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Post Info TOPIC: Starting Treatment 10-15-15 ROUND TWO !!
Tig


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RE: Starting Treatment 10-15-15 ROUND TWO !!
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<15 IU/ml is nothing RC, congrats buddy! It wasn't too long ago that would've been considered undetectable. The sensitivity of the new viral loads goes down as low as 5 IU/ml at many labs. The tests are incredibly sensitive now. I will place bets that your next test will come back undetected, if it isn't already. You're on your way RC! You've got every reason to be happy about this result. Looking good smile



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Tig

67yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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   Got my  week 2  RNA  <15  IU/ml   Must still be a few critters left??  any thoughts on <15

RC

 

 



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Hi RC,

His VL was undetected on 10/12 lab results.  He's doing pretty well as far as side effects; some fatigue, brain fog and insomnia, but overall quite well. He has another 8 weeks of tx to go.  

We have our routine monthly appointment with the hepatologist today.  I'll post up if anything new pops us.   Thanks for asking, RC.

Penny    



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65;  Dx 1997 1a; VL 1.1m; TX naïve; SOT 7/20/15; 12 wks viek/riba 1200mg

09/14/15 draw: Undetected 8 wks into tx

10/12/15 draw: Undetected at EOT

01/05/16 draw: Undetected at E0T+12



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Thank you Penny.  Hows you husband doing on his treatment?  RC



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I'm so glad it continues to go well.  This time's the charm - keep up the good work!

Penny 



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65;  Dx 1997 1a; VL 1.1m; TX naïve; SOT 7/20/15; 12 wks viek/riba 1200mg

09/14/15 draw: Undetected 8 wks into tx

10/12/15 draw: Undetected at EOT

01/05/16 draw: Undetected at E0T+12



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Thanks Jill and Mike



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Well done, RC, that`s 4 shots you won`t have to do again! 

Looking forward to seeing your first undetected result!   smile



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Jill 

(71 yo, lives in UK)

Was Gen 3a, 

24wks Peg Ifn/Riba, Sep 2010 - Mch 2011

UND @ Wk.4, UND @ EOT, 

SVR Nov 2011 --> Still UND @ EOT + 4 yrs.

 

 



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That's good news Robert. Keep it up.



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60 yo, geno 1a, Dx 1994 HCV-HIV co-inf, Dx 2013 decompensated cirrhosis
Tx #1 - 24wks Sov+Riba /SOT 7-24-2014/UND@EOT/DETECTED@EOT+16 wks
Tx #2 - 24wks Harvoni /SOT 7-25-2015/UND@EOT,+12,+24,+52 = SVR

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Thanks Matt & Greg



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Hey Robert

Congrats on your first four weeks, your most likely UND by now, looking forward to your progress reports.

matt



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"And in the end, the love you take is equal to the love you make"

61 year old Geno type A1, F4 Cirrhotic, started 24 weeks on Harvoni 12-17-14 ,EOT-5 week = UND, 8-31-15 =UND , SVR-24 Baby YES! 



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Glad you're doing ok RC.  The meds are working and time goes by quickly.  SVR is in your future. :)



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1b  Int/Riba relapse @ 48 weeks.  Stop tx Peg Int/Riba 12 weeks ill. Relapse S/O 6/23/14 :(   Started Harvoni 11/12/14  EOT 4/28/15.  EOT+4 UND :)  SVR! 8/4/15  :)     Thankful for every morning.



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Just got shot #4 down the old hatch!   Still no word on week two blood work. I"m doing ok. RC



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Excellent looking numbers there, RC!   A brilliant result so soon after starting treatment, I bet you haven`t stopped smiling yet!!  biggrin

Onwards and upwards, you`re well on your way.----.>>> to SVR!!



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Jill 

(71 yo, lives in UK)

Was Gen 3a, 

24wks Peg Ifn/Riba, Sep 2010 - Mch 2011

UND @ Wk.4, UND @ EOT, 

SVR Nov 2011 --> Still UND @ EOT + 4 yrs.

 

 

Tig


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That's outstanding RC! My money says by now you're undetected and will stay that way forever. Sounds pretty good doesn't it, FOREVER? Yep, yep, yep.....  



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Tig

67yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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That's an awesome viral response (AVR) biggrin You, my friend, are on a roll. That's a good indication this "Round Two" will be the final round. Roll on Robert!



