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Hep C Discussion Forum -> On Treatment -> Bummed out
Post Info TOPIC: Bummed out
onabugeisha


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RE: Bummed out
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Thanks all,  I will have this on my question list for the Dr.  whether 24 weeks   48 weeks.   No cirrhosis.  Biopsy showed 2.   At least i am breathing.   Maybe 8 weeks i will be und.  Hope keeps me going.  And my fuzzy friends  who i must be around to care for. 



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     Gen2-diagnosed 2012  probly infected 1982   tx started 10-19-12   peg/riba  24 wks
Cinnamon Girl


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Cathy, I have a feeling that the standard tx duration for gen 2 is 24 weeks, unless you have cirrhosis in which case you need to do 48 wks, and I`m not sure how important the 4 wk result is apart from being an indication of how well you are responding.  I agree with Malcolm that you need to follow your doctor`s advice on this.

Best of luck!  Jill xx



__________________

Jill 

(71 yo, lives in UK)

Was Gen 3a, 

24wks Peg Ifn/Riba, Sep 2010 - Mch 2011

UND @ Wk.4, UND @ EOT, 

SVR Nov 2011 --> Still UND @ EOT + 4 yrs.

 

 
mallani


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Hi Cathy, Your question about Rx length for Geno 2's is difficult to answer. There are many references to increased SVR with an RVR (undet. at 4 weeks), but treatment duration is hardly mentioned. It seems that you need to be undet. at 12 weeks to continue Rx, but increasing treatment length from 24 weeks to 48 weeks doesn't get a mention. Be guided by your doc. Cheers.



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Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm
Phil G


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Cathy, The discusions around 4 weeks is for Gen 1 on Incivik. Gen 1 on Vivtrelis is the same, exept 8 weeks. As a Gen 2 on SOC, don't know if he 4 week labs are that significant. Just don't know. Others may.



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Geno 1A, VL 1.9 mm, SOT 12/2/11 - Pegintron/Ribavirin/Victrelis, UND since wk 8, EOT 6/15/12 (28 wks), SVR 11/30/12
Bouba


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By the way, for those who are about to start with Incivek, draw your doctor's attention to an intake schedule. Ask a question.

Recent studies showed that 2 x 3 pills a day with 12 hours interval as effective as 3 x 2 pills with 8 hours interval.

For all us, fat lovers, who are already on 8 hours protocol, it would have been a huge relief.

I still have 7 weeks to go and decided not to change it half way. But its worth asking a question for those who gonna start.



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58 yo male, HCV since 1981. Gen 1B (IL28B, CT). Diagnosed 1999,  VL before tx 100'000. Biopsy A2, F3 fibrosis. Naive, SOT (with Incivek) Oct 26, 2012. UND @ week 4, 12, 18, 24, UND 12 and 24 weeks post-RX
Bouba


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Hi Julie and everyone,

Here is a link to easy to read triple tx with Incivek workbook, with treatment track duration, depending on VL

http://www.hepatitis.va.gov/pdf/telaprevir-workbook.pdf



__________________

58 yo male, HCV since 1981. Gen 1B (IL28B, CT). Diagnosed 1999,  VL before tx 100'000. Biopsy A2, F3 fibrosis. Naive, SOT (with Incivek) Oct 26, 2012. UND @ week 4, 12, 18, 24, UND 12 and 24 weeks post-RX
mallani


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Hi Julie, Here's a link to Rx duration with Incivek.

 

 

http://www.incivek.com/hcp/treatment-duration-treatment-history



__________________

Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm
Mary Jane


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also depends on Geno type and as Joanne stated what stage or level of disease you liver is in..MJ



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Do not go where the path may lead, go instead where there is no path and leave a trail.Ralph Waldo Emerson

1a - VL 22 million  F2- IL28B- CT / Inck-Riba- Peg triple therapy 9/15/12 UND 4/8/14  8 wks BT ..3/1/2013 done! 3wks Post UND
JoAnneh


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Cathy, I have cirrhosis so I think that's
One reason I need 48 weeks. But my NP
Did say 24 weeks when I had 2 week UND
And changed it to 48 week at 4 week UND.
But it's my own understanding I should never
Have been considered 24 weeker anyway w cirrhosis!
Would u believe when I went in for routine blood work
At 23 weeks my nurse said Congratulations u only
Have a week left! Haha! I had to remind her.
It's just smart to be proactive in our care.
I can't say for certain u need 48 weeks.
But I decided if I stopped at 24 and relapsed I would
Always wonder.
I am determined to do all I can for the cure!!

