Hep C Discussion Forum

Members Login
Username 
 
Password 
    Remember Me  
Chatbox
Please log in to join the chat!
Post Info TOPIC: Epclusa for gt3 - Started May 27
Tig


Admin

Status: Offline
Posts: 8531
Date:
RE: Epclusa for gt3 - Started May 27
Permalink  
 


Hey JB,

Your Bilirubin is normal. The result is within normal limits. These tests fluctuate inside of normal parameters, so nothing to worry about.

Bilirubin, Total   Normal: 0.1-1.2 mg/dL

 



__________________

Tig

62 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 1-4 years!

Hep C FAQ   Lab Ref. Ranges

Signature Line Set Up/Abbreviations   Payment Assistance

 

JB


Veteran Member

Status: Offline
Posts: 31
Date:
Permalink  
 

Canuck - Aside from the VL, the doctor ran a comprehensive metabolic panel, CBC w/Plat Automated Diff and Protime INR. There may be others, but these are the results I got back so far from the web portal. Everything seemed normal, but one thing stood out to me -- the Total Bilirubin was 1.0 mg/dl. The last time I had blood drawn it was .07. Should this be concerning? If I get any other results, I'll keep you posted. Anything else I should look out for with all these results that I don't understand?

JB

__________________

39/M, Dx Apr 2018. GT3. Possible HCV since birth. Pre-treatment VL 653,000; ALT 201, AST 116, Fibroscan w/ Fscore of 3 w/ some fatty liver, Tx 12 weeks Epclusa ended Aug 18. MRI June showed no cirrhosis, but something on liver - possibly artifact 1.4x0.6cm. EOT VL undetected w/ ALT/AST normal. 



Moderator

Status: Offline
Posts: 408
Date:
Permalink  
 

Great to hear, JB!  I'll bet that brought on a big SIGH.  How are you feeling, besides the toe.  It will be good to get the meds flushed out, too.  Onward and upward!

 



__________________

GT2a, VL 681,500, Less than F1, Treatment Naive

12 wks Sovaldi/Ribavirin, SOT 2/25/16, EOT 5/17/16

UND at 2,4,8 and 12 wks during treatment but ribavirin crazy.

ALT/AST normal EOT

SVR12 8/13/2016!!!!!!!!!  I WON!!

EOT 6 Months 11/12/2016  CURED

 



Guru

Status: Offline
Posts: 2893
Date:
Permalink  
 

Ah! Welcome to Club Zero JB! biggrin We've all been awaiting your arrival to this exclusive club for some time now. Armed with your UNDs, and you already have that nice beach umbrella, you've got every important thing you need right now. All you got to to is put your feet up a bit. Celebrate! Rest that toe a little. You're UND and done. More milestones coming your way, SVR12 party coming up next, and, boring MRI's are in store for you. Now, what were the other bloods they took along with this last VL (and ALT/AST, of which you said both were normal)? - I am interested in all the bloods they took, what bloods did they test for aside from VL/ALT/AST? And what was your ALT/AST result BTW? Congrats on being a Club 0 member bro. wink C. 

 

Image result for on beach with feet up

 



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 63 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)

Tig


Admin

Status: Offline
Posts: 8531
Date:
Permalink  
 

Great news, JB! It was never in doubt On to SVR12!

 



__________________

Tig

62 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 1-4 years!

Hep C FAQ   Lab Ref. Ranges

Signature Line Set Up/Abbreviations   Payment Assistance

 



Senior Member

Status: Offline
Posts: 278
Date:
Permalink  
 

Awesome JB! Good luck with your liver MRI we will keep our fingers crossed and pray for the very best!



__________________

F, 51, GT3, HCV since 1989, no alcohol since 1999, Fibrosis score F0-1 (.36), VL 216,000, ALT 23, AST 26, Epclusa SOT 7/26/18 EOT 10/18/18. Thank you God. 



Guru

Status: Offline
Posts: 647
Date:
Permalink  
 

yeehaw JB biggrinbiggrinbiggrin



-- Edited by 5-1-18 on Friday 24th of August 2018 07:48:34 PM

__________________

Gt:1a-36yrs .Started Intron-A in 96' for 2.5mo-VL still too high.taken off. Labs on 3.6.18:. A1 activity.  f3@60: fibrosur bloodtst. AFP=norm. enz=mostly norm.VL=3.9 million.sot=5.1.18>Harvoni>[8wks]: 4WEEKS=UND. Eot 6/25=Waiting for 3mo.VL.July=norm liverpanel.13weeks=UND

JB


Veteran Member

Status: Offline
Posts: 31
Date:
Permalink  
 

My EOT blood work came back undetected again! Thank goodness! ALT/AST and everything else were normal, the doc said. Now I've just got to pray that the "thing" they saw on on my liver is nothing. I'll be doing another MRI in November, along with EOT + 12 week blood work. I'm very thankful for this treatment and all the support and my new friends on this message board. Thank you!

