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Post Info TOPIC: Zepatier Warriors


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RE: Zepatier Warriors
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TIG, as long as we are all breathing, there is hope, and hope like you all gave me keeps it alive.

I think my Doctor wanted me to run blood work at the 6 month mark of clearing the virus, so I will chime back in again around January or Febuary.

I feel great, so no worries on my end.

 

John 



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Fox-1

Male- 60yrs- GT-1-A, Pre-ALT-55-AST-33- VL-5mil+; 4wks=Undetected, ALT-27, AST-23

Tig


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Hi John!

Merry Christmas, Happy Hanukkah and Happy New Year to you and yours! 2017 was quite a ride, let’s hope 2018 is a blessing for all smile



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Tig

62 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 1-4 years!

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I just wanted to wish everyone a Happy Hanukkah and a Merry Christmas, oh and the best one coming , a Happy New Year on the horizon! God bless you all my new found friends.

 

John



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Fox-1

Male- 60yrs- GT-1-A, Pre-ALT-55-AST-33- VL-5mil+; 4wks=Undetected, ALT-27, AST-23



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Ah! Splains a lot! Well, that is unfortunate I did not know about you special worry, if I had known I would have commiserated right along with you during your  treatment. You have certainly had your fair share of unwanted and unfair things happen to you as child and young adult!! I am especially very glad then that HCV is no longer one of those things.

Perhaps your kidneys and other various bits of you will very much appeciate no longer being forced to deal with the things HCV can do to us.

So, now that I have a much better picture of your hx, how is your blood pressure BTW and what do they say about your blood sugars (over time, how have they been)? Are you on any other ongoing treatment meds for anything?

I too fretted over my kidneys during treatment (I was on a sof-containing regime), I was not ever seriously worried, no real good reason to be but fretted anyway, just out of habit. You on the other hand had justifiable reason to fret. I was never really followed for my kidney "function" much, of all my life, after a childhood of being very sickly with many things, but mostly chronic unresolved, untreated UTI's and stubborn kidney infections right into early adulthood.

Eventually I found out that I ended up with one of my kidneys scarred, a little wizened up from the wear and tear, calcifications and scar tissue, smaller, detached from it moorings it flops down to pout, slosh and lay somewhere about my lower pelvis, over time and later as an aging adult it was obvious i was still functioning quite OK (renal-wise), even though I had really not been followed much. When my longstanding HCV was finally discovered in 2015, and through HCV work-ups, this was really the first time repeated creatinines and clearances (and many other bloods and U/S's were done on me), it was good my creatinine clearance was never below 58.6 as I got to HCV treatment, they stayed around the 60 mark, good, and now post-tretament are still higher, 78ish I think, and still normal. So, all was and is well. But ... I fretted for my kidney twins anyway.

Buddy's we cradle in our body, like our liver friend, we want the best for them!

Thanks for filling me in - I will be so excited for you if your kidney function starts to improve some now, now that you are free from the sometimes very weird insults HCV can throw at us.biggrin C.

PS - yes, one of the labs I have gone to uses the 1.2 mg/dL mark as being the highest end of normal, another uses a completely dif unit of measure and their own ref range.

PPS - oops, forget to explain my "creatinine clearance" of 58.6 properly! Folks won't understand how you could be at a number like 1.7 when we are talking "creatinines", and I had a number like 58.6 talking about creatinine "clearance"! The particular lab (used at the begining of my HCV drug trial) used a method and were doing what is called "CC&G" creatinine and clearance test - where the result is measured in mL/min, (more akin to algorythims used in GFR system and other tests like that) - my weight and sex (and age I assume) were used aside from serum creatinine levels, with the upper end of normal for a creatinine set at 1.14 mg/dL. For a "CC&G creatinine and clearance result" the normal ref. range is between 75 - 115 mL/min. So, my trial CC&G result would look have looked like this on paper ... C&G Crt&clr 58.6 mL/min (ref.75-115.0 mL/min.).

