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Hep C Discussion Forum -> On Treatment -> Treatment Failed
Post Info TOPIC: Treatment Failed
dragonfly


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RE: Treatment Failed
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I'm sorry but at least the treatment however harsh will have bought you time.  Please do no be disenheartened; we are all here to suppport you.

Dragonflyxxx



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Caryn


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Thanks all. I am still just trying to take it all in,  but I knew going in the chances. I gave it my all and it just didn't work. There are many other people out there that have had a much harder time. I count my blessings and am glad things happened when they did instead of it being later. Who knows Bills, we may be on the next go around at the same time!!

Matt, that was a nice post - thanks from me too!!!



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1a, CT. Incivek triple 1/2013, vl 810 @ 2 weeks, 610 @ 4 weeks, 3000 @ 8 weeks, tx stopped. 

4/2014 - tx with Sovaldi/Olysio/Riba. VL 39 mil. - VL 230 @ 1 week, VL 40 @ 3 weeks, 5 weeks UND, EOT - UND, EOT @ 4 weeks UND, EOT @ 12 weeks UND!
Mary Jane


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xxx hugs Caryn... take a deep breath, it just wasn't in the cards this time... the new drugs are coming and with the info you gave only a liver bx will shed light on the your next course of action ...you gavetx your best shot ... chillax and regroup... all the best   P & L   MJ



-- Edited by Mary Jane on Wednesday 27th of March 2013 12:28:57 AM

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Do not go where the path may lead, go instead where there is no path and leave a trail.Ralph Waldo Emerson

1a - VL 22 million  F2- IL28B- CT / Inck-Riba- Peg triple therapy 9/15/12 UND 4/8/14  8 wks BT ..3/1/2013 done! 3wks Post UND
Bills


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Hi Cayrn

That's hard to take I relapsed in Jan I was told to Remember it's not you that failed. That was a big help to me. Hope it is to you as well. 

I think the inhibitors worked but the Interferon and Riba could't hold me the rest of the way Another thing that made me feel better was I've made up my mind to wait for a 1 or 2 pill cure. I had enough of the poison I'm glad to see all this excitement about the new drugs and almost want in but for now I wait and watch. My hope for you and me is next time is the last time.  

Bills

BY The way Matt very nice post thanks

 



-- Edited by Bills on Tuesday 26th of March 2013 09:33:42 PM

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Bills

Harvoni started 12-12-14 for 24 wks PrevTX Geno 1 stage 3 cirrhosis - non resp Int/ ribv. Started Trial  in Aug 2011 -July 2012 into Incivek relapsed  Feb 2013 Had 72 weeks on interferon & Riba.

Cinnamon Girl


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Yes, I was reading about that trial too, Matt, and have just posted a link in the `News and Events` section.  The race is on to develop the best treatment drugs, and great progress is being made on the experimental front right now.   The future of Hep C treatments has never looked more promising! 

Keep searching, Caryn, you have good reason to be optimistic!  smile

 



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Jill 

(71 yo, lives in UK)

Was Gen 3a, 

24wks Peg Ifn/Riba, Sep 2010 - Mch 2011

UND @ Wk.4, UND @ EOT, 

SVR Nov 2011 --> Still UND @ EOT + 4 yrs.

 

 
Matt Chris


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Caryn

Your future has not been written yet, at your age there will be a lot more options coming up with many, many more DAA's and other cutting edge technologies.

These drugs companies are chasing a money rainbow, the competition is feeding a race which will benefit all of us in the future.

For example Benitec Selects the Duke Clinical Research Unit as a Site for Hepatitis C Phase I/II Clinical Tria

RNAi-based therapeutics company Benitec Biopharma Limited (asx code:BLT) today announced the selection of the Duke Clinical Research Unit, the early phase unit of the Duke Clinical Research Institute (DCRI), Durham, North Carolina, USA as a site for its upcoming phase I/II first-in-man trial for TT-034 in Hepatitis C. TT-034 is being developed as a potential "one-shot-cure" for Hepatitis C 

here is the link http://hepatitiscnewdrugs.blogspot.com/2013/03/benitec-selects-duke-clinical-research.html

Your faith in future is very important for you well being,  you are going to make it!

