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Hep C Discussion Forum -> Clinical Trial Participants -> Fingers crossed, 4 week undetected
Post Info TOPIC: Fingers crossed, 4 week undetected
Paul B


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RE: Fingers crossed, 4 week undetected
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Way to go on the SVR !!!



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57 Yr old, Diagnosed 1994 Geno 1a. 1995: Interferon 12 weeks.  1998: Int/Rib 10 weeks.  2014: VL 106,000. Peg Int, Ribavirin, Victrelis 48 weeks (commenced June 2014). UND after Peg/Int lead in week 4. Still UND at week 8, 24, EOT. SVR 12.

wmlj1960


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Congrats on the SVR Jim!!!

 



__________________

60 yo, geno 1a, Dx 1994 HCV-HIV co-inf, Dx 2013 decompensated cirrhosis
Tx #1 - 24wks Sov+Riba /SOT 7-24-2014/UND@EOT/DETECTED@EOT+16 wks
Tx #2 - 24wks Harvoni /SOT 7-25-2015/UND@EOT,+12,+24,+52 = SVR

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Rockyfeller


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probably about 20-25 mph



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genotype 1a, viral count 7 M

7/12/12 started triple with GS-7977(400 mg 1/day), Peginterferon and Ribavirin  12 wk  trial

11/2012 no svr

12/10/13 new trial with sofosbuvir/ledispavir combo and riba12 wks

3/10/14 UND

3/16/15 still UND, and feeling great
mallani


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Hi Jim,

Great video but I'm not sure about the cloudy sky! Come to Australia and do some kite-surfing in the sunshine! Cheers buddy.



__________________

Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm
Isiscat2011


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Rockyfeller wrote:

Thanks all, I appreciate the report.  The comment about windsurfing made me look through my last posts, as it was a coincidence that I got my 24 week SVR notice also while I was at the lake sailing.  Attached is a 2 minute clip I shot while sailing.

[video=https://www.dropbox.com/s/om26p6rkrw6oi0s/Lake%20Swann.mp4?dl=0]

 

I hope that link works 

 The link worked fine for me.  Very cool.  I felt like I was there.  I want to try that!  How fast were you going?  



__________________

Diagnosed in 2011, Incivek triple in 2011, tx discontinued, Genotype 1a, CT, VL 7mill, cirrhosis dx in 2012, age 67, waiting for new DAAs.
Rockyfeller


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Thanks all, I appreciate the report.  The comment about windsurfing made me look through my last posts, as it was a coincidence that I got my 24 week SVR notice also while I was at the lake sailing.  Attached is a 2 minute clip I shot while sailing.

[video=https://www.dropbox.com/s/om26p6rkrw6oi0s/Lake%20Swann.mp4?dl=0]

 

I hope that link works

 

 



__________________

genotype 1a, viral count 7 M

7/12/12 started triple with GS-7977(400 mg 1/day), Peginterferon and Ribavirin  12 wk  trial

11/2012 no svr

12/10/13 new trial with sofosbuvir/ledispavir combo and riba12 wks

3/10/14 UND

3/16/15 still UND, and feeling great
pl1952


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Congrats Jim!  Good to hear --- gives me hope!



__________________

Me: 62 yr. old female, GT 1b, fibroscan 4.5; VL 650,975 as of 2/4/14;started Harvoni 3/6/15; SVR


Hubby: 59 yrs.; GT1b; fibroscan 25-cirrhotic; S/O for 12 weeks started tx 3/20/14; SVR56; fibroscan done 7-7-15 = 8.5
Gator Man


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Congratulations Jim! It looks like the new S/L combo with Riba did the trick. SVR indeed! I think you've blazed the path for others who have failed prior treatments.

Enjoy life! Never tried windsurfing, but it looks like fun.



__________________

Geno 1b, compensated cirrhotic, 54 yo, prior null responder. Pre tx VL approx 595,000, tx with Sovaldi/Olysio (no Riba) started 1/8/14. VL 40 @ 2 weeks, UND @ 4 weeks. Still UND @ EOT + 1 year.