My hep doc actually does not like the CC&G method, or, so I think i heard him say to me once.  



-- Edited by Canuck on Sunday 17th of December 2017 10:43:17 PM

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HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 63 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



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Iâve had Ckd for over 20 years probably due to having chemo and other crazy cancer drugs as a child . Gfr has remained pretty close all these years. It bounces from 55-50 . My drs range says creatine of 1.3 is the upper level for males. I am at stage 3 ckd according to usa values. Gfr was 50 when creatnine was 1.7 and that was back in Sept. It has never jumped that high so i was kinda worried but i guess thats not a big jump . So i guess 1.4 now isnt too bad but i have always had proteinurea

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Genotype1b . 2 million VL on june 5th now undetected july 6 th.


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Ah! I didn't recall from your history that you had any pre-existing kidney disease problem. Maybe we never really discussed that. I do recall that increase in your blood sugar worried you a bit while on treatment, so, that's nice for you to see it back to being within normal limits now. But as far as "kidney disease", how long before treatment did you and your doc know you had kidney disease?? What were some of your previous creatinines/GFR's (before treatment)? Until now, when you were listing your "on treatment", and your "post- treatment" creatinines, for comparative purposes, I didn't think you mentioned any other creatinines OR GFR's.

Do you have a current GFR to go with that last creatinine? Would be interesting to me to know more.

So, perhaps your kidney function was one (of many) reason(s) why your doc might have thought Zep a good treatment choice for you, as Zep is more renal sparing. But that might not be the only reason you ended up with Zep. Until your creatinines are really quite high and your GFR's are really quite low do they start to deliberate over which regime to give you.  

Your lab obviously uses serum creatinine measures (like some Canadian labs do) in "mg/dL's" ... your "on-treatment" creatinine being 1.7 mg/dL and your post-treatment one being 1.4 mg/dL, but of course I don't not know what your lab considers a "normal range of reference". 

Canadian and US labs can vary from one another (even labs within the same country) in what they consider "normal" ranges and what "units" of measure they go by.

In "mg/dL", I have found labs who consider "normal" serum creatinine ranges going from as low as 0.6 up to 1.4 mg/dL (male). So, some labs would not have considered your 1.7 too abnormal.

When pts. have been diagnosed and are firmly known to have had long-standing (chronic) kidney disease (CKD), and docs are choosing HCV treatments for them, they will have generally assessed your kidney function well, especially if your kidney disease has been long-standing and well-watched prior with labs, you would have been "staged" (1-5) in your CKD (at least based by GFR's), and, you can see in the recs (the link Tig sent you), regime choices are not even very restricted until your GFR is downtrending to 30 or less.

I don't know how long or what stage your kidney disease may have been, but it is very correct what Tig tells you, that can be associations with HCV and kidneys. Perhaps, now, not having HCV you will see even more improvements.

I am so glad you did not feel too many negatives for very long after EOT. Funny that the diarrhea lasted for a while (not!), but, you know what i mean. What a relief it is to lose those things eh? - like the fog, and being able to sleep better, those things must feel huge! I'm SO glad you generally feel much better. YAY!

Good you will get an U/S with your 24week check. biggrin C. 

 

 



-- Edited by Canuck on Sunday 17th of December 2017 02:49:26 AM

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HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 63 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)

Tig


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Hard to say if the Zepatier was the cause for the creatinine fluctuations. HCV by itself is responsible for causing renal problems. All of these DAA’s are powerful drugs, in spite of their relatively low side effect profile. Trust me, the old drugs were good at reminding you how powerful they were. Lots of remaining issues as a result too. Zepatier clears your system quickly, so your next test should be improved if the Zepatier was influencing it. I’m including an article I found. Zep is commonly used in patients with renal impairment. Just informational...

Article: Pts. w/Renal Impairment



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Tig

62 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 1-4 years!