__________________

39/M, Dx Apr 2018. GT3. Possible HCV since birth. Pre-treatment VL 653,000; ALT 201, AST 116, Fibroscan w/ Fscore of 3 w/ some fatty liver, Tx 12 weeks Epclusa ended Aug 18. MRI June showed no cirrhosis, but something on liver - possibly artifact 1.4x0.6cm. EOT VL undetected w/ ALT/AST normal. 



Moderator

Status: Offline
Posts: 408
Date:
Permalink  
 

Amen, JT!

Perfect quote.  I hope you are wearing a smug little smile.



__________________

GT2a, VL 681,500, Less than F1, Treatment Naive

12 wks Sovaldi/Ribavirin, SOT 2/25/16, EOT 5/17/16

UND at 2,4,8 and 12 wks during treatment but ribavirin crazy.

ALT/AST normal EOT

SVR12 8/13/2016!!!!!!!!!  I WON!!

EOT 6 Months 11/12/2016  CURED

 



Senior Member

Status: Offline
Posts: 278
Date:
Permalink  
 

//With a new day comes new strength and new thoughts//

 Thank you JB and thank you Eleanor Roosevelt for that one Im going to hold onto it during this new phase of my treatment. 



__________________

F, 51, GT3, HCV since 1989, no alcohol since 1999, Fibrosis score F0-1 (.36), VL 216,000, ALT 23, AST 26, Epclusa SOT 7/26/18 EOT 10/18/18. Thank you God. 

Tig


Admin

Status: Offline
Posts: 8531
Date:
Permalink  
 

Great and appropriate quote, JB! It was an unusual but welcome feeling waking up to no more medication and no more fire breathing Dragon!



__________________

Tig

62 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 1-4 years!

Hep C FAQ   Lab Ref. Ranges

Signature Line Set Up/Abbreviations   Payment Assistance

 

JB


Veteran Member

Status: Offline
Posts: 31
Date:
Permalink  
 

Saw this quote today and had to share it on my social media. Perfect for today. My alarm went off at 9:30am as it had for the past 12 weeks - and I just smiled. ”With the new day comes new strength and new thoughts.“ -Eleanor Roosevelt



__________________

39/M, Dx Apr 2018. GT3. Possible HCV since birth. Pre-treatment VL 653,000; ALT 201, AST 116, Fibroscan w/ Fscore of 3 w/ some fatty liver, Tx 12 weeks Epclusa ended Aug 18. MRI June showed no cirrhosis, but something on liver - possibly artifact 1.4x0.6cm. EOT VL undetected w/ ALT/AST normal. 



Guru

Status: Offline
Posts: 647
Date:
Permalink  
 

awesome news jb.. enjoy



__________________

Gt:1a-36yrs .Started Intron-A in 96' for 2.5mo-VL still too high.taken off. Labs on 3.6.18:. A1 activity.  f3@60: fibrosur bloodtst. AFP=norm. enz=mostly norm.VL=3.9 million.sot=5.1.18>Harvoni>[8wks]: 4WEEKS=UND. Eot 6/25=Waiting for 3mo.VL.July=norm liverpanel.13weeks=UND



Senior Member

Status: Offline
Posts: 408
Date:
Permalink  
 

Glad youre finished your treatment, JB...    

I hope your toe heals quickly and you can get back to your walking. 

I still drink a lot of water... almost 3 years after my treatment, its a great habit/practice to stay in.

 



__________________

60y/o, Infected via transfusion Oct'83, GT-1a, F-4 cirrhotic,
tx Holkira pak/moderiba 12 weeks

2.5years...post tx... successful dragon slayer 



Senior Member

Status: Offline
Posts: 278
Date:
Permalink  
 

Congrats JB!

 



__________________

F, 51, GT3, HCV since 1989, no alcohol since 1999, Fibrosis score F0-1 (.36), VL 216,000, ALT 23, AST 26, Epclusa SOT 7/26/18 EOT 10/18/18. Thank you God. 

Tig


Admin

Status: Offline
Posts: 8531
Date:
Permalink  
 

Congrats on reaching the end of the line, JB! It always seems like a mile away when you start, but when you finish, it seems like it went by in a blink of the eye. That’s another one of the benefits of these new DAA’s, rapid action and short treatment times. So many improvements, thank goodness!

The EOT testing generally includes the LFT’s, a CBC and a viral load. Same thing at EOT+12. Please let us know when you get them back. I know the anxiety, but these new drugs are miraculous and it‘s rarer than worm teeth that the results are anything but great. 

Good luck with the toe/foot. It’ll be nice to get back to those 10K steps per day. Just get back into easy and build your strength and endurance back up gradually. I’m sure your foot will remind you if you overdo it. You’ll get there in no time, I’m certain of it!



__________________

Tig

62 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 1-4 years!

Hep C FAQ   Lab Ref. Ranges

Signature Line Set Up/Abbreviations   Payment Assistance

 



Moderator

Status: Offline
Posts: 408
Date:
Permalink  
 

That is wonderful JB, the last pill.

