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Post Info TOPIC: starting mavyret
Tig


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I'm glad things are going well for you Jammers! Water and rest are always a great way to help your body deal with treatment. I'm not surprised that you're experiencing few side effects, that's a great big plus with these new DAA's. It's a wonderful thing!

As for these medications and their impact on COV19, it just so happens that they are studying the efficacy of these antivirals on the virus. Gilead is in the forefront of pharmaceutical researchers dealing with this right now. So everything we have done in the past, related to the trials, is being studied again for use against this current crisis. We continue to provide that pioneer spirit when our world needs us the most. We'll succeed, I'm sure of it. If we don't soon, I'll be 300 pounds! That's the last thing I need. Puzzles and food have been my life the last two weeks.

Keep up the good work, that Dragon has received it's eviction notice.



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Tig

63 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 6+ years!

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Week 6! Here comes jammers ... that dragon is well and truly slayed.....now jammers is sealing the deal.  

so glad the sides are so mild and easily dealt with with water and an aspirin 

and yes wouldnt it be great if it was a treatment for covid 19 ....fingers crossed they find one soon



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61 y/o, Infected via transfusion Oct'83, GT-1a, F-4 cirrhotic,
tx Holkira pak/moderiba 12 weeks

4 years.... successful dragon slayer 



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That would be so great. Sleep on, as much as you need. Sleep is medicine!



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GT2a, VL 681,500, Less than F1, Treatment Naive

12 wks Sovaldi/Ribavirin, SOT 2/25/16, EOT 5/17/16

UND at 2,4,8 and 12 wks during treatment but ribavirin crazy.

ALT/AST normal EOT

SVR12 8/13/2016!!!!!!!!!  I WON!!

EOT 6 Months 11/12/2016  CURED

 



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On to week six. Side effects have been surprisingly mild. Stay ahead of the headaches with water and a couple aspirin. I welcome the fact that I could sleep more in lieu of what we are all going through at the moment. Wouldn't it be nice if this medication did a number on the coronavirus?

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Virus und    

that music to the soul ... yay



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61 y/o, Infected via transfusion Oct'83, GT-1a, F-4 cirrhotic,
tx Holkira pak/moderiba 12 weeks

4 years.... successful dragon slayer 



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I am doing ok.

Been sleeping more than usual but this is a welcome thing.

 



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Great, Jammer! That's good news. Are you feeling okay? Any side effects?



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GT2a, VL 681,500, Less than F1, Treatment Naive

12 wks Sovaldi/Ribavirin, SOT 2/25/16, EOT 5/17/16

UND at 2,4,8 and 12 wks during treatment but ribavirin crazy.

ALT/AST normal EOT

SVR12 8/13/2016!!!!!!!!!  I WON!!

EOT 6 Months 11/12/2016  CURED

 



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jammers!!!! so awesome, that is the best news.

 

5



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Gt:1a-36yrs .Started Intron-A in 96' for 2.5mo-VL still too high.taken off. Labs on 3.6.18:. A1 activity.  f3@60: fibrosur bloodtst. AFP=norm. enz=mostly norm.VL=3.9 million.sot=5.1.18>Harvoni>[8wks]: 4WEEKS=UND. Eot 6/25=L.J*13weeks=UND * 6 m =UND: CLUB ZERO.1yr.=0



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Got a call from my liver doctors today Four week labs show the virus undetectable. Onward with the rest of this treatment. Peace and love and a lot of water

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Yay jammers...how are you feeling?



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61 y/o, Infected via transfusion Oct'83, GT-1a, F-4 cirrhotic,
tx Holkira pak/moderiba 12 weeks

4 years.... successful dragon slayer 



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You got this!  

How are you feeling overall now that you are several weeks into it?? 

time to paint?

best wishes, Iris



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in the silence of the woods, you will not be alone- Chief Seattle

60 years on planet, Female, diagnosed 1978 as non-a non-b, VL 8mill+, Fibro f-1f-2, Genotype 1a, treatment naïve....UNTIL 7-01-18  !!!! started Harvoni 12 weeks. :)

4 weeks=UND, 8 weeks=UND, 12 weeks=UND (EOT= 09-23-2018)



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woohoo jammers! keep on truckin'



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Gt:1a-36yrs .Started Intron-A in 96' for 2.5mo-VL still too high.taken off. Labs on 3.6.18:. A1 activity.  f3@60: fibrosur bloodtst. AFP=norm. enz=mostly norm.VL=3.9 million.sot=5.1.18>Harvoni>[8wks]: 4WEEKS=UND. Eot 6/25=L.J*13weeks=UND * 6 m =UND: CLUB ZERO.1yr.=0

Tig


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Go Jammers! Woot!!  



