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Post Info TOPIC: Finished on saturday
JLynch30


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RE: Finished on saturday
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You are correct Mallani.

 

By the way I did do a round of interferon with BMS-790052 which is a NS-5A inhibitor

 

 

 

 



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John   non-responder  

Undetected at week 2 on solvaldi/rib/interferon:  stayed through week 12 but virus came back as soon as I stopped.  on   Harvoni and ribravirin 24 weeks undetected after two. 8/2/15  12 week EOT  UNDETECTED!  SVR

1991-2015 RIP

 
Tig


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Rudy,

It's not necessary to repost the same thing in multiple threads. Everyone can see the original. Thank you for your understanding. I answered your question in the previous thread.



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Tig

68yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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RUDY


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DOES ANYONE HAVE DOCTOR RECORDS,NOTES, ETC.. NAME AND ADDRESS OF CLINIC OR HOSPITAL THAT CAN SAY HEALED NOT COMING BACK..... I'LL BE WAITING FOR THAT FOR A LONG TIME.....HEALED FOREVER... PLEASE SEND IT IF YOU HAVE IT !!!!!! I HAVE UNDETECTABLE VL,,,,,,,AND THATS ALL ANY OF YOU MAY GET,,, NOT A YOU ARE HEAL FOREVER..  THE END,, PROVE ME WRONG,,, MONEY MAKING DRUG COMPANIES,, YOU AND I, GINNY PIGS..



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mallani


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Hi John,

You'll worry yourself sick looking at relapse rates. Relax mate, you'll be fine.

Your problem has always been Interferon. You are obviously not Interferon sensitive.

Matt makes the good point that the 71% relapse rate pertains to those who had previously relapsed after 8 or 12 weeks of Harvoni. We all agree that the best treatment for cirrhotics is 24 weeks of Harvoni- whether to add Riba is up to the doctor, but it doesn't seem to make much difference.

As you had not had an NS-5A inhibitor before, RAV's at this site will not be a problem, even though some baseline RAV's may exist naturally.

Your SVR chances are well over 90% so just stop reading. Cheers.



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Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm
JLynch30


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great read.

 

I have had 6 treatments (all interferon based) and one solvaldi treatment and a study way back with bms900 which is similar yo ledsprivar.

 

I have never been tested for any RAV'S... can you believe it.

 

My viral was undetected at week 3 and my alt ast is normal for the first time since 91 so we will see.  



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John   non-responder  

Undetected at week 2 on solvaldi/rib/interferon:  stayed through week 12 but virus came back as soon as I stopped.  on   Harvoni and ribravirin 24 weeks undetected after two. 8/2/15  12 week EOT  UNDETECTED!  SVR

1991-2015 RIP

 
Matt Chris


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Hello John

Congrats on completing your 24 weeks of Harvoni, I am 6 weeks behind you.

The SVR rate you alluded to was for patients that used the protocol of "Sofosbuvir & Ledipavir" (Harvoni) before. In other words the key factor being RAV's that developed at the NS5A site that Ledipasvir did not handle well enough. With your last treatment being only Sovaldi (Sofosbuvir) your not included in that lower SVR percentage that you mentioned.

Like you I also added Ribavirin to my treatment with 24 weeks of Harvoni to give the extra benefit to help control the NS5A RAV's issue and increase the SVR percentage by an couple of percentage points. I would estimate that your SVR chances in the higher 90% range IMO. 

The key factor on any treatment protocol when a patient relapses is, was it caused from RAV's and what site (NS5A etc.) and address. The study show the patients that had 1 or more baseline RAV's had the lowest SVR rates, so it can be important to know if and what RAV's you may have developed after EOT for future treatment options.

BTW John did you happen to know what your baseline RAV's were?

Try this link to the Clinical study page http://www.clinicaloptions.com/Hepatitis/Conference%20Coverage/Vienna%202015/HCV%20Approved/Capsules/O005.aspx

You may have to sign up to read

matt



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"And in the end, the love you take is equal to the love you make"

61 year old Geno type A1, F4 Cirrhotic, started 24 weeks on Harvoni 12-17-14 ,EOT-5 week = UND, 8-31-15 =UND , SVR-24 Baby YES! 
JLynch30


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http://www.aidsmap.com/New-EASL-guidelines-prioritise-interferon-free-hepatitis-C-treatment/page/2965042/



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John   non-responder  

Undetected at week 2 on solvaldi/rib/interferon:  stayed through week 12 but virus came back as soon as I stopped.  on   Harvoni and ribravirin 24 weeks undetected after two. 8/2/15  12 week EOT  UNDETECTED!  SVR

1991-2015 RIP

 
Greg D


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Congrats on finishing treatment John! Sending positive energy your way!



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60 yo (2013), genotype 2b, started 28 week tx Sept.14, 2013. Triple Therapy (ribavirin, victrelis, peginterferon), VL 235k prior to tx, UND right through. EOT March 29, 2014. EOT24 Sept. 15, 2014 and EOT + ONE YEAR April 1, 2015 UND.... SVR!

 
Groupergetter


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John, do you have a link for this?  Guess we'll find out in a few weeks.  Almost all relapses come by the 4 week eot labs.  Good luck, hoping this works for all of us finishing tx.



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1b  Int/Riba relapse @ 48 weeks.  Stop tx Peg Int/Riba 12 weeks ill. Relapse S/O 6/23/14 :(   Started Harvoni 11/12/14  EOT 4/28/15.  EOT+4 UND :)  SVR! 8/4/15  :)     Thankful for every morning.
JLynch30


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Finishing up 24 weeks Harvoni and Ribravirin

 

Now i am hearing cirrhotics who failed solvaldi are only 70 % cure rates?  Did anyone else hear hear this?



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John   non-responder  

Undetected at week 2 on solvaldi/rib/interferon:  stayed through week 12 but virus came back as soon as I stopped.  on   Harvoni and ribravirin 24 weeks undetected after two. 8/2/15  12 week EOT  UNDETECTED!  SVR

1991-2015 RIP

 
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