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Post Info TOPIC: Covid-19 vaccine- side effects


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Covid-19 vaccine- side effects
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Tig wrote:

Hi Mike,

I saw the data you posted, but I wasn't clear on all of it. So your Ab test came back >250? That positive must've been a bit concerning for you! Did you experience any Covid like symptoms during that period, other than the sore arm? I know the vax has that effect on some patients. Hopefully you're not dealing with any of that. When will you repeat your blood work? I'm curious how the antibodies affect your HIV numbers going forward.


The vaccine's purpose is to initiate production of antibody's that target the spike protein of the virus. Since this test is measuring antibodies against the spike protein then the higher the quantity (U/ml) the better my immune response. Anything greater than 0.79 U/ml shows the immune system has produced these antibody's. The test upper limit is 250 U/ml. So my antibody response exceeded the limit of the test, which is good. Based on my results, I suspect most anyone's response to the vaccine, with a healthy immune system, would also test above the upper limit.
Note: The vaccines available in the United States all induce production of antibody's that target the spike (S) protein but not the nucleocapsid (N) protein of the virus. There are other test to determine levels of antibody's to the nucleocapsid protein which indicate a prior infection of the virus itself. So if you've had Covid-19 already you will likely test positive for both spike and nucleocapsid antibody's. The vaccines target the spike protein because, theoretically, that is the entry point of the infection.
I had no noticeable side effects from the vaccine. But evidentially, side effects are not necessarily an indicator of robust vs weak immune response resulting from the vaccine. More time and data are needed to understand these vaccine Sx's, which is true of many things about this novel virus.
Yes I'll likely repeat this Ab test in the future. Based on what we know about immune durability so far based on trial data and 4 months of extensive real world application, I could be good for at least 6-10 months, although there are caveats with this.
One thing is very likely. SARS-CoV-2 is with us to stay to some extent. Whether we will need continued boosters (like with influenza) or not depends on the durability of our immune system's continued ability to respond to this virus. These data also remain to be determined over time.
The main thing is that if I do get exposed to the virus, I know that, for now, I already have some level of protection which greatly increases my chances of fighting off infection, or at least severe disease or even death.
As far as my HIV, my CD4 T-cell level is higher, post-vaccination, than it's been in a long time. I don't know if that's a result of the vaccine or something else, but I'm happy about it.



-- Edited by wmlj1960 on Saturday 1st of May 2021 10:35:11 AM



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Hi Mike,

I saw the data you posted, but I wasn't clear on all of it. So your Ab test came back >250? That positive must've been a bit concerning for you! Did you experience any Covid like symptoms during that period, other than the sore arm? I know the vax has that effect on some patients. Hopefully you're not dealing with any of that. When will you repeat your blood work? I'm curious how the antibodies affect your HIV numbers going forward.



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Tig wrote:

So Mike, what's your status? Did you achieve the response desired, or did that quantification score show a false positive? My mind fails me this afternoon. I'm curious how your Sars CV2 antibodies and your HIV scores relate? I don't know how you stay on top of all that!


I posted the results on April 25. Look down 2 post in this thread. The result was positive and surprised me.

SARS-CoV-2 Semi-Quant Total Ab (Spike)
>250.00 U/mL

Interpretation:
Negative <0.80
Positive >0.79

Test range 0.40 - 250.00



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Protease Inhibitors? We have relied on them for years, almost a full decade where Hep C is concerned. I hope they release the information soon. I'd like to know which ones they're studying. Can you imagine people being introduced to Incivek or Victrelis to battle this? The thought of that chills me to the bone! I don't think there are many folks that could withstand a course equal to what we went through with that stuff. Those of us that had to use them, will know what I mean. Brutal stuff, but in the end, they worked. Incivek has to hold the award for the worst. Remember the 20 grams of fat at 6AM and the rectal pain/rashes? Lets hope they have refined them, or have far more tolerable medications.

So Mike, what's your status? Did you achieve the response desired, or did that quantification score show a false positive? My mind fails me this afternoon. I'm curious how your Sars CV2 antibodies and your HIV scores relate? I don't know how you stay on top of all that!



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I just read this

KEY POINTS

Pfizers experimental oral drug to treat Covid-19 at the first sign of illness could be available by the end of the year, CEO Albert Bourla told CNBC on Tuesday.

The drug is part of a class of medicines called protease inhibitors and works by inhibiting an enzyme that the virus needs to replicate in human cells.

Protease inhibitors are used to treat other viral pathogens such as HIV and hepatitis C.



-- Edited by wmlj1960 on Friday 30th of April 2021 02:19:47 PM

Image edited to fit forum width limits.



