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Hep C Discussion Forum -> On Treatment -> Low ALP indicator for relapse?
Post Info TOPIC: Low ALP indicator for relapse?
Gracie


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RE: Low ALP indicator for relapse?
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I understand. When I got my meds, they seemed so valuable I didn't want to let them out of my sight. And of course the interferon has to be stored in the fridge and my power went out for 24 hours so had to store it on ice. Then of course I worried it was too cold or not cold enough... Crazy that these meds will cost more than all three of our cars brand new. 



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  1. Gracie

1A. Previously treated non responder Rebetron in 2000 And Incevik in 2014 with a breakthrough at week 12. Fibroscan 15.5. VL 6,000,000. Finished 24 weeks harvoni on Dec. 19, 2015. SVR. Latest Fibroscan 8.8.
Enavigo3891


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Thanks all ... I think I will heed the advice and just not worry about it.  FedEx was here about 20 minutes ago and delivered my meds!  I feel like i should have a safe room or something to be storing them in until Tuesday!  

Have a great weekend everyone.



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Born HepC + in 1983 ... diagnosed @ age 13 ... GT2 ... 12 wks of Sovaldi/Riba from 2/11/14 to 5/5/14  #ribazombie

1/30/14 - Starting VL 1,922,967 * 3/11/14 - UND @ 4 wks * 7/29/14 - SVR12 * 11/6/14 - SVR24 * May 2015 - SVR52 * MAY 2016 - STILL UND * FEB 2018 - STILL UND

 
mallani


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Hi Enavigo,

Personally, I wouldn't be concerned about an ALP of 36.  Eat a couple of bananas and it will probably be normal.  When researching, look at the date of any publications.  Before Victrelis and Incivek, there was endless research about why SOC failed. I know a low ALP was mentioned ( along with a host of others), but was never proven.  At your age, with Geno 2 and your enzymes, you have little to worry about. Cheers.



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Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm
Matt Chris


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Hello Enavigo

Interesting topic, sometimes we read these reports that correlate a certain lab report or LF level with achieving a better or worse result . Like a lot a reports there is not a lot of hard data to connect the dots in every case. What they can do is make us aware of what we need to consider, possibly more balance in our nutrition area?  

From what I read of your posts you seems to be very bright and informed about your HCV and the up coming treatment. At you age and current liver condition you are in a fantastic position to achieve SVR.

I think what Tig said carries great import for you he said "Each one understood and corrected is another concern eliminated"

Remember our lab result and LFT can change daily based on lots of variables, with that in mind your ALP change was very minor, so don't stress out over that. Your good nutrition and proper rest can balance your body out even when you are old and wore out like us old dudes. So take care of your food choices and don't take a lot of supplements to make up for it, make up for with great foods that contain what you need.

Hoping all goes well

matt    



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"And in the end, the love you take is equal to the love you make"

61 year old Geno type A1, F4 Cirrhotic, started 24 weeks on Harvoni 12-17-14 ,EOT-5 week = UND, 8-31-15 =UND , SVR-24 Baby YES! 
Tig


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Yes, so true! the thought of my upcoming 12 week post Tx VL is weighing on my mind greatly. Our friend Nicole (libgirl07) and I started the same triple Tx at roughly the same time. She was just a month ahead approx. and as she mentioned today, the dragon returned for another battle. That's one persistent, yet stupid creature. Why fight a losing battle? We will prevail!

I would ask your doctor to try and determine what is responsible for your low ALP and correct it before Tx. That would eliminate that factor from your list of negatives. Each one understood and corrected is another concern eliminated. My pre Tx ALP was slightly elevated and there are no additional results on any of my recent blood work. I'll be curious to see how everything stands. I did look specifically for info on this topic and there wasn't much available. Hang in there, the fun is about to start! Just remember that it's a whole new world for fighting this disease and the ball is in our court!

Tig

PS: I would check with Malcolm (Mallani) about this, he likely has a good thought on the subject.



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Tig

68yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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Enavigo3891


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Thank you for the response Tig, I actually read all three of those and then some prior to posting. I apologize, I should have been more clear - I did not go searching how a low ALP score would or would not affect chances of SVR, I was searching for clarification as to what causes it in general. In those results were some articles about retroactive studies - cases where people who had relapsed had their PRE-TX ALP's reviewed and it was suggesting that after review, most of those who relapsed had a low PRE-TX ALP. As everyone here seems to have done their research I was curious if anyone else had ever come across that information.

However, yes of course I have thought about relapse - since the moment I started thinking about treatment. I believe many others have probably thought along the lines of "what if it goes away and then comes back" or "what if I'm not UND at 24 weeks post tx".



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Born HepC + in 1983 ... diagnosed @ age 13 ... GT2 ... 12 wks of Sovaldi/Riba from 2/11/14 to 5/5/14  #ribazombie

1/30/14 - Starting VL 1,922,967 * 3/11/14 - UND @ 4 wks * 7/29/14 - SVR12 * 11/6/14 - SVR24 * May 2015 - SVR52 * MAY 2016 - STILL UND * FEB 2018 - STILL UND

 
Tig


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Hi Enavigo,

I have to ask you, why the concern of relapse at this time? Since you have yet to start treatment, the low ALP level would be an indicator of an underlying cause and not one indicating the likelihood of relapse. Now had you achieved SVR or an extended undetectable time frame and then exhibited a drop in your ALP from a normal level, I would think your concern might be a consideration worth investigating. I would follow your doctor's lead and not be terribly concerned at this time. I've included some reading material on the enzyme and it's impact on us. Good luck!

Tig

 

http://www.newhealthguide.org/Low-Alkaline-Phosphatase.html

http://en.wikipedia.org/wiki/Alkaline_phosphatase

http://en.wikipedia.org/wiki/Elevated_alkaline_phosphatase

 



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Tig

68yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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Enavigo3891


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Happy Friday Friends

I got my complete pre-tx labs in the mail today, only one thing was out of the "normal" range. My doc did not speak to it in his letter so I am guessing he's not concerned however I of course "googled it". My ALP is low at 36 - normal range is 39 to 117. I looked back to last years labs and it was 39. When searching "Low ALP and Hepatitis C" I came across some articles suggesting that low ALP could be an indicator for relapse. Can anyone way in on this?

Here is last years vs. this years labs.

DATE:           Feb 2013              Feb 2014           NORMAL RANGE

VL:               305,756               1,922,967                    --

WBC:                --                          9.5                     4.1 - 10.7

HGB:                13                         13.2                    11.5 - 15

Platelet:           --                          318                      153 - 376

Albumin:           4.8                        4.2                      3.5 - 4.8

Ttl Bilirubin:       .03                       .03                        .2 - 1.4     

ALP:                  39                         36                       39 - 117

ALT:                   20                        33                       14 - 54

AST:                  18                         21                       15 - 41

Vit D:                17                          48                       30-80



__________________

Born HepC + in 1983 ... diagnosed @ age 13 ... GT2 ... 12 wks of Sovaldi/Riba from 2/11/14 to 5/5/14  #ribazombie

1/30/14 - Starting VL 1,922,967 * 3/11/14 - UND @ 4 wks * 7/29/14 - SVR12 * 11/6/14 - SVR24 * May 2015 - SVR52 * MAY 2016 - STILL UND * FEB 2018 - STILL UND

 
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