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Hep C Discussion Forum -> On Treatment -> WEEK 4 RESULTS - UND!!!
Post Info TOPIC: WEEK 4 RESULTS - UND!!!
Sed3


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RE: WEEK 4 RESULTS - UND!!!
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!!!!!!!!!!!!!!!!!!!!!

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Type 1B - Unknown for 30 years, diagnosed September 2011, started treatment February 2012

8 weeks Incivik - stopped early due to rash.

Continuing Pegasys and Ribavirin until January 2013 - 48 weeks

Undetectable from week 4 --> present
jrc209


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If Und Weeks 8 through 24 on victrelis the stats show 95 or so percent success rate ill find the link



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Geno 1 A Started Tx 8-3-11, Viral Load  21.2 Million,  4 Week Lead of Soc ,9-1-11 <43 On Soc alone started victrelis 9-3 ,8 week pcr vL und.Week 12 Vl Und, Did Week 24 PCR Results UND @ Week 24!!! 1-11-12,End Of Tx 2-15-2012 !!
Katie


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Thank you for all info. as I am 4 weeks UND. too. It is so encouraging to hear from all of you.
Katie.

I am diagnosed Gen. 1b in Dec. 2010. Started triple therapy in Jan. 2012. Contracted Hep C. in 1988 through blood transfusion when giving birth to my son.

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Iris Dragonfly


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more hope for all...Congratulations Alex!!!  BB, Iris



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in the silence of the woods, you will not be alone- Chief Seattle

60 years on planet, Female, diagnosed 1978 as non-a non-b, VL 8mill+, Fibro f-1f-2, Genotype 1a, treatment naïve....UNTIL 7-01-18  !!!! started Harvoni 12 weeks. :)

4 weeks=UND, 8 weeks=UND, 12 weeks=UND (EOT= 09-23-2018)
deny_zoo29


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WooHoo! Congrats! It's a first big mile stone!



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Denyel- Genotype 1a -Triple Therapy Txt began Sept 29, 2011 - Ready to KICK this thing! - UND since Week 4!!

Visit my farm website: www.fuzzandfurfarm.com
kannon


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Congrats.

I clicked on the link supplied by Step and found this.... it should help answer your question.

"A rapid virological response (RVR) is observed in 5660% of treatment naïve patients. Patients who achieve a RVR can be treated with a shorter course of therapy (2428 weeks) and still achieve a SVR rate of 90% or higher."



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Kellyw


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Congratulations!, woot woot

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Kelly 2b dx 8/11. Tx begun 12/30/11. Apparently had it for decades.
hrsetrdr


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WEEK 4 RESULTS - UND

That's what we wanna hear!

 

 



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"hrsetrdr"=Tim

Treatment halted on Aug.8,2012 due to vision problem.  6 month post tx labs

Aug.2013 SVR

Be strong when you are weak, brave when you are scared, and humble when you are victorious.
- Unknown

 

 
alohaKim


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Congrats!!!! Awesome news!

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Genotype 1a, non responder to Peg/Riba in 2005. Started triple therapy 1-27-12 with Victrelis.  UNDETECTABLE as of 8wk labs (after 4 weeks of Victrelis) 4-3-12. UND at week 8, 12, 16 & 20 of tx. Completed triple therapy Oct 2012. relapsed 10/2012
wilsondog


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Congratulations!!!!



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wilsondog
Anna Christie


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Hi again Alex. I googled thses clinical trial results for TX naieve patients on Bocrevir. SVR rate is 88% in those who were UDT at 8 weeks .