Gator Man SVR12, Dragon 0, Final Score.
Matt Chris


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Hey Jim

Super congrats on making it to 24 UND and yes SVR!  Yahoo !

matt



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"And in the end, the love you take is equal to the love you make"

61 year old Geno type A1, F4 Cirrhotic, started 24 weeks on Harvoni 12-17-14 ,EOT-5 week = UND, 8-31-15 =UND , SVR-24 Baby YES! 
Isiscat2011


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Congrats, Jim!  

Really appreciate you letting us know how your tx went.  As you know many of us hope to be on that combo (with or without riba) and it is great to read about your experience.  



__________________

Diagnosed in 2011, Incivek triple in 2011, tx discontinued, Genotype 1a, CT, VL 7mill, cirrhosis dx in 2012, age 67, waiting for new DAAs.
mallani


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Hi Jim,

Congrats. Persistence pays off! Enjoy life.



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Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm
Tig


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Hey Jim,

Congratulations Brother!!! You've really had quite the battle and you really deserve this great news! Keep us in the loop, I have a feeling that your news is going to continue to get better with each visit! Good luck Jim...

Tig  



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Tig

67yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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Huey


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congrats, : biggrin



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  HCV Genotype 3a , now Psot-Tx was on S/riba. First VL was 5.8 mil on 7-5-13 then "und" at 3.8 weeks. 06/13/14 still und. off meds 3 days back on 7/29 Last pill 08/10/14 SVR+4

 
Rockyfeller


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24 weeek SVR
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Got my test results today.  24 week svr.  Wahoo



__________________

genotype 1a, viral count 7 M

7/12/12 started triple with GS-7977(400 mg 1/day), Peginterferon and Ribavirin  12 wk  trial

11/2012 no svr

12/10/13 new trial with sofosbuvir/ledispavir combo and riba12 wks

3/10/14 UND

3/16/15 still UND, and feeling great
Matt Chris


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RE: Fingers crossed, 4 week undetected
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Hey Jim 

Its so wonderful to hear your continued good results and guess the hard to treat guys like you and me and many others will be doing 24 weeks of the Gilead combo it really seems to do the trick. Nice to hear about your upswing in energy, enjoy and thanks for letting us all know and get faith from your story.

matt 



__________________

"And in the end, the love you take is equal to the love you make"

61 year old Geno type A1, F4 Cirrhotic, started 24 weeks on Harvoni 12-17-14 ,EOT-5 week = UND, 8-31-15 =UND , SVR-24 Baby YES! 
Isiscat2011


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Rockyfeller wrote:

Issicat,

It was actually 14 months between treatments, October 2012 to December 2013

 Wow, that's even more interesting.  Those little buggers were back in full swing by the second go around and the 12 weeks still got 'em.  Good stuff.  



__________________

Diagnosed in 2011, Incivek triple in 2011, tx discontinued, Genotype 1a, CT, VL 7mill, cirrhosis dx in 2012, age 67, waiting for new DAAs.
Rockyfeller


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Issicat,

It was actually 14 months between treatments, October 2012 to December 2013



__________________

genotype 1a, viral count 7 M

7/12/12 started triple with GS-7977(400 mg 1/day), Peginterferon and Ribavirin  12 wk  trial

11/2012 no svr

12/10/13 new trial with sofosbuvir/ledispavir combo and riba12 wks

3/10/14 UND

3/16/15 still UND, and feeling great
Rockyfeller


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Thanks all, and I hope that everyone else can soon attain the same results.  In the 3 months since ending treatment I have noticed a considerable improvement in my health, a lot of which is due to my workout schedule, but a lot is due to the new energy I seem to have found.  I was at the lake windsurfing today when I got the call from my nurse practitioner, and I haven't felt like windsurfing for a couple of years.

It definitely took the better part of 2 months for the effects of the meds to wear off.  The riba took it's normal toll, and made me somewhat anemic, but I think the sofosbuvir added an edge to it.  When trying to swim while taking it, I experienced some severe chest pains.  An exam showed nothing wrong, and within 5 weeks of ending treatment I was able to swim again with no problems.

Good luck to all, and I hope to repeat this good news in 12 weeks.



__________________

genotype 1a, viral count 7 M

7/12/12 started triple with GS-7977(400 mg 1/day), Peginterferon and Ribavirin  12 wk  trial

11/2012 no svr

12/10/13 new trial with sofosbuvir/ledispavir combo and riba12 wks

3/10/14 UND

3/16/15 still UND, and feeling great
Isiscat2011


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Very good news, Jim.  Congrats!

