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Hep C Discussion Forum -> On Treatment -> Genotype 3 (might) start sovaldi/peg/riba?
Post Info TOPIC: Genotype 3 (might) start sovaldi/peg/riba?
robertsamx


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RE: Genotype 3 (might) start sovaldi/peg/riba?
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Mopey, I"m just checking in with you.  Did you start treatment? Hows it going?  RC



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 M-68, 3 Treatments)( SOF-RIBA 2014)(SOF-RIBA-PEG 2016)(HCC 2016) (LIVER TRANSPLANT 8-2017)(VOSEVI-RIBA 2017)   SVR-12. 3-13-18   
Mopey


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Thanks for the replies, and thanks Robertsamx for the good info. I will indeed be starting the course on October 27th. 86% cure rate is pretty good. I hope it works out this time!!! I really, really hope treatment is easier this time around too. Will keep you all updated.



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42 year old male

Genotype 3; co-infected with Hep B.

Ended 24 week course of Interferon + Ribavirin on November 17, 2014. UND at end of treatment, relapsed 3 months post-TX.  

ISHAK Score: Fibrosis 5-6/6    Grade 6/18

 

 

 
robertsamx


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Info on how SOF-RIBA-PEG  works

PEG--First off hcv virus hides out in the liver because its able to almost become invisible to the immune system, and if the immune system cant see it , how can it kill it? Now add Interferon and it staines (marks) the invisible cells so the immune system can target and destroy the infected cells. Interferon also attaches to healty liver cells and defends against invading viruses.So Peg Interferon helps the immune system stop virus replacation,attaching to healthy cells to defend,and ridding body of infected cella and preventing healthy cells from becoming infected

SOF--This one"s easier to explaine! Sofosbuvir attaches to the RNA of the infected cell and screws up the cells ability to replacate, the cell dies, One HCV cell can produce 100,000 or more copies of itself. Its a no wonder our V/L is in the millions . The enemy is making solders faster than our immune system"s can kill them!!

RIBA-- This one is  misunderstood. There are a few theories. (1) error catastrophe-The virus may think Riba is one of it"s own building blocks,and cant copy itsself because of this error? (2)Riba may inhibit an enzyme "Inosine monophosphate dehydrogenase" that HCV virus needs to copy itself.          R.C.

 



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 M-68, 3 Treatments)( SOF-RIBA 2014)(SOF-RIBA-PEG 2016)(HCC 2016) (LIVER TRANSPLANT 8-2017)(VOSEVI-RIBA 2017)   SVR-12. 3-13-18   
robertsamx


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Hi Mopey, us 3"s can expect a 86% cure with the  SOF-PEG-RIBA X12 weeks. This includes F3/4.  They say that 12 weeks of this combo is a lot easier than the 24 weeks of peg- riba

I have never done peg, only sof-riba and the riba was bad enough!!    I may be looking at the same treatment your looking at. Will know soon if I am going to do it.  

The next best thing coming for 3"s is  sof-gs5816  (velpatasvir)     the gs5816 is not quite aproved in usa for treatment of 3's, but it is coming soon. Also keep an eye out for gs-9857   the triple of sof-5816-9857 will be very good .  RC



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 M-68, 3 Treatments)( SOF-RIBA 2014)(SOF-RIBA-PEG 2016)(HCC 2016) (LIVER TRANSPLANT 8-2017)(VOSEVI-RIBA 2017)   SVR-12. 3-13-18   
basser


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mallani and gill are both right if it means you are f3-f4 then sooner you start the better. spect if you opt for interferon/solvidi/riba it won't take much time at all to get on meds.wish you well.be great if you can post to let us know how things are going                                                                                                                                                                                                                                                   william



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 william.61 yo.lives in uk.geno 1b.started sol/dac/riba sept 2014 12wks.am now svr and now had liver transplant on 19/07/ 16
mallani


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Hi again Mopey,

Welcome back and good luck this time.

Where we live dictates treatment and I would agree that Sovaldi/Peg/Riba would be a good option. I'd question the 95% SVR rate, but it's worth a try. As Jill said, you don't want to wait.

Best of luck. Cheers.



__________________

Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm
Cinnamon Girl


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Hello again, Mopey, welcome back!

