn't sensitive enough to quantify them, but will still pick up the few stragglers remaining and categorize it as "<15 IU/ml - Detected" That's not uncommon, especially when they do the viral load early on. Many doctors don't test the viral load until the end of treatment, some even wait until EOT +12.

Mak, don't worry about it. Your viral load dropped to almost nothing and did it fast. You're responding exactly as you should be. I'm sure by now, you're undetected, considering how close the last test results were. You don't need to do these weekly or biweekly viral loads, they can be deceiving. You're doing fine. Wait until the end of treatment and 12 weeks after that. The EOT + 12 is the money shot, all the rest are just to confirm something is happening and it is. You don't need to be taking a bunch of supplements during treatment either. Some of them aren't recommended, so be sure you get permission from your doctor before taking anything while on treatment. If they said to take a bunch of vitamins, then follow their instructions. Don't just add stuff without checking first.

You're doing fine, don't overthink all of this.



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Tig

63 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 6+ years!

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Huh? Do you have another bottle/pack coming?  If you have 28 more, you are definitely early.

I thought <15 is considered undetected.  Tig? Canuk? Even if you are undetected "early" treatment continues to flush out any hiders, or replicators trying to sneak through.  We're not taking any chance.  We're kicking dragon butt!

Call your doctor. Find out your actual treatment time.  

And, enjoy your good looking labs.



__________________

GT2a, VL 681,500, Less than F1, Treatment Naive

12 wks Sovaldi/Ribavirin, SOT 2/25/16, EOT 5/17/16

UND at 2,4,8 and 12 wks during treatment but ribavirin crazy.

ALT/AST normal EOT

SVR12 8/13/2016!!!!!!!!!  I WON!!

EOT 6 Months 11/12/2016  CURED

 



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Is it all Normal? 34 day which is almost 5 weeks and still virus is there But on so low level? When it usually disappears? I am so worried.

I started to take D3 + K2 vitamin to boost my immune system a bit as it was low in those vitamins 



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2nd Vosevi12wks- SOT Sept 12,2018 to EOTDec 5, 2018. Pre-trtmnt - VL 1.4 mil, ALT 45, AST __, ALP 69, GGT 90. 2 week - VL 49, ALT 26, AST __, GGT 53. 4 week-VL <15, GGT42 other normal, 5week: ALT 17,AST 27, Bili 11.8, ALP 68,GGT 36,15X VL12., 6week ALT 19,AST 26,Bili 16,20,GGT35, VL<12,8W UND

Tig


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mcmaklin wrote:

in fact there are 28 pills only in the box. So the treatment is not 12 weeks


 Three bottles or packs of 28 pills, 4 weeks X 3? That equals 12 weeks on my calendar! wink



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Tig

63 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 6+ years!

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You, should be very happy you are showing such wonderful looking labs and VL's, early. 

 Is it early?



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2nd Vosevi12wks- SOT Sept 12,2018 to EOTDec 5, 2018. Pre-trtmnt - VL 1.4 mil, ALT 45, AST __, ALP 69, GGT 90. 2 week - VL 49, ALT 26, AST __, GGT 53. 4 week-VL <15, GGT42 other normal, 5week: ALT 17,AST 27, Bili 11.8, ALP 68,GGT 36,15X VL12., 6week ALT 19,AST 26,Bili 16,20,GGT35, VL<12,8W UND



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in fact there are 28 pills only in the box. So the treatment is not 12 weeks



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2nd Vosevi12wks- SOT Sept 12,2018 to EOTDec 5, 2018. Pre-trtmnt - VL 1.4 mil, ALT 45, AST __, ALP 69, GGT 90. 2 week - VL 49, ALT 26, AST __, GGT 53. 4 week-VL <15, GGT42 other normal, 5week: ALT 17,AST 27, Bili 11.8, ALP 68,GGT 36,15X VL12., 6week ALT 19,AST 26,Bili 16,20,GGT35, VL<12,8W UND



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The 2 VL's you had done (only about a week apart!) one slightly shy of (early of) 4 weeks and then again the next one, not a week later, just barely starting into your 5 week!, are bound to show about the same result - which (as we can see) they do!