Looks like 24 weeks with Sovaldi as the core drug did the trick even with a 3 month break in between.  That is very interesting.  I'm wondering if the next SOC will become 12 weeks for all GT1s (with various DAA combos) and then another 12 asap if no SVR after the first round.  That sounds reasonable to me as long as the break in between doesn't compromise the tx.  I wonder if it would have worked without the Riba.



__________________

Diagnosed in 2011, Incivek triple in 2011, tx discontinued, Genotype 1a, CT, VL 7mill, cirrhosis dx in 2012, age 67, waiting for new DAAs.
mallani


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Hi Jim,

Congrats buddy. It's interesting that you didn't make it with Sovaldi/Peg/Riba but Sovaldi/Ledipasvir/Riba did the trick. Retreatment works! Cheers.



__________________

Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm
Groupergetter


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Congratulations Jim, you've made it.  Glad to hear you're doing so well.  I'm trying to figure out how get out of the chronic fatigue routine.  Had it for so long it's become part of me.  Just finished tx so hopefully in time things will improve.   Really happy for you.   Be well, enjoy your newfound life.



__________________

1b  Int/Riba relapse @ 48 weeks.  Stop tx Peg Int/Riba 12 weeks ill. Relapse S/O 6/23/14 :(   Started Harvoni 11/12/14  EOT 4/28/15.  EOT+4 UND :)  SVR! 8/4/15  :)     Thankful for every morning.
Tig


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Hey Jim,

Congratulations!!! Thanks for sharing your great news! There have been so many good reports recently, and here again, you offer us more good news and another indication that they have finally found treatments that work. Continued good luck my friend, and keep us advised....

Tig



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Tig

67yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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pl1952


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Awesome!!!  Congrats!!!

 



__________________

Me: 62 yr. old female, GT 1b, fibroscan 4.5; VL 650,975 as of 2/4/14;started Harvoni 3/6/15; SVR


Hubby: 59 yrs.; GT1b; fibroscan 25-cirrhotic; S/O for 12 weeks started tx 3/20/14; SVR56; fibroscan done 7-7-15 = 8.5
Loopy Lisa


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Congratualtions, that is great news :D



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Genotype: 3b

VL.�over 15, 000 000

Failed TX 2014: Interferon/Riba.

Cured using Sof/Dak combination.

I can eat cake again! <3 
Rockyfeller


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RE: Fingers crossed, now 12 weeks undetected
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I got the call today from the clinic that I tested negative after 12 weeks.  Wahoo.  I was more relieved than I thought I would be.



__________________

genotype 1a, viral count 7 M

7/12/12 started triple with GS-7977(400 mg 1/day), Peginterferon and Ribavirin  12 wk  trial

11/2012 no svr

12/10/13 new trial with sofosbuvir/ledispavir combo and riba12 wks

3/10/14 UND

3/16/15 still UND, and feeling great
hrsetrdr


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RE: Fingers crossed, 4 week undetected
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Jim,
congratulations on the good turn your life has taken! Thanks for the update, pls keep us informed of your future progress.

Best of luck,

Tim

__________________

"hrsetrdr"=Tim

Treatment halted on Aug.8,2012 due to vision problem.  6 month post tx labs

Aug.2013 SVR

Be strong when you are weak, brave when you are scared, and humble when you are victorious.
- Unknown

 

 
Rockyfeller


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Maybe the first round weakened it, and being able to do the second round 14 months later helped.



__________________

genotype 1a, viral count 7 M

7/12/12 started triple with GS-7977(400 mg 1/day), Peginterferon and Ribavirin  12 wk  trial

11/2012 no svr

12/10/13 new trial with sofosbuvir/ledispavir combo and riba12 wks

3/10/14 UND

3/16/15 still UND, and feeling great
maddie


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Great news Jim.  Congratulations!  Appears to back up the assurance of many Hepatologists, that re-treatment with Sovaldi in the mix a second time, can be successful. 

Continued UND..... and SVR in 8 weeks!!!