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I had a positive response to the Pfizer vaccine, especially considering my HIV status (Absolute CD4 280 /uL - Reference 540-1660 /uL). I had my doubts because I had no noticeable side effects after either shot other than a slightly sore arm.

SARS-CoV-2 Semi-Quant Total Ab (Spike)
>250.00 U/mL

Interpretation:
Negative <0.80
Positive >0.79

Test range 0.40 - 250.00

More information on this test



-- Edited by wmlj1960 on Friday 30th of April 2021 01:29:55 PM

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Iris Dragonfly wrote:

Mike, how are you dong now? it's the 10th, you should be out and about and enjoying re-intergration. Did you have any other side effects after your second dose?


Hello Iris. I'm doing fine and had very little side effects from either Pfizer dose. I'm not re-intergrating yet though. I had routine lab work done by my HIV doctor on March 12 and results were just posted yesterday on the patient portal, although some important info was left out, CD4 (T-helper) cell count in particular. But it does give an absolute lymphocytes value of 1384. Based on my last results 6 months ago, absolute lymphocytes 1058 yielding a CD4 value of 221, I can calculate my latest CD4 to possibly be in the neighborhood of 289, which is a substantial positive increase. This does not particularly indicate any value concerning SARS-CoV-2 antibodies although the Pfizer vaccine likely had a positive effect on these results. So I'll be having blood drawn in the morning for Labcorp test: 164090 (SARS-CoV-2 Semi-Quantitative Total Antibody, Spike). This should give an indication of how robust of a benefit I received from the Pfizer vaccine. Also it will give a baseline to calculate antibody waning in the future, which is normally expected - it's really the memory T cells that need to stick around for lasting durability. I'll post the antibody test result when I receive it.



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Tx #2 - 24wks Harvoni /SOT 7-25-2015/UND@EOT,+12,+24,+52 = SVR

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Additional information regarding the incidence of rare clotting disorders related to the vaccine. Be sure you ask your doctor to perform all appropriate testing before the vaccination. It's simply a wise recommendation.

Covid 19 Vaccine Safety Update



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Tig wrote:

Here's some information, pre Covid, but still explains the theory of vaccines.

Vaccine Dosing Safety


Thanks Tigsmile, I read most of it and will go back and read the whole thing but it's so interesting so far.



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Gt:1a-36yrs.Started Intron-A in 96' for 2.5mo-VL still too high.taken off. Labs on3.6.18:.A1 activity. f3@60: fibrosur bloodtst. AFP=norm. enz=mostly norm.VL=3.9 million.sot=5.1.18>Harvoni>[8wks]: 4WEEKS=UND.Eot 6/25=L.J*13weeks=UND * 6 m =UND: CLUB ZERO.1yr.=0

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Here's some information, pre Covid, but still explains the theory of vaccines.

Vaccine Dosing Safety



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Hello 5,

No, the vaccines aren't based on height and weight. Here are a couple of websites that will help answer several questions.

Mayo Clinic Guidance

Covid Questions



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Tig

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Are these doses individualized? How can they be when we are so varied in height and weight? That has always bothered me to think about vaccinations.



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Gt:1a-36yrs.Started Intron-A in 96' for 2.5mo-VL still too high.taken off. Labs on3.6.18:.A1 activity. f3@60: fibrosur bloodtst. AFP=norm. enz=mostly norm.VL=3.9 million.sot=5.1.18>Harvoni>[8wks]: 4WEEKS=UND.Eot 6/25=L.J*13weeks=UND * 6 m =UND: CLUB ZERO.1yr.=0

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There are complaints of arm discomfort, nausea and flu like symptoms following these vaccines. It's an immune system response to the vaccine, but still, it's got to be uncomfortable. There are a lot of reports of lymph node enlargement, especially on the side of the injection. Armpits and neck nodes seem to be most affected. There was a recent report advising women to wait two or three months (post vaccine) to get their mammograms, because breast lymph nodes inflame as well. If it's something that can't be put off temporarily, be absolutely certain to tell the doctor and mammo tech to notate that on your chart. I hope you get to feeling better soon, Iris.



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Tig

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Iris,maybe you should see your family doctor...they might know if it's an allergic reaction and shouldn't take the second dose.

Or maybe it will clear up in a few more days? I hope so.

5



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Gt:1a-36yrs.Started Intron-A in 96' for 2.5mo-VL still too high.taken off. Labs on3.6.18:.A1 activity. f3@60: fibrosur bloodtst. AFP=norm. enz=mostly norm.VL=3.9 million.sot=5.1.18>Harvoni>[8wks]: 4WEEKS=UND.Eot 6/25=L.J*13weeks=UND * 6 m =UND: CLUB ZERO.1yr.=0



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Mike, how are you dong now? it's the 10th, you should be out and about and enjoying re-intergration. Did you have any other side effects after your second dose?