They are showing you that you have the tiniest of a VL, one that can hardly be detected, and is proof that you are being cured as we speak! Proof not only by your VL response but by how all your labs have responded.

You have had an astoundingly strong, successful and early response to the Vosevi.

These 2 VL's (taken too close together) wouldn't tell you much more than you already knew from last week!

One lab says <15, the other similarly says 12 detected - I am not surprised at this similarity between the two results, given that both these VL tests were done so close together.

15 may be the lowest level of detection (at the first lab) using their particular PCR equipment, and 12 may happen to be the lowest level of detection (at the other lab you used), because of the particular type of PCR equip they happen to use.

You, should be very happy you are showing such wonderful looking labs and VL's, early. 

Nice new sig line BTW - I hope you saved your old sig line to put in your bio info for hx. wink C.



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 64 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



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How should it be?

Message from 15 of Oct. 

Virus detected method real-time PCR using m2000rt Abott. Sensitivity of method 95% in the range of method. Result: 12IU/ml

In the results from 8th of Oct it was not possible to count which was <15 iu/ml 

 

Is it normal? Why it is not going down? 



__________________

2nd Vosevi12wks- SOT Sept 12,2018 to EOTDec 5, 2018. Pre-trtmnt - VL 1.4 mil, ALT 45, AST __, ALP 69, GGT 90. 2 week - VL 49, ALT 26, AST __, GGT 53. 4 week-VL <15, GGT42 other normal, 5week: ALT 17,AST 27, Bili 11.8, ALP 68,GGT 36,15X VL12., 6week ALT 19,AST 26,Bili 16,20,GGT35, VL<12,8W UND

Tig


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Hi Mak,

HBV & HCV are known causes of lowered Vitamin D levels. Often it’s due to the inability of the liver to process and absorb it properly. Research shows that SVR may correct that, but your intake (diet) and sun exposure has to be adequate. If you’re not getting enough, you can’t expect things to just automatically correct themselves. Diet and supplementation can turn it around fairly easily. You want to provide yourself the recommended intake and D3 seems to be the easiest to process. Are you taking a daily multi vitamin? That may be enough. Drink milk and get some sun. Sun exposure helps greatly.

Here‘s an article that will help:

Dietary supplements

In supplements and fortified foods, vitamin D is available in two forms, D2 (ergocalciferol) and D3 (cholecalciferol) that differ chemically only in their side-chain structure. Vitamin D2 is manufactured by the UV irradiation of ergosterol in yeast, and vitamin D3 is manufactured by the irradiation of 7-dehydrocholesterol from lanolin and the chemical conversion of cholesterol [6]. The two forms have traditionally been regarded as equivalent based on their ability to cure rickets and, indeed, most steps involved in the metabolism and actions of vitamin D2 and vitamin D3 are identical. Both forms (as well as vitamin D in foods and from cutaneous synthesis) effectively raise serum 25(OH)D levels [2]. Firm conclusions about any different effects of these two forms of vitamin D cannot be drawn. However, it appears that at nutritional doses vitamins D2 and D3 are equivalent, but at high doses vitamin D2 is less potent.

Vitamin D Info



__________________

Tig

63 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 6+ years!

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Thank You. 

I did this privately in a different Place- I am curious about my viral count. 

Another thing - I am low on D vitamin. What can I take safely?

Too low would be <10 ng/ml

not enough is 10-30

Enough is 30-100

I have: 14

shall I take D3 vitamin ? And how much?

