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Hi Canuck,

Thanks for your kind words! Saw my specialist today. He says my pre-treatment kPa was 12.4, also that 10-15% of his patients are genotype 2a/2c. In the minority yes but not that rare. He said I was a fast responder to Epclusa, not that uncommon with the new DAAs and thinks my chances of zero viral load at 12 weeks are closer to 99% than 95%. Nice to hear good news: I'll take that:) He also said with Epclusa there is no need for an SVR24 test anymore. If viral load is zero at EOT and SVR12 is also zero you are considered cured now. Hep C DAA treatment is changing fast with new drugs and prices are coming down. Many patients don't realize that Gilead licenses many countries outside the USA to manufacture generic Epclusa. I have been told e.g. in India you can get three months of Epclusa for about $1000.



-- Edited by lamassu on Thursday 5th of April 2018 06:45:39 PM



-- Edited by lamassu on Thursday 5th of April 2018 06:50:27 PM

__________________

Male, 65, Dx 1990, GT 2a/2c. Pre-tx VL 11,500,000, ALT 10, AST 18, F3, 12.4 kPa. Rx: 12 weeks Epclusa, SOT 3/8/18, EOT 5/30/18. Week 2 VL 50, ALT 12, AST 21. Week 10 VL not detected, ALT 12, AST 18. EOT + 12 weeks: VL not detected, ALT 11, AST 19. EOT + 24 weeks VL not detected, ALT 9, AST 24.



Guru

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Sounds all good. I hear ya about the period of heavy fatigue. But so glad things have improved since then! That's what we like to hear - good pills, good food and water! smile Yay today - "week 4" under your belt already! Congrats. Wishing you a good visit with your doc tomorrow. C.



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 63 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



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Hi Canuck,

Heavy fatigue first four days of Epclusa then lifted fast started feeling better each week that passes. No fatigue, stamina improving, no side effects of note like headaches. Finished first month today see doc tomorrow will ask about kPa and genotype. Taking Epclusa with meal drinking plenty of water. Thanks for the tips.



__________________

Male, 65, Dx 1990, GT 2a/2c. Pre-tx VL 11,500,000, ALT 10, AST 18, F3, 12.4 kPa. Rx: 12 weeks Epclusa, SOT 3/8/18, EOT 5/30/18. Week 2 VL 50, ALT 12, AST 21. Week 10 VL not detected, ALT 12, AST 18. EOT + 12 weeks: VL not detected, ALT 11, AST 19. EOT + 24 weeks VL not detected, ALT 9, AST 24.



Guru

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Hi lamassu,

Hey, nice sig line BTW! biggrin Interesting and good your pre-treatment ALT/AST was nice and low - one very good thing!

How's it all goin'? 

You had mentioned that for the about 6 months prior to tretament that you had been having fatigue get in the way, and that you sense some relief on that front already since starting the epclusa - how nice, I wish I had experienced some of that while on treatment, I was not lucky to sense that for quite a while until after treatment, it's quite a rewarding bonus. I had to be pleased with just my stellar virological response to the magic vel and other drugs Gilead so kindly created for me, and with watching my labs improve miraculously! I am still reveling in my improvements! I thank my lucky stars, everyday, for wining a seat in my trial and for Gilead and my doc for curing me.

Hey, did your doc ever elaborate to you on your unique GT2a/2c status? Just curious if he defined or explained anything on this interesting subject to you.

Hope you are continuing to feel OK, and are drinking that LOTS of water! Are you taking your epclusa with a meal or without? Later, smile C.

 

 



-- Edited by Canuck on Wednesday 4th of April 2018 05:38:32 PM

__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 63 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)

Tig


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I received this recall today. 

Kratom Recall; Salmonella



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Tig

62 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 1-4 years!

Hep C FAQ   Lab Ref. Ranges

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Tig


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Can I ask that you use the ”Reply” to posts instead of using the “Quote” option each time? Using the quote for general responses makes the length of the thread twice as long and harder to refer back to previous posts. It makes it easier for readers to follow. Quotes work well when adding small sections of a comment. There is also a quick reply at the bottom of each thread that makes replying quick and easy. Thanks for understanding!

If you need additional help with the signature function, there’s a link in my signature.



__________________

Tig

62 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 1-4 years!

