Hep C Discussion Forum

Canuck · Canuck

There was a fair bit of "talk" in the Journals, about safety profiles, and "Shingrex" getting approved for use over the "live" Zostavax in 2018. Between 2015 and as late as 2017 studies were still being completed about the effectiveness of Hep B and Zostavax immunizations in folk in association wit...

Canuck · Canuck

Funny (not) how "real world" data takes so long to "come out"! Here is a recent publication (2018), all about "Viekirax" (ombitasvir/paritaprevir/ritonavir) and "Exviera" (dasabuvir) - also known as "OPrD" (similar to later and further formulations named Viekira Pak and then Viekira XR).B...

skewedButNotBroken · skewedButNotBroken

https://www.hepmag.com/article/HCV-Brain-Endothelium-21818-1287637502

Canuck · Canuck

Published in Gastroenterology - News · January 18, 2018Psoriasis Remission Described After Hepatitis C Virus TreatmentCase report: After initiation of ledipasvir-sofosbuvir, HCV RNA decreased, and skin lesions improvedHealthDay WEDNESDAY, Jan. 17, 2018 (HealthDay News) -- A case of...

Canuck · Canuck

EDITORIAL - HCV Next, January/February - Dr. Ira M. JacobsonManaging the Fruits of HCV Cure: How Much Care do the Cured Need? The feature by Eric Lawitz, MD, very nicely encapsulates the revolutionary changes occurring within hepatitis C therapy over the past few years. As he explains, this ex...

Canuck · Canuck

Helio - HCV Next, January/February - Eric Lawitz, MD COVER STORYLooking Back on an Unprecedented Revolution in Medicine As we conclude another year now past the peak of hepatitis C research, HCV Next asked me to consider where we came from, where we are now, and where we're headed. They wanted me...

Tig · Tig

Time to thank all of you that continue to make our forum the best it can be! We have thousands of you to thank for being there for each other through our journey. We are just one of the support groups that have made a difference. A tip of the hat to each of them! Unsung Heroes

Canuck · Canuck

Tig found and posted this very interesting one - it's aptly under "clinical trials", but I don't want to loose track of this new NS5B, so borrowed Tig's find to be over here as well, so it can be seen as new "news" as well! Hope that's OK Tig. Janssen 2a trial

Canuck · Canuck

News about Abby's Pan 8 week Glec (NS3/4A) and Pib (NS5A). No SOF. Especially intersting for those with compromized renal function, TN/TE/cirrhotics. They are stiving for shorter treatment times for these Pans. FDA grants priority review for AbbVie's pan-genotypic HCV regimen - February 3, 2...

Canuck · Canuck

Hm, we have entered into this topic before ... what about those of us who, out of medical necessity and via deemed "best practices" of the times, received not transfusions per say, but various forms of "immunoglobulins" , see (U.K. Tainted Blood Inquiry), see (Viet Nam era veterans/ They gave us t...

Tig · Tig

Looks like Merck is going after different markets and dropping out of the HCV drug business. Zepatier is their last. Not a bad finish! It has cured a lot of people. Merck‘s Out

Canuck · Canuck

Nonprofit challenges Gilead's patents on sofosbuvir October 27, 2017 - HelioInitiative for Medicines, Access & Knowledge - a U.S.-based nonprofit also known as I-MAK - filed a set of patent challenges against sofosbuvir, according to a press release from the organization. According to...

Tig · Tig

If you would like to educate yourself or have something to share with others, this organization has an informative website that will help. HepCHope Official Site

Canuck · Canuck

https://clinicaltrials.gov/ct2/show/record/NCT02429583

Canuck · Canuck

Updated ACIP Recommendations Nix LAIV, Expand HBV VaccinationDiana Swift - February 06, 2017 The final 2017 adult vaccination schedule has been issued by the Advisory Panel on Immunization Practices (ACIP) of the Centers for Disease Control and Prevention (CDC).Published in the February 6...

Canuck · Canuck

Fatty Liver Disease Fastest-growing Reason for Transplants in Young U.S. Adults By Carolyn Crist - October 18, 2017(Reuters Health) - Nonalcoholic fatty liver disease and its more aggressive form, nonalcoholic steatohepatitis, have become the fastest-growing reasons for liver transplan...

Canuck · Canuck

Apparently they have recently inserted some updates, including recommendations for re-treating TE (treatment-experienced). https://www.hcvguidelines.org/

Tig · Tig

This is wonderful news! All you coffee drinkers can rejoice!!Increased coffee consumption lowers mortality risk in HIV/HCV coinfection Carrieri MP, et al. J Hepatol. 2017;doi:10.1016/j.hep.2017.08.005.September 26, 2017Elevated coffee consumption of three or more cups per day halved...

