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MissusB


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RE: New Member Missusb
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Moving Over to the On Treatment Thread thread



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66 yr old female; polio survivor; hbv that wasnt treated but cleared; chronic hcv gt1a; diagnosed 2018 but likely infected during surgery as child; Metavir score F2-F3; mild to mod fibrosis; RNA 3,951,412; AST 40; ALT 47
5-1-18


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MissusB wrote:

Guru....it is a good feeling

 

i am 5 , actually 5.1.18 is when i started tx so used that as my name, but i go by 5,

many of us are gurus cos we post a lot



__________________

Gt:1a-36yrs .Started Intron-A in 96' for 2.5mo-VL still too high.taken off. Labs on 3.6.18:. A1 activity.  f3@60: fibrosur bloodtst. AFP=norm. enz=mostly norm.VL=3.9 million.sot=5.1.18>Harvoni>[8wks]: 4WEEKS=UND. Eot 6/25=L.J*13weeks=UND * 6 m =UND: CLUB ZERO.1yr.=0
MissusB


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Guru....it is a good feeling



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66 yr old female; polio survivor; hbv that wasnt treated but cleared; chronic hcv gt1a; diagnosed 2018 but likely infected during surgery as child; Metavir score F2-F3; mild to mod fibrosis; RNA 3,951,412; AST 40; ALT 47
5-1-18


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MissusB wrote:

So far...all is good after  first dose last night.  Started on my water this morning 

 it's a great feeling to wake up and be ok after the first dose, isn't it?



__________________

Gt:1a-36yrs .Started Intron-A in 96' for 2.5mo-VL still too high.taken off. Labs on 3.6.18:. A1 activity.  f3@60: fibrosur bloodtst. AFP=norm. enz=mostly norm.VL=3.9 million.sot=5.1.18>Harvoni>[8wks]: 4WEEKS=UND. Eot 6/25=L.J*13weeks=UND * 6 m =UND: CLUB ZERO.1yr.=0
MissusB


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So far...all is good after  first dose last night.  Started on my water this morning 



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66 yr old female; polio survivor; hbv that wasnt treated but cleared; chronic hcv gt1a; diagnosed 2018 but likely infected during surgery as child; Metavir score F2-F3; mild to mod fibrosis; RNA 3,951,412; AST 40; ALT 47
Sticker


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Right on with the water MissusB! You might get sick of having to force it all down on a daily basis but try to stay the course, it helps for sure. I take my Mavyret with supper each night and it is working well for me. Please dont be shy about posting here if you feel lousy or if you feel fantastic. Your reports may encourage others who harbor worries about taking this medication. I am confident that you are going to do very well with your treatment and you will achieve SVR. You and I are only separated by a few weeks and I look forward to our virtual high-five in the near future!!



__________________

52 y/o male, Genotype 1B, F3, Dx - 1992, likely contracted virus 1977, Current Tx - 8 weeks Mavyret 07/23/2019. Tx - 1st time, Rebetron 6/2000-6/2001, 2nd time, Pegasys 11/2002-4/2003. VL - 636,000 AST - 49, ALT - 77

UND - 08/22/19!!!

SVR 12 - 12/17/2019, AST - 17, ALT - 14

 

 

 
Observer


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Omg I know what you mean about peeing nonstop.... the worst part for me were the 3 visits to the loo in the middle of the night.  

drinking a lot of water is totally worth it though ... as with polosilver, it has now become a life long habit for me. 

 

Congrats on day 1, that dragon doesnt stand a chance 



-- Edited by Observer on Wednesday 7th of August 2019 04:56:04 AM

__________________

61 y/o, Infected via transfusion Oct'83, GT-1a, F-4 cirrhotic,
tx Holkira pak/moderiba 12 weeks

4 years.... successful dragon slayer 
Sticker


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Hey MissusB, I am glad you are getting started on the Mavyret. This stuff is a game changer! I just started week 3 of my 8 week course and things are going very well. I noted on the medication box that its recommended to take in 2-4 liters of water daily. Im going for the 4 liters, Im floating on water for crying out loud! My first dose I felt a little something but not exactly sick, and that was it! All the way into week 3 with no side effects. Listen to your body though and respect it, I know you will. You have a fantastic attitude and we are here for you, to listen, and to offer support. Keep us posted. 