__________________

Dx. 2005-liver bx.: stg 2/gr 1. at that time  - GT 1a multiple transfusions in 1981.  Started Sovaldi and Olysio 1/16/14  (No prior treatments) Q80K present.  UND week 4,8 and at EOT.   UND at wk 4EOT, Und at wk 8EOT  SVR 12!!!..SVR 24 :-)
mallani


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Hi Jim,

Welcome back. It appears that you have done it, this time.

It's interesting that you relapsed after 12 weeks of Sovaldi/ Peg/Riba but appear to have done so well after 12 weeks of Sovaldi/Ledipasvir. It's a strange disease.

Glad you're feeling better. Cheers.



__________________

Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm
OldenSlow


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Hi Jim,

Thanks for posting back and best of luck on sustaining that UND. Really happy to hear your workout energy returned within a few weeks of stopping treatment. I'm not a swimmer but a runner, and fatigue has been my biggest problem. Pretty much dead in the water since about week 3. I put it on the riba. I'm only mildly anemic, but think I need all the Hb I can get to sustain any serious effort. Anyway, that's been it's effect on me. Good to hear about the light at end of tunnel. Thanks!

wayne



__________________

66 y/o male - Geno 1b - F4 cirrhotic dx 2001 - 16 wk treatment w/ Sovaldi/Olysio/Riba - Und @ EOT+24 SVR

 
Cinnamon Girl


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Hi Jim, good to hear from you again, and congrats on your 4 wks post tx Und result!

It certainly sounds like you were suffering badly from the side effects of the ribavirin, and it must have been a scary experience thinking you were having a heart attack!  Most probably your Hb count was low and you were overdoing it at that point, and it must feel great to be back in the pool and swimming again, that is excellent.

Best of luck with your next results which I guess will be at 12 weeks, and thanks for sharing your news, it will give hope and inspiration to many!   



__________________

Jill 

(71 yo, lives in UK)

Was Gen 3a, 

24wks Peg Ifn/Riba, Sep 2010 - Mch 2011

UND @ Wk.4, UND @ EOT, 

SVR Nov 2011 --> Still UND @ EOT + 4 yrs.

 

 
Matt Chris


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Hey Jim

Way to go! that is super fantastic news for you and all of us other relapsers and your odds only get better every day that passes UND your percentage of SVR gets greater.

I guess I have some swimming in my future as well.

Hooray for you!

matt 



__________________

"And in the end, the love you take is equal to the love you make"

61 year old Geno type A1, F4 Cirrhotic, started 24 weeks on Harvoni 12-17-14 ,EOT-5 week = UND, 8-31-15 =UND , SVR-24 Baby YES! 
Rockyfeller


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I finished up my clinical trial with sofosbuvir/ledispavir on March 4, got my 4 week results today and was undetected.  I won't start celebrating yet, but I didn't make it this far after the first try, so I'm optimistic.

I retired 1 month into the treatment.  I had been going to the health club infrequently prior to this, but started going daily hoping to offset some of the side effects.  The lack of interferon made this trial easier than the first, but fatigue was still a factor.  Swimming used to be a major part of my work out, but in January when I tried swimming, I could barely make a single lap, and had serious thoughts as to whether or not I was having a heart attack, so after a couple of attempts I put swimming off until after treatment.  One week after finishing up I tried again, and had similar pains, although to a lesser degree.  I sent an email to my doctor asking about "angina like symptoms", and got a call from her to go the emergency room immediately.  I told her I was not in any distress at the moment, but I could see her the next day.  She had me do a nuclear stress test, x-rays and treadmill, and the results were that I had no problems, so I went back to the pool.  Now, 5 weeks after finishing treatment I can knock out 20 laps with no problem, so it was all a side effect from the meds, probably the ribavirin.

Overall,I feel  better than I have in years.  I would like to attribute it to maybe being hep c free (fingers crossed), but i is probably that I'm not sitting at a desk all day, and working out regularly.  Now 69 doesn't feel as old as it used to.

Now I just hope they can make this more affordable.



__________________

genotype 1a, viral count 7 M

7/12/12 started triple with GS-7977(400 mg 1/day), Peginterferon and Ribavirin  12 wk  trial

11/2012 no svr

12/10/13 new trial with sofosbuvir/ledispavir combo and riba12 wks

3/10/14 UND

3/16/15 still UND, and feeling great
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