As Master Tig pointed out, there is a period of adjustment.  I hope your wheels are greased.  You probably have not been "normal" for some time.  First the disease, the ensuing trauma, and the bombardment of antivirals.  

And now the damn toe!  Don't push that! It makes it take longer.  I just got over one of those foot things.

 

Best to you.  Please keep the updates coming.

 

 



__________________

GT2a, VL 681,500, Less than F1, Treatment Naive

12 wks Sovaldi/Ribavirin, SOT 2/25/16, EOT 5/17/16

UND at 2,4,8 and 12 wks during treatment but ribavirin crazy.

ALT/AST normal EOT

SVR12 8/13/2016!!!!!!!!!  I WON!!

EOT 6 Months 11/12/2016  CURED

 

JB


Veteran Member

Status: Offline
Posts: 31
Date:
Permalink  
 

Thanks, Canuck. I think I need to update my signature. Sorry for the confusion. I have had blood work done at 4 weeks and 8 weeks. I'll get blood work again on Wednesday for 12 weeks and then again in 12 more weeks. Make sense? Do I need to specifically tell the doctor that I want LFT's AND a VL, or is that assumed?

Tig - I've also kept the empty pill bottles. I'll probably hold onto them for a little while as a reminder.

I am so thankful for the new drugs and the ease of this process. I can't say it enough. I just pray now that my followup MRI in November shows that the "thing" on my liver is nothing (or gone for that matter). That's my big worry now.

As far as my toe goes... It is my big toe, Canuck. An important one. Haha. It is still hard to walk on and and I still am walking with a limp. I went to a different doctor last week to get another x-ray and get a second opinion. I thought that after 4 weeks I would be walking a little better, but I wasn't. The new doctor told me that things are healing nicely and that it is normal for the toe to still be stiff and difficult to walk. He said in another week or so, I'll start to see a big difference. It is generally a 6-week healing process. I am wearing the walking boot only when I am going to be on my feet for a while and have to walk a lot.

I'm just bummed because when I started on Epclusa I was walking 8,000 to 10,000 steps per day. Heck, as you know, I even participated in a 10K . I feel like I've been a lazy bum for the past 5 weeks. It stinks, but as soon as I can start walking well again, I'm going to get back into it. I want to keep my body healthy and active. And yes, I've already told myself I'll continue to drink water. I lacked that prior to treatment.

The final pill is in my stomach as I type this.

Thanks guys!

JB

__________________

39/M, Dx Apr 2018. GT3. Possible HCV since birth. Pre-treatment VL 653,000; ALT 201, AST 116, Fibroscan w/ Fscore of 3 w/ some fatty liver, Tx 12 weeks Epclusa ended Aug 18. MRI June showed no cirrhosis, but something on liver - possibly artifact 1.4x0.6cm. EOT VL undetected w/ ALT/AST normal. 



Guru

Status: Offline
Posts: 940
Date:
Permalink  
 

Oh Yeah!!! That's probably going to take a moment to get to be used to. But refreshingly so biggrin

Down the HATCH ! 

Blessings, Iris



__________________

in the silence of the woods, you will not be alone- Chief Seattle

59 years on planet, Female, diagnosed 1978 as non-a non-b, VL 8mill+, Fibro f-1f-2, Genotype 1a, treatment naïve....UNTIL 7-01-18  !!!! started Harvoni 12 weeks. :)

4 weeks=UND, 8 weeks=UND, 12 weeks=UND (EOT= 09-23-2018)



Guru

Status: Offline
Posts: 2893
Date:
Permalink  
 

Ah lovely JB, just one more sleep, and just one more pill, and hoo-rah you're done!

I thought you got an "early" optional VL done at 8 weeks (and then you would not be getting another VL done until EOT+12 weeks, but, i must not have understood you before - I do hope it is true that you will be getting LFT's AND a VL (again) at EOT - I always fnd the lab feedback SO rewarding. You deserve more and more rewards (and you will keep getting them) your liver has already starting to thank you, and we can all thank Gilead for making things right. smile 

So, toe-man, how is that toe now, is it still hurtin'?, did you wear the boot long and did it help? (are you still wearing the boot?) I hope it is healing OK, if not, please do go back for another xray and opinion. BTW,  I don't think you ever said ...WHICH toe was it? 

Soon, no more middle of the night urgency trips (and tangled up in the bed clothes foot trips!) to the bathroom for you due to all the water drinking you had to do - you can drink much more conveniently as soon as you finish your epclusa, but still, do keep the water drinking up, I found I needed to even after I finished my Vosevi,  it was like my body was insisting that i still needed to keep flushing things out of me with enough water.  

Nice the sound of that last lonely pill rattling around in the bottle and then ... the blessed silence of none - and virus gone! biggrin C.



