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thepoet


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RE: Questions????
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Thanks guys for your responses. I spoke with the pharmacist and he also said that throwing up 7 - 8 hours after ingestion, should not have an affect.

 



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DJ...dx 2005...geno 4c...twice interferon/riba failure....completed 24 weeks Sovaldi & Riba on 10/18/14....SOT VL 600,000 after 16 days VL <43. Day 45 <43 again. Day 59...8 weeks UNDETECTED.

Happy and grateful to God for new life....
Cinnamon Girl


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mallani wrote:

Sounds like US toilet humour!

 Exactly what I was thinking, Malcolm!  wink



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Jill 

(71 yo, lives in UK)

Was Gen 3a, 

24wks Peg Ifn/Riba, Sep 2010 - Mch 2011

UND @ Wk.4, UND @ EOT, 

SVR Nov 2011 --> Still UND @ EOT + 4 yrs.

 

 
mallani


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Sounds like US toilet humour!



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Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm
Tig


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Ha, ha! Yeah, the porcelain Greyhound? That's good Lee! With the advent of the Tablet, it's much easier to drive the bus now with one of them as your wheel... But I agree completely, Malcolm does provide us with plenty of great information to read, regardless of where you get to do it!

Tig



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Tig

68yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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longld


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Mallani gives us much to think about while 'driving the porcelain Greyhound (bus)'....hope that is not an American expression and not easily understood! 



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62 Yrs Old, CHC Geno 3, Cirrhosis, Kidney Transplant (13 yrs), On Sovaldi/Riba Treatment (24 week) since Feb 01,2014

Viral Load 7M on 1/8/2014,  UND at EOT 7/18/2014
TazKat


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Thanks Mallani. Boy you are a wealth of knowledge for sure!!!! headbang.gif   Taz 



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TazKat Genotype 1A null responder x 3 riba & iterferon twice, relapsed from Incivek 2012 with only 12 weeks left to do. stage 4 mild cirrhosis 4/25/2014/ started sovaldi riba & interferon.. finished treatment 7/17/14  results 7/25  cleared..

 

 
mallani


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Sovaldi is absorbed from the small intestine. Like most drugs, there is little absorption in the stomach, due to the thick mucosa and rapid transit time.

The coating of the pill is to resist the gastric acid. This coating ( called an enteric coating) is dissolved by the acid, making the active drug available when the drug reached the small bowel. The acidity gradually drops from the duodenum (pH 4) to the terminal ileum (pH 8). Some drugs are best absorbed at a certain pH so various drugs are absorbed at certain points in the small bowel. The process is mostly by passive diffusion across a membrane, but some drugs and vitamins have active transporters.

Sovaldi is mostly absorbed within 2 hours of ingestion. This is why the instructions are to repeat the dose if vomiting occurs within 2 hours, but if more than 2 hours, don't worry. Cheers.



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Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm
Huey


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TazKat wrote:

good to know that huey. since I did the 1000.00 barf last week about 3 to 4 hrs after taking it.. I forgot who said that. the 1000.00 bary but it was funny.. well not at the time but when I read it..smile

It was mallani that told me about the 2 hour time frame and the plasma has a half life of 27 hours. 



-- Edited by Huey on Sunday 8th of June 2014 08:57:54 PM

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  HCV Genotype 3a , now Psot-Tx was on S/riba. First VL was 5.8 mil on 7-5-13 then "und" at 3.8 weeks. 06/13/14 still und. off meds 3 days back on 7/29 Last pill 08/10/14 SVR+4

 
Isiscat2011


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thepoet wrote:

Thanks guys for your responses. From what I saw, the Sovaldi is time released because it had swollen to almost three times the normal size. It actually looked like a piece of plastic.

 

 Interesting.  Does all time released medicine actually swell up and what causes that?  I've never heard of this before.