Matt



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"And in the end, the love you take is equal to the love you make"

61 year old Geno type A1, F4 Cirrhotic, started 24 weeks on Harvoni 12-17-14 ,EOT-5 week = UND, 8-31-15 =UND , SVR-24 Baby YES! 
Caryn


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I know, I have been searching. There was one in another city, but it is closed. I am going to talk to my doctor when I see him and keep looking. Once I made the decision to treat it became a mission. I am not done!!  All the best to you Z, keep up the fight!  

Thanks Jill - I will keep everyone posted!



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1a, CT. Incivek triple 1/2013, vl 810 @ 2 weeks, 610 @ 4 weeks, 3000 @ 8 weeks, tx stopped. 

4/2014 - tx with Sovaldi/Olysio/Riba. VL 39 mil. - VL 230 @ 1 week, VL 40 @ 3 weeks, 5 weeks UND, EOT - UND, EOT @ 4 weeks UND, EOT @ 12 weeks UND!
Zlikster


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;-(  damn mutating liver hijacker

i wish you get on DAAs trial soon! just look at great results Jime and his friends acheived on clinical trial with 2 DAAs+Riba. More than optimistic! I wish you get on trial soon, if not i hope you stay healthy until new meds get on market.

best



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GT 3 dg. 08-2012 / FibroScan: 5 kPa F1 / FibroTest: F0-1 A1 / SoC TX: PegInt 120mcg+Riba 1000mg UND from w8 relapse EOT+4w
01-2016 Sof+Dac+Riba UND from w8, SVR24!
Caryn


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Hi Malcolm,

i have not had a biopsy. i have had two mris and blood tests and I don't think those are very accurate. I am 46 years old and will discuss a biopsy with my doctor when I see him. I would prefer not to wait to be honest so if I can get on a trial I will do so. I felt so run down pre tx. 



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1a, CT. Incivek triple 1/2013, vl 810 @ 2 weeks, 610 @ 4 weeks, 3000 @ 8 weeks, tx stopped. 

4/2014 - tx with Sovaldi/Olysio/Riba. VL 39 mil. - VL 230 @ 1 week, VL 40 @ 3 weeks, 5 weeks UND, EOT - UND, EOT @ 4 weeks UND, EOT @ 12 weeks UND!
mallani


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Hi Caryn,

So you were stopped after 8 weeks. I guess if the VL was increasing there was little point in continuing to 12 weeks.Time to stop and consider your options. I can't find your age anywhere, and you don't seem to have a liver biopsy. You mention 'Stage 2-3' but only in relation to blood tests. It's probably a good time to think about a biopsy- this will give you an idea of how urgent Rx is. It will tell you whether you can afford to wait 2-3 years, or whether you should be trying to get on a Trial. Good luck!



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Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm
Caryn


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Hi Jime,

It looks like you responded like I did with triple therapy.  At least I know there is hope with your results!!!!!



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1a, CT. Incivek triple 1/2013, vl 810 @ 2 weeks, 610 @ 4 weeks, 3000 @ 8 weeks, tx stopped. 

4/2014 - tx with Sovaldi/Olysio/Riba. VL 39 mil. - VL 230 @ 1 week, VL 40 @ 3 weeks, 5 weeks UND, EOT - UND, EOT @ 4 weeks UND, EOT @ 12 weeks UND!
JIme


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Better things await you Caryn. Rest up, recover, and stay as healthy as you can. The next time will be a charm. Good luck!