Hep C FAQ   Lab Ref. Ranges

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Guru

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Very good you and your doc are thorough. That your Hep A and B immunity was up to snuff before your epclusa start.

When you have time, you could use a signature line (for ease of reference). Could I suggest something like this? ...

Male, Age, Dx 1990, GT 2a/2c. Pre-treatment VL 11,000,000, ALT ___, AST ___, Fibroscan F3, U/S. Rx 12 weeks Epclusa, SOT Mar ___ EOT Jun ___, 2018. Week 2 VL 50, ALT 12, AST 21.

Or whatever you are wanting to post, or are comfortable with posting as a sig. line.

smile C.



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 63 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



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Canuck wrote:

Hi lamassu,

You have it right, to always inquire, then you with your doc can doc make the best decisions.

There are subtleties in the effects with drug to drug interactions, and even things as simple as an "antacid" or "food" that you can eat, that can have an effect on drug absorbtion.

The bottom line for epclusa, is that a patient may take epclusa with food or without, but, if you read through the epclusa monograph carefully you will see how thoroughly drug to drug and other interactions have been studied.

http://www.gilead.ca/application/files/3415/0695/6820/Epclusa_English_PM_e186388_GS-002.pdf

See: (Regarding even a simple antacid) - "Table 7".

See: (Regarding food) - "Action and Clinical Pharmacology" -  aprox. page 29 - "Effects of Food". Note that there IS an effect of food (moderate/high fat/versus no food) on the "extent" of absorbtion, and/or the "delay" of absorbtion, but that the bottom line is that there is NO "SIGNIFICANT" reason to advise a pt. to take epclusa with or without food.

My regime was different than yours, I had a NS3/4A added (VOX) - the "Vosevi" monograph dictates I should take my med with a meal

Just thought I would bring to your attention all of these other things, being that we were exploring "interactions".

 

Here's that link I spoke of previousy, regarding differing GT's and their "clades": About Genotype/Subtype - Lists - Geographical Locations , there is also a story around here about some of Gileads early trials where they were wishing to recruit only certain limited GT's for an epclusa trial, one fellow got started in the trial, along with all the rest, identified as the appropriate GT - only by happenstance with further admission genetic following was it discovered that his prior GT was REALLY, in fact, uncovered, to reveal he was truly a GT6! No GT 6's were supposed to be recruited for inclusion in this particular trial. He was (luckily) included and of course cured. Bonus for Gilead was that they now had to include this cured GT6 fellow, which only helped to boast (earlier than planned) how panogenic their epclusa was! There can and have been other odd cases of "mistaken identity" when it comes to genotyping! So, it's a good rule, determine GT, then pick the best treatment.

BTW - did your doc thoroughly check your hep A/B immunity levels prior to your epclusa start?

Sorry, to hear about your arthritic discomforts. Hope you and your doc get that covered well enough. smile C.

 


 Yes he is very thorough. I had been vaccinated against both hep B and A years ago and immunity levels were fine.



__________________

Male, 65, Dx 1990, GT 2a/2c. Pre-tx VL 11,500,000, ALT 10, AST 18, F3, 12.4 kPa. Rx: 12 weeks Epclusa, SOT 3/8/18, EOT 5/30/18. Week 2 VL 50, ALT 12, AST 21. Week 10 VL not detected, ALT 12, AST 18. EOT + 12 weeks: VL not detected, ALT 11, AST 19. EOT + 24 weeks VL not detected, ALT 9, AST 24.



Guru

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Hi lamassu,

You have it right, to always inquire, then you with your doc can doc make the best decisions.

There are subtleties in the effects with drug to drug interactions, and even things as simple as an "antacid" or "food" that you can eat, that can have an effect on drug absorbtion.

The bottom line for epclusa, is that a patient may take epclusa with food or without, but, if you read through the epclusa monograph carefully you will see how thoroughly drug to drug and other interactions have been studied.

http://www.gilead.ca/application/files/3415/0695/6820/Epclusa_English_PM_e186388_GS-002.pdf

See: (Regarding even a simple antacid) - "Table 7".