__________________

52 y/o male, Genotype 1B, F3, Dx - 1992, likely contracted virus 1977, Current Tx - 8 weeks Mavyret 07/23/2019. Tx - 1st time, Rebetron 6/2000-6/2001, 2nd time, Pegasys 11/2002-4/2003. VL - 636,000 AST - 49, ALT - 77

UND - 08/22/19!!!

SVR 12 - 12/17/2019, AST - 17, ALT - 14

 

 

 
MissusB


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Drank 2 liters today and peed all day long!  Will get up and start drinking water first thing in am!



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66 yr old female; polio survivor; hbv that wasnt treated but cleared; chronic hcv gt1a; diagnosed 2018 but likely infected during surgery as child; Metavir score F2-F3; mild to mod fibrosis; RNA 3,951,412; AST 40; ALT 47
polosilver


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Righteous, way to go MissusB! You got the right ticket and are on the train...drink lots of water..



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New: Hepatomegaly 07/30/2019, AST 29 & ALT 15

Female,1a,F2 mod fibrosis,HCV 06/2017,SOT 08/04/2017, Harvoni

HCV VL 414,000, AST 54, ALT 74.  4 weeks AST 34 and ALT 31, SVR, Jan 2018. 

12 week EOT, AST 20 & ALT 23 and still VL UND.

Club Zero Member.

 
MissusB


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Ate a plate of spaghetti and a piece of garlic bread and swallowed those 3 bad boys right down. First dose in my tummy!  Journey is on!



__________________

66 yr old female; polio survivor; hbv that wasnt treated but cleared; chronic hcv gt1a; diagnosed 2018 but likely infected during surgery as child; Metavir score F2-F3; mild to mod fibrosis; RNA 3,951,412; AST 40; ALT 47
5-1-18


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MissusB wrote:

Meds are here!! Will take first dose at evening meal.  Prayers for no side effects 

  awesome! i will def pray for you thru-out your tx



__________________

Gt:1a-36yrs .Started Intron-A in 96' for 2.5mo-VL still too high.taken off. Labs on 3.6.18:. A1 activity.  f3@60: fibrosur bloodtst. AFP=norm. enz=mostly norm.VL=3.9 million.sot=5.1.18>Harvoni>[8wks]: 4WEEKS=UND. Eot 6/25=L.J*13weeks=UND * 6 m =UND: CLUB ZERO.1yr.=0
Iris Dragonfly


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Hi from me!

you're well on your way to healing now, Congratulations

blessings, Iris



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in the silence of the woods, you will not be alone- Chief Seattle

60 years on planet, Female, diagnosed 1978 as non-a non-b, VL 8mill+, Fibro f-1f-2, Genotype 1a, treatment naďve....UNTIL 7-01-18  !!!! started Harvoni 12 weeks. :)

4 weeks=UND, 8 weeks=UND, 12 weeks=UND (EOT= 09-23-2018)
Tig


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Not to worry, MrsB, you're going to fly through this without a second thought. I'm sure of it! They are what we call "Magic Beans", prepare to be amazed...



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Tig

67yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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Shemp


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That's great!! Start drinking water now. Remember at least a gallon per day. Bon voyage.



__________________

62 yo male GT 1b/2 ALT 60 AST 51 V/L 985,000 Fibro A2 F 3/4 began 12 wks Mavyret 9/13/2018

6 wk labs ALT 12 AST 18 V/L NOT DETECTED EOT 12/05/2018 V/L NOT DETECTED

12 Wk post EOT ALT 11 AST 16 V/L NOT DETECTED  Thank you GOD

Take that stupid dragon

1/2/2020 SVR 12
Cheddy


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Let me add my welcome Missusb.  I'm glad to hear that the gang was helpful in assuaging your worries.  It's so normal to have concerns and to speculate about scary stuff.  The diagnosis is scary enough.

About your blood draw schedule: I suggest you call or email your doc and/or lab to let them know you got started on a different date.  They may not be willing to do the draw when you get there at three weeks.  Four weeks is a pretty standard marker.

I'll be interested to hear how your first few days go and if there is a period of adaptation.  You may find the treatment very tolerable, but remember, these DAAs are some powerful medication making big changes, so go easy and take good care of yourself!

Best of luck and good health.  You've already made a very good choice to get cured!

Cheddy 



__________________

GT2a, VL 681,500, Less than F1, Treatment Naive

12 wks Sovaldi/Ribavirin, SOT 2/25/16, EOT 5/17/16

UND at 2,4,8 and 12 wks during treatment but ribavirin crazy.