I'm still getting weird brain fog that feels like buzzing in my head. Really agitating and I just feel yuk. I don't feel bad really, I just don't feel well.

I also heard women are having more side effects than men, something to do with estrogen. One thing I have also noticed is a spike in hot flashes, although they say chills are a side effect.

Stomach ache too like... bleh, I don't want to eat. But once I do it's ok.

oi, hope this passes soon, it's scaring me for the second dose.

bb, Iris



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Got my first Moderna dart today! Good Friday!!

so far ...sore arm, really tired, and brain fog (worse than normal, which really had been improving since SVR)...and like, spelling extra bad! LoL



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60 years on planet, Female, diagnosed 1978 as non-a non-b, VL 8mill+, Fibro f-1f-2, Genotype 1a, treatment nave....UNTIL 7-01-18 !!!! started Harvoni 12 weeks. :)

4 weeks=UND, 8 weeks=UND, 12 weeks=UND (EOT= 09-23-2018)

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Thanks for the information, Mike. I'm glad you have the protocol completed and are now waiting on full protection. It'll be soon Keep safe and stay healthy!



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Tig

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I'm fine. No side effects from the second dose except a little sore at the injection site. I should be considered fully protected on April 9 (2 weeks after 2nd dose). I'll still follow CDC guidelines (mask, distancing, etc) to keep from getting infected but, if I do, I feel much better knowing I'm protected against serious complications or death.

I'm sorry to hear about your friends mother. That's an unusual case. Most elderly people don't have as much of a reaction because of their weaker immune system. I'm only 60 but my HIV (low CD4 cell count) is likely why I had very little reaction. smile



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Hey Mike,

You should've had the second dose by now (3/26). Did you have any side effects from it? My friend's Mother got the first dose of the Moderna vaccine and ended up in the hospital. She got ill the second day, and we had to call 911 and get her to the hospital. She couldn't walk, high fever, and total loss of balance, couldn't hold anything down, not even water. She ended up in the ICU and then the cardiac floor. They indicated that it was likely a vaccine reaction, because they couldn't attribute it to anything else. She came home after a week and was home for two days and is back in the hospital. She's 80 years old, so this is concerning. She's insistent on getting the second dose, but the doctors are hesitant to administer it. You get partial protection from the first shot, so she might have to settle for that.

I hope you're doing well!



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Second COVID Shot Packs the Big Punch

What you may experience, appears to be short term. Nonetheless, there might be a rough day or two.

Second Vaccine Dose



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Congratulations Mike all the best for the future our country has decided to focus on buying the pfizer vaccine because of its high success rate 95%



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Congrats Mike



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Gt:1a-36yrs.Started Intron-A in 96' for 2.5mo-VL still too high.taken off. Labs on3.6.18:.A1 activity. f3@60: fibrosur bloodtst. AFP=norm. enz=mostly norm.VL=3.9 million.sot=5.1.18>Harvoni>[8wks]: 4WEEKS=UND.Eot 6/25=L.J*13weeks=UND * 6 m =UND: CLUB ZERO.1yr.=0

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I'm glad you got in, Mike. A warm, moist compress will help that discomfort. You should've been qualified for immediate vaccination. You've got co-morbidities that should have been recognized to begin with. Whatever the case, I'm happy you got that first dose. Big thumbs up, Bro!



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I received dose #1 of the Pfizer vaccine yesterday after waiting for all the scheduled people and any unscheduled eligible for phase 1B in my state (65yr+, Educators, food manufacturing, etc.) to be completed. There was a long line of non-eligible (phase 1C - underlying health conditions) people but only a few of us got the vaccine (what was left in opened vials). I got there early so I was 8th in line. Only a couple more got in after me. Today my arm is a little sore at the injection site and after a busy morning I'm a little fatigued but otherwise feel fine (and grateful!). Dose #2 is scheduled for March 26. smile



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Tx #1 - 24wks Sov+Riba /SOT 7-24-2014/UND@EOT/DETECTED@EOT+16 wks
Tx #2 - 24wks Harvoni /SOT 7-25-2015/UND@EOT,+12,+24,+52 = SVR

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Hello brothers and sisters. As a survivor of hep-c Triple Therapy way back in 2013 you will have to forgive me for being a tad hesitant on rushing in for my Covid-19 vaccine. Mind you, my doctor may be a little pissed if I say "I'd like to wait please" lol.

I flash back to those days when I hear of a possible cure that hasn't really been around long and then of course to this site, and you good people and Tig, CinnamonGirl and the gentleman with medical training from Australia who gave so unselfishly, freely and often. Sacrificing their time for our well-being. Cheers to them and you.



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