See: (Regarding food) - "Action and Clinical Pharmacology" -  aprox. page 29 - "Effects of Food". Note that there IS an effect of food (moderate/high fat/versus no food) on the "extent" of absorbtion, and/or the "delay" of absorbtion, but that the bottom line is that there is NO "SIGNIFICANT" reason to advise a pt. to take epclusa with or without food.

My regime was different than yours, I had a NS3/4A added (VOX) - the "Vosevi" monograph dictates I should take my med with a meal

Just thought I would bring to your attention all of these other things, being that we were exploring "interactions".

 

Here's that link I spoke of previousy, regarding differing GT's and their "clades": About Genotype/Subtype - Lists - Geographical Locations , there is also a story around here about some of Gileads early trials where they were wishing to recruit only certain limited GT's for an epclusa trial, one fellow got started in the trial, along with all the rest, identified as the appropriate GT - only by happenstance with further admission genetic following was it discovered that his prior GT was REALLY, in fact, uncovered, to reveal he was truly a GT6! No GT 6's were supposed to be recruited for inclusion in this particular trial. He was (luckily) included and of course cured. Bonus for Gilead was that they now had to include this cured GT6 fellow, which only helped to boast (earlier than planned) how panogenic their epclusa was! There can and have been other odd cases of "mistaken identity" when it comes to genotyping! So, it's a good rule, determine GT, then pick the best treatment.

BTW - did your doc thoroughly check your hep A/B immunity levels prior to your epclusa start?

Sorry, to hear about your arthritic discomforts. Hope you and your doc get that covered well enough. smile C.

 

 

 

 



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 63 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



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Tig wrote:

I would give Kratom a pass while youre on treatment. You can go 12 weeks without it. Youre right to discuss it with your doctor, there are no experts here, especially when the question is as serious as this. There could be a serious drug interaction between the three medications, Kratom, Sofosbuvir and Velpatasvir. You dont want to interfere with the absorption or excretion pathways. Too much or too little of either could have some severe results. The rule is to avoid any and all supplements and use only approved medications with these DAAs. Thats just a knowledgeable opinion. Hope it helps.

 P-gpinducersand/ormoderatetopotentCYPinducers(e.g., rifampin, St. Johns wort, carbamazepine): May decrease concentrations of sofosbuvir and/or velpatasvir. Use of EPCLUSA with P-gp inducers and/or moderate to potent CYP inducers is not recommended


Well reasoned advice Tig thank you kindly. In my experience you can put up with almost anything for three months. Those who had to endure the earlier treatment options for Hep C might take issue with that though. When I talk to my specialist next week I will see what he thinks is best to moderate my chronic pain from arthritis but would not interfere with Epclusa.



__________________

Male, 65, Dx 1990, GT 2a/2c. Pre-tx VL 11,500,000, ALT 10, AST 18, F3, 12.4 kPa. Rx: 12 weeks Epclusa, SOT 3/8/18, EOT 5/30/18. Week 2 VL 50, ALT 12, AST 21. Week 10 VL not detected, ALT 12, AST 18. EOT + 12 weeks: VL not detected, ALT 11, AST 19. EOT + 24 weeks VL not detected, ALT 9, AST 24.

Tig


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I would give Kratom a pass while you’re on treatment. You can go 12 weeks without it. You’re right to discuss it with your doctor, there are no experts here, especially when the question is as serious as this. There could be a serious drug interaction between the three medications, Kratom, Sofosbuvir and Velpatasvir. You don’t want to interfere with the absorption or excretion pathways. Too much or too little of either could have some severe results. The rule is to avoid any and all supplements and use only approved medications with these DAA’s. That’s just a knowledgeable opinion. Hope it helps.

 “P-gpinducersand/ormoderatetopotentCYPinducers(e.g., rifampin, St. John’s wort, carbamazepine): May decrease concentrations of sofosbuvir and/or velpatasvir. Use of EPCLUSA with P-gp inducers and/or moderate to potent CYP inducers is not recommended”



__________________

Tig

62 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 1-4 years!

Hep C FAQ   Lab Ref. Ranges

Signature Line Set Up/Abbreviations   Payment Assistance

 



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Canuck wrote:

Hey, neat lamassu, to hear back from you already.

Thanks for all the info. smile

Ya, I caught on that the F3 WAS by fibroscan (just like you had written the first time - had I not overlooked it at first!) but good to know that you have not had a fibrotest in addition? 