Hope u are having a good day,
JoAnne

__________________

JoAnne

Genotype 1a, Triple therapy w/Invicek started May 19, 2012

DET 4 wk. UND 2,6,12,24 48 treatment. Achieved SVR 2013!
Mary Jane


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Hello Julie,

Welcome.. there have been many discussions on this topic.. It depends on your lab and what test or method they are using.. If you go to the top of the page you can click  on "Search " and type in UND  and read up on some of the other threads about this subject.   There are Guru's on this site who can explain it better than I.

Funny thing no matter where you live it seem there are some discrepancies in testing.

I have really bad brain fog ... not sure which method,  if you where less than a 1000 it was considered UND?? 

All the best.. don't be discouraged hang in there.. peace and love MJ

http://www.medhelp.org/posts/Hepatitis-C/Labcorp-QuantaSure-vs-Quest-Heptimax/show/285457

http://www.uptodate.com/contents/predictors-of-a-sustained-virologic-response-following-treatment-with-peginterferon-and-ribavirin-for-chronic-hepatitis-c-virus-infection?source=related_link



__________________

Do not go where the path may lead, go instead where there is no path and leave a trail.Ralph Waldo Emerson

1a - VL 22 million  F2- IL28B- CT / Inck-Riba- Peg triple therapy 9/15/12 UND 4/8/14  8 wks BT ..3/1/2013 done! 3wks Post UND
zuzusfam


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onabugeisha wrote:

Am I understanding that if you are det at 4 weeks you automatically have to do 48.  My vl was 130 at 4 weeks.  The dr. never mentioned doing more than 24.  

 Yup!



__________________

53 y.o. female, diagnosed in 1998. Started tx Oct 8th 2012. Genotype 1a. VL 600,000 before treatment; VL 98 11/12; UND 12/12. Reduced interferon to 135mcg 12/12. 12/17/12 stopped incivek due to rash. 12/20/12 Stopped all meds due to sx
onabugeisha


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Am I understanding that if you are det at 4 weeks you automatically have to do 48.  My vl was 130 at 4 weeks.  The dr. never mentioned doing more than 24.  



__________________

     Gen2-diagnosed 2012  probly infected 1982   tx started 10-19-12   peg/riba  24 wks
JoAnneh


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I was UND at 2 weeks, DET 4, UND 8,12 and 24week.
I am having to do 48 weeks. I was bummed but did like Capt 12 Step
Suggested just hope to stay UND and cross one bridge at a time.
My outlook is its a process. Can't go to next step till u pass a step!
When I reached 24 weeks I went thru few weeks of struggling
W acceptance and let it get me down.
Finally started seeing my blessings and just accepted
My fate! I might add its not easy but it's doable.
FORTUNATELY for this forum! People have helped
Get me thru it. I get lot of hope from others.
Thinking of you, JoAnne

__________________

JoAnne

Genotype 1a, Triple therapy w/Invicek started May 19, 2012

DET 4 wk. UND 2,6,12,24 48 treatment. Achieved SVR 2013!
zuzusfam


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I have my 8 wk vl checked on Monday. If that is und, is 24 still a possibility?



__________________

53 y.o. female, diagnosed in 1998. Started tx Oct 8th 2012. Genotype 1a. VL 600,000 before treatment; VL 98 11/12; UND 12/12. Reduced interferon to 135mcg 12/12. 12/17/12 stopped incivek due to rash. 12/20/12 Stopped all meds due to sx
12Step Guy


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I hear you, it is a bummer. I did 48 weeks in 99 and then 18 months in 2006.

Just keep pulling for UND at 8 or 12 weeks. Cross the other bridges when you get to them.



__________________

Genotype 1a, IL 28 = CT  Interferon and riba 48 wks in 99, Daily Peg and Riba 18 months in 2007, Started Incivek, Peg, Riba 6/21/12. 4th stage cirrhosis. Last Dart will be May 23 2013.
zuzusfam


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I emailed my Rn this morning and received a reply. My ?? was that since my vl at week 4 was 98 and not und, am I still in the running for a 24 course of treatment. Instead of finishing in April, I will now finish in Sept. Bummed out = yes. Devastated = no. But bummed out does = yes.no



__________________

53 y.o. female, diagnosed in 1998. Started tx Oct 8th 2012. Genotype 1a. VL 600,000 before treatment; VL 98 11/12; UND 12/12. Reduced interferon to 135mcg 12/12. 12/17/12 stopped incivek due to rash. 12/20/12 Stopped all meds due to sx
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