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Hep C Discussion Forum -> On Treatment -> Update: Week 4 Sovaldi + RIBA and brain fog link
Post Info TOPIC: Update: Week 4 Sovaldi + RIBA and brain fog link
robertsamx


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RE: Update: Week 4 Sovaldi + RIBA and brain fog link
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im into my rx 3 weeks, my brain fog  and lack of sleep seem to hold hands. My Dr uped my ambien from 5mg to 10mg   and the last two nites i have sleep well, im talking 6.5 hrs. now this morning i feel much better, i was starting to think the riba was going to slow me down, but now i feel it was the lack of sleep.  ask for sleep aids,makes your day stronger and nites shorter (your not up all nite thinking and raceing in your head) best to all  RC



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 M-68, 3 Treatments)( SOF-RIBA 2014)(SOF-RIBA-PEG 2016)(HCC 2016) (LIVER TRANSPLANT 8-2017)(VOSEVI-RIBA 2017)   SVR-12. 3-13-18   
OldenSlow


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An older study, but worth a look.  Also from NATAP:

http://www.natap.org/2002/april/041702_1.htm



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66 y/o male - Geno 1b - F4 cirrhotic dx 2001 - 16 wk treatment w/ Sovaldi/Olysio/Riba - Und @ EOT+24 SVR

 
OldenSlow


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Welcome to the Up At All Hours club, Dee! It's been my most persistent complaint with treatment. Well... that and the increasing fatigue. So it goes. Small price to pay.  Thanks for the links.  I've wondered for some time what relationship there might be between the virus and cognitive dysfunction, especially for us longer term chronics.  Think I'll keep researching this for awhile.  I knew there had to be a reason for my occasionally odd behavior. ;)



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66 y/o male - Geno 1b - F4 cirrhotic dx 2001 - 16 wk treatment w/ Sovaldi/Olysio/Riba - Und @ EOT+24 SVR

 
zavr


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These are fascinating links, Dee! I have always had terrible spatial memory (can never find my car in the parking lot, get lost all the time, that sort of thing), and I wonder if hep c might be to blame... :)

Good to hear you are on 4th week of treatment! have you had any news as far as the drop in viral load? It sounds like your hemoglobin is in tip-top shape, which is great news for brain fog and fatigue (although I'm sure that insomnia can't be helping...). Have you found any relaxation strategies that have worked? Perhaps some gentle yoga, and candlelight before sleep?



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Gen 1b, 33yo. Started 12wk Viekira Pak on 2/28/2015. 

Baseline: VL=517K, AST=34, ALT=56. 

Wk4: VL=<15, AST=16, ALT=14.

Wk8: VL=UND, AST=17, ALT=14.

Wk12: VL=UND, Fibroscan: 3.4kPa, F0.

--->Viekira Pak financial and nurse support<---
Dee738


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And one more interesting article on successful treatment improving cognition in people with HCV:

www.natap.org/2012/HCV/PIIS0168827811008038.pdf

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Dee738


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Hi everyone,

Tomorrow begins my 4th week of treatment. Insomnia is increasing (it's 2:30 AM), and I've had daily morning diarrhea, but generally all is well. My hemoglobin count dropped from baseline 13 to 12 at 2.5 weeks, but that's not a significant drop or low number, so my MD is fine with keeping me at 1000 mg RIBA until my week 4 blood draw, which hopefully won't reveal anemia (my main concern). They'll also do a viral load at that visit. I had a high count the last time that was done, which was years ago; it was 1.something million, but she said there was no real point in getting that number at the start of treatment. The did run a genotype again, just to confirm I am still infected with 2b as I have been for 40 years.

On another subject, I am quite interested in cognition , "brain fog," and the possible impact of HCV and cure on that. My visual memory is horrible, and I wonder how much the virus might have to do with that. Thought you all might find the following study of interest in that regard. Excerpt below is followed by linK.

 

At the time of last follow up (Time 3), SVRs had significant improvements in total verbal learning recall (z=-2.02, p=0.04), verbal memory recognition (z=-2.21, p=0.03) and visuo-spatial memory (z=-1.99, p=0.04) when compared to baseline. This trend was not matched in non-responders/relapsers. Moreover, while improvements across verbal recognition and visuo-spatial memory domains were within a 'healthy' normative range, the median scores for total verbal learning recall were 2 SDs below the normative mean in the case of HCV controls and 1.4 SDs below in the case of HCV treatment recipients. Case summary analyses revealed between 50% and 71% of all HCV study participants exhibited impaired scores on verbal learning domains at baseline. Additionally, retrospective analysis showed that little difference in cognition existed between SVRs and NR/R at baseline with NR/Rs performing worse relative to SVR counterparts only on a measure of visuo-spatial memory (U=6.5, z=-2.143, p=0.035, r=0.59).

- See more at: http://hepatitiscresearchandnewsupdates.blogspot.com/2012/01/hcv-svr-improves-quality-of-life-brain.html#sthash.7iujreDa.dpuf

 

Age 59, genotype 2b, contracted in 1974 or 1975. Treatment naive, fibrospect 0-1, persistently normal enzymes, started Sovaldi + ribavirin February 1, 2014

 

 



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