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Post Info TOPIC: 7977 results


Guru

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RE: 7977 results
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Unfortunately, Rocky's treatment didn't work out cry He has posted about this in another thread and as it's not possible to move part of a thread, I'm putting the link here to Rocky's post and the responses from other members.

http://hepcfriends.activeboard.com/t51711709/3-months-post-treatment/?a=73&subForumID=388113&commentID=51711709

Steff xx



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Geno 3a. 24 wks tx 20/10/05 - 06/04/06. Achieved SVR.

K2


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Fantastic results and really exciting for the future. Thanks for update.

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genotype 1a. started pegasus and riba on 25/03/2012 added victrelis after 4 weeks, treatment naive. CHC. 4 weeks UND & continue to be so far. Finish tx 6/10/12. Fingers crossed for SVR.



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Outstanding news!   wootj.gif



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"hrsetrdr"=Tim

Treatment halted on Aug.8,2012 due to vision problem.  6 month post tx labs

Aug.2013 SVR

Be strong when you are weak, brave when you are scared, and humble when you are victorious.
- Unknown

 

 



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Jime and Rocky!!! You are early frontiers for 7977!
Thank you!!!! JoAnne

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JoAnne

Genotype 1a, Triple therapy w/Invicek started May 19, 2012

DET 4 wk. UND 2,6,12,24 48 treatment. Achieved SVR 2013!



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Good going Rocky. GS7977 is 2 for 2 so far with you and Jime. Hoping for SVR for both of you !!



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58 yrs, cirrhotic, Genotype 1b 48 weeks Victrelis triple, SOT 7/13/12 victrelis started week 5. Starting VL 4,000,000  Wk 8 33 copies  Wk 24 UND, EOT UND 6 months post Tx DET. The battle goes on.



Guru

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12 weeks! Awesome! 48 weeks-----start week 25 Friday!
Thanks for posting. Journal 7977, hurry on the market.
JoAnne

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JoAnne

Genotype 1a, Triple therapy w/Invicek started May 19, 2012

DET 4 wk. UND 2,6,12,24 48 treatment. Achieved SVR 2013!



Guru

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Hi Rocky, very happy for you! What bliss, 12 weeks instead of 48. Roll on trials.



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Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm



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Fantastic Rocky. It is an amazing drug so far. All the people on my study are still UND too. 15 of us. Congrats to you!

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jim

GT1a, St2 Lv2 last biopsy 2002, VL  11.4m,  start triple tx 9/30/11

VL 470 @4wks.....VL 22,000 @8wks  stopped tx

Round 2-  Started 3/16/12   PSI-7977, BMS-790052, Riba Undetectable day 14

Did 24 weeks Still UND 12 weeks post tx, SVR24!!!!!!! 2/14/13

 

 

 

 

 



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The list is a bit obsolte but very promising ... Seems that there is a healthy competition outthere. For new meds as well as generics of the existing ones will be breathing the neck. This should make HCV treatment options wider and cheaper. 



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58 yo male, HCV since 1981. Gen 1B (IL28B, CT). Diagnosed 1999,  VL before tx 100'000. Biopsy A2, F3 fibrosis. Naive, SOT (with Incivek) Oct 26, 2012. UND @ week 4, 12, 18, 24, UND 12 and 24 weeks post-RX



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Bouba wrote:

Believe we will hear more of these optimistic stories in the near future. Even the pioneers like Vertex and Merck are coming with more. Interesting link :

 

http://hcvdrugs.com/



-- Edited by Bouba on Wednesday 31st of October 2012 06:38:46 PM


 Thanks for posting this  By the way   The one   Bristol-Myers Squibb / Pharmasset  from the site you sent is the one that should have went to phase 3 and is on hold and could have been available in 2013 



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Bills

Harvoni started 12-12-14 for 24 wks PrevTX Geno 1 stage 3 cirrhosis - non resp Int/ ribv. Started Trial  in Aug 2011 -July 2012 into Incivek relapsed  Feb 2013 Had 72 weeks on interferon & Riba.



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I love hearing these stories. Way to go, sir.

Alan



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Geno 1A  Started Pegasys/Ribavirin/Incivek Nov. 20, 2011 .  Completed July 28, 2012 (36 weeks). For a treatment history, see:  https://jshare.johnshopkins.edu/xythoswfs/webview/_xy-9921874_1

SVR on January 14, 2013!!



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Great news Rocky  very happy for you      Love your Idea for Halloween costume LOL

a 12 week tx That's really good to hear  as Iris says hope the put that out on the market soon I'm curious what the expected success rate is

to see how many others did it and what % will achieve SVR ( Non responders ? with Geno 1 ?  and cirrohis ?)

It would be a huge help to get an effective 12 week triple drug tx  even if it still has  Ribv and Peg it brings us closer to an oral Tx with little side affects 99% of us would have opted for what you did in 12 weeks   than the 36-48 week horror we got   Were not done yet    We still need to keep after Gilead  for that 100% cure with Bristol Meyers no Ribv and no Peg

For the newbies    There is no doubt 7977 seems to be the drug to watch

please read this regarding 7977  and sign the petition     http://www.change.org/petitions/gilead-sciences-please-collaborate-with-bristol-myers-for-the-cure-for-hepatitis-c-now    If you havent read anything about GS 7977 it's a good place to start there is much more out there    If I could stop tx now and switch I would

again good news Rocky

BillS



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Bills

Harvoni started 12-12-14 for 24 wks PrevTX Geno 1 stage 3 cirrhosis - non resp Int/ ribv. Started Trial  in Aug 2011 -July 2012 into Incivek relapsed  Feb 2013 Had 72 weeks on interferon & Riba.



Guru

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wow Rocky! Good News.. Hope they approve that one soon...Blessings, Iris



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in the silence of the woods, you will not be alone- Chief Seattle

60 years on planet, Female, diagnosed 1978 as non-a non-b, VL 8mill+, Fibro f-1f-2, Genotype 1a, treatment naïve....UNTIL 7-01-18  !!!! started Harvoni 12 weeks. :)

4 weeks=UND, 8 weeks=UND, 12 weeks=UND (EOT= 09-23-2018)



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Well done, congrats!!! I have heard about that one, they expeect the tx to be reduced to 4-6 weeks over time. Trials and FDA approval may take another 2-3 years though, before it becomes available to all.
And then its hopefully gonna be a completely new HCV free era !

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58 yo male, HCV since 1981. Gen 1B (IL28B, CT). Diagnosed 1999,  VL before tx 100'000. Biopsy A2, F3 fibrosis. Naive, SOT (with Incivek) Oct 26, 2012. UND @ week 4, 12, 18, 24, UND 12 and 24 weeks post-RX



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On October 5th I finished up a 12 week clinical trial with Pegasys, Ribavirin, and GS 7977 from Gilead.  Since they won't release the results to us until all the participants are done, I had the VA run new viral load tests for me.  Took 2 weeks to get the results back, but both test came back "target undetectable"  Woo Hoo!!

Just reading those words put new energy into my life.  Good luck to the rest off you, and I hope 7977 works out and becomes available to all. 

Happy Halloween  (I'll be the one dressed as a happy man)



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genotype 1a, viral count 7 M

7/12/12 started triple with GS-7977(400 mg 1/day), Peginterferon and Ribavirin  12 wk  trial

11/2012 no svr

12/10/13 new trial with sofosbuvir/ledispavir combo and riba12 wks

3/10/14 UND

3/16/15 still UND, and feeling great



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Believe we will hear more of these optimistic stories in the near future. Even the pioneers like Vertex and Merck are coming with more. Interesting link :

 

http://hcvdrugs.com/



-- Edited by Bouba on Wednesday 31st of October 2012 06:38:46 PM

__________________

58 yo male, HCV since 1981. Gen 1B (IL28B, CT). Diagnosed 1999,  VL before tx 100'000. Biopsy A2, F3 fibrosis. Naive, SOT (with Incivek) Oct 26, 2012. UND @ week 4, 12, 18, 24, UND 12 and 24 weeks post-RX

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