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Diagnosed in 2011, Incivek triple in 2011, tx discontinued, Genotype 1a, CT, VL 7mill, cirrhosis dx in 2012, age 67, waiting for new DAAs.
TazKat


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good to know that huey. since I did the 1000.00 barf last week about 3 to 4 hrs after taking it.. I forgot who said that. the 1000.00 bary but it was funny.. well not at the time but when I read it..smile



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TazKat Genotype 1A null responder x 3 riba & iterferon twice, relapsed from Incivek 2012 with only 12 weeks left to do. stage 4 mild cirrhosis 4/25/2014/ started sovaldi riba & interferon.. finished treatment 7/17/14  results 7/25  cleared..

 

 
Huey


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Sovaldi is quickly absorbed and into the liver within 2 hours. As I have learned from others here.



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  HCV Genotype 3a , now Psot-Tx was on S/riba. First VL was 5.8 mil on 7-5-13 then "und" at 3.8 weeks. 06/13/14 still und. off meds 3 days back on 7/29 Last pill 08/10/14 SVR+4

 
thepoet


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Thanks guys for your responses. From what I saw, the Sovaldi is time released because it had swollen to almost three times the normal size. It actually looked like a piece of plastic.

I would, if I ever threw up again, pick it up and swallow it again.

It wasn't the medicine that made me sick, it was a stomach virus.

Well, at least my numbers didn't go up. I pray for undetected on the next round. Have a great day guys.

 

 



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DJ...dx 2005...geno 4c...twice interferon/riba failure....completed 24 weeks Sovaldi & Riba on 10/18/14....SOT VL 600,000 after 16 days VL <43. Day 45 <43 again. Day 59...8 weeks UNDETECTED.

Happy and grateful to God for new life....
Tig


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Hi Debra,

It can take anywhere from 15 minutes to an hour for a pill to be absorbed in the stomach. Of course it's going to depend on the stomach contents when the medication is taken. Some medication is designed to pass through the stomach and be absorbed (digested) in the intestinal tract. A pill with an enteric coating is an example of such a medication. So certainly after several hours, you had no risk of throwing up the medication or any part of it.

Tig



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Tig

68yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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hrsetrdr


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Hi Debra,

According to Gilead's Sovaldi information it sounds like they are more concerned about an overdose, and less so for an "underdose".    When I was on the Interferon+Riba+Victrellis tx I missed a dose, and was mortified, but was reassured that all was not lost.

I think that you are O.K., but as always it's best to inform your doctor.



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"hrsetrdr"=Tim

Treatment halted on Aug.8,2012 due to vision problem.  6 month post tx labs

Aug.2013 SVR

Be strong when you are weak, brave when you are scared, and humble when you are victorious.
- Unknown

 

 
Scruffy


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If you threw up 7 or 8 hrs. after taking your Sovadi you should be alright. Unless there time released? Did you see the pills? I didn't throw up or even get that kind of sick on my tx. But I was ready to puke in my hands and take those pills again. I was gonna show the tx and hepc who was boss!!! So I guess you know what to do if you should puke right after taking them biggrin



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Geno 1a null responder 2004 inter/riba   finished incivek,peg/riba 48 weeks May 17th 2014. undetect weeks 4-12-32.  EOT+7 undetect. EOT+24 SVR!!!!! EOT+!YEAR SVR!!!!
thepoet


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When I was sick last week, twice I threw up my Sovaldi about 7 or 8 hours after I had taken it. I had my blood drawn on Tuesday which was2 days into week 5 and my numbers didn't change. I'm still at less than 43. Should I be concerned? Could , my throwing up those 2 pills truly have an effect? Thanks for your responses.

 



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DJ...dx 2005...geno 4c...twice interferon/riba failure....completed 24 weeks Sovaldi & Riba on 10/18/14....SOT VL 600,000 after 16 days VL <43. Day 45 <43 again. Day 59...8 weeks UNDETECTED.

Happy and grateful to God for new life....
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