Hep C Discussion Forum

Members Login
Username 
 
Password 
    Remember Me  
Chatbox
Please log in to join the chat!
Hep C Discussion Forum -> On Treatment -> .. Has anyone on here done the twelve weeks of olysio/sovaldi and it didnt work for them?
Post Info TOPIC: .. Has anyone on here done the twelve weeks of olysio/sovaldi and it didnt work for them?
Dee Dee


Senior Member

Status: Offline
Posts: 109
Date:
RE: .. Has anyone on here done the twelve weeks of olysio/sovaldi and it didnt work for them?
Permalink  
 

Wishing you great results Gator Man!



__________________
G1a prior tx 2005 with peg & RIBA -quit due to bad side effects. Follow up visit showed it was back. Current tx Olysio/sovaldi 673,000 vl on 3/21/14. May 1st undetected vl. EOT 12 weeks undetected!
Dee Dee


Senior Member

Status: Offline
Posts: 109
Date:
Permalink  
 

biggrinGood luck Rybronco!!



__________________
G1a prior tx 2005 with peg & RIBA -quit due to bad side effects. Follow up visit showed it was back. Current tx Olysio/sovaldi 673,000 vl on 3/21/14. May 1st undetected vl. EOT 12 weeks undetected!
Rybronco


Veteran Member

Status: Offline
Posts: 79
Date:
Permalink  
 

Gator Man,

Can't wait to see your EOT + 4 results!

I'm going for my 8 week VL test tomorrow. Cross dem fingers!!



__________________

49 yo. G1a prior tx 2005 with peginf and RIBA 12 weeks dc due to side effects. vl 7.8mm Current tx Sovaldi/Olysio 12 weeks started 2-21-2014,  UND at 4 weeks, EOT+12 SVR
Gator Man


Senior Member

Status: Offline
Posts: 442
Date:
Permalink  
 

My doctor told me that he has knows of post-EOT relapse with Sovaldi/Olysio, but the numbers were small. He didn't specify if any were his patients or other colleagues in the COSMOS study. I do know that he had a few patients with tx compliance problems, e. g. not taking meds as prescribed, continued alcohol or drug abuse. The final cohort 2 numbers from COSMOS found that overall 94% of Metavir F3-F4, genotype 1 patients achieved SVR12. The numbers were small, but still impressive for a hard to treat group that includes me as a fellow member.

My Hep C clinic is still collecting data from the Sovaldi/Olysio combo, as I'm sure many other clinics and physicians are around the U.S. and abroad. The recently initiated phase 3 Optimist trial of the combo should have a much larger patient base to compare with the COSMOS results.

My next VL test will be at EOT + 4 weeks on April 30th.

 





-- Edited by Gator Man on Wednesday 16th of April 2014 05:02:39 PM

__________________

Geno 1b, compensated cirrhotic, 54 yo, prior null responder. Pre tx VL approx 595,000, tx with Sovaldi/Olysio (no Riba) started 1/8/14. VL 40 @ 2 weeks, UND @ 4 weeks. Still UND @ EOT + 1 year.

Gator Man SVR12, Dragon 0, Final Score.
Rybronco


Veteran Member

Status: Offline
Posts: 79
Date:
Permalink  
 

I asked my doctor the same question.  He participated in clinical studies with the same regimen and he says none of those he follows has failed.

Since approval, his patient are just reaching EOT now.m I think this quesiton will be an interesting one in the near future when the masses reach EOT + 12 or 24.

Rockon!



__________________

49 yo. G1a prior tx 2005 with peginf and RIBA 12 weeks dc due to side effects. vl 7.8mm Current tx Sovaldi/Olysio 12 weeks started 2-21-2014,  UND at 4 weeks, EOT+12 SVR
Barnacle


Senior Member

Status: Offline
Posts: 125
Date:
Permalink  
 

good question I had wondered the same thing. You may want to post it again in 6mo


__________________

57yo male gen 1a since '70s. Fib F3-4 VL >2M Tx started 5 Apr 14 Sov/Oly/Rib

wk 4 UND wk 8 UND, wk 12 EOT UND...keep em coming 24wks UND = SVR!
OldenSlow


Senior Member

Status: Offline
Posts: 380
Date:
Permalink  
 

Hi Dee Dee,

Since the drugs were just approved late last year, there hasn't been enough time to get much post-tx followup info.  The few forum members that have completed treatment have only recently done so.  I haven't seen any reports of viral breakthroughs.  Those on clinical trials are the only ones who would have had enough time to finish both tx and the following 12 weeks required to claim SVR. If any relapses were posted, I missed them.  

wayne



-- Edited by OldenSlow on Wednesday 16th of April 2014 03:17:13 AM

__________________

66 y/o male - Geno 1b - F4 cirrhotic dx 2001 - 16 wk treatment w/ Sovaldi/Olysio/Riba - Und @ EOT+24 SVR

 
Dee Dee


Senior Member

Status: Offline
Posts: 109
Date:
Permalink  
 

Has anyone on here done the twelve weeks of olysio/sovaldi  and it didnt work for them?



__________________
G1a prior tx 2005 with peg & RIBA -quit due to bad side effects. Follow up visit showed it was back. Current tx Olysio/sovaldi 673,000 vl on 3/21/14. May 1st undetected vl. EOT 12 weeks undetected!
Page 1 of 1  sorted by
 
Quick Reply

Please log in to post quick replies.
Hep C Discussion Forum -> On Treatment -> .. Has anyone on here done the twelve weeks of olysio/sovaldi and it didnt work for them?
Legal Disclaimer:

THIS FORUM, IT'S OWNERS, ADMINISTRATORS, MODERATORS AND MEMBERS DO NOT AT ANY TIME GIVE MEDICAL ADVICE AND IN ALL CASES REFER ANYONE HERE TO SEEK APPROPRIATE MEDICAL ADVICE FROM THEIR DOCTOR.