Patients Who Have Never Received Therapy 
(Treatment-Na¨ve Patients) Boceprevir. The SPRINT-2 trial 

The SVR rates among Caucasian patients were 67% in the RGT, 69% in the fixed duration, and 41% in the SOC arms, respectively.12 In black 
patients, the SVR rates were 42% in the RGT, 53% in the fixed duration, and 23% in the SOC arms, respectively (Fig. 1).12 A total of 54% of Caucasian recipients of BOC experienced a rapid virological response 
(RVR; HCV RNA undetectable, <10-15 IU/mL at week 8, this interval selected because of the 4 week lead-in). By contrast, only 20% of black recipients of BOC experienced an RVR. Regardless of race, among 
those patients who became HCV RNA negative at week 8 (57% in both BOC arms and 17% in SOC arm), the SVR rates were 88% in the RGT arm, 90% in the fixed duration arm and 85% in the arm treated 
by SOC, compared to SVR rates of 36%, 40%, and 30%, respectively, if HCV RNA remained detectable at week 8 

http://www.aasld.org/practiceguidelines/Documents/2011UpdateGenotype1HCVbyAASLD24641.pdf
Blank
RGT is response guided therapy  meaning they have this arm of tthe study patients complete tx based on UDT status which in your case if all goes as expected and it should for you 28 weeks total treatment. The fixed duration are had to treat for a set time no matter when became undetected guess was 48 weeks. SOC are was only on Peg/Riba and did 48 weeks.
You are on your way to SVR baby. 88% 92 % statistically negible. You are young and healthy . You got this one aced. Take care.And party down over this wonderful result.


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Anna Christie


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Hi Alex. That is awesome. I only know Incevik  4 week undetectable success rate for sustained viral response and it is 92%. Victrelis ought to be pretty similar. I am so happy for you. Hope you are feeling OK. Hugs



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AlexNY


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Tio wrote:

That's Great!  Was this with Incivec?  Best wishes for sustained und!

 I think I became UND, the about the same time I started taking Victrelis. Lemme know how u doing



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I'm Alex. Diagnosed with hep c 12 years ago. Genotype 1a. Started tx on 1/31/12 Ironically, I'm an RN. VL 15.9 (!) mil.  Wk 5, 8, 12, 16, 20 - all UND :)
Cinnamon Girl


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Nice one Alex!  smile

Keep on with the good work!

Jill xx



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Jill 

(71 yo, lives in UK)

Was Gen 3a, 

24wks Peg Ifn/Riba, Sep 2010 - Mch 2011

UND @ Wk.4, UND @ EOT, 

SVR Nov 2011 --> Still UND @ EOT + 4 yrs.

 

 
Shep


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Yippee Alex!

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Diagnosed 1996 genotype 1b VL alot tx starting 12/23/11 Victrelis UND week 8!!! 28 weeks of tx

Completed tx 7/6/12--still UND!!!!
greenqueen


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Hi Alex,

That's great news smile Anyone who's undetectable at week 4 is considered an RVR ( Rapid virologic response ), which is a VERY good sign, Here's some more info that I hope will help.

http://hepatitiscnewdrugs.blogspot.com/2012/01/triple-therapy-for-hcv-geno1-telaprevir.html

Love Steff xx




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Geno 3a. 24 wks tx 20/10/05 - 06/04/06. Achieved SVR.
innerview


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Nice going, Alex!

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Peace, Mark

1A, stage 2/3, TT, began TX with Incivo 1/31/12, Week 4 VL<15, week 7 UND, week 12 UND, week 18 UND!!! End of Tx July 31 VL UND!!!  I had to do 26 weeks total and was on half Riba and half Interferon for most of Tx. 12 week post Tx VL UND!
AlexNY


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-- Edited by AlexNY on Sunday 11th of March 2012 05:22:45 PM

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I'm Alex. Diagnosed with hep c 12 years ago. Genotype 1a. Started tx on 1/31/12 Ironically, I'm an RN. VL 15.9 (!) mil.  Wk 5, 8, 12, 16, 20 - all UND :)
Tio


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That's Great!  Was this with Incivec?  Best wishes for sustained und!



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AlexNY


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Hey guys, just wanted to share that 4.5 weeks labs are in and YES, it's undetectable, little lower WBC levels, but RN says it's not concern. Who knows any data/stats on tx success after 4th week UND? Thanks all



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I'm Alex. Diagnosed with hep c 12 years ago. Genotype 1a. Started tx on 1/31/12 Ironically, I'm an RN. VL 15.9 (!) mil.  Wk 5, 8, 12, 16, 20 - all UND :)
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