ALT/AST normal EOT

SVR12 8/13/2016!!!!!!!!!  I WON!!

EOT 6 Months 11/12/2016  CURED

 
MissusB


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Meds are here!! Will take first dose at evening meal.  Prayers for no side effects 



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66 yr old female; polio survivor; hbv that wasnt treated but cleared; chronic hcv gt1a; diagnosed 2018 but likely infected during surgery as child; Metavir score F2-F3; mild to mod fibrosis; RNA 3,951,412; AST 40; ALT 47
Shemp


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MissusB, Whatever time works for you is fine. I took my daily dose right before bed because it worked for me. My schedule is all over the place. What's really important is that you take it at the same time everyday. Wishing you a smooth journey.



__________________

62 yo male GT 1b/2 ALT 60 AST 51 V/L 985,000 Fibro A2 F 3/4 began 12 wks Mavyret 9/13/2018

6 wk labs ALT 12 AST 18 V/L NOT DETECTED EOT 12/05/2018 V/L NOT DETECTED

12 Wk post EOT ALT 11 AST 16 V/L NOT DETECTED  Thank you GOD

Take that stupid dragon

1/2/2020 SVR 12
MissusB


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Thanks Canuck....no, my md did not say my hbv was chronic!  After talking with you and reading this forum, my fears about the hbv reactivation are gone.  Just looking forward to getting started on this jour and joining the cured group!  My first lab draw is scheduled for Aug 28 so that will be 3 weeks after treatment (would have been 4 if my shipment arrived last week as scheduled). 

I was planning to take the doses between 6-7 after evening meal so hopefully I would sleep through any potential side effects.  Got any recommendations on best time for dosing?



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66 yr old female; polio survivor; hbv that wasnt treated but cleared; chronic hcv gt1a; diagnosed 2018 but likely infected during surgery as child; Metavir score F2-F3; mild to mod fibrosis; RNA 3,951,412; AST 40; ALT 47
Canuck


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MissusB,

Hey, nice job on the signature line! It's handy helpful info to have that completed.

Hope your shipment arrives tomorrow and you get your start. The 8 weeks might feel both a little bit long, but likely, mostly short.

: ) 

Amazing, these nowaday treatments, that we can be cured so easily and in such short timeframes.

Likely your doc has already laid out the blood letting (testing) plan for you for while you are on treatment and after? - i hope you get a 4 week blood draw, some docs do not offer a 4 week blood draw whilst on a short 8 week course of treatment but I like to see what's happening as i go along! I would ask for this if it has not been discussed or offered. If it were me I would want blood draws done at 4 weeks, and at 8 weeks "end of treatment" (EOT), with both 4 and 8 week draws including VL and LFT's, and then of course the same at 12 weeks after your EOT which would be your SVR12 draw. Another draw was commonly done at 24 weeks after EOT, a SVR24 draw. Some docs are not doing any blood draws (that include a viral load) until 12 weeks after EOT. It will be interesting to see what labs your doc has planned for you.

Back to clarifying your HBV status:

Sorry, I am still not quite clear on this, perhaps it is semantics or a typo or it's just me not understanding, so, please be patient, and bear with me in trying to clarify this a little further.

It is not because I am concerned regarding reactivation, it is just to know that I am understanding your current B status, that's all.

We have little to fret about just because people like you and me have been unlucky enough to have experienced both B and C viruses - like we have reviewed, the risk of B reactivation whilst treating C on DAA's is remote. 

You said ... " my Hep B is not active and is chronic   ".

Maybe you meant ... " my Hep B is not active and is not chronic  " ?

Just because we have had a bout of hep b in the past, that does not mean we have chronic hep b now. Considering the info you have given us thus far on your B antigen/antibody test results, I would guess you possess a good amount of immunity to hep b, likely "naturally" (spontaneously) acquired by the very fact that you went through a hep b infection, successfully resolving the infection on your own, and coming out the other side possessing antibodies currently at 15.4, with 10 being the minimum for a level sufficient for immunity.

Has your doc actually told you that you currently have "chronic" hep B?

Hope tomorrow is day one on Mav! Have you decided what the best time of day for dosing yourself will be? C.