Tig · Tig

Here's a professional article on the various options used to determine levels (stages) of liver fibrosis. It includes the pros and cons of each. It's a 5 page article and may require free registration. I believe you will find it very informative. Assessing Fibrosis

Canuck · Canuck

I was a little disappointed with this news, not in a treatment plan for kids, nor in use of ledi, but with the age/size caveats - must wait until age 12 and weigh 35kgs (there is a lot of food for thought in that scenario). More so I am troubled and would be conflicted in only being able to offer sofa/riba to m...

wendyo · wendyo

Avella HCV Mobile App Received email today about Avella's HCV mobile app and there is some good info in the tabs so thought I would share. I shortened the URL, Wendy! -- Edited by Tig on Thursday 10th of August 2017 05:18:31 PM

Tig · Tig

HCV News Alerts > Grazoprevir + Ribavirin linked to rapid SVR in GT1: Grazo+Riba SVR > FDA places RG 101 on clinical hold: RG-101/FDA Healio articles may require a free registration

Tig · Tig

New information from the Hep C Advocate blog on the currently approved HCV drugs for 2017. Thanks to Alan Franciscus and the team there. HCV Medications 2017

Tig · Tig

The FDA approved AbbVie’s Mavyret to treat adults with hepatitis C genotypes 1 through 6 without cirrhosis or with mild cirrhosis, including those who failed previous direct-acting antiviral treatment, according to an agency press release. The new approval indicates only 8 weeks of treatment n...

Tig · Tig

Today, July 28, 2017 is World Hepatitis Day! Encourage those you know to get tested, it's a simple process that may save your life or that of someone you know. Hep C treatment has never been easier or more effective. Please spread the word and turn on your advocacy machine! Together we can eliminate thi...

Canuck · Canuck

Hmm, seems a litle brief to me, this little "brief". Perhaps a wee bit short on numbers and shy on data and details, but good that they announce they are "looking into things"! We shall see how the info grows and what more and all is revealed. Dejavu all over again, smacks of the tainted blood scandals in...

Tig · Tig

C-Crest trial data on new Merck coformulation. This is one to watch in the future. We need to pay attention to the Phase 3 results and trial opportunities. C-CREST DATA Coming Phase 3 Trials/EU (Scroll down)Efficacy and Safety of the Fixed-Dose Combination Regimen of Grazoprevir/Ruzasvir/Uprif...

Tig · Tig

Here's an update on the ongoing medical position regarding pregnant women and the unborn, as well as addressing the current pediatric dilemma and trials. Pediatric HCV

Tig · Tig

We have a name for the latest and greatest triple DAA from Gilead, it's called "VOSEVI". The trial name(s) of the three drug combination that comprises Vosevi, should ring a bell for you. We have a few good folks here that have traveled this path, Canuck being one of them. She'll be happy to know they've...

Tig · Tig

Another resource of guidelines and practices from the US Veterans Administration. Topics range from HBV, HCV, coinfection to HCC. HCV Tx Considerations Guidelines and Practices