 

 

 

https://www.wjgnet.com/1007-9327/full/v24/i4/445.htm



-- Edited by mcmaklin on Tuesday 16th of October 2018 05:34:52 AM

__________________

2nd Vosevi12wks- SOT Sept 12,2018 to EOTDec 5, 2018. Pre-trtmnt - VL 1.4 mil, ALT 45, AST __, ALP 69, GGT 90. 2 week - VL 49, ALT 26, AST __, GGT 53. 4 week-VL <15, GGT42 other normal, 5week: ALT 17,AST 27, Bili 11.8, ALP 68,GGT 36,15X VL12., 6week ALT 19,AST 26,Bili 16,20,GGT35, VL<12,8W UND



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Great numbers Mak! biggrin 

Everything is working as it should be.

I am bumping your "suggested" signature line up here: and I've added your latest figures ... I'm still hoping you can use this sig. line ...

M, GT1b, TT, F1 ... Viekira/Exviera failed 2016 ...  2nd treatment - Vosevi 12 weeks - SOT Sept 12?, 2018 to EOT Dec 5, 2018. Pre-treatment - VL 1.2 mil, ALT 45, AST __, ALP 69, GGT 90. 2 week labs - VL 49, ALT 26, AST __, GGT 53. 4 weeks labs - VL <15, ALT 17, AST 27, Bili 11.8,  ALP 68, GGT 36 ...

Nice BTW, that you found your 4 week AST!

I am wondering something though (if i have your Sep 12 SOT date right, and your other blood draw dates correct), then ... you had your 2 week blood draw aprox Sep 26, and your 4 week blood drawn aprox. Oct 10 (or very near Oct 10), so ... why would you be saying today (Oct 16) that you are going to have more bloods drawn privately today (when you have just had your 4 week bloods drawn near Oct 10 and we even have your current 4 week a PCR VL and your LFT result back here)? confuse

But very good news and numbers for you Mak - congrats on a very good start! This is going to go as it is supposed to. biggrin How are you feeling? C.

 



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 64 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)

Tig


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Hey Mak,

I replied on the Harvoni thread, so here’s a copy of my reply. Your results are good.

 

Depending on the lab providing your results, they may not use the term of Zero viral load. What determines an "Undetected" result, the test will show a "<15 IU/ml" AND it will say "Undetected". It sounds to me like your results at week 4 are "<15 IU/ml - Detected". That's not uncommon at all and is nothing to be concerned about. Your numbers are going in the right direction and having the viral load unquantifiable, is good news. Next time, the results will likely be "Undetected".

The Vitamin D testing is up to you. It should have no bearing on your treatment or the results. Some people get their vitamin levels tested when determining anemia. If that's a problem for you or you're simply curious, go ahead.

 

 



__________________

Tig

63 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 6+ years!

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I did my test privately today. The viral count PCR test will be available in 2,3 days.

For now from today:

AST is 27   

ALT is 17

Bilirubin is 11,80qmol/l

Phosphatase is 68

GGTP is 36

 

All normal 

 



__________________

2nd Vosevi12wks- SOT Sept 12,2018 to EOTDec 5, 2018. Pre-trtmnt - VL 1.4 mil, ALT 45, AST __, ALP 69, GGT 90. 2 week - VL 49, ALT 26, AST __, GGT 53. 4 week-VL <15, GGT42 other normal, 5week: ALT 17,AST 27, Bili 11.8, ALP 68,GGT 36,15X VL12., 6week ALT 19,AST 26,Bili 16,20,GGT35, VL<12,8W UND



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it is good news Mak you're doing great! Keep it up!! Hang in there you're headed for a cure for sure!!



__________________

F, 51, GT3, HCV since 1989, no alcohol since 1999, Fibrosis score F0-1 (.36), VL 216,000, ALT 23, AST 26, Epclusa SOT 7/26/18 EOT 10/18/18. Thank you God. 



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Hello,

Please advice me if it is OK.

Pre treatment: 1.44 million iu/ml
2 weeks: 49 iu/ml
4 weeks: <15 iu/ml

It is still detected but below number that they can measure it accurately.