 

 

 



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 64 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)
5-1-18


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MissusB wrote:

Thanks Shemp!  Just checked UPS tracking...scheduled for delivery tomorrow and I will start the journey 

 they made me sign for each delivery, i was so anxious and didn't want to miss the delivery



__________________

Gt:1a-36yrs .Started Intron-A in 96' for 2.5mo-VL still too high.taken off. Labs on 3.6.18:. A1 activity.  f3@60: fibrosur bloodtst. AFP=norm. enz=mostly norm.VL=3.9 million.sot=5.1.18>Harvoni>[8wks]: 4WEEKS=UND. Eot 6/25=L.J*13weeks=UND * 6 m =UND: CLUB ZERO.1yr.=0
MissusB


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Thanks Polosilver



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66 yr old female; polio survivor; hbv that wasnt treated but cleared; chronic hcv gt1a; diagnosed 2018 but likely infected during surgery as child; Metavir score F2-F3; mild to mod fibrosis; RNA 3,951,412; AST 40; ALT 47
polosilver


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Welcome MissusB!

Glad you found this site, there is amazing support here. You are in good hands to answer Q&A too, listen and keep you rolling along. I see you are already informed about drinking lots of water! My Avatar is the reminder from me. I started Harvoni treatment 2 years ago yesterday and drinking water, allowing myself to rest and checking in here helped me get through it. I also made some online friends here that been special for me. 

I recall the truck pulling up with my first month's supply in a large starfoam container. Look forward to hangin with you through the process.

 

ps

 



__________________

 

New: Hepatomegaly 07/30/2019, AST 29 & ALT 15

Female,1a,F2 mod fibrosis,HCV 06/2017,SOT 08/04/2017, Harvoni

HCV VL 414,000, AST 54, ALT 74.  4 weeks AST 34 and ALT 31, SVR, Jan 2018. 

12 week EOT, AST 20 & ALT 23 and still VL UND.

Club Zero Member.

 
MissusB


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Thanks Shemp!  Just checked UPS tracking...scheduled for delivery tomorrow and I will start the journey 



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66 yr old female; polio survivor; hbv that wasnt treated but cleared; chronic hcv gt1a; diagnosed 2018 but likely infected during surgery as child; Metavir score F2-F3; mild to mod fibrosis; RNA 3,951,412; AST 40; ALT 47
Shemp


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Welcome MissusB, I also took Mavyret for 12 weeks and completed TX December 2018. That dragon is dead. Let us know when you start, we're all here for you.



__________________

62 yo male GT 1b/2 ALT 60 AST 51 V/L 985,000 Fibro A2 F 3/4 began 12 wks Mavyret 9/13/2018

6 wk labs ALT 12 AST 18 V/L NOT DETECTED EOT 12/05/2018 V/L NOT DETECTED

12 Wk post EOT ALT 11 AST 16 V/L NOT DETECTED  Thank you GOD

Take that stupid dragon

1/2/2020 SVR 12
MissusB


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My md did say my Hep B is not active and is chronic

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66 yr old female; polio survivor; hbv that wasnt treated but cleared; chronic hcv gt1a; diagnosed 2018 but likely infected during surgery as child; Metavir score F2-F3; mild to mod fibrosis; RNA 3,951,412; AST 40; ALT 47
MissusB


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So glad I found this site. You guys have already made me fell soooo much better about this journey! My MD did tell me the risk of Hep b reactivation was almost non existent and he will monitor. My Hep B surface Antigen is Negative; Core Surface Antibody is Positive; Core Surface Antibody value is 15.40. I had no idea I had Hep B and was not treated so my body fought it and I never had symptoms! I was shocked at this and even my Hep C dx was a shock. However, after reading through posts on this forum, I definitely had symptoms that are probably contributed to this nasty Hep C that I thought were just part of aging. Now I am excited about getting my Mavyret...hopefully today. Was scheduled to be delivered to me via UPS on Friday but didnt arrive....have already left message for MD to call me this morning. Will update you all later. Thanks again for your support..I feel so much better about this whole thing!

__________________

66 yr old female; polio survivor; hbv that wasnt treated but cleared; chronic hcv gt1a; diagnosed 2018 but likely infected during surgery as child; Metavir score F2-F3; mild to mod fibrosis; RNA 3,951,412; AST 40; ALT 47
Tig


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Welcome to the forum, MissusB! Looks like you have met some of our group and expect more to be along soon. We’ve got a great bunch and everyone is here to help. If you have any questions now or along the way, please let us know.

Canuck is on top of the Hep B news and can explain the questions regarding reactivation. As she mentioned, the risk is low.

