Hep C Discussion Forum

Members Login
Username 
 
Password 
    Remember Me  
Chatbox
Please log in to join the chat!
Hep C Discussion Forum -> On Treatment -> Starting treatment
Post Info TOPIC: Starting treatment
Cinnamon Girl


Guru

Status: Offline
Posts: 5629
Date:
RE: Starting treatment
Permalink  
 

That`s amazing, John, you`ll be undetected next time for sure!  smile



__________________

Jill 

(71 yo, lives in UK)

Was Gen 3a, 

24wks Peg Ifn/Riba, Sep 2010 - Mch 2011

UND @ Wk.4, UND @ EOT, 

SVR Nov 2011 --> Still UND @ EOT + 4 yrs.

 

 
JLynch30


Senior Member

Status: Offline
Posts: 292
Date:
Permalink  
 

I was told undetectable on my test is 43.  I am at 48.  so close!



__________________

John   non-responder  

Undetected at week 2 on solvaldi/rib/interferon:  stayed through week 12 but virus came back as soon as I stopped.  on   Harvoni and ribravirin 24 weeks undetected after two. 8/2/15  12 week EOT  UNDETECTED!  SVR

1991-2015 RIP

 
Cinnamon Girl


Guru

Status: Offline
Posts: 5629
Date:
Permalink  
 

JLynch30 wrote:

Yes 2 week labs - what is considered undetectable?

Hi John, it depends which PCR test your lab is using.  Tests do vary and some labs still use ones that have a LLOQ (lower limit of quantification) of 43.  What exactly does it say on your results, does it say `detected` or `target detected`, or `undetected`?

That is a huge drop in viral load anyway for 2 weeks into treatment, excellent result!  smile



__________________

Jill 

(71 yo, lives in UK)

Was Gen 3a, 

24wks Peg Ifn/Riba, Sep 2010 - Mch 2011

UND @ Wk.4, UND @ EOT, 

SVR Nov 2011 --> Still UND @ EOT + 4 yrs.

 

 
jimbob


Senior Member

Status: Offline
Posts: 247
Date:
Permalink  
 

Yes John, I see now you are on the same tx as I. I think its a good one. Good luck buddy.

jimbob

__________________

jimbob: 64 y/o, GT 1A, F1-F2, diagnosed 1996. Since 1970. SOT 3.5 mil VL on 3/10/14 with Sov/Rib/Peg for 12 weeks. Tx naive. UND @ week 4,8,12. EOT 6/2/14.
Gracie


Guru

Status: Offline
Posts: 618
Date:
Permalink  
 

Undetected is less than 15. You were very close to that. I'd say you are responding terrifically. I'm watching you guys carefully as I also failed Incevik. Keep up the good work.



__________________
  1. Gracie

1A. Previously treated non responder Rebetron in 2000 And Incevik in 2014 with a breakthrough at week 12. Fibroscan 15.5. VL 6,000,000. Finished 24 weeks harvoni on Dec. 19, 2015. SVR. Latest Fibroscan 8.8.
JLynch30


Senior Member

Status: Offline
Posts: 292
Date:
Permalink  
 

Yes 2 week labs - what is considered undetectable?



__________________

John   non-responder  

Undetected at week 2 on solvaldi/rib/interferon:  stayed through week 12 but virus came back as soon as I stopped.  on   Harvoni and ribravirin 24 weeks undetected after two. 8/2/15  12 week EOT  UNDETECTED!  SVR

1991-2015 RIP

 
Caryn


Senior Member

Status: Offline
Posts: 305
Date:
Permalink  
 

JLynch30 wrote:

viral load went from 2 million to 43.

 Two week labs? Either way, yeah!!!! Awesome news!!!

 I am about to come unglued waiting for my results!  They had me go in at one week. First orders were for 2 weeks and 3 weeks, then re sent for 1 week and 3 weeks. Not real sure what's up with that!! 



__________________

1a, CT. Incivek triple 1/2013, vl 810 @ 2 weeks, 610 @ 4 weeks, 3000 @ 8 weeks, tx stopped. 

4/2014 - tx with Sovaldi/Olysio/Riba. VL 39 mil. - VL 230 @ 1 week, VL 40 @ 3 weeks, 5 weeks UND, EOT - UND, EOT @ 4 weeks UND, EOT @ 12 weeks UND!
JLynch30


Senior Member

Status: Offline
Posts: 292
Date:
Permalink  
 

viral load went from 2 million to 43.