They wrote me that there will never be ZERO on the blood report. Anything below 15, its cannot be measurable. It was 2 weeks without 1 day.

 

2. Shall I measure the level of D vitamin???

 



__________________

2nd Vosevi12wks- SOT Sept 12,2018 to EOTDec 5, 2018. Pre-trtmnt - VL 1.4 mil, ALT 45, AST __, ALP 69, GGT 90. 2 week - VL 49, ALT 26, AST __, GGT 53. 4 week-VL <15, GGT42 other normal, 5week: ALT 17,AST 27, Bili 11.8, ALP 68,GGT 36,15X VL12., 6week ALT 19,AST 26,Bili 16,20,GGT35, VL<12,8W UND

Tig


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Hey Mak,

They may have left out the AST. While it’s an important liver enzyme, it is also present in various levels whenever you have muscle injury elsewhere. It will often elevate in patients with heart damage, so they may not do it where you’re getting your tests done. It may also be listed as “SGOT”. That is an old way it was referenced, so I doubt it, but stranger things happen all the time. The ALT and GGT are more directly indicative of liver function.



__________________

Tig

63 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 6+ years!

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Tig


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Well done, Brad! EOT it is... Now, the hard part is waiting three months to get the good news. I have no doubt, you will continue to be undetected. Plan on it!



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Tig

63 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 6+ years!

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I got labs done at 2 months and was clear



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Brad


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I take my last Vosevi tomorrow 12 weeks



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Brad


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AST (or aspartate aminotransferase) should be grouped in with your other LFT's (in or near there anyway), in a section on your lab papers that indicate LFT's (liver function tests) - ooor, perhaps near or around where you might see bilirubin, GGT, but perhaps near albumin, ALP (alkaline phosphatase) - it's hard to say where AST might appear on your labs - why don't you just post your labs in full, and we can help you read them (it will also likely show us what your lab considers to be normal reference levels). Maybe it is not easy for you to post a copy of labs, I know it is not easy for me, as i am not good at computer stuff. C.



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 64 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



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the purpose of this mail was to ask you which of those is AST? Is it possoble

they do a liver profile without the AST?



__________________

2nd Vosevi12wks- SOT Sept 12,2018 to EOTDec 5, 2018. Pre-trtmnt - VL 1.4 mil, ALT 45, AST __, ALP 69, GGT 90. 2 week - VL 49, ALT 26, AST __, GGT 53. 4 week-VL <15, GGT42 other normal, 5week: ALT 17,AST 27, Bili 11.8, ALP 68,GGT 36,15X VL12., 6week ALT 19,AST 26,Bili 16,20,GGT35, VL<12,8W UND



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Hey Bradtexas,

Did I understand you correctly - did you say you only had 2 days of Vosevi left? - meaning ... you are soon to be finished your 12 week course?  And, can you clarify if your treatment was indeed 12 weeks long (or was it 8 weeks)?

If I'm understanding correctly where you are currently at in your treatment - did you not have bloods drawn at 4 weeks into treatment?, and will you not get bloods drawn at your end of treatment (EOT)?

I hear ya about the stress and strain and worry - it's too bad your doc did not seem to keep you better informed as to your progress and lab results as you went through treatment - you may have found this comforting/reassuring to know that you and your labs were responding well to the Vosevi.

I bet if you ask, they will give you paper copies of any of your lab test results they have taken on you while you were on Vosevi (VL's and ALT/AST's, etc).

I would love to hear more info and details from you - how you have been feeling, physically, before and during treatment.

I was glad to know they think you have little liver damage even though you probably had HCV for about 30 years, and to know your prior VL was aprox. 3.5 million.

If you are at your end of treatment (EOT), then i bet you anything you have already been cured - it is just not "official" yet, not until your SVR12 VL draw at EOT+12 weeks.

What was your Vosevi start of treatment (SOT) and your end of treatment (EOT) dates?

When did you do the prior harvoni?

Did you have any questions for us?