Topic		Started By	Replies	Views	Last Post
	Herpes Zoster Vaccination - "Shingrex" versus "Zostavax" (Preview) There was a fair bit of "talk" in the Journals, about safety profiles, and "Shingrex" getting approved for use over the "live" Zostavax in 2018. Between 2015 and as late as 2017 studies were still being completed about the effectiveness of Hep B and Zostavax immunizations in folk in association wit...	Canuck	5	3239	Mar 11, 2018 by Canuck
	Viekirax and Exviera (OPrD) - Real World Data (Preview) Funny (not) how "real world" data takes so long to "come out"! Here is a recent publication (2018), all about "Viekirax" (ombitasvir/paritaprevir/ritonavir) and "Exviera" (dasabuvir) - also known as "OPrD" (similar to later and further formulations named Viekira Pak and then Viekira XR).B...	Canuck	2	2285	Mar 7, 2018 by Tig
	Hep C crosses the brain barrier (Preview) https://www.hepmag.com/article/HCV-Brain-Endothelium-21818-1287637502	skewedButNotBroken	4	2633	Jan 24, 2018 by LamontCranston
	Harvoni SVR and then case of psoriasis remission (Preview) Published in Gastroenterology - News · January 18, 2018Psoriasis Remission Described After Hepatitis C Virus TreatmentCase report: After initiation of ledipasvir-sofosbuvir, HCV RNA decreased, and skin lesions improvedHealthDay WEDNESDAY, Jan. 17, 2018 (HealthDay News) -- A case of...	Canuck	3	2426	Jan 22, 2018 by Canuck
	"Following" after SVR - Dr. Ira M. Jacobson (Preview) EDITORIAL - HCV Next, January/February - Dr. Ira M. JacobsonManaging the Fruits of HCV Cure: How Much Care do the Cured Need? The feature by Eric Lawitz, MD, very nicely encapsulates the revolutionary changes occurring within hepatitis C therapy over the past few years. As he explains, this ex...	Canuck	2	1742	Jan 22, 2018 by Canuck
	Looking Back ... on HCV Treatment - Dr. Eric Lawitz (Preview) Helio - HCV Next, January/February - *Eric Lawitz, MD* COVER STORYLooking Back on an Unprecedented Revolution in Medicine As we conclude another year now past the peak of hepatitis C research, HCV Next asked me to consider where we came from, where we are now, and where we're headed. They wanted me...	Canuck	0	1714	Jan 21, 2018 by Canuck
	The Unsung Heroes of HCV (Preview) Time to thank all of you that continue to make our forum the best it can be! We have thousands of you to thank for being there for each other through our journey. We are just one of the support groups that have made a difference. A tip of the hat to each of them! Unsung Heroes	Tig	8	2876	Jan 18, 2018 by Canuck
	A "new?" NS5B - "AL-355" (Preview) Tig found and posted this very interesting one - it's aptly under "clinical trials", but I don't want to loose track of this new NS5B, so borrowed Tig's find to be over here as well, so it can be seen as new "news" as well! Hope that's OK Tig. Janssen 2a trial	Canuck	7	4291	Dec 8, 2017 by Canuck
	Abby's - Pan 8 week Glec/Pib (Preview) News about Abby's Pan 8 week Glec (NS3/4A) and Pib (NS5A). No SOF. Especially intersting for those with compromized renal function, TN/TE/cirrhotics. They are stiving for shorter treatment times for these Pans. FDA grants priority review for AbbVie's pan-genotypic HCV regimen - February 3, 2...	Canuck	17	11687	Dec 3, 2017 by Canuck
	HCV and Tainted Blood Product Inquiries/Studies (Preview) Hm, we have entered into this topic before ... what about those of us who, out of medical necessity and via deemed "best practices" of the times, received not transfusions per say, but various forms of "immunoglobulins" , see (U.K. Tainted Blood Inquiry), see (Viet Nam era veterans/ They gave us t...	Canuck	0	1526	Dec 2, 2017 by Canuck
	Merck Drops Out (Preview) Looks like Merck is going after different markets and dropping out of the HCV drug business. Zepatier is their last. Not a bad finish! It has cured a lot of people. Merck‘s Out	Tig	6	3620	Nov 11, 2017 by Canuck
	About Access to Sofa (Preview) Nonprofit challenges Gilead's patents on sofosbuvir October 27, 2017 - HelioInitiative for Medicines, Access & Knowledge - a U.S.-based nonprofit also known as I-MAK - filed a set of patent challenges against sofosbuvir, according to a press release from the organization. According to...	Canuck	1	2220	Oct 28, 2017 by Tig
	Hep C Hope - The Forgotten Virus (Preview) If you would like to educate yourself or have something to share with others, this organization has an informative website that will help. HepCHope Official Site	Tig	0	1374	Oct 25, 2017 by Tig
	Trials - Hep B or Shingles Immunization - (if never immunized for these) and if you have HCV (Preview) https://clinicaltrials.gov/ct2/show/record/NCT02429583	Canuck	0	1418	Oct 22, 2017 by Canuck
	Have your HBV immunity level checked if you have HCV or any other chronic liver disease state(s) (Preview) Updated ACIP Recommendations Nix LAIV, Expand HBV VaccinationDiana Swift - February 06, 2017 The final 2017 adult vaccination schedule has been issued by the Advisory Panel on Immunization Practices (ACIP) of the Centers for Disease Control and Prevention (CDC).Published in the February 6...	Canuck	0	1246	Oct 19, 2017 by Canuck