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Tig

63 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 6+ years!

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Onward to week 5 - still alive.

Water is life.

 



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onward to week 4...yay

got the rhythm going now...

and the mavyret express will soon be coasting 

how are your itchies and mild headaches?  



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61 y/o, Infected via transfusion Oct'83, GT-1a, F-4 cirrhotic,
tx Holkira pak/moderiba 12 weeks

4 years.... successful dragon slayer 



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right on jammers biggrin



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Gt:1a-36yrs .Started Intron-A in 96' for 2.5mo-VL still too high.taken off. Labs on 3.6.18:. A1 activity.  f3@60: fibrosur bloodtst. AFP=norm. enz=mostly norm.VL=3.9 million.sot=5.1.18>Harvoni>[8wks]: 4WEEKS=UND. Eot 6/25=L.J*13weeks=UND * 6 m =UND: CLUB ZERO.1yr.=0



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Great!! You will also notice that you are stronger all around. It's good to know what you can face.  Stay clean.  Wash your mittens. Hole up at home if you can.

biggrin



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GT2a, VL 681,500, Less than F1, Treatment Naive

12 wks Sovaldi/Ribavirin, SOT 2/25/16, EOT 5/17/16

UND at 2,4,8 and 12 wks during treatment but ribavirin crazy.

ALT/AST normal EOT

SVR12 8/13/2016!!!!!!!!!  I WON!!

EOT 6 Months 11/12/2016  CURED

 



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Three weeks done on to week four and there's so much more. You gotta love water.

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Tig


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You’re going to be amazed by the changes in your liver function and of course, your viral load, if they do one. You can always ask your doctor to perform one. They used to check the viral count during treatment, but have begun waiting til the end of treatment and very often until 12 weeks after. Regardless, you’ll be able to see the improvements in all the other results.



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Tig

63 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 6+ years!

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My first round of tests will be on March 30 at the four week mark



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Tig


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Jammers,

Great job and update! Has your doctor mentioned a testing schedule? Will they test at the end of treatment or make you wait until 12 weeks post?



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Tig

63 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 6+ years!

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Yay...

youre getting there...

it will be so nice for you to be virus free

water...the elixir of the gods biggrin



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61 y/o, Infected via transfusion Oct'83, GT-1a, F-4 cirrhotic,
tx Holkira pak/moderiba 12 weeks

4 years.... successful dragon slayer 



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right on jammers! , the tx will be over before you know it and you will be cured



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Gt:1a-36yrs .Started Intron-A in 96' for 2.5mo-VL still too high.taken off. Labs on 3.6.18:. A1 activity.  f3@60: fibrosur bloodtst. AFP=norm. enz=mostly norm.VL=3.9 million.sot=5.1.18>Harvoni>[8wks]: 4WEEKS=UND. Eot 6/25=L.J*13weeks=UND * 6 m =UND: CLUB ZERO.1yr.=0



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Jammin Jammers! Rock On!

BB, Iris



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in the silence of the woods, you will not be alone- Chief Seattle

60 years on planet, Female, diagnosed 1978 as non-a non-b, VL 8mill+, Fibro f-1f-2, Genotype 1a, treatment naïve....UNTIL 7-01-18  !!!! started Harvoni 12 weeks. :)

4 weeks=UND, 8 weeks=UND, 12 weeks=UND (EOT= 09-23-2018)



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Week two done. On to number three. Thanks for the water of life

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Yay week one done

that nasty virus doesnt stand a chance 

keep drinking the magic elixir

(glad you know of dry brush massage... has it or anything helped the itch?)



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61 y/o, Infected via transfusion Oct'83, GT-1a, F-4 cirrhotic,
tx Holkira pak/moderiba 12 weeks

4 years.... successful dragon slayer 

Tig


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Hey Sticker!  Good to hear from you

Jammer, this guy can help you a lot. He walked the Mavyret walk! One week down, the rest will fly by. Keep sucking down the water and all will continue to go smoothly!



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Tig

63 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 6+ years!

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That big first week is over. I understand any uncertainty that you could possibly have. During treatment I likely amplified any signal my body gave, was that a twinge? , am I experiencing liver pains? The incidence of these moments decreased after the first week so it was hard to say whether it was psychosomatic or not. In your case there are measurable findings and its not all in your head. You are going to be free of this thing very soon, Im pulling for you! Drink up!