__________________

John   non-responder  

Undetected at week 2 on solvaldi/rib/interferon:  stayed through week 12 but virus came back as soon as I stopped.  on   Harvoni and ribravirin 24 weeks undetected after two. 8/2/15  12 week EOT  UNDETECTED!  SVR

1991-2015 RIP

 
Matt Chris


Guru

Status: Offline
Posts: 1782
Date:
Permalink  
 

Hey John 

Welcome to the forum, sounds like you have made up your mind. Sovaldi will certainly provide a power house treatment but interferon is very important part of the treatment so its important to make sure your not interferon intolerant or insensitive. Ask your doctor

matt



__________________

"And in the end, the love you take is equal to the love you make"

61 year old Geno type A1, F4 Cirrhotic, started 24 weeks on Harvoni 12-17-14 ,EOT-5 week = UND, 8-31-15 =UND , SVR-24 Baby YES! 
Tig


Admin

Status: Offline
Posts: 9284
Date:
Permalink  
 

Good luck John! Keep us posted on your progress and tests. We're rooting for you!

Tig



__________________

Tig

68yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

Hep C FAQ   Lab Ref. Ranges  HCV Resistance

Signature Line Set Up/Abbreviations   Payment Assistance

 
JLynch30


Senior Member

Status: Offline
Posts: 292
Date:
Permalink  
 

I am going for it - the people I have talked to say the re is very little chance I would not be eligible for new treatments next year if this fails.  Here i go!



__________________

John   non-responder  

Undetected at week 2 on solvaldi/rib/interferon:  stayed through week 12 but virus came back as soon as I stopped.  on   Harvoni and ribravirin 24 weeks undetected after two. 8/2/15  12 week EOT  UNDETECTED!  SVR

1991-2015 RIP

 
JLynch30


Senior Member

Status: Offline
Posts: 292
Date:
Permalink  
 

thanks - please keep me posted!



__________________

John   non-responder  

Undetected at week 2 on solvaldi/rib/interferon:  stayed through week 12 but virus came back as soon as I stopped.  on   Harvoni and ribravirin 24 weeks undetected after two. 8/2/15  12 week EOT  UNDETECTED!  SVR

1991-2015 RIP

 
mallani


Guru

Status: Offline
Posts: 3398
Date:
Permalink  
 

Hi John,

I would worry about going on Interferon again. I know you failed the Incivek triple, and people who relapse while on Rx usually do so because they are not Interferon sensitive.

Jill is correct about the antiprotease RAV's that you may, or may not have. Sovaldi would take care of them, but Sovaldi also needs backup with another antiviral. If it was me, I'd want to wait for an Interferon-free combo. Sovaldi/Olysio is available now, or if you wait 6 months, Sovaldi/Ledipasvir will be available. Just my opinion. Cheers.



__________________

Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm
AngieV123


Senior Member

Status: Offline
Posts: 160
Date:
Permalink  
 

I am a former tx relapser and have been on the new triple for a month..awaiting my 4 week lab results. I should know if it's working by tomorrow. My doctor said the rates are around 90% for cure on this therapy for the majority of people. I'm not clear on the statistics. I do know that everyone on this tx is having a vast drop in VL numbers very quickly. Good luck.

__________________

Type 1a. Had HCV my entire life via blood transfusion. Did peg & riba in 2000, relapsed. Did triple tx with sovaldi in early 2014 & I am now undetected 
Cinnamon Girl


Guru

Status: Offline
Posts: 5629
Date:
Permalink  
 

Hi John, that`s great news, at last.  We do have members who have failed previous treatments and who are now doing well on Sovaldi plus ribavirin with or without interferon, and mostly they have had undetected results after just a few weeks.

As you`ve already done one treatment that included a protease inhibitor (telaprevir/incivek) then I should think this is the best treatment option for you at the moment.  You may well have developed RAV`s, which are resistant virus mutations, to incivek and so retreatment with another protease inhibitor, for example Olysio (Simeprivir), wouldn`t be advisable. 

You should do well on the Sovaldi triple and I wish you all the best of luck!  Stay in touch, and do keep us updated.



__________________

Jill 

(71 yo, lives in UK)

Was Gen 3a, 

24wks Peg Ifn/Riba, Sep 2010 - Mch 2011

UND @ Wk.4, UND @ EOT, 

SVR Nov 2011 --> Still UND @ EOT + 4 yrs.

 

 
JLynch30


Senior Member

Status: Offline
Posts: 292
Date:
Permalink  
 

I found a doctor who will put me on interferon, rib and solvaldi even though I failed triple therapy with Telaprivar.  Is anyone hearing any good results yet for us non responders and solvaldi?  What about tolerance failure?



__________________

John   non-responder  

Undetected at week 2 on solvaldi/rib/interferon:  stayed through week 12 but virus came back as soon as I stopped.  on   Harvoni and ribravirin 24 weeks undetected after two. 8/2/15  12 week EOT  UNDETECTED!  SVR

1991-2015 RIP

 
Page 1 of 1  sorted by
 
Quick Reply

Please log in to post quick replies.
Hep C Discussion Forum -> On Treatment -> Starting treatment
Legal Disclaimer:

THIS FORUM, IT'S OWNERS, ADMINISTRATORS, MODERATORS AND MEMBERS DO NOT AT ANY TIME GIVE MEDICAL ADVICE AND IN ALL CASES REFER ANYONE HERE TO SEEK APPROPRIATE MEDICAL ADVICE FROM THEIR DOCTOR.