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Yes i will be getting 24 week test plus ultrasound. Im feeling alot better know that treatment is over with . Sleeping is better diahrea took a few weeks after treatment to go away . I have kidney disease so they are not sure if zep had anything to do with the rise and fall of creatnine. Probably from not drinking enough water while on treatment. The brain fog has went away so now its time to let my liver rest and revitalize.

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Genotype1b . 2 million VL on june 5th now undetected july 6 th.


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Hey Jmiff!

Great EOT+12 report. Continued happy SVR. Big congrats! You did so well on Zep, UND from week 4!. Thanks for keeping us all updated.

You had "some" things you noticed (while on treatment) some insomnia, weird taste in mouth, things like that, and you were wondering at one point how long it takes for the treatment drugs to dissipate from your body ... so, did those things you noticed (back then), how you were feeling, disappear and improve quickly after EOT, to now?

How are you feeling now? Perfect I hope.

It's lovely to be freed from that virus eh. 

Good that you, and they, will be following you and your labs, and your good results. Your next exam and bloods draws should be for EOT+24 weeks?, or, when  did they tell you to return. What kinds of things will they be asking you to have done in future (now that you are all cured up). Aside from EOT+24 week labs, will they be doing a abd. U/S or a fibroscan?

I am betting your next set of bloods as well will just keep showing those lovely improvements, sugars/creatinines etc. It s always such as reward and so reassurring to see those thing improve and normalize! Magic!

Please do keep us posted on how you are doing and feeling. C.



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HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 63 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



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Great news!

we live in a time of miracles 



-- Edited by Observer on Saturday 16th of December 2017 04:24:25 AM

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61 y/o, Infected via transfusion Oct'83, GT-1a, F-4 cirrhotic,
tx Holkira pak/moderiba 12 weeks

3 years...post tx... successful dragon slayer 

Tig


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WOOT! That’s fantastic, congratulations! It’s obvious from your lab results that you are recovering exactly as one could hope for. Nice!

SVR 12 - How sweet it is...  Another Dragon bites the dust!

B343DF65-7242-4961-8074-443FAEB14DB2.jpeg



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Tig

62 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 1-4 years!

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Been a while since ive been on here but i have got some good news . 12 weeks post Zepatier still undetected . Creatnine was 1.7 during treatment now itâs 1.4 . Glucose was in the 120-140 range pre now itâs 98. Platlets pre were 120-130 now are 190. ALT and AST are low 20s . Good luck to all you fighting this silent killer.

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Genotype1b . 2 million VL on june 5th now undetected july 6 th.


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MY friends, it was so good to hear your words. As the saying goes, you never miss what you have until its gone, well, all of you were never gone, just sitting by the sidelines rooting for me and others to arrive safely at our destination.

I'm glad all is well with everyone who helped carry me when I needed some help and encouragement.

In regards to my question about "B", I was the one who came in contact, never showed any signs while one of mine got deathly sick from it, go figure, we shared the same syringe, he got it and my anti-bodies fought it off. I showed signs of having had it,  but never  any ill health from it. Guess my system was strong enough to fight it off, go figure, I was at my sickest point in life, a strung out hopeless junkie of 19 years of age. Thank God for God, I just celebrated in September 23 years of sobriety.

I will pass this information on as I have been doing for years now, helping others with hope, both for recovery, and now for recovery of Hep-C, yes we do recover.

Wishing all of you, wonderful Holidays as we embark on the season. I'm quite sure I will check in again, as I missed everyone here.

John

 



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Fox-1

Male- 60yrs- GT-1-A, Pre-ALT-55-AST-33- VL-5mil+; 4wks=Undetected, ALT-27, AST-23



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Hey John,

So good to hear from you, and really glad to hear that you are "feeling back to me". Were we surprised to hear you have been training in the gym? .... no! biggrin Good for you! (Ya, me too Tig, my chin-up would look much much like a melty blob of playdough too I am afraid). I find it easy to hurt myself in the weight room, what with all those 5 lbs weights! Lassitude yoga is a little safer for me. Be careful John, try not to do TOO much, don't strain anything else.