It is very nice to have another fellow Vosevian on board! I consider us the lucky ones! biggrin C. 



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 64 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



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Hi Mak,

Yes, it does all sound good (your 2 week and your 4 week lab results) especially knowing that they don't say anything to you about your labs, unless the results are not normal.

Lots of docs do that, if all is well, they don't say anything to you about normal results.

Nice your GGT has steadily come down!

Everything seems to be going along very well, just as could be predicted with this amazing new DAA Vosevi!

So, when you had your 2 week bloods drawn, and then your 4 week bloods drawn - did you also get to have a doc appointment at those times?? Have you seen the doc since you started your Vosevi? If so, what has he said to you?

You asked about ... Sodium, potassium, chloride,urea, acute kidney injury, creatinine, EGFR CKD - EPI ...

Just like you had differential and hgb blood tests, there are many tests they will routinely do on you periodically, just to keep tabs on how all your systems are doing from pancreas to your kidneys - many of those tests you listed (above) mostly have to do with kidney function - and they are just routinely done. That's good - they are being thorough. 

It won't be much longer to wait - soon we'll know your 4 week VL, when those results return to you. smile C.



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 64 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



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I have been confirmed that GGT from 2 days ago is 42 and normal. This sounds good. They are not saying much other  so it means it is normal. It is not easy to ask remotely. 

I do not know where is AST

 

There is only liver profile which is :

Sodium, potassium, chloride,urea, acute kidney injury, creatinine, EGFR CKD - EPI (what is it??)

Albumin

Bilirubin total

ALT

Gamma GT

 

Alkaline Phostopatase



__________________

2nd Vosevi12wks- SOT Sept 12,2018 to EOTDec 5, 2018. Pre-trtmnt - VL 1.4 mil, ALT 45, AST __, ALP 69, GGT 90. 2 week - VL 49, ALT 26, AST __, GGT 53. 4 week-VL <15, GGT42 other normal, 5week: ALT 17,AST 27, Bili 11.8, ALP 68,GGT 36,15X VL12., 6week ALT 19,AST 26,Bili 16,20,GGT35, VL<12,8W UND



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I know but gonna be hard not to worry.  This 3 months on treatment seemed like a year. 

Brad



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Brad
Tig


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Hi Brad,

Welcome to the forum! You have nothing to worry about. This stuff is the best there is and your chance of success is extremely high, far higher than the chance of failure. 95+% rates of success are the norm. I know of no one, that has failed Vosevi! Be confident smile



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Tig

63 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 6+ years!

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I don't know the numbers like you guys. My load was 3 1/2 million prior to 8 weeks of Harvoni. I am lucky not to really have any liver damage. I had probably 30 years so feel pretty good about that.  The wait for my 3 month post treatment labs is gonna be a long one. 



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Mak,

I agree with Cheddy, go with the flow in how you are feeling, and keep drinking lots of water.

Everyone will feel slightly different things, and everything you have described experiencing thus far, does not sound unusual.

Just keep doing what you are doing, modify your diet/water and activities (as best you can, or as you are able) so that you feel as good as is possible. Just use your own good judgement and common sense as to what might make you feel better or worse. Water IS the number one important thing not to overlook, water often helps prevent or minimize bad feelings.

You are already 1/3 done - only another 8 weeks of having to modify anything because of the treatment drugs - not a long time to put up with any inconvenience. Makes sense to lighten up on exercise routines if energy is not there.

I like Tigs suggestion, maybe you could move some of your prior treatment details (taking up all the room in your signature line) to be over in your bio, so you can show your Vosevi "re-treatment" info on your sig line instead ... perhaps start your new sig line with ...

M, GT1b, TT, F1 ... Viekira/Exviera failed 2016 ...  2nd treatment - Vosevi 12 weeks - SOT Sept 12?, 2018 to EOT Dec 5, 2018. Pre-treatment - VL 1.2 mil, ALT 45, AST __, ALP 69, GGT 90. 2 week labs - VL 49, ALT 26, AST __, GGT 53. 4 weeks labs - VL __, ALT__, AST __ ...

