Hep C Discussion Forum

Members Login
Username 
 
Password 
    Remember Me  
Chatbox
Please log in to join the chat!
Post Info TOPIC: Vosevi


Member

Status: Offline
Posts: 21
Date:
RE: Vosevi
Permalink  
 


Thanks man....I will really try to add my signature line shortly.    I have found the Vosevi much better tolerated than the Harvoni...and I am very hopeful.   I see the doctor in 10 days and he will give me the results of my last bloodwork.   I have no cirrhosis and my liver seems good.  Im sure the itch thing is unrelated but was just checking.   I did an ultrasound and fibroscan and everything seems really good.   I will keep you posted after results....thanks



__________________


Guru

Status: Offline
Posts: 3224
Date:
Permalink  
 

Hey Android!

Aside from yer bum, how is ya otherwise?

We haven't heard from you much since your SOT (around March 20?), I have to assume everything has been going relatively OK for you?

Hey, see my post to you (below) from March 19, where I was drafting you a suggested signature line - please do feel free to use any of that to create a signature line for yourself - sig. lines are good handy info things for everyone to refer to.

It is so nice you are posting here - there are not so many of us Vosevi people to provide and share info for the benefit of others who may follow. : ) 

On the "pain in the butt" issue, do get it checked out (as Tig suggested). It may have absolutely nothing to do with treatment, it could be happening for many reasons from soup to nuts, anal irritation (or itching) could be anything from pin worms, to dehydration, constipation, an overgrowth some yeasty or other flora which can lodge on mucosa (or maybe you got rectal itch for no darn good reason at all - and it may just go away as fast as it arrived - how long have you had it now?). A quick boo and chat with the doc might give you a script for something soothing that will thwart the itch quickly. Would be nice to inhibit that which might be inhabiting you. : )

Well ... what blood draws have you done since your SOT, when and what were the results?? 

Congrats - you are ALMOST finished!!!!!!!! : )  C.



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 64 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



Member

Status: Offline
Posts: 21
Date:
Permalink  
 

Thank you

__________________
Tig


Admin

Status: Offline
Posts: 8910
Date:
Permalink  
 

You’re the first person I’ve heard from that has had issues with anal itching, on any of the new DAA’s. There are reports of generalized itching in some cases, but not anal specific. If you recall past NS3 protease inhibitor, Incivek, then you remember the nightmare of horrid anal itching and outright burning it caused. We called it “fire in the hole”... It was severe and caused many to stop treatment.

The common treatment was purely symptomatic and aside from suffering through it, the use of antihistamines, oatmeal sitz baths and hydrocortisone creams were used. Be sure you mention this to your doctor. There’s nothing more aggravating than uncontrolled rectal itching, the discomfort is real, not to mention embarrassing when it flares up while in the company of others.



__________________

Tig

63 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 5+ years!

Hep C FAQ   Lab Ref. Ranges  HCV Resistance

Signature Line Set Up/Abbreviations   Payment Assistance

 



Member

Status: Offline
Posts: 21
Date:
Permalink  
 

Well I have 6 days left of my 12 week Vosevi program. Here is a crazy question....has anyone ever heard of anal itching while treating for Hep c as a result of the drugs?

__________________


Moderator

Status: Offline
Posts: 693
Date:
Permalink  
 

Oh yes, Android.  This will do it.  I'm so glad you got approved for Vosevi.  

I know how defeating the fatigue can feel, but getting rid of the HepC anchor will help.  It does take time, sometimes even after treatment, but it sure is the right thing to do, and, it will get better.

Keep us posted.  We are pretty devoted to seeing this through.  Kick it hard.  It's your time to have this over with!  

Drink, drink, drink, lots of water.  It keeps the side effects down

 

WOW lamassu.  I just saw your update. That's incredible! Happy!

 



__________________

GT2a, VL 681,500, Less than F1, Treatment Naive

12 wks Sovaldi/Ribavirin, SOT 2/25/16, EOT 5/17/16

UND at 2,4,8 and 12 wks during treatment but ribavirin crazy.

ALT/AST normal EOT

SVR12 8/13/2016!!!!!!!!!  I WON!!

EOT 6 Months 11/12/2016  CURED

 



Senior Member

Status: Offline
Posts: 182
Date:
Permalink  
 

Hi Android6,

Sorry to hear of your relapse and the brutal fatigue. I had the same, before Epclusa I was walking with a cane and could not walk to my mailbox without sitting down to rest. Using a shopping cart at the store to lean on. At end of treatment my fatigue was gone, I no longer need a cane and get around fine and exersize every day. Have faith, once Vosevi clears the virus your fatigue will lift also. Please keep us informed and best wishes!