Sorry about your friend. It is hard from the limited info he presented to you to really know what caused his liver Ca (HBV/HCV/or having both), we cannot know whether he had active or "chronic" B, perhaps he just had a "naturally resolved" case HBV?, and if he did have active or chronic B, it might be hard to know over what period, for how long, and whether it was in tandem with the chronic C or not, but it IS well within the realm of possibility that "all of the above" (having single or multiple kinds of hepatitis's) can take tolls on livers with damage progressing on to liver Ca despite being "cured" of either of these viruses. There is quite a high incidence of Ca with HBV. But there are also co-relations between liver Ca and HCV, or, just by owning a damaged liver due to toxins, drugs, alcohol, fatty liver diseases and other causes. Of course, it would not be a good scenario to have had both C and B at the same time, or both within your lifetime, a double insult, stands to reason there could possibly be more increased risk of developing Ca subsequently. People can have many forms of hepatitis, A,B,C,D,E,F and G!, with some of these occuring at the same time. There is an interesting theory that if you pick up C and B at the same time, one may win out for dominance over the other, ie. resolve the C and carry on with chronic B, or resolve the B and carry on with chronic C! 

HBV is a funny complicated disease, but basically you can only be in about 5 states of HBV: either active, chronic, resolved, never been exposed to it, show that you are immune to HBV (either) by successfully being immunized against B, or, by gaining your own immunity (the hard way), by successfully recovering from an acute case of hep B, where you resolved the infection on your own without going on to being chronically infected. For those proven to be chronic Hep B carriers, who then receive successful treatment for it, they too are considered cured of their Hep B.

Generally, if you show positive surface antigens - you likely have an active/and or chronic case of B.

If you show positive surface antibodies/and postive core antibodies - you are likely immune to B (from either havng the HBV infection one time and naturally spontaneously resolving it yourself) or, you could be immune by way of being immunized.

There ARE other variations found in antigen/and antibody states tho which are harder to interpret, like ... if all you show is core antibodies, it might mean you ARE a resolved HBV, not chronic, but ... perhaps not!

It's one of my favourite topics of interest (and a bone of contention with me), that they stop short of doing further expensive testing on people (like me) who are assumed "spontaneously resolved" but only show core antibodies. (Bore yourself silly reading this thread 'til your eyes cross ... About contracting HBV and HCV at the same time , and there other threads on the site about all the other kinds of hepatitis's too.)

I am sure you (like me, even tho we had a case of HBV in the past), both showed up as having NO surface antigen during our pre-treatment assessments - they check that, which is good, and with a negative surface antigen, that is the end of the pre-assessment testing story for most people awaiting HCV treatment - (unless of course he finds you do not possess enough immunity against HBV, in which case he would have immunized you, or re-immunized you as the case may be, against HBV) - but generally with a negative surface antigen it means you are not active and he can go ahead and safely treat you for your HCV.

It has been extremely rare the cases of HBV reactivation while being treated for HCV, simply because they do make sure you do not have any B surface antigens first. If you had shown surface antigens they would have automatically tested you further, and had you been discovered as having a need for HBV treatament first, they would have done so, and started HBV treatment before or with your HCV treatment.

Not to worry (except about your poor friend), but good you are aware of these things, you can suggest to others you may run into awaiting HCV tretament to be sure they have their HBV status's checked before they enter into HCV treatment. Do keep going (as much as they will allow you and spend money on you) to have your health and liver checks done as frequently as you can get, just good practise to keep following your health and liver health as closely as you can muster. 

It is pretty standard (as a minimum) to have your VL, LFT's (and perhaps some other bloods) repeated at EOT +12 weeks, and then again at EOT + 24 weeks, I would also want them done a year later. You may get repeat ultrasounds and fibroscans (perhaps other imaging) being offered or done to you at the 6 month mark and/or perhaps annually - just depends on how much your doc wants to do (or offers) in the "following" of you. Following is good, I would seek and welcome it.