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 63 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)

Tig


Admin

Status: Offline
Posts: 8531
Date:
Permalink  
 

Well done, JB! EOT is a very special day and one I’ll never forget. I still keep a photo of my last Interferon injection and even kept the empty auto injector for a few years, just as a reminder of that special day. I had an alarm on my iPhone, the one that sounds like Crickets. To this day, I can’t stand the sound of that alarm, even as a reminder of that occasion.

Enjoy your achievement, it’s well earned and well deserved!

 



Attachments
__________________

Tig

62 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 1-4 years!

Hep C FAQ   Lab Ref. Ranges

Signature Line Set Up/Abbreviations   Payment Assistance

 

JB


Veteran Member

Status: Offline
Posts: 31
Date:
Permalink  
 

Tomorrow is the big day. Last pill... Thank goodness this was a pretty easy ride for me. I go to the doctor on Wednesday for followup and EOT blood work. It'll be weird when the alarm on my phone doesn't go off anymore at 9:30 a.m. reminding me to take my meds.

Hope everyone has a good weekend.

__________________

39/M, Dx Apr 2018. GT3. Possible HCV since birth. Pre-treatment VL 653,000; ALT 201, AST 116, Fibroscan w/ Fscore of 3 w/ some fatty liver, Tx 12 weeks Epclusa ended Aug 18. MRI June showed no cirrhosis, but something on liver - possibly artifact 1.4x0.6cm. EOT VL undetected w/ ALT/AST normal. 



Guru

Status: Offline
Posts: 647
Date:
Permalink  
 

i had a few weird things , nothing i couldn't handle. just make a note of what goes on. 

the weirdest thing for me was canker sore on my gums and they were sore....... when i took the antibiotic for the sinus infection the gums healed along with it.

just let us know and we someone here might have a story for you about that.

so far so good for me a cpl weeks in a row .



__________________

Gt:1a-36yrs .Started Intron-A in 96' for 2.5mo-VL still too high.taken off. Labs on 3.6.18:. A1 activity.  f3@60: fibrosur bloodtst. AFP=norm. enz=mostly norm.VL=3.9 million.sot=5.1.18>Harvoni>[8wks]: 4WEEKS=UND. Eot 6/25=Waiting for 3mo.VL.July=norm liverpanel.13weeks=UND

Tig


Admin

Status: Offline
Posts: 8531
Date:
Permalink  
 

There can be a similar adjustment period, as your body readjusts to life without a powerful anti-viral floating around killing Dragon spawn. Some people that have noticed a surge of energy while on the medication, come back down over time. Don’t confuse that with fatigue, it’s just a normalization of sorts, if that is ever a question. You may notice a change in your sleep habits, better or worse, again during this brief period of adjustment. That said, nothing will be cause for concern. Continue to hydrate and don’t add any supplements to your routine. Wait until your EOT+12 bloodwork before adding anything that can alter those test results. You shouldn’t have anything unusual, just adjusting to being healthy again! wink



__________________

Tig

62 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 1-4 years!

Hep C FAQ   Lab Ref. Ranges

Signature Line Set Up/Abbreviations   Payment Assistance

 

JB


Veteran Member

Status: Offline
Posts: 31
Date:
Permalink  
 

As I wind down treatment (only 11 pills left), I am curious. Do some experience side effects when they stop taking the drugs? I'm wondering if one's body becomes "used" to the medicine that when they stop they may experience something.

Thanks!

JB

__________________

39/M, Dx Apr 2018. GT3. Possible HCV since birth. Pre-treatment VL 653,000; ALT 201, AST 116, Fibroscan w/ Fscore of 3 w/ some fatty liver, Tx 12 weeks Epclusa ended Aug 18. MRI June showed no cirrhosis, but something on liver - possibly artifact 1.4x0.6cm. EOT VL undetected w/ ALT/AST normal. 



Guru

Status: Offline
Posts: 2893
Date:
Permalink  
 

Ah, I git ya now, only the week 8 one will happen (with no "additional" week 12 one happening). Nice your doc is giving you a fairly full compliment of VL testing, I like that. (4 weeks/8 weeks, then EOT+12 and EOT+24). smile  I hope you do not have to pay out of pocket for this 8 week one! That he agreed with you. That the week 8 would be covered as standard testing? 

Well hop-along, aside from the toe, how has the rest of the body been feeling? Hope you're feeling as good as your labs are looking! wink C.



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 63 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)

JB


Veteran Member

Status: Offline
Posts: 31
Date:
Permalink  
 

Hey Canuck - My doctor said if I wanted to do 8-week blood work, it was up to me. It was not necessary. Because it was still detectible after 4-weeks, I decided to get it done at 8. I'll also do EOT+12 and EOT+24.

JB

__________________

39/M, Dx Apr 2018. GT3. Possible HCV since birth. Pre-treatment VL 653,000; ALT 201, AST 116, Fibroscan w/ Fscore of 3 w/ some fatty liver, Tx 12 weeks Epclusa ended Aug 18. MRI June showed no cirrhosis, but something on liver - possibly artifact 1.4x0.6cm. EOT VL undetected w/ ALT/AST normal. 