__________________

Male, 66, Dx 1990, GT 2a/2c. Pre-tx VL 11,500,000, ALT 10, AST 18, F3, 12.4 kPa. Rx: 12 weeks Epclusa, SOT 3/8/18, EOT 5/30/18. Week 2 VL 50, ALT 12, AST 21. EOT + 12 weeks: VL not detected, ALT 11, AST 19. EOT + 24 weeks VL not detected, ALT 9, AST 24. 8/15/19 F2 8.8 kPa.

Tig


Admin

Status: Offline
Posts: 8910
Date:
Permalink  
 

It is better to stick to one thread and keep your discussion in a central location, such as the On Treatment section, especially since you have started again. I can change this thread to represent that, if you choose to continue here. It’s easier to stay current and on topic with one thread.

The use of a signature line is very valuable to those replying to your posts, too. I think Canuck explained the procedure well. If you need any assistance setting it up, let us know.



__________________

Tig

63 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 5+ years!

Hep C FAQ   Lab Ref. Ranges  HCV Resistance

Signature Line Set Up/Abbreviations   Payment Assistance

 



Guru

Status: Offline
Posts: 3224
Date:
Permalink  
 

Hey Android! 

Congrats on starting your Vosevi tomorrow! I see today, that you have made two recent posts, but they are in 2 dif areas, i think most often you have  started a new thread just about everytime you come back to the site to update us, or to ask a question. 

But maybe now (now that you are starting your Vosevi treatment) you could try to post about this Vosevi treatment mostly on one thread (on an "On Treatment" thread) - it will make it easier for us to follow you if most of your info is in one place.

Also, a signature line would be very helpful (makes for easy reference for everyone) ... you could try something like this? ... until you can update it with better further info? ...

... M. 62 Y.O. Canada. HCV 30 years. GT 1?. Biopsy 10 yrs ago. Still stage 1 by (what test)? Pre-treatment VL 3,270,442. Pre-treatment ALT/AST? Failed first 8 week Harvoni treatment - SOT (day/month/2018) to EOT (day/month/2018). Labs during Harvoni ALT/AST? Failed Harvoni tretament with post-Harvoni-treatment VL of 311,230 at EOT+12 weeks. ...  New(second) re-treatment with 12 weeks Vosevi  SOT March 20, 2019 EOT June 12, 2019? Pre-treatment labs just prior to Vosevi start ALT/AST? ...

Please correct this suggested sig line, or add items, or create one of your liking. And do let us know and/or add info like ... if you have had any abd. ultrasounds and/or fibroscans, or what any of your recent labs are (LFT's) like ALT's/AST's. All of these bits of info are helpful data.

Did they provide you a schedule of when you will have bloods drawn for VL's and LFT's during your 12 weeks of Vosevi?

I am sorry that you have been having fatigue feelings - I also had bad fatigue prior to cure, and it took a while for the fatigue to leave, but eventually, thanks to the cure, it did! Everyone is different as far as how they feel before, during and after treatment. Hopefully you will sail right through this and on to the cure you should have already earned. Vosevi will do it for you this time! You mentioned work, should you need time off can you take some leave? We have had lots of folk around here work right through their treatments, but it is always nice to know you can bank on time off should you decide you want it/need it.

Happy day one tomorrow! C.



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 64 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



Member

Status: Offline
Posts: 21
Date:
Permalink  
 

Just got the news today..I have been approved for 12 of Vosevi.

supposed to begin tomorrow....I cannot say enough about this board....I was a little crushed with Harvoni failure but now I feel hopeful again.   Meds coming just in time as my fatigue is brutal now...tough to keep working....but I think I see a light of in the distance again...thank you one and all.

 



__________________
Tig


Admin

Status: Offline
Posts: 8910
Date:
Permalink  
 

Hi Mike,

Fill us in, Brother. What’s your time table for Vosevi? I know how tough relapsing is and nothing I can say will take away the sting of that disappointment. However, I can tell you this, I have no knowledge of anyone failing to respond to the rescue course of Vosevi. Once you get the chance, it will be successful. I don’t say that without confidence!



__________________

Tig

63 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 5+ years!

Hep C FAQ   Lab Ref. Ranges  HCV Resistance

Signature Line Set Up/Abbreviations   Payment Assistance

 



Moderator

Status: Offline
Posts: 693
Date:
Permalink  
 

Good to hear from you, Mike.  

Have you started the Vosevi yet?  If not, do you know when you will. What a great treatment it is.  I hear it's much more tolerable then Harvoni and so highly effective.  I can't wait to hear when you hit that target and get to enjoy being (finally) HepC free.  Take aim. You'll be a sharp shooter this time.



__________________

GT2a, VL 681,500, Less than F1, Treatment Naive

12 wks Sovaldi/Ribavirin, SOT 2/25/16, EOT 5/17/16

UND at 2,4,8 and 12 wks during treatment but ribavirin crazy.