Glad you checked in, to hear from you again, and that you are doing well. Are the guts behaving better? C.

 

 



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 63 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)

Tig


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Hi John,

It is good to hear from you! Sounds like life is treating you pretty well, too. That pinched nerve is a way time reminds us we are 60+ years young! I’ve got some spine issues, so I can feel your discomfort. Sorry to hear that, but honestly, I can’t remember what decade it was since I did my last pull up! I see a vision of two arms hanging from the bar and the rest of me in a blob on the floor. Not pretty! Good for you though!

If I‘m understanding things right, you are simply HBV antibody +. Right? In that case you don’t have to do anything but follow your doctors testing recommendations. If you were exposed and eliminated the virus spontaneously, you’re not now actively infected. They monitor you for the low chance of B reactivation because you were treated for HCV. If you had been actively infected with B prior to starting tx, you’d know it and your doctor would’ve informed you. 

I’m sorry to hear about your friend. It’s hard to comment on what was specifically responsible for his trouble. If he was carrying active HBV around untreated for decades and had active HCV lurking around for a period of time too, the possibility of ESLD was imminent. Very often we have to accept the fact that while we stopped the virus with treatment, the damage caused by these viruses take years to improve, if they do at all. Fortunately for the majority, we do see positive results!

Take care! smile



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Tig

62 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 1-4 years!

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John - so good to hear from you and that you are doing well other then your self inflicted gym injury. (Takes one to know one)

I will let Tig, RC or C answer your question about the Hep B as I do not for sure. 

Having a cup of coffee as I worked half a day today and then goin to bootcamp!

hugz,

wendy



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Wendy 53 y/o, DX 1994, geno 1A F1

1999 TX 1 - Inter -non responder 2001 TX 2 - Peg + Riba - viral load tripled and taken off

T3:  Harvoni 12 weeks Sept. 19, 2015 ALT 41 AST 30 VL 541800 UND at EOT and SVR 24 ALT 18 AST 26 platelets 223

 



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I just wanted to check back in and say- Still alive and well!!! Hope everyone had a great Thanksgiving filled with gratitude and blessings.

I think my Doctor wanted me to come back in 6 months after treatment stopped clearly the virus, so I think that is somewhere around the corner, January or February.

Health feels good, I'm back to me..... minus pinching a nerve in the gym doing pull-ups, hard to imagine that I am really 60 year s of age soon to be 61.....shhh don't tell anyone.

I had thanksgiving dinner yesterday and we all wrote done things we are grateful for and then we went around the room and shared them with Family and friends.

My Brother in law, said he was grateful God cleared him of the Hep-C virus, and I sat there listening, feeling the gratitude as well for clearing the virus too. Thank God.

Hey, I wanted to throw this out to you GURU's... So I have had Hep-B, never coming down with symptoms nor reactivating the B with the treatment of Zepatier....one of my friends cleared Hep-C long ago and is now dying of liver cancer..... he attributes it to the Hep-B, never treating the Hep-B, even after it was dormant in his body after clearing Hep-C.

My question is, do we need to treat the Hep-B now......I mean mine never reactivated so why would i need to treat the "B" now? In the same breath though, my friend who I think the Cancer has now affected his brain......maybe he is on to something.... he claims having had the Hep-B, and it laying dormant, without ever treated it..... it somehow without showing any symptoms brought on his Liver Cancer..... could this be????

Well, I hope everyone is doing well. Christine, TIG, Canuck, Wendy, love all of you unconditionally !!!

 

John



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Fox-1

Male- 60yrs- GT-1-A, Pre-ALT-55-AST-33- VL-5mil+; 4wks=Undetected, ALT-27, AST-23



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Jmiff and Coco,

Regarding zep excretion,  http://www.accp1.org/ACCP1/5Publications___News/FDA_Approves_ZEPATIER.aspx - this link is very similar to the info that is already in the Zep drug leaflet.