Senior Member

Status: Offline
Posts: 195
Date:
Permalink  
 

Great News JB biggrin.gif and glad you are finally getting some relief with the toe. That will certainly be some story to tell in the years to come. "How I broke my toe" lmao.gif



__________________

66/F Contracted Early 80's First Diagnosed Early 2000's 2017 re diagnosis and referral for treatment Gen 3a Fibroscan 8.7

Epclusa 12 weeks commenced 1 May 2018 ALT 72 AST 67

28 May 2018 4 weeks ALT 16 AST 23 ...... 23 July 2018 EOT ALT 23 AST 30 .....Oct 16 2018 SVR12 UND



Guru

Status: Offline
Posts: 2893
Date:
Permalink  
 

Bloodwork at EOT+12 weeks and EOT+24 weeks is what would usually be your "Sustained virological response", (your "official" SVR12 and SVR24)  - the UND you have acquired while on treatment, it will be retested and ascertained again  (via taking VL's) at EOT+12 weeks and EOT+24 weeks. In all likelyhood they will do LFT's at those times too. (I think you and your doc had previously discussed doing labs at EOT+12 and EOT+24, right?)

What I was really asking/getting at, was why you had a VL done at 8 weeks, versus (more commonly) a VL done at 12 weeks (nearer to the EOT) - perhaps it was just your docs preference/choice/planning/managing/timing. I wondered if he might STILL do a EOT VL on you, even though you had one done at 8 weeks (perhaps your 8 week VL was an extra one for some reason or as is his preference), or maybe the 8 week one will just suffice to be considered your EOT one (basically). 

Aug 18 EOT is not far away, your toe should be feeling way better by then, and I think your liver is already feeling waaay better right now. biggrin C. 



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 63 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)

JB


Veteran Member

Status: Offline
Posts: 31
Date:
Permalink  
 

Thanks, everyone!

To answer your questions, Canuck...

I'll start with the easy one. Yes, it is a medical walking boot. It did take some time to get used to, but I can already tell the toe is healing better while wearing it.

I didn't get the full results in my patient portal yet. Just what the doctor told me: Undetected ... and ALT and AST were both at 22. Which is down from 27/28 last time and 58/91 the previous time.

I am getting 12 week and 24 week blood work. I assume it'll be VL too, but I'm not sure to be honest.

Have a good weekend!

JB

__________________

39/M, Dx Apr 2018. GT3. Possible HCV since birth. Pre-treatment VL 653,000; ALT 201, AST 116, Fibroscan w/ Fscore of 3 w/ some fatty liver, Tx 12 weeks Epclusa ended Aug 18. MRI June showed no cirrhosis, but something on liver - possibly artifact 1.4x0.6cm. EOT VL undetected w/ ALT/AST normal. 



Senior Member

Status: Offline
Posts: 278
Date:
Permalink  
 

CONGRATS JB!



__________________

F, 51, GT3, HCV since 1989, no alcohol since 1999, Fibrosis score F0-1 (.36), VL 216,000, ALT 23, AST 26, Epclusa SOT 7/26/18 EOT 10/18/18. Thank you God. 



Guru

Status: Offline
Posts: 2893
Date:
Permalink  
 

UND, and that's just the way we do it bro! Us epclusa folk are jes killin it! Welcome to Club Zero.  biggrin 

Whadya mean you were disappointed with your 4 week!, jeez, <15, crashing virus and labs all over the place - it was a huge messy massacre "done deal" way back then!

I sound like a waiter - would you like a little ALT and AST with that delicious UND. If you did get LFT's for this 8 week VL let us know what they are.

So, if you got an 8 week VL, does that mean they skip any EOT VL? I know you said they planned on doing the SVR12 of course, and a SVR24.

Hey, so glad you got the boot (heehee), you DO mean a "medical" type boot  don't you? That would please me no end, as I think they are seriously a good helpful idea for a toe fracture. They take some gittin used to in themselves though, like crutches do, you can break something else learning how to walk "with " appliances! 

Wish you could take a bit of beach time off and rest that foot, and have nothing to fret over cept keeping the sand from getting inside it. 

So glad to know you are UND now. C. 



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 63 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)

Tig


Admin

Status: Offline
Posts: 8531
Date:
Permalink  
 

Congratulations, JB! The Dragon has left the building.....

0BB78D21-37FA-4D8A-93F0-8586C924F6AD.jpeg



__________________

Tig

62 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 1-4 years!

Hep C FAQ   Lab Ref. Ranges

Signature Line Set Up/Abbreviations   Payment Assistance

 



Senior Member

Status: Offline
Posts: 408
Date:
Permalink  
 

JB  

that UND is music to the ears.smile

Congrats...

Glad you found a walking boot that helps. Hope your toe recovers soon.