If you are looking for AST's on your labs and are not finding them, then maybe they don't use the initials "AST" on your labs - it may say "aspartate aminotransferase" (same thing).

Hope you get your 4 week blood test results back fast. smile C.

 



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 64 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



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Hi Bradtexas! 

Welcome here - I am very happy to meet another fellow Vosevi taker. 

We are glad for your company! 

So, you are just about finished! - congrats - your hepc is finally going to be over! 

Mak is just into his second bottle (he has completed over 1/3 of his 12 week treatment).

You are both going to do well on Vosevi - it is such a potent triple designed just exactly for people like you and Mak who were failed by a first treatment. 

Please tell us about your labs as your treatment has gone along - I bet anything your labs are looking good! Can you share some of them? Are you going to have EOT labs?

I am very much looking forward to hearing more from you. Personally, I am very excited to meet another lucky Vosevi taker on this site. There has been a small group of us here (all cured) who belong to this exclusive Vosevi club. (By trial) i was cured, easily, on a mere 8 weeks of Vosevi.

I know you have said you are a 1b and your first treatment was Harvoni, but please feel free to share whatever you wish, we will be all ears. I hope we can be of assistance in some way, and keep you company. smile C. 

 



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 64 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



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Not to fear!  These treatments work so well these days, Brad.  I know prior treatment didn't do you right, but try not to worry until you get actual test results.  The "what ifs" wear you down, experiencing what hasn't even happened.  I know it's hard, but try keep your eye on the prize.  If you can't, then keep checking in.  We'll hang with you all the way.

 



__________________

GT2a, VL 681,500, Less than F1, Treatment Naive

12 wks Sovaldi/Ribavirin, SOT 2/25/16, EOT 5/17/16

UND at 2,4,8 and 12 wks during treatment but ribavirin crazy.

ALT/AST normal EOT

SVR12 8/13/2016!!!!!!!!!  I WON!!

EOT 6 Months 11/12/2016  CURED

 



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This is your last day? I have 2 more and scared ****less.  



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Brad
Tig


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Hey Mak,

Maybe you could remove some of the old dates and just add your current start date. You can always put anything else in your Bio, on your Profile. It’s up to you.



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Tig

63 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 6+ years!

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And I will not update, sorry it can be only 300 characters

 

By the way the DO NOT DO AST - only the AST. I do not why but I cannot find it in my tests



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2nd Vosevi12wks- SOT Sept 12,2018 to EOTDec 5, 2018. Pre-trtmnt - VL 1.4 mil, ALT 45, AST __, ALP 69, GGT 90. 2 week - VL 49, ALT 26, AST __, GGT 53. 4 week-VL <15, GGT42 other normal, 5week: ALT 17,AST 27, Bili 11.8, ALP 68,GGT 36,15X VL12., 6week ALT 19,AST 26,Bili 16,20,GGT35, VL<12,8W UND



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Take it easy Mc.  There will be plenty of time for push ups after recovery.  

I remember how very long the days were when I was on treatment.  It seemed like a weeks to get through some of the days.  You just have to put your head down and let the time go by.  This is not your real life, in a way.  It's a side journey that can feel worse, but you are getting better.

Really, rest, drink even more water, and wait it out.  Once the drugs we are thankful for are out of your system, they will leave you alone.  Hang in and keep up the hope.

With confidence,

Cheddy

 



__________________

GT2a, VL 681,500, Less than F1, Treatment Naive

12 wks Sovaldi/Ribavirin, SOT 2/25/16, EOT 5/17/16

UND at 2,4,8 and 12 wks during treatment but ribavirin crazy.

ALT/AST normal EOT

SVR12 8/13/2016!!!!!!!!!  I WON!!

EOT 6 Months 11/12/2016  CURED

 

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