	Fatty Liver Disease and Transplants in US Youth (Preview) Fatty Liver Disease Fastest-growing Reason for Transplants in Young U.S. Adults By Carolyn Crist - October 18, 2017(Reuters Health) - Nonalcoholic fatty liver disease and its more aggressive form, nonalcoholic steatohepatitis, have become the fastest-growing reasons for liver transplan...	Canuck	1	1305	Oct 19, 2017 by Tig
	AASLD HCV Treatment Guideline Updates (Preview) Apparently they have recently inserted some updates, including recommendations for re-treating TE (treatment-experienced). https://www.hcvguidelines.org/	Canuck	0	1165	Oct 7, 2017 by Canuck
	Healio/HCV Updates (Preview) This is wonderful news! All you coffee drinkers can rejoice!!Increased coffee consumption lowers mortality risk in HIV/HCV coinfection Carrieri MP, et al. J Hepatol. 2017;doi:10.1016/j.hep.2017.08.005.September 26, 2017Elevated coffee consumption of three or more cups per day halved...	Tig	0	1604	Sep 30, 2017 by Tig
	Assessing Fibrosis in HCV (Preview) Here's a professional article on the various options used to determine levels (stages) of liver fibrosis. It includes the pros and cons of each. It's a 5 page article and may require free registration. I believe you will find it very informative. Assessing Fibrosis	Tig	2	2288	Aug 25, 2017 by Lindsmatt52
	HCV Drugs for Kids (Preview) I was a little disappointed with this news, not in a treatment plan for kids, nor in use of ledi, but with the age/size caveats - must wait until age 12 and weigh 35kgs (there is a lot of food for thought in that scenario). More so I am troubled and would be conflicted in only being able to offer sofa/riba to m...	Canuck	4	2595	Aug 24, 2017 by Tig
	Avella Specialty Pharmacy (Preview) Avella HCV Mobile App Received email today about Avella's HCV mobile app and there is some good info in the tabs so thought I would share. I shortened the URL, Wendy! -- Edited by Tig on Thursday 10th of August 2017 05:18:31 PM	wendyo	9	4478	Aug 13, 2017 by Canuck
	Healio Updates - HCV Alerts (Preview) HCV News Alerts > Grazoprevir + Ribavirin linked to rapid SVR in GT1: Grazo+Riba SVR > FDA places RG 101 on clinical hold: RG-101/FDA Healio articles may require a free registration	Tig	14	4525	Aug 5, 2017 by Tig
	Hep C Advocate Approved Drugs 2017 (Preview) New information from the Hep C Advocate blog on the currently approved HCV drugs for 2017. Thanks to Alan Franciscus and the team there. HCV Medications 2017	Tig	0	2978	Aug 4, 2017 by Tig
	FDA Approves Mavyret (closed) (Preview) The FDA approved AbbVie’s Mavyret to treat adults with hepatitis C genotypes 1 through 6 without cirrhosis or with mild cirrhosis, including those who failed previous direct-acting antiviral treatment, according to an agency press release. The new approval indicates only 8 weeks of treatment n...	Tig	0	3224	Aug 3, 2017 by Tig
	World Hepatitis Day (Preview) Today, July 28, 2017 is World Hepatitis Day! Encourage those you know to get tested, it's a simple process that may save your life or that of someone you know. Hep C treatment has never been easier or more effective. Please spread the word and turn on your advocacy machine! Together we can eliminate thi...	Tig	0	1816	Jul 28, 2017 by Tig
	U.K. Tainted Blood Inquiry (Preview) Hmm, seems a litle brief to me, this little "brief". Perhaps a wee bit short on numbers and shy on data and details, but good that they announce they are "looking into things"! We shall see how the info grows and what more and all is revealed. Dejavu all over again, smacks of the tainted blood scandals in...	Canuck	1	1705	Jul 15, 2017 by Tig
	C-Crest-1&2/A&B GRZ/RUZ-ELB/UPR (Preview) C-Crest trial data on new Merck coformulation. This is one to watch in the future. We need to pay attention to the Phase 3 results and trial opportunities. C-CREST DATA Coming Phase 3 Trials/EU (Scroll down)Efficacy and Safety of the Fixed-Dose Combination Regimen of Grazoprevir/Ruzasvir/Uprif...	Tig	0	1490	Jul 12, 2017 by Tig
	Pediatric HCV (Preview) Here's an update on the ongoing medical position regarding pregnant women and the unborn, as well as addressing the current pediatric dilemma and trials. Pediatric HCV	Tig	1	1473	Jul 5, 2017 by legionscube
	Gileads Vosevi (Sofo/Velpa/Vox) (Preview) We have a name for the latest and greatest triple DAA from Gilead, it's called "VOSEVI". The trial name(s) of the three drug combination that comprises Vosevi, should ring a bell for you. We have a few good folks here that have traveled this path, Canuck being one of them. She'll be happy to know they've...	Tig	1	1486	Jun 26, 2017 by Canuck
	U.S. Veterans Admin. Guidelines + Practices (Preview) Another resource of guidelines and practices from the US Veterans Administration. Topics range from HBV, HCV, coinfection to HCC. HCV Tx Considerations Guidelines and Practices	Tig	1	1946	Jun 12, 2017 by Tig
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