There will be many sources of info to read (about absorption/excretion/half-lives etc.), of any drugs we happpen to be on, but they still may not provide an answer as to how soon a person may feel "better" after treatment (any treatment). But know that the drugs in Zep ARE a totally dif animal than riba.

What I never read about is a totally unsubstantiated pet theory that I personally harbour ... that doing NS 3/4A's (like grazo) in zep, or the NS3/4A (like vox) in vosevi, may feel (during and after treatment), different for us than those people who are doing doubles comprized of only NS5A's and NS5B's.

Your "Zep double" is comprised of a  NS3/4A (grazo) and a NS5A (elba). My "Vosevi triple" also contained a NS3/4A (vox) as well as a NS5A (vel), and it also contained a NS5B (sof).

My personal (off the wall) theory is that regimes that contain NS3/4A's, although very effective, may feel harsher? It's just a theory - i have found nothing to substantiate it.

Just remember everyone feels differently - how sick (or not) we may have felt before treatment, how we felt on treatment, and so too can each of us feel differently from one another after treatment.

I know from experience that I needed to keep drinking water, treating myself well, and eating well for a lond period after treament.

It is hard to compare ourselves to another person's experience, in how good or bad one should be feeling, on a given timeline - almost impossible to guage, as there are so many personal variables at play. 

Measurable drugs may not be in your body within hours/days/weeks of finishing a course of treatment, it does not necessarily mean you will feel "better" at some certain moment. We all have dif conditions.

Generally tho, we tend to read here that people do, fairly quickly, start feeling some relief and improvements not too long after finishing their treatments, and we have also read here that some people did not feel badly before treatment! nor while on treatment! - we are all dif. Riba does seem to take longer to feel better from tho. That is why ongoing/continued feedback from folks cured is invaluable here. C.



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 63 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



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A presentation from the University of Florida entitled "Basic Biopharmaceutics" clarifies that, "It takes [a medication] one half-life to reach 50%, 2 half-lives to reach 75%, 3 half-lives to reach 87.5%, 3.3 half-lives to reach 90%, 4 half-lives to reach 93.75% of steady state.     The 1/2 life of Zepatier is 24 hours.    Hope this helps.  RC



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 M-61(3 Treatments)( SOF-RIBA 2014)(SOF-RIBA-PEG 2016)(HCC 2016) (LIVER TRANSPLANT 8-2017)(VOSEVI-RIBA 2017)   SVR-12. 3-13-18 https://aasldpubs.onlinelibrary.wiley.com/doi/pdf/10.1002/hep4.1280   



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Hi Jmiff I'm two-thirds of the way through a course of Zepatier, with four weeks to go. Saw my nurse practitioner yesterday and she said it can take up to three months from the end of treatment for the side effects to dissipate...

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52 yo.Genotype 1a Dx 17/05/17 Infected 25-30 years Viral load at diagnosis 440,000 Fibroscan 6.2 kPa, ALT 29

27/7/17 commenced 12 weeks treatment with Zepatier 10/8/17 VL 110 after 2 weeks of treatment.

24/8/17 VL UND after 4 weeks of treatment.

17/10/17 EOT - UND!!

25/01/18 SVR12 - I am free!!!



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I 've seen post in regards to riba and how long it takes to get out of your system . Does anybody know how long Zepatier takes to be completely out of ones system?

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Hey Ducky,

Don't go all stealth on us, we'll be in withdrawl around here without your updates and company!

I too am hoping the cryo/rhuemy things will lessen as you go along - maybe?, we can hope, by the time you get that follow-up rheumy appointment, perhaps corners will have already started to turn? That appoint. was supposed to in Sept for the rheumy guy? So, if your EOT was around the end of Jul, maybe by Sept the cryo's might not have been resolving themselves (yet), but maybe your body will and has been trying - we'll see. Be hopeful for that, all my readings have indicated that you do have a very good chance on these things lessening - sometimes completely, and sometimes quickly, but sooner or later all or any improvements we will welcome.