Stay in touch and let us know when the medication arrives. You should expect few, if any side effects from the drug itself. The biggest complaint, which is occasional headaches and increased fatigue, can be mitigated or eliminated by drinking 3-4 liters of water everyday. Without fail! You won’t regret developing a good routine to assure that.

I’m glad you found us. Good luck, Warrior!



__________________

Tig

67yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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Observer


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Welcome Missusb,

Im sure no expert so I cant allay your concerns regarding the hep B...Im just a cheerleader smile who is  super glad you are getting treatment for the HCV.

You sound like you have informed yourself on the importance of drinking lottsa water while on treatment...its also really important to take your meds at the same time every day so the virus is consistently being bombarded.

Let us know when the meds arrive so we can cheer you on biggrinon the first day of your dragon slaying journey 



__________________

61 y/o, Infected via transfusion Oct'83, GT-1a, F-4 cirrhotic,
tx Holkira pak/moderiba 12 weeks

4 years.... successful dragon slayer 
Canuck


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Adding ...

- re-reading your info, if you mean YOUR testing showed antibodies and NO surface antigen, then that is likely, in part, why your doc would be telling you not to worry. Still, it would be good to know all the other particulars about your past and current Hep b status/testing to better determine where your hep b status is at.  : )  C.



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 64 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)
Canuck


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Hey! 

That's great MissusB, so glad to see you started your new member thread here.

Welcome to the site.

Yup, always a good place to come for company and questions. Lots of folk here will try to assist you.

Regarding your Hep B reactivation concern - keep in mind there have only been very rare instances of hep B re-activations documented - the incidence of this happening is very low. That said, we would need to know what your current HepB status is to be able to start to delve into Hep B reactivation risks. 

- Have you been told you currently HAVE CHRONIC Hep B?

- Were you ever treated (were you given any drug treatment/therapy for your Hep B)?

- Have you ever (at any time) been innoculated/vaccinated/ "immunized" for Hep B?

Perhaps you were like me and had a bout of Hep B once in the in the past, but spontaneously and successfully beat the Hep B infection off all by yourself, and now are NOT ACTIVELY infected with chronic hep B..

What did your most recent Hep B immunity/status testing show (exactly)? Did you show that you have some "naturally acquired immunity to Hep B" due to successfully fighting off a previous Hep B infection of the past?  Were you told you possess some or any immunity to Hep B?  ie - Do you have/show:  surface antigen/surface antibody/core antibody?? Perhaps as a result of recent testing you have been told you currently have a sufficient level of "immunity" to Hep B?

These further details about your Hep B testings/reports (whatever you have or know) would be helpful for discussion purposes. 

For the vast majority tho, Hep B reactivation risks are a non-issue.

Welcome again, glad you are here, others will be along shortly to welcome you and see what we can do to help. : ) C.



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 64 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)
5-1-18


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welcome to the friendly forum missusB.

my hub had both and the b did not reactivate. they will monitor you from now till forever so anything unusual will be spotted early.

i'm so glad you are going on tx to get well. 

yes it's sad that we have to even get cured, but it's great they found some cures for us.

i hope you keep us posted on your journey.



__________________

Gt:1a-36yrs .Started Intron-A in 96' for 2.5mo-VL still too high.taken off. Labs on 3.6.18:. A1 activity.  f3@60: fibrosur bloodtst. AFP=norm. enz=mostly norm.VL=3.9 million.sot=5.1.18>Harvoni>[8wks]: 4WEEKS=UND. Eot 6/25=L.J*13weeks=UND * 6 m =UND: CLUB ZERO.1yr.=0
MissusB


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Hi to All:  I have chronic hep c (genotype 1a)with a previous hep b.  I am a polio survivor and MD suspects I contacted both virus during polio corrective surgeries  as a child.  I only became aware of the hep dx about a year ago.  Have had all the bloodwork and liver ultrasound (mild to moderate fibrosis).  Starting Mavyret 8 week treatment as soon as meds are delivered.  Excited to start the journey to cure but also a little concerned about the warning of possible Hep B reactivation, however my MD said I shouldnt be concerned about that. Hep B antigen is negative and antibody is positive.  Bilirubin 0.7. RNA 3,952,422.  Any advice?



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66 yr old female; polio survivor; hbv that wasnt treated but cleared; chronic hcv gt1a; diagnosed 2018 but likely infected during surgery as child; Metavir score F2-F3; mild to mod fibrosis; RNA 3,951,412; AST 40; ALT 47
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