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52 y/o male, Genotype 1B, F3, Dx - 1992, likely contracted virus 1977, Current Tx - 8 weeks Mavyret 07/23/2019. Tx - 1st time, Rebetron 6/2000-6/2001, 2nd time, Pegasys 11/2002-4/2003. VL - 636,000 AST - 49, ALT - 77

UND - 08/22/19!!!

SVR 12 - 12/17/2019, AST - 17, ALT - 14

 

 

 



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Week one behind me.

Seven to go.

Water...the magic elixir.

 

j



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Thanks I will.



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jammers, keep a log of your heart rate and either call the pharmacy or your doctor to ease your worries about it. That's why they get the big dollars $$$$$$$$$$$$$$$$$$$$$$ ....to answer our questions



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Gt:1a-36yrs .Started Intron-A in 96' for 2.5mo-VL still too high.taken off. Labs on 3.6.18:. A1 activity.  f3@60: fibrosur bloodtst. AFP=norm. enz=mostly norm.VL=3.9 million.sot=5.1.18>Harvoni>[8wks]: 4WEEKS=UND. Eot 6/25=L.J*13weeks=UND * 6 m =UND: CLUB ZERO.1yr.=0



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Jammers,

That's great that you are paying close attention to deviations from your norm. I'm not surprised that things are changing as you have some heavy duty anti virals running though your entire system. I agree, that you have to allow a period of adjustment. Still, keep paying attention and don't let that heart rate get too high without reporting it.  

It's pretty amazing that we have cures now that don't make you just plain sick, like the ones that Tig and others went through.  The sides back then caused some people to have to quit, and even worse, fail. My was no walk in the park as Ribaviren was included.  I was a mess and was rescued by Tig and others seeing me through. I think it's expected that your body is going to say, "Whoa! What the heck is this?" It will pay off, really.

Keep up the water. Eat well, and be patient.  It will all be over and gone soon. Stay in touch. I'm very interested in seeing how your journey continues.

 

Best wishes,

Ched



__________________

GT2a, VL 681,500, Less than F1, Treatment Naive

12 wks Sovaldi/Ribavirin, SOT 2/25/16, EOT 5/17/16

UND at 2,4,8 and 12 wks during treatment but ribavirin crazy.

ALT/AST normal EOT

SVR12 8/13/2016!!!!!!!!!  I WON!!

EOT 6 Months 11/12/2016  CURED

 

Tig


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I found my heart rate greatly accelerated at times, but some of it I'm sure was stress related. Do you have a blood pressure cuff at home? It's good to have one for so many reasons. That's the thing to keep an eye on. I also suggest that you cut out any stimulants, coffee, chocolate (sorry), tea, etc. Anything with caffeine should be avoided or greatly reduced if you're experiencing higher than normal pulse rates. Try decaf for the time being.

Have you noticed any increased sweating? I did, terrible stuff! All medicine related. Certainly, if you're experiencing anything that is well above and beyond normal, for an extended period, call your doctor. If you have that blood pressure cuff, keep track of your vital signs for a couple of days, BP, Pulse and Respiration. I recommend doing it every 2-3 hours while you're awake and switch arms occasionally. If you end up calling the doctor, that will be a great help. It may also help you determine if there are lifestyle issues that may be causing it, other than the medication of course.

As I mentioned earlier, the first couple of weeks will be an adjustment period. You're going to experience some changes. As long as they aren't worrisome, don't worry about it. It's very likely just your metabolism adjusting to treatment and should level out fairly quickly. These are powerful medications and even though you're not going through a minefield of side effects, you'll still require time to adjust. They're in there doing some awesome Dragon Butt kicking! Exactly what is needed. smile



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Tig

63 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 6+ years!

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Is it normal to experience a higher than normal heart rate?

I am usually in the 60-70 bpm but today after taking day four of the med, just relaxing my rate is around 90 bpm.

 

j



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Oh I am very familiar with the dry brush.