I was glad to hear you were getting a few more winks of sleep since EOT albeit with required help. Without the zep and HCV in the picture, and some time, for more health resolutions/improvements, perhaps you will get back to sleeping better, i hope so.

Let us know how you're feeling about now, we gotta know, ya know!

So your last EOT ALT/AST was about the same as your stellar 4 week one of 15/25?  Wunderbar! So, will your EOT+12 week bloods be coming up around what - the later part of Oct?

Treat yourself with every loving lavish care, like a roman goddess within your temple. : )  C.



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HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 63 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

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Hey John,

You've come a far piece in short time my man!! EOT not that long ago, and all the right signs you are on the mend! A sure sign ... is that itchin to get back into gym again! 

Man, I wish you were my gym coach! (You and Wendy!) I will model after you two.

Just imagine where you will soon be, by EOT+12 weeks (around end of OCT?) you will be stronger, and with a healthy liver to back it all up, and I can't imagine your ALT/AST can get too much better than the lovely 17/13 it is now!! But it will be lovely to hear your next UND then!

Give us blow by blows on your recouping, and your work-outs and all. Like Tig says slow and easy, but you already know all abut "training", what you should let your body do, how much and when. The 0 to 60 rule does not always apply.

Betcha the blood sugar thing is just a mere transient thing. Let us know how the guts feel and perform in the next few month post-treatment. Hope you continue a sure and steady progress in improvements over the next weeks and months. 

Keep treatin the temple good, take some time. : )  C.



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HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 63 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



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You know Robert, the Water was the key along with Coconut water and Gatorade. Lots of it, in fact all that has slowed downed since i cleared the virus I need to pick it back up and drink more water. But drinking the water, ton's of it , saved me from a lot of side effects, TIG and everyone else here were right about the water.

DRINK PLENTY OF WATER PEOPLE! PLENTY!!!



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Male- 60yrs- GT-1-A, Pre-ALT-55-AST-33- VL-5mil+; 4wks=Undetected, ALT-27, AST-23



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Hi all- John your doing so well. Bouncing back really quickly. It seems the new DAA's wash out very quickly.  Just a couple years ago everyone had that nasty Riba added to there R/X and that just kicks your butt. I did the riba two times and both times it took at least 6 months to washout the riba.  Add a little Peg to the potion and you got your self a really bad case of the flu (drug induced) for months.  It sounds like you kept moving and drinking your water and its paying off right now. Keep up the good work!!   RC



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All in all, it was a walk in the park for me. I've known people my brother in law who actually worked while on the old treatment, interferon, so my suggestion is take the meds they worked and worked well. Your energy level all depends on you. Overall, it did not effect me negatively.

Good luck, you'll be fine.

 

John



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Hi guys, I was able to workout while on Harvoni. I hit the gym 4 days a week while on treatment as well as still worked 40 hours a week. Everyone is different so you have to listen to your body. While on Interferon and riba I missed 2 half days of work and did not belong to a gym back then. Steve you will be fine as long as you hydrate properly.



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Wendy 53 y/o, DX 1994, geno 1A F1

1999 TX 1 - Inter -non responder 2001 TX 2 - Peg + Riba - viral load tripled and taken off

T3:  Harvoni 12 weeks Sept. 19, 2015 ALT 41 AST 30 VL 541800 UND at EOT and SVR 24 ALT 18 AST 26 platelets 223

 



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JohnAnton1 wrote:

Its been almost a month now since the end of my 90 day cycle with Zepatier, it certainly did its job. Knocked the virus out in 30 days.... 90 day lab work great, although high Glucose showing..... the fatigue that I did feel, legs unstable, weak, and low energy has ceased. My legs are getting stronger, body beginning to bounce back, and the best yet is, I joined another gym now!

I love to work out, so I slowly grabbed the weights, ran a routine doing chest , triceps, one day, back