Maybe, aside from the kPa number from the fibroscan, you could also inquire whether they additionally did a fibrotest that was not mentioned as yet.

Good about the U/S, but it is not just cancers (or HCC) they look for, just a simple U/S can provide them a wealth of info about your spleen, gallbladder, pancreas, kidneys, liver (sizes/shapes/conditions) even indications of fatty livers etc., so very good you had one. If you are curious, you could ask for a copy of the radiologists interpretive report (his impressions) regarding your U/S, and see the written description of what the radiologist notes/sees.

I agree with folks who have posted to you here, about water drinking and about how stellar your (now) liver function test (LFT) numbers are!! Really good news that they are within normal limits. Do you have a "pre-treatment" ALT/AST to compare back to? 

Sorry about this, but am I ever tickled about knowing the nuance of your GT2! I have heard of/read about people possessing more than one "sub-type" but as far as I know we (until now) have not known a multiple on this site! Very exciting for some of us who are nerdy interested! There are some fairly rarely occurring things (and amazingly interesting things, to me!) one can read about many of the various GT's - some GT's that "can change", other GT's that mimick other GT's, differing GT's that are "co-related" to other GT's , and others who possess two sub-types such as in your case. Very interesting to me. (We were discussing this in a prior thread once, I'll see if I find that again and later link it to you here). As a GT2a/2c you are unique, but it will NOT be any kind of an obstacle whatsoever as far as your treatment, so no need to fret on that account.

So, with you going back to the doc next week for an appointment, I am thinking he might be doing a 4 week VL on you (maybe) in addition to your 2 week VL already done. Look forward to as many as he will do for you through treatment, the feedback is always reassurring. You should also get a VL near or at end of treatment (EOT) - week 12.

Other than HCV, do you have any other health issues for which you are having any ongoing treatment/being followed for?

Glad you have met a few of us here now, we are glad to keep company with you! smile C.

 

 


Hi Canuck,

The only other concern is osteoarthritis pain. OTC meds don't help much I do have an rx for tramadol when I have a bad day but for some reason tramadol does not work well for me. Hydrodocone does and I can get a script but I do not want to become dependent on pain killers.

This may sound off the wall but at the urging of a good friend I tried Kratom for arthritis pain and got surprisingly good results. I stopped kratom before Epclusa based on this information but will talk to my specialist about kratom use with Epclusa next week. I certainly can not risk any med that would interfere with the Epclusa clearing the virus.

Any experts here on this forum with an opinion on Kratom alkaloids interacting with Epclusa? Thanks.



__________________

Male, 65, Dx 1990, GT 2a/2c. Pre-tx VL 11,500,000, ALT 10, AST 18, F3, 12.4 kPa. Rx: 12 weeks Epclusa, SOT 3/8/18, EOT 5/30/18. Week 2 VL 50, ALT 12, AST 21. Week 10 VL not detected, ALT 12, AST 18. EOT + 12 weeks: VL not detected, ALT 11, AST 19. EOT + 24 weeks VL not detected, ALT 9, AST 24.



Guru

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Hey, neat lamassu, to hear back from you already.

Thanks for all the info. smile

Ya, I caught on that the F3 WAS by fibroscan (just like you had written the first time - had I not overlooked it at first!) but good to know that you have not had a fibrotest in addition? 

Maybe, aside from the kPa number from the fibroscan, you could also inquire whether they additionally did a fibrotest that was not mentioned as yet.

Good about the U/S, but it is not just cancers (or HCC) they look for, just a simple U/S can provide them a wealth of info about your spleen, gallbladder, pancreas, kidneys, liver (sizes/shapes/conditions) even indications of fatty livers etc., so very good you had one. If you are curious, you could ask for a copy of the radiologists interpretive report (his impressions) regarding your U/S, and see the written description of what the radiologist notes/sees.

I agree with folks who have posted to you here, about water drinking and about how stellar your (now) liver function test (LFT) numbers are!! Really good news that they are within normal limits. Do you have a "pre-treatment" ALT/AST to compare back to? 