-- Edited by wmlj1960 on Saturday 31st of October 2015 03:51:18 AM

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60 yo, geno 1a, Dx 1994 HCV-HIV co-inf, Dx 2013 decompensated cirrhosis
Tx #1 - 24wks Sov+Riba /SOT 7-24-2014/UND@EOT/DETECTED@EOT+16 wks
Tx #2 - 24wks Harvoni /SOT 7-25-2015/UND@EOT,+12,+24,+52 = SVR

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Just got a call from study Nrs.   My V/L is  147      It went from  42700000  to  147  in 7.5 days of treatment!  Also got early results from yesterdays blood draw and my pl went up to 94  but the HG went down to 13.4     It took me 30 days on my first treatment to get my V/L down to 137   So this is looking really good to me!!  RC



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 I'm curious to see your lab results too RC. I predict improvement since I know you know what to do. Keep it up!



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60 yo, geno 1a, Dx 1994 HCV-HIV co-inf, Dx 2013 decompensated cirrhosis
Tx #1 - 24wks Sov+Riba /SOT 7-24-2014/UND@EOT/DETECTED@EOT+16 wks
Tx #2 - 24wks Harvoni /SOT 7-25-2015/UND@EOT,+12,+24,+52 = SVR

Mike

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Tig


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Hang in there RC! I'm almost as curious about the lab work as you are. You've completed 25% of the Peg, it won't take long and you'll be over the hump. One day at a time....



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Tig

67yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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Dart three today, doing ok.   Had week two blood draw today, should see results next week RC



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My base day blood results   were all down a little.  The v/l went down 1 mil   P/L 110

hg 14.9  alt 231  ast  96     br 0.4   

I"m a couple days into the second shot and doing fairly well.  Geting the riba shake and just a little rash on front of my arms      RC



-- Edited by robertsamx on Sunday 25th of October 2015 02:51:54 AM

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Sounds good Robert. Be sure to keep well hydrated. I'm looking forward to your results too. Keep up the good work! smile



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60 yo, geno 1a, Dx 1994 HCV-HIV co-inf, Dx 2013 decompensated cirrhosis
Tx #1 - 24wks Sov+Riba /SOT 7-24-2014/UND@EOT/DETECTED@EOT+16 wks
Tx #2 - 24wks Harvoni /SOT 7-25-2015/UND@EOT,+12,+24,+52 = SVR

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Dart #2 done!!    7 days into this     Im doing ok. Just starting to get the riba buzz, and dry skin.  Did the shot 4 hours ago, I dont have a mark at the first injection site, and so far nothing at site #2.    going to Dr tomorrow for week 1 blood work, will post that  when I get it.  Tomorrow I should get day one blood results and will post.  Im looking forward to week one results.   RC



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Thanks for posting those, Robert, it`s good to have a baseline to measure your progress against.

I`m sure you`ll soon be seeing those ALT and AST levels coming down, along with your viral load.  Your Hg is likely to drop a bit as well, as a result of the riba, but that will just show that it`s doing its job.

Onwards and upwards! 



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Jill 

(71 yo, lives in UK)

Was Gen 3a, 

24wks Peg Ifn/Riba, Sep 2010 - Mch 2011

UND @ Wk.4, UND @ EOT, 

SVR Nov 2011 --> Still UND @ EOT + 4 yrs.

 

 



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Thought I would post my starting LFT. Screening results 15 days before SOT

HG 15.9  PL 142  ALT 230  AST 146 BR 0.6 LIPASE 90 AMYLASE 85 LOG 6.72 VL 5290000



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You'll win the SVR game this time Robert, one bullseye at a time.



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60 yo, geno 1a, Dx 1994 HCV-HIV co-inf, Dx 2013 decompensated cirrhosis
Tx #1 - 24wks Sov+Riba /SOT 7-24-2014/UND@EOT/DETECTED@EOT+16 wks
Tx #2 - 24wks Harvoni /SOT 7-25-2015/UND@EOT,+12,+24,+52 = SVR

Mike

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Very good to hear your first shot went so well, Robert!  You`re on your way now!  smile



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Jill 

(71 yo, lives in UK)

Was Gen 3a, 

24wks Peg Ifn/Riba, Sep 2010 - Mch 2011

UND @ Wk.4, UND @ EOT, 

SVR Nov 2011 --> Still UND @ EOT + 4 yrs.

 

 



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Hi Robert,

Good luck this time. 12 weeks of Peg will be a breeze. Look forward to hearing your good news. Cheers.



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Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm

Tig


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Cool.... Stay in touch and we'll be singing "Another One Bites the Dust" before you know it!



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Tig

67yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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first shot went pretty uneventful. No reaction at the shot site,a couple days of riba at 1200mg and three sofs down the hatch!!   Just a tight feeling in my head, headache?