I remember you from last year and I`m glad to hear you`re ready to start treatment again.  The treatment combo you`ve been offered is currently the standard for Gen 3 in England, as it is considered to offer the highest success rates for this genotype.  It would mean that you could start straight away, and with an Ishak score of 5/6 (Metavir equivalent = F3/4) you don`t want to have to wait too long.

Yes, I agree that you`re likely to experience side effects, but a 12 week course with Sovldi included should be a lot easier on you than your last course of treatment.  We have another member from England who relapsed after the first attempt with Peginterferon + riba and who is about to start the same treatment combo.

You could push for an all oral combo, with Daclatasvir, but you could have a long wait.  It is available for some people over here in England, through a `Compassionate Use Programme` but usually that only applies to people with advanced liver damage who are considered to be intolerant to interferon.  That is how our member William (basser) was able to do his interferon free treatment. 

Sovaldi/Olysio wouldn`t be suitable for you as a Gen 3, it is only prescribed for people with Gen 1.

Best of luck with whatever you decide to do, do keep in touch!  smile

 

 

 

 



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Jill 

(71 yo, lives in UK)

Was Gen 3a, 

24wks Peg Ifn/Riba, Sep 2010 - Mch 2011

UND @ Wk.4, UND @ EOT, 

SVR Nov 2011 --> Still UND @ EOT + 4 yrs.

 

 
basser


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hi mate.seems here in the uk if your willing to go the interferon route you can get on tx straight away.most people i know without bad liver damage opt to wait for the non interferon tx.have never heard of ishak scale.new one to me.do know though with solvidi added to the peg riba the success rates are really good.think its a case if you can wait the interferon free tx is easier on the body.and side effects are less. way things are going interferon will be a thing of the past. the interferon free meds are now taking over.all the best to you mate                                                                                                                                                                                                                                                     william



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 william.61 yo.lives in uk.geno 1b.started sol/dac/riba sept 2014 12wks.am now svr and now had liver transplant on 19/07/ 16
Mopey


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Hello everyone,

I posted on this forum last year and earlier this year. As my siggie states, I am a 42 year old male currently in the UK who has genotype 3 Hep C, and is co-infected with Hep B. Last year I did a 24 week course of Peg/Riba, and ended up relapsing 3 months after treatment ended. Treatment was utterly miserable. I also have a 5/6 on the Ishak scale in terms of liver damage.

 

My doctor now wants to start me on a 12 week course of Sovaldi/Peg/Riba at the end of this month, as she says that this course will give me around a 95% chance of success. I asked about daclatasvir, and she said the success rate was not so great for my genotype since this was my second go-around, and insisted on Sovaldi/Peg/Riba. I have verified her information on daclatasvir, but from what I've read on this forum, it seems that that sovaldi/peg/riba is not considered an entirely safe or effective course to be on? For what it's worth, I don't seem to have any lingering side-effects from completing Peg/Riba last year, but I am certainly willing to believe that it can cause lasting damage. I didn't know to ask about Sovaldi/Olysio, but should I push for that treatment instead?

 

There are several factors that will affect my decision. One is time. With Sovaldi/Peg/Riba, I can start right away. With other courses, I may have to wait. I'm due to move back to the United States some time early next year, so if I don't get treatment now in the U.K, I will have to sign up for some form of insurance in the U.S. and cost or accessibility may become an issue. The doctors here have said that another wait of about a year for treatment shouldn't make a difference to my liver, if I do end up having to wait for treatment when I get to the U.S. I guess I just want to understand how I should weigh the pros/cons here.

Another factor may be my Hep. B co-infection. I asked my docs if I could get on any other clinic trials, and I heard her talking on the phone with somebody who told her that because of my Hep B co-infection, I couldn't get on the trial for their particular drug. Wish I knew which one it was!

I'm also concerned about side effects. Doc told me that my side effects would be diminished this time around because of the Sovaldi, but that doesn't sound very convincing. People on this forum still seemed to have had a lot of side effects with this treatment, even with the Sovaldi. Last time the Peg/Riba was hell, so I would love to avoid that again. But obviously, I am willing to undergo it for the sake of treatment success.

So any thoughts or recommendations would be welcome on this matter. Thanks in advance.



__________________

42 year old male

Genotype 3; co-infected with Hep B.

Ended 24 week course of Interferon + Ribavirin on November 17, 2014. UND at end of treatment, relapsed 3 months post-TX.  

ISHAK Score: Fibrosis 5-6/6    Grade 6/18

 

 

 
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