Sorry about this, but am I ever tickled about knowing the nuance of your GT2! I have heard of/read about people possessing more than one "sub-type" but as far as I know we (until now) have not known a multiple on this site! Very exciting for some of us who are nerdy interested! There are some fairly rarely occurring things (and amazingly interesting things, to me!) one can read about many of the various GT's - some GT's that "can change", other GT's that mimick other GT's, differing GT's that are "co-related" to other GT's , and others who possess two sub-types such as in your case. Very interesting to me. (We were discussing this in a prior thread once, I'll see if I find that again and later link it to you here). As a GT2a/2c you are unique, but it will NOT be any kind of an obstacle whatsoever as far as your treatment, so no need to fret on that account.

So, with you going back to the doc next week for an appointment, I am thinking he might be doing a 4 week VL on you (maybe) in addition to your 2 week VL already done. Look forward to as many as he will do for you through treatment, the feedback is always reassurring. You should also get a VL near or at end of treatment (EOT) - week 12.

Other than HCV, do you have any other health issues for which you are having any ongoing treatment/being followed for?

Glad you have met a few of us here now, we are glad to keep company with you! smile C.

 

 



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 63 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



Senior Member

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Welcome from me too.

Im super excited for you to be feeling better already...and those numbers are amazing. Yay

A



__________________

60y/o, Infected via transfusion Oct'83, GT-1a, F-4 cirrhotic,
tx Holkira pak/moderiba 12 weeks

2.5years...post tx... successful dragon slayer 

Tig


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Welcome John,

Glad you’re here! You’re on one of the best treatment drugs known to man or beast, beast being the keyword here! We often refer to this disease as the Beast or the Dragon. Whatever you call it, you’re on an excellent Dragon tamer and destroyer! Your viral load reduction and perfect enzymes should show you that. 

Even though you’re not cirrhotic (F4) you’re still packing around some advanced fibrosis as an F3. You got started in time to avoid some additional concerns, good for you. Successful treatment will allow you to regain your health in time, so concentrate on finishing and doing everything you can to speed the process. It takes time, but all things are possible.

Your recent tests are very encouraging. I have a good feeling that you’re going to see that undetected viral load by the end of treatment, if you aren’t already! 

Best bit of advice? Drink a gallon of water, everyday. It’s your best friend!

694D980E-FADB-492B-BAED-14608066D069.jpeg



__________________

Tig

62 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 1-4 years!

Hep C FAQ   Lab Ref. Ranges

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Senior Member

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Canuck wrote:

Hi lamassu, 

Welcome here, glad you joined in.

Very glad you finally succeeded in getting a treatment, and a very good treatment at that too I must say.

Sorry about your reasons for delay along the way since the '90's. I know what you mean, about the lack of confidence in the meds available until Harvoni-times. And sorry about the difficulties in accessing/affording the new DAA's, but thank goodness about getting on Medicare and how that opened the door for you. A long wait, but you'll be OK now!

Epclusa is your new best friend, and you have friends here too, just fire away if you have any questions or want to discuss anything.

I was lucky enough to get epclusa as well, but mine was via a trial and I also had another (third) drug added (vox) - I was on "vosevi". I would have never got it had I not been successful in pursuing my trial seat.

You and i are lucky to have recieved Gilead drugs (me as a GT3a and you as a GT2), very good your doc got it for you. I know how you felt with your first viral load (VL) returning at a puny 50! Same for me, felt miraculous.

Do you happen to know what your ALT/AST/billirubin or AFP lab results are? Did you have an abd. ultrasound (U/S) done? Was your F3 determined by blood test or by fibroscan? So your first VL was done at 2 weeks, so then how many more blood tests/VL's will you have done  during your 12 weeks of treatment?

As a non-cirrhotic and a GT2 you will do well on epclusa. Very nice you are feeling some better already! Truly miraculous eh?

Drink LOTS of water!!! And were not kidding about that. 

Feel free to post any questions or comments you feel like. smile C.

PS (aha!, I should read twice /write once - just noticed you DID say your F3 WAS by fibroscan, do you happen to know what the fibroscan kPa number was as well?)

 

 



-- Edited by Canuck on Friday 30th of March 2018 12:33:45 AM



-- Edited by Canuck on Friday 30th of March 2018 12:43:10 AM


Hi Canuck,

Thanks for your encouraging words.

F3 determined by fibroscan not fibrotest. Don't have the kPa at present but can get from my specialist when I see him next week and will know more about additional blood tests/VL at that time.

