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Post Info TOPIC: Side effects lessen over time?


Guru

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RE: Side effects lessen over time?
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Hi Ginny
My experience with Victrelis triple was that things gradually got worse--particularly the emotional side effects. I had to start taking Procrit around week 13-14--I only had to do the 27 weeks. I didn't have much rash but lots of rage. And oh my the brain fog was thick. I believe I began referring to myself as a zombie princess. Hang in there!! The forum will keep you going!

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Diagnosed 1996 genotype 1b VL alot tx starting 12/23/11 Victrelis UND week 8!!! 28 weeks of tx

Completed tx 7/6/12--still UND!!!!



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Dr. cut down the Riba at 24 weeks to lessen the low blood counts.  It has helped that symptom, but some rash and dry skin still present.  Other usual symptoms - fatigue, nausea, general malaise, insomnia, bad taste, blurry vision, etc - still around but they seem to cycle through, get stronger and then lessen for no apparent reason.  I think I have just learned to tolerate the symptoms and am used to the comings and goings of the side effects.  When I am feeling bad, it is hard to remember when I felt better and when I have fewer symptoms, I wonder if they were really that bad. 

They were.  Glad when this is done, and keeping an eye on the end result is a motivator allowing me to accept the discomfort, knowing there is an end to it and it will all work out when the tx concludes and the side effects lessen.

Good luck, you can do it, HCV Warrior.



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1a, 35+ years; liver cancer survivor 7-2012 surgery; triple therapy 12-2012 (Interferon, riba, victrelis) - end 48-week treatment Nov. 29, 2013 - post tx 24 weeks undetected - SVR.



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Ginny you are spot on - it will take patience and perseverance.  My husband did 48 weeks of Victrelis and although he worked full time for the duration, he did get progressively weaker, sore muscles/joints and more tired.  The good news is that humans are incredibly resilient at times.  So all the very best as your go along your journey.  Caroline



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My husband had genotype 1a, 46yo, started triple therapy (peg/rib/vic) 23rd July 2012, VL prior to treatment 14 million, UNDET 12, 24 weeks, EOT 24th June 2013, EOT +1.5 weeks UNDET, EOT +12 weeks & EOT +27 weeks UNDET; SVR January 2014



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Your replays are very helpful and I appreciate you all for taking the time to answer. I will do the same for others down the line. Anyway you look at this, it's going to take perseverance and patience!  



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Hi Ginny,

You probably don't want to hear this, but I was on the same Rx, and my Sx just got gradually worse. My Riba rash didn't start until week 30, and my Riba rage kicked in at about week 36. I am older, and my doc didn't believe in Riba dose reductions, so my Hb gradually dropped. From week 25-36, my Hb was in the low 9's, high 8's. From week 36 to week 48, the Hb dropped to the low 8's and high 7's. With 2 weeks to go, it had dropped to 7.2. He was overseas, so his nurse rang to say drop the dose, but I refused to.  I have no idea whether he was correct, but I'm sure medicolegal issues would prevent that in the USA. Be guided by your doctor. Cheers.



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Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm



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I can only reflect my experiences and those of others that post regularly.  Tig pretty much hit my experience on the nail.  I have 4 weeks of treatment left.  The first 3 months while taking Incevik were terrible.  I had a procrit shot at about 14 weeks and have not needed one since.  At that point I was feeling pretty good, relatively.  I cruised until about week 30. At that point I really started feeling bad, particularly on Monday and Tuesday.  I generally wake up nauseated in the morning and dry heave or throw up depending on what is in my stomach.  I would estimate that I have thrown up 4 days per week for 44 weeks.   I have noticed that a lot of our members start complaining of sx more towards the end of treatment.  I don't know if I am exhausted from 44 weeks of treatment or the sx have increased.  I have continued working.  Nausea and sleep difficulties are my big problems.



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Hep C 1a since probably 1981.  Incivek, riba and interferon-48 weeks.  UND at weeks 2-4-6-8-10-12-16-20-24.  Previously Interferon alone for 6 months non-responder.  SVR 48 weeks 12/11/14



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wow,i totally agree w/ that tig. the 1st 3 months were sx after sx nonstop. my 4th & 5th month brought relief. tonight's dart 22/24 and the sx are coming back fierce & strong. the muscle aches and fatigue are something else. even the rash is trying to wiggle on in. it's worth it to be hepc free...

sandy,ucbgal



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Tig


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Hi Ginny and welcome to the forum

That is entirely an individual situation if you ask me. I'm about to start week 27 and my side effects fluctuate in severity and number. The first three months were very unpleasant but tolerable. I noticed the SFX were easier to tolerate the next two months, but now during my last month, they're getting worse with each week. Worse being the same kinds of SFX just more intense and uncomfortable. I asked my Hepa about this recently and he said they aren't going away, but your body has learned how to tolerate and adjust to them. So in my case, the SFX did lessen in severity periodically but I wouldn't tell anyone that this is something they should count on. I hope that thought works in your favor nonetheless!!



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Tig

68yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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The PA at my doctors office has told me that the side effects of PEGINF/RIB/VICTRELLIS tend to lessen after about week 25.  Has anyone else experienced this?  



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