ALT/AST normal EOT

SVR12 8/13/2016!!!!!!!!!  I WON!!

EOT 6 Months 11/12/2016  CURED

 



Member

Status: Offline
Posts: 21
Date:
Permalink  
 

Thank you

 



__________________


Senior Member

Status: Offline
Posts: 227
Date:
Permalink  
 

Great News Android. clap.gifclap.gifclap.gifIt must have been so disappointing to have failed. With Vosevi that wont happen again. Look forward to following your journey



__________________

66/F Contracted Early 80's First Diagnosed Early 2000's 2017 re diagnosis and referral for treatment Gen 3a Fibroscan 8.7

Epclusa 12 weeks commenced 1 May 2018 ALT 72 AST 67

28 May 2018 4 weeks ALT 16 AST 23 ...... 23 July 2018 EOT ALT 23 AST 30 .....Oct 16 2018 SVR12 UND



Moderator

Status: Offline
Posts: 693
Date:
Permalink  
 

That's terrific, Mike.  You've earned the new hope and the outcomes it will reap. Keep us posted on the Vosevi treatment. I hear it is better tolerated.  Do let us know.



__________________

GT2a, VL 681,500, Less than F1, Treatment Naive

12 wks Sovaldi/Ribavirin, SOT 2/25/16, EOT 5/17/16

UND at 2,4,8 and 12 wks during treatment but ribavirin crazy.

ALT/AST normal EOT

SVR12 8/13/2016!!!!!!!!!  I WON!!

EOT 6 Months 11/12/2016  CURED

 



Guru

Status: Offline
Posts: 1059
Date:
Permalink  
 

android, i'm so glad to hear you are going forward with vosevi and we will also be here for this journey



__________________

Gt:1a-36yrs .Started Intron-A in 96' for 2.5mo-VL still too high.taken off. Labs on 3.6.18:. A1 activity.  f3@60: fibrosur bloodtst. AFP=norm. enz=mostly norm.VL=3.9 million.sot=5.1.18>Harvoni>[8wks]: 4WEEKS=UND. Eot 6/25=L.July=norm liverpanel.*13weeks=UND * 6 months =UND: CLUB ZERO



Guru

Status: Offline
Posts: 3224
Date:
Permalink  
 

Hey, Hi again Android,

Nice to see you back again with your good news.

So, after our Nov chats, you finally got to see that new "wizard" doc you had mentioned before, the doc who you thought you might switch to, and he confirmed yesterday he is going to get you on vosevi?

Perfect news!

I think you said in the summer that they were expecting to make you wait at least 6 months for re-treatment after your Harvoni failure, then, you might have also had a "wait" to see this new doc?? Regardless of how it went down and the timeline of the past, we will just celebrate with you today that the new doc is going to fast track you for vosevi! Ideal for you. : )

How have you been feeling physically, do you have any new labs results to share?

I am thrilled for you. C.

 



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 64 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)

Tig


Admin

Status: Offline
Posts: 8910
Date:
Permalink  
 

Hey Mike,

It’s good to hear from you! You should be jumping for joy over that. Vosevi is the drug of choice (IMO) when anyone relapses on any DAA. The medical community agrees that it’s the best option available.

Vosevi will do the trick, it’s a 3 way whammy and the Dragon doesn’t stand a chance against it. It’s very rare that we witness relapses now, but sadly, until these treatment success rates hit 100% every time, we’re going to have them sneak into the equation. With Epclusa, Mavyret and Vosevi, I think we’re going to see the rates of success approaching the golden 100% mark. 

I wish you all the best and invite you to share your journey with us, again. We’re here for you  and will enjoy riding the Vosevi Train with you!



__________________

Tig

63 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 5+ years!

Hep C FAQ   Lab Ref. Ranges  HCV Resistance

Signature Line Set Up/Abbreviations   Payment Assistance

 



Member

Status: Offline
Posts: 21
Date:
Permalink  
 

Went to see a new doctor yesterday and he immediately fast tracked me for Vosevi.  I know I do not post often but wanted to thank everyone on this board for their encouragement last November when I got the news that I failed on Harvoni.  

I felt more than a little disappointed and this board was a source of hope and encouragement for me.  

Thank you everyone for all the good vibes.  I feel great hope again.

 

 



__________________
Page 1 of 1  sorted by
 
Quick Reply

Please log in to post quick replies.

Legal Disclaimer:

THIS FORUM, IT'S OWNERS, ADMINISTRATORS, MODERATORS AND MEMBERS DO NOT AT ANY TIME GIVE MEDICAL ADVICE AND IN ALL CASES REFER ANYONE HERE TO SEEK APPROPRIATE MEDICAL ADVICE FROM THEIR DOCTOR.