 

Thanks



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Good advice and info.

thanks

 



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Sorry bout spelling keyboard stuffed,

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Hi everyone ,hope al BBH l going ok , Thankfully summer almost gone,the humidity here is high atm, hope this new coronavirus gets wiped out soon, went to supermarket yesterday people are already nearly in state of panic,buying up on toilet ect, I spoke with naturepath recently he told me that a lot of the pain issues we have Poste treatment might be caused by carting the virus around for so long, seems to make sense as a lot of people have similar symptoms neuropathic nerve bloating ect, I also had high VL which worried me about doing treatment, especially if they were doing damage ,at least getting rid of virus hopefully stops any more damage to our system, take care everyone.

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Tig


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We used to experience horrible itching with the old regimens. We would use a number of methods to combat it. An oatmeal bath often works wonders. I got permission to use Zyrtec (certrizine), which is a antihistamine. It was very effective and doesn’t cause drowsiness, like Benadryl does. There’s a number of over the counter lotions that help, too.

As Obs mentioned, most of the early reactions to these friendly, but powerful meds, will resolve on their own. It takes a week or two to adjust to the drug. Keep hydrating and getting the rest your body requires. The time will go by fast.



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Tig

63 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 6+ years!

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Great jammers, 

isnt it amazing that these new drugs are so *user friendly* compared to the misery so many suffered through with the interferon and ribivaron treatments of 5 years ago?  Im so happy for you that a mild and treatable headache is the main issue you are having... hopefully the itching will pass soon...I found most of my odd side effects only lasted  for a few days.  I was on an earlier DAA and ribivaron , the sides from  ribivaron were pretty awful.

The itching is one of the bodys mechanisms for removing waste...if it persists might I suggest you look into doing a dry brush massage... you can buy a body brush at any pharmacy (near the loofas) and google dry brush massage..



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61 y/o, Infected via transfusion Oct'83, GT-1a, F-4 cirrhotic,
tx Holkira pak/moderiba 12 weeks

4 years.... successful dragon slayer 



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hey jammers, sounds good so far........ maybe extra lotion for now?

happy trails

5



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Gt:1a-36yrs .Started Intron-A in 96' for 2.5mo-VL still too high.taken off. Labs on 3.6.18:. A1 activity.  f3@60: fibrosur bloodtst. AFP=norm. enz=mostly norm.VL=3.9 million.sot=5.1.18>Harvoni>[8wks]: 4WEEKS=UND. Eot 6/25=L.J*13weeks=UND * 6 m =UND: CLUB ZERO.1yr.=0



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Just popped Day 3.

Nothing much to report. No sides to speak of. Occasional mild headache, but i take a few aspirin and water and it's gone. Today though my skin itches a little, nothing major though.

 

Water water water.....

 

j



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Thank you.



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Yay jammers,

day one done.

I really like your painting...yummy colours. 



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61 y/o, Infected via transfusion Oct'83, GT-1a, F-4 cirrhotic,
tx Holkira pak/moderiba 12 weeks

4 years.... successful dragon slayer 



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Day one still in progress so far so good nothing to speak of besides a very mild headache waking up from a nap took two aspirins and some water and it vanished.

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You’re going to do great, Jamie! We’re here with our Pom Poms ready, woohoo!!



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Tig

63 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 6+ years!

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heeeeeeereeeee you go! let the healing begin , water water water..... and rest

 

5



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Gt:1a-36yrs .Started Intron-A in 96' for 2.5mo-VL still too high.taken off. Labs on 3.6.18:. A1 activity.  f3@60: fibrosur bloodtst. AFP=norm. enz=mostly norm.VL=3.9 million.sot=5.1.18>Harvoni>[8wks]: 4WEEKS=UND. Eot 6/25=L.J*13weeks=UND * 6 m =UND: CLUB ZERO.1yr.=0



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Home with first month supply.

 



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Yeah!! You got this   Before you know it, the dragon will be in the history books and out of your life, for good. Stay the course, never miss a dose and hydrate like the water will run out tomorrow. That's almost as important as the medication! It makes for great outcomes and no side effects.

Stay in touch and don't hesitate to ask questions when you have them. We're here to not only guide the way, but cheer you on to the last station - SVR-Ville wink



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Tig

63 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 6+ years!

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that's great jammers! getting on board the healing train to wellsville

5



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Gt:1a-36yrs .Started Intron-A in 96' for 2.5mo-VL still too high.taken off. Labs on 3.6.18:. A1 activity.  f3@60: fibrosur bloodtst. AFP=norm. enz=mostly norm.VL=3.9 million.sot=5.1.18>Harvoni>[8wks]: 4WEEKS=UND. Eot 6/25=L.J*13weeks=UND * 6 m =UND: CLUB ZERO.1yr.=0

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