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jim

GT1a, St2 Lv2 last biopsy 2002, VL  11.4m,  start triple tx 9/30/11

VL 470 @4wks.....VL 22,000 @8wks  stopped tx

Round 2-  Started 3/16/12   PSI-7977, BMS-790052, Riba Undetectable day 14

Did 24 weeks Still UND 12 weeks post tx, SVR24!!!!!!! 2/14/13

 

 

 

 

 
Biggyb


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Yea bummer, i know how it is after failing twice before. But gotta stay strong and live life to its fullest..w



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58 yo..Relapsed in 99 and again in 2004. Started triple therapy with Victrelis July 22,2012.  genotype 1a. week 8,12,16,24 VL Undetectable..E.O.T -- 6-22-2013,,,EOT + 24., UND. 

SVR !!!

 

~Bob~
Caryn


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Thanks Joanne and 12 step....just a little discouraged. I was on the money with my meds - never missed a dose and never late. I only hope for the best for everyone that is treating. I will keep moving on and hope for a trial or new treatment soon. 



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1a, CT. Incivek triple 1/2013, vl 810 @ 2 weeks, 610 @ 4 weeks, 3000 @ 8 weeks, tx stopped. 

4/2014 - tx with Sovaldi/Olysio/Riba. VL 39 mil. - VL 230 @ 1 week, VL 40 @ 3 weeks, 5 weeks UND, EOT - UND, EOT @ 4 weeks UND, EOT @ 12 weeks UND!
12Step Guy


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WOW, sure wish you got a better outcome then this. At the very least keep in mind that HCV is such a slow moving virus that the new drugs can offer more hope.



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Genotype 1a, IL 28 = CT  Interferon and riba 48 wks in 99, Daily Peg and Riba 18 months in 2007, Started Incivek, Peg, Riba 6/21/12. 4th stage cirrhosis. Last Dart will be May 23 2013.
Caryn


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My viral load has increased to 3000. Treatment has been discontinued.  I am disappointed, but had a feeling when I had such a small decrease from 2 weeks to 4 weeks. I am still trying to take it all in at this point, but I wll be fine. I will update once I see my doctor to get some answers. 



__________________

1a, CT. Incivek triple 1/2013, vl 810 @ 2 weeks, 610 @ 4 weeks, 3000 @ 8 weeks, tx stopped. 

4/2014 - tx with Sovaldi/Olysio/Riba. VL 39 mil. - VL 230 @ 1 week, VL 40 @ 3 weeks, 5 weeks UND, EOT - UND, EOT @ 4 weeks UND, EOT @ 12 weeks UND!
Cinnamon Girl


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Sorry to hear you`ve had to stop tx, Caryn, that`s disappointing.  You gave it your best shot though, and it`s not the end of the story, other opportunities will be along and you`ll get your chance to beat this thing once and for all.

A trial sounds like a good plan, although bear in mind that you won`t be able to do one that includes another protease inhibitor after being on the triple with incivek.

Take care and look after yourself, and all the best of luck!  smile  ~ Jill

 

 

 

 



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Jill 

(71 yo, lives in UK)

Was Gen 3a, 

24wks Peg Ifn/Riba, Sep 2010 - Mch 2011

UND @ Wk.4, UND @ EOT, 

SVR Nov 2011 --> Still UND @ EOT + 4 yrs.

 

 
JoAnneh


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Wow! What a shock! This doesn't happen often that I
Know of But I know you are glad to find out now than later! 

That's why I continue to thank God
Daily that I get to stay on medicine even at week 45:)

You are young and have time to wait
For new and easier drugs.
Thank you  for your friendship and encouragement.
Please Keep me posted!

New drugs are on the horizon and you always have this great forum!

with love, JoAnne

 



-- Edited by JoAnneh on Monday 25th of March 2013 09:17:36 PM



-- Edited by JoAnneh on Monday 25th of March 2013 09:20:03 PM

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JoAnne

Genotype 1a, Triple therapy w/Invicek started May 19, 2012

DET 4 wk. UND 2,6,12,24 48 treatment. Achieved SVR 2013!
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