 



__________________

60y/o, Infected via transfusion Oct'83, GT-1a, F-4 cirrhotic,
tx Holkira pak/moderiba 12 weeks

2.5years...post tx... successful dragon slayer 



Guru

Status: Offline
Posts: 647
Date:
Permalink  
 

JB !!! , money well spent to hear "undetectable". so awesome. congrats biggrinbiggrinbiggrinbiggrin

 

5



__________________

Gt:1a-36yrs .Started Intron-A in 96' for 2.5mo-VL still too high.taken off. Labs on 3.6.18:. A1 activity.  f3@60: fibrosur bloodtst. AFP=norm. enz=mostly norm.VL=3.9 million.sot=5.1.18>Harvoni>[8wks]: 4WEEKS=UND. Eot 6/25=Waiting for 3mo.VL.July=norm liverpanel.13weeks=UND

JB


Veteran Member

Status: Offline
Posts: 31
Date:
Permalink  
 

Greetings, friends!

I'll start with the boring news. My toe still hurts. I was just wearing a comfortable sneaker and it wasn't helping. Today I started with a walking boot and it helps so much when I need to be on my feet (which I must do for work). This will certainly help the healing process and make things a bit more comfortable for me. 

And now the good news! I had my 8 week blood work done on Monday. The doctor called today to let me know that I'm undetectable! Finally. I was annoyed after the four week blood that I was still <15. Fingers crossed it's smooth sailing to the finish line and to the 12 weeks post treatment blood draw.

On a side note, I had to pay $79 out of pocket for the blood work because I wasn't a liver transplant patient. It seemed odd, but I didn't care. That's not even my deductible for insurance. I thought for sure since the doctor ordered it, it would be covered by insurance. I told the doctor this today and she was pissed and said that wasn't right. Maybe I'll get a refund :)

Hope everyone has a good rest of the week!

JB 



__________________

39/M, Dx Apr 2018. GT3. Possible HCV since birth. Pre-treatment VL 653,000; ALT 201, AST 116, Fibroscan w/ Fscore of 3 w/ some fatty liver, Tx 12 weeks Epclusa ended Aug 18. MRI June showed no cirrhosis, but something on liver - possibly artifact 1.4x0.6cm. EOT VL undetected w/ ALT/AST normal. 



Guru

Status: Offline
Posts: 2893
Date:
Permalink  
 

Details, details JB!

Which toe, which bone, what kind of fracture? How bad is the break?

Are you required to work, you mentioned a desk?? hm, OK to sit at a desk but ... still, the foot ends up being dependant too long, if you are still having swelling/pain issues.

The ideal would be not to weight bear much on it, move it/use it/abuse it (the fracture line that is) at all, until you have sucessfully knitted the fracture intact again. Worst thing is to keep distrubing/disrupting/moving a fracture line while it is in that important initial process of trying to heal fracture. 

Now, if it we me? I'd book off work, get someone to carry me around, get to a beach (like that nice one in your avatar) for some R&R therapy, and make use of lolling around on floaty things in the water. smile C.

Image result for floating in pool cast on leg

 



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 63 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



Senior Member

Status: Offline
Posts: 408
Date:
Permalink  
 

Ah darn it!  Broken toe = annoying pain. I guess the Universe wants you to take it easy while you kick dragon butt ...and is making sure you do. 



__________________

60y/o, Infected via transfusion Oct'83, GT-1a, F-4 cirrhotic,
tx Holkira pak/moderiba 12 weeks

2.5years...post tx... successful dragon slayer 



Senior Member

Status: Offline
Posts: 195
Date:
Permalink  
 

Yes bummer JB....Broken toes are no fun...they are only little but by crikey they hurt. An arm or a leg once they put a plaster on the pain almost vanishes but with toes where they can't do anything. Hope the pain eases quickly for you...

Last month coming....Great. Pity the toe getting in the way, and what a way to break it! You poor devil. Thinking of you. nod.gif

 



__________________

66/F Contracted Early 80's First Diagnosed Early 2000's 2017 re diagnosis and referral for treatment Gen 3a Fibroscan 8.7

Epclusa 12 weeks commenced 1 May 2018 ALT 72 AST 67

28 May 2018 4 weeks ALT 16 AST 23 ...... 23 July 2018 EOT ALT 23 AST 30 .....Oct 16 2018 SVR12 UND

Tig


Admin

Status: Offline
Posts: 8531
Date:
Permalink  
 

OUCH!! 

I had a feeling it was fractured, bummer. Sorry you’ll have to put up with it, but at least you know why it hurts so much. Time to kick back, elevate the sore toe and catch up on some daytime TV!



__________________

Tig

62 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 1-4 years!

Hep C FAQ   Lab Ref. Ranges

Signature Line Set Up/Abbreviations   Payment Assistance

 

JB


Veteran Member

Status: Offline
Posts: 31
Date:
Permalink  
 

Well, I went to the doc today for my toe... and its broken! Woo hoo! Nothing really to do but take it easy and wear a spacer between the big toe and my second toe. Not much else they can do about it. No boot or special shoe. Just my comfortable sneakers. Thanks for the support. Glad I got it checked out. Now, the focus of my last 30-days or so of the Epclusa. Blood work in another week or so for 8 weeks.