ALT is 12 U/L
AST is 21 U/L
Bilirubin is 0.3 mg/dL
AFP tumour marker was 1.5 ng/mL

So all tests WNR. I am 2a2c by the way. I did have an abdominal ultrsound and my liver specialist says negative for cancer.

 



__________________

Male, 65, Dx 1990, GT 2a/2c. Pre-tx VL 11,500,000, ALT 10, AST 18, F3, 12.4 kPa. Rx: 12 weeks Epclusa, SOT 3/8/18, EOT 5/30/18. Week 2 VL 50, ALT 12, AST 21. Week 10 VL not detected, ALT 12, AST 18. EOT + 12 weeks: VL not detected, ALT 11, AST 19. EOT + 24 weeks VL not detected, ALT 9, AST 24.



Guru

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Hi lamassu, 

Welcome here, glad you joined in.

Very glad you finally succeeded in getting a treatment, and a very good treatment at that too I must say.

Sorry about your reasons for delay along the way since the '90's. I know what you mean, about the lack of confidence in the meds available until Harvoni-times. And sorry about the difficulties in accessing/affording the new DAA's, but thank goodness about getting on Medicare and how that opened the door for you. A long wait, but you'll be OK now!

Epclusa is your new best friend, and you have friends here too, just fire away if you have any questions or want to discuss anything.

I was lucky enough to get epclusa as well, but mine was via a trial and I also had another (third) drug added (vox) - I was on "vosevi". I would have never got it had I not been successful in pursuing my trial seat.

You and i are lucky to have recieved Gilead drugs (me as a GT3a and you as a GT2), very good your doc got it for you. I know how you felt with your first viral load (VL) returning at a puny 50! Same for me, felt miraculous.

Do you happen to know what your ALT/AST/billirubin or AFP lab results are? Did you have an abd. ultrasound (U/S) done? Was your F3 determined by blood test or by fibroscan? So your first VL was done at 2 weeks, so then how many more blood tests/VL's will you have done  during your 12 weeks of treatment?

As a non-cirrhotic and a GT2 you will do well on epclusa. Very nice you are feeling some better already! Truly miraculous eh?

Drink LOTS of water!!! And were not kidding about that. 

Feel free to post any questions or comments you feel like. smile C.

PS (aha!, I should read twice /write once - just noticed you DID say your F3 WAS by fibroscan, do you happen to know what the fibroscan kPa number was as well?)

 

 



-- Edited by Canuck on Friday 30th of March 2018 12:33:45 AM



-- Edited by Canuck on Friday 30th of March 2018 12:43:10 AM

__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 63 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



Senior Member

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Hi,

Glad to be a part of the community. I have been living with Genotype 2 HCV at least since 1990 when testing was developed. I have been very fortunate that until the past year the progress of the disease was slow for me. Because I was not confident in success of treatment regimens until Harvoni was introduced I delayed treatment. I did not want a failed treatment that could lead to resistance. I don't use alcohol or smoke which may have been a factor in the slow disease progression.

The last six months however the disease started interfering with my life due to fatigue. I was also unable to afford Harvoni but could not qualify for help. Once I got on Medicare my specialist got me approved for Epclusa immediately. I was informed waiting was no longer an option. Medicare made Epclusa affordable.

In two weeks of taking Epclusa my viral load dropped from 11,000,000 to 50/ml which I consider a miracle. Still have to finish the three month course and wait for SVR 12 of course. I don't have cirrhosis according to my specialist Fibroscan was F3.

In only three weeks of treatment I feel remarkably better; I never thought Epclusa would work this fast. Getting stronger each week. Fingers crossed I am optimistic I may see zero viral load at the end of my three month course of Epclusa.



__________________

Male, 65, Dx 1990, GT 2a/2c. Pre-tx VL 11,500,000, ALT 10, AST 18, F3, 12.4 kPa. Rx: 12 weeks Epclusa, SOT 3/8/18, EOT 5/30/18. Week 2 VL 50, ALT 12, AST 21. Week 10 VL not detected, ALT 12, AST 18. EOT + 12 weeks: VL not detected, ALT 11, AST 19. EOT + 24 weeks VL not detected, ALT 9, AST 24.

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