Its early in treatment, but so far so good!   RC



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Tig


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Hey RC,

How are you feeling buddy? The next day was always a tell tale sign of the week to come for me. I'm wishing you 12 weeks of greater days and easier tomorrows! SVR is your next destination on this train. I'll meet you in the Club Car for a game of Darts!!! Good luck...



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Tig

67yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

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Hi Robert, how did your first shot go?  Hope you had a good night and the side effects were manageable!  smile



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Jill 

(71 yo, lives in UK)

Was Gen 3a, 

24wks Peg Ifn/Riba, Sep 2010 - Mch 2011

UND @ Wk.4, UND @ EOT, 

SVR Nov 2011 --> Still UND @ EOT + 4 yrs.

 

 



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Had my first dart (shot) today! 3 riba and 1 sof. all about 2:30 pm, feel fine so far.  RC



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Thanks everybody!!  I"m heading over to Hospital in a couple hours for my first doseing. Then a 4 hour drive home, I will post tonite on how the first 8 hours go .RC



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HI Robert, I`m very pleased you`ve got your treatment in place at last!!

This is definitely the best combination for you at the present time, and at least you only have to do a short duration of 12 weeks..  Just do your best to keep a positive outlook, look after yourself well, drink plenty of water and generally treat yourself kindly.  This is your time, and we`re looking forward to seeing another dragon slain!!

Wishing you all the best of luck, you know we`ll be here cheering you on!!  smile

And a new Gen 3 darts club sounds like an excellent idea!!

 



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Jill 

(71 yo, lives in UK)

Was Gen 3a, 

24wks Peg Ifn/Riba, Sep 2010 - Mch 2011

UND @ Wk.4, UND @ EOT, 

SVR Nov 2011 --> Still UND @ EOT + 4 yrs.

 

 



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Hey Robert

Congrats on starting your treatment, hopfully this time will do it for you. Your over due for a break. Stay positive & compliant as you can knowing its only 12 weeks and all should go well.

Pulling for your SVR

matt 



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"And in the end, the love you take is equal to the love you make"

61 year old Geno type A1, F4 Cirrhotic, started 24 weeks on Harvoni 12-17-14 ,EOT-5 week = UND, 8-31-15 =UND , SVR-24 Baby YES! 



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We're hear for you, my Best to you   ~ One day at a time



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65 YO F, GT 1a1b, ast 14 alt 21, fibrosis 3/4 DX 1968 non a or b, TX 12 wks Harvoni, SOT 6.1.15, 1st bld wk: detected unquantifiable EOT 8.28.15 detected unquantifiable, 3 mo.EOT mid Nov.~SVR 12: ) UNDETECTED



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Robert,

I wish you an uneventful and sure trip to SVR this time around.

Penny



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65;  Dx 1997 1a; VL 1.1m; TX naïve; SOT 7/20/15; 12 wks viek/riba 1200mg

09/14/15 draw: Undetected 8 wks into tx

10/12/15 draw: Undetected at EOT

01/05/16 draw: Undetected at E0T+12



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Good luck Robert, hoping this does it for you.  The 12 weeks will pass quickly.  Keepa go, and stay hydrated.



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1b  Int/Riba relapse @ 48 weeks.  Stop tx Peg Int/Riba 12 weeks ill. Relapse S/O 6/23/14 :(   Started Harvoni 11/12/14  EOT 4/28/15.  EOT+4 UND :)  SVR! 8/4/15  :)     Thankful for every morning.



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 This may be best because of known SVR %'s and waiting on Sof/gs5816/9857 etc. could cost time you might best not spend. After 16 months I know your itching to get the show back on the road anyway. At least 12 weeks Sof/Riba/Peg will be easier on you than 24 weeks Peg/Riba. I'm happy for you Robert and I wish you well on your final fight with the dragon. SVR here we come!



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60 yo, geno 1a, Dx 1994 HCV-HIV co-inf, Dx 2013 decompensated cirrhosis
Tx #1 - 24wks Sov+Riba /SOT 7-24-2014/UND@EOT/DETECTED@EOT+16 wks
Tx #2 - 24wks Harvoni /SOT 7-25-2015/UND@EOT,+12,+24,+52 = SVR

Mike

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After a 16 month wait for a re-treatment, I start tomorrow at 1:oo PM.  I will be doing 12 Weeks Sof-Riba-Peg.  I was hopeing (waiting) for a triple W/O Peg, But Doctors say this has the best SVR for 3a treatment experienced W/cirrhosis, so I"m going for it.  Looks like  a few of us type 3"s need to start a new DART club??  That Riba really screwed me up, still dont feel normal, now I get to do it again and add peg!   RC

 



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