__________________

39/M, Dx Apr 2018. GT3. Possible HCV since birth. Pre-treatment VL 653,000; ALT 201, AST 116, Fibroscan w/ Fscore of 3 w/ some fatty liver, Tx 12 weeks Epclusa ended Aug 18. MRI June showed no cirrhosis, but something on liver - possibly artifact 1.4x0.6cm. EOT VL undetected w/ ALT/AST normal. 



Guru

Status: Offline
Posts: 647
Date:
Permalink  
 

we're on our way over for rice and beans JB,  

guess we'll have to do the cooking and serving tho cos of your foot.. 

5



__________________

Gt:1a-36yrs .Started Intron-A in 96' for 2.5mo-VL still too high.taken off. Labs on 3.6.18:. A1 activity.  f3@60: fibrosur bloodtst. AFP=norm. enz=mostly norm.VL=3.9 million.sot=5.1.18>Harvoni>[8wks]: 4WEEKS=UND. Eot 6/25=Waiting for 3mo.VL.July=norm liverpanel.13weeks=UND



Guru

Status: Offline
Posts: 2893
Date:
Permalink  
 

OK, JB, rice and beans for everyone eh? wink C.



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 63 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



Guru

Status: Offline
Posts: 647
Date:
Permalink  
 

ok, now i want some rice.



__________________

Gt:1a-36yrs .Started Intron-A in 96' for 2.5mo-VL still too high.taken off. Labs on 3.6.18:. A1 activity.  f3@60: fibrosur bloodtst. AFP=norm. enz=mostly norm.VL=3.9 million.sot=5.1.18>Harvoni>[8wks]: 4WEEKS=UND. Eot 6/25=Waiting for 3mo.VL.July=norm liverpanel.13weeks=UND

Tig


Admin

Status: Offline
Posts: 8531
Date:
Permalink  
 

Glad you’re feeling better, John. That entire statin thing sounds like it was hard on you. Good thing you discovered that right away and didn’t suffer through weeks or months of it before figuring it out. Sadly, that happens to a lot of people while they figure out something that will work for any given condition.

JB, stay off that toe! Don’t keep ice on it too long. If the swelling doesn’t go down, you need to get it looked at. There are meds they can give you to help with any inflammatory processes, your doctor can advise you on them. It is unfortunate that just about everything we take is filtered by the liver and all cause varying degrees of hepatic stress. I‘m still a firm believer in that organ though. It’s a tough and has to be simply because of the job it was designed to do. It can take a lot of punches, but we have to help it dodge and weave as many blows as possible! How’s that for a boxing analogy? Ha, ha!



__________________

Tig

62 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 1-4 years!

Hep C FAQ   Lab Ref. Ranges

Signature Line Set Up/Abbreviations   Payment Assistance

 



Veteran Member

Status: Online
Posts: 94
Date:
Permalink  
 

I will never take Tylenol again. I want to keep the meds my F3 liver has to clear as low as possible. On prescription I take one 50 mg tramadol daily for arthritis pain; two on the occasional bad day when I have significant pain. As well as a centrally-acting opioid analgesic tramadol also has anti-inflammatory activity (the mechanism underlying the peripheral anti-inflammatory effect of tramadol remains unknown.) Still cleared the virus at ten weeks.

6 more weeks before I check viral load again at EOT + 12 weeks. Very thankful for this forum. Thinking about buying a rice cooker now:) Canuck I'm feeling better as each week passes once that side effect problem I had with the Crestor incident passed. Sorry to hear about your toe JB hope you are feeling better soon.



-- Edited by lamassu on Saturday 14th of July 2018 11:48:14 PM

__________________

Male, 65, Dx 1990, GT 2a/2c. Pre-treatment VL 11,500,000, ALT 10, AST 18, Fibroscan F3, 12.4 kPa. Rx 12 weeks Epclusa, SOT Mar 8, 2018, EOT May 30, 2018. Week 2 VL 50, ALT 12, AST 21. Week 10 VL not detected, ALT 12, AST 18. EOT + 12 weeks: VL not detected, ALT 11, AST 19.



Guru

Status: Offline
Posts: 2893
Date:
Permalink  
 

heehee JB, I LOVE rice! Reminds me of my cousin when we were kids, being served supper by my Mom, cous says ... "what's THAT"! ... "rice" my Mom says, cous being an Prairie Orangeman farmers daughter I guess and never eating anything but good ole spuds, informs my Mom, "we don't eat rice" ... my Mom informed her that ... "here you will eat rice and you will like it!" hahaha. Oddly enough, in the end as it turned out, she did like it! 

You are not alone in the toe dept JB! It seems to me that we have had a few here with the very same or very simlar unfortunate nocturnal mishap, some just to do it in the dark of the night, with the help of pets, or furniture we swore had mysteriously aligned itself to show it's not known before hardest corner, or just blame it on a urinary urgency race, but all had to do with being on hep c treatment. A temporary occupation hazard it seems. I guess be glad you did not do a header as well. 

4 grams, 3, 2, 1 or 0 grams of tylenol (or, more often than not) no drugs or sups of any kind while on treatment or when you have liver disease is a call lots of people make all by themselves, all on their own, and, right or wrong, folk often just naturally decide they do not want to add anything to the mix of having a body that is already busy dealing with a systemic disease - can't blame them either, but nor do we want to see anyone suffer for lack of a little medication - it all boils down to common sense, and perhaps a little advice when one is unsure or unfamiliar, and your doc preferences. Good you had already cleared tylenol use with your doc aforehand, as you and he know the most about you - to ask ahead of time, that was the wise thing to do.

If we must nuance tylenol opinions/studies, then I agree with Dr. Eric Yoshida, the evolution of extra-strength 500 mg tablets versus 325 mg tablets and other OTC acetaminophnen products at least present a problem as far as overdosing. Seems a person jes kint be too kareful these days! I agree with you JB in the lament about how it is too bad about tylenols lack of anti-inflammatory properties. Aspirin will always have it's place of honor at the table too, when deciding on choosing a safe and appropriate med for what ails ya. Some docs forbid aspirin-based (acetylsalicylic acid) ones, others do not, and for their own good reasons. Common sense consensus is the thing.  wink  C.

PS - I always love gazing at your avatar, how did you get an advance booking/seat at the exclusive Club Zero, which umbrella is yours? Soft warm sand between the toes will be good rehab/phisio. 

 



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 63 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)

JB


Veteran Member

Status: Offline
Posts: 31
Date:
Permalink  
 

Thanks everyone! I've taken Canucks' advice and am eating lots of RICE. Thank you! I enjoy brown - a bit healthier.

On a more serious note, I appreciate everyone's concern. I did confirm that my doctor did state initially that I can take Tylenol as needed for pain. I took one yesterday evening and it helped. Too bad Tylenol doesn't help with the swelling, though. As you all know, I was advised not to take any NSAIDS. I'm not in so much pain, though (knock on wood). It is just uncomfortable when I walk and feels very stiff. 

I had to work yesterday (at a desk) - so I stayed off my feet and iced it and elevated it when I could. When I got home I didn't get off the bed - and have my foot elevated and am icing it. I applied some tape today to stabilize it and that seems to help as well. I cancelled all my weekend plans and will just be taking it easy. No 10,000 steps for me for the next several days. 

If it is not better on Monday, I'll go to the doctor for x-rays. However, there is not much to do for a broken or sprained toe. Lots of doing what I'm doing now - RICE. 

Thanks again, guys! 

JB

 



__________________

39/M, Dx Apr 2018. GT3. Possible HCV since birth. Pre-treatment VL 653,000; ALT 201, AST 116, Fibroscan w/ Fscore of 3 w/ some fatty liver, Tx 12 weeks Epclusa ended Aug 18. MRI June showed no cirrhosis, but something on liver - possibly artifact 1.4x0.6cm. EOT VL undetected w/ ALT/AST normal. 

Tig


Admin

Status: Offline
Posts: 8531
Date:
Permalink  
 

willbb wrote:
Always best to discuss any medication with your physician

 Exactly! As much as we would like to advise people on what medications to take, we can't do that. That's my rule here. The references are always welcome, but you're right, Will, people should always consult with their physician before adding any new medications. Especially while they're on treatment with these DAA's. My niece OD'd on Tylenol, by accident and her liver suffered greatly from it. I always get a bit nervous when I see people taking large doses of Tylenol when they are already experiencing a hepatic injury or disease.

Good article!



__________________

Tig

62 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 1-4 years!

Hep C FAQ   Lab Ref. Ranges

Signature Line Set Up/Abbreviations   Payment Assistance

 



Member

Status: Offline
Posts: 11
Date:
Permalink  
 

Hello JB,

I negated to reference(which is always a good idea) one of the  "many" peer-reviewed articles(inclusive of exerts from the CDC,American Liver Foundation and the FDA) on pain mgmt. in patients with chronic liver disease,when I commented(not advised)on your statement: I'm pretty sure I can take 2000mg. of Tylenol per day".

Always best to discuss any medication with your physician

https://www.practicalpainmanagement.com/treatments/pharmacological/non-opioids/safe-usage-analgesics-patients-chronic-liver-disease-review.

 



__________________
1 2  >  Last»  | Page of 2  sorted by
 
Quick Reply

Please log in to post quick replies.

Legal Disclaimer:

THIS FORUM, IT'S OWNERS, ADMINISTRATORS, MODERATORS AND MEMBERS DO NOT AT ANY TIME GIVE MEDICAL ADVICE AND IN ALL CASES REFER ANYONE HERE TO SEEK APPROPRIATE MEDICAL ADVICE FROM THEIR DOCTOR.