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Hep C Discussion Forum -> On Treatment -> drug resistant blood test?
Post Info TOPIC: drug resistant blood test?
JoeV


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RE: drug resistant blood test?
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Hello! I'm participating in the Hallmark QUAD phase 3 clinical trial, which 1 of the 4 drugs is a protease inhibitor (Asunaprevir), and I do not believe that I was given the test you all are referencing as a means to determine resistance to the protease inhibitor. The Mayo Clinic in Jacksonville, Florida, is administering the trial on behalf of Brystol Meyers and my end of week 4 appointment is on 11/21, so I will be absolutely sure to ask about it. I'm glad that I read your discussions on this topic. If the test is a reliable test, it should be applied to every patient prior to determining the specific treatment drugs to be prescribed for the patient. Again, thank you. Joe

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LanaiSurferGirl


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yeah...I am interested in exactly what the assay is targeting as well.  I did some more research and found this article...I am actually trying to reach the quoted "Chris Petropoulos" in the article...small world!  My question is that this article is dated on Aug. 25, 2011 so why didn't we all have this test before treatment??  It seems to me that before establishing treatment protocols the attending physician would want to know if a patient had a resistance to protease inhibitor to determine what meds to rx!  And it is for commercial use, not RUO as stated in this article.  I get my blood work done at Labcorp...why have I not known about this??

Link to other article: http://www.businesswire.com/news/home/20110825005056/en/LabCorp-Introduces-HCV-Resistance-Testing-Monogram-Biosciences

 

Thanks for asking....My brother is hangin in there with 7 weeks to go...he is on the home stretch!  :)  He is in good spirits and with the holidays this time will fly by.

aloha,

Meghan



-- Edited by LanaiSurferGirl on Saturday 17th of November 2012 05:49:50 AM

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geno 1a, mother & brother also hep c +...mom got a blood transfusion and passed it along.  Started tx with incivik 11/23/11 and brother started 2/8/2012.  Both of us und. at 4,8,12 and me at 24.  I am going 36 wks and brother is going 48 weeks.
LanaiSurferGirl


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I recently started a new job in the biotech field and durring me prospecting for new clients I came across Monogram Biosciences.  They recently developed an assay (test) for resistance to boceprevir and telapravir.  Have any of you had this?  I didnt...I had my IL28B tested but not this test...I don't know when it came out though.  If you go to www.monogrambio.com and click "download a product brochure" next to the HCV genosure you can see the info.

 

aloha,

Meghan



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geno 1a, mother & brother also hep c +...mom got a blood transfusion and passed it along.  Started tx with incivik 11/23/11 and brother started 2/8/2012.  Both of us und. at 4,8,12 and me at 24.  I am going 36 wks and brother is going 48 weeks.
mallani


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Hi Meghan, Interesting that this is now available. It was previously used by Researchers in Rx failures to measure which RAV's were present. I'm not sure about it's clinical application. The VL test includes RAV's, so if that is Undet. I presume the new test will not find any mutations. In Rx failures, the RAVs are thought to disappear fairly quickly, and be replaced by the original 'in-the-wild' virus. The Geno 1b RAVs are mostly gone in a few months, but the Geno 1a RAVs can hang around for 1-2 years. This test may be useful for patients that wish to be retreated with a drug combination that includes an NS3 protease inhibitor. Currently these patients are excluded.   Cheers, hope you're almost back to normal. How's your brother?



-- Edited by mallani on Friday 16th of November 2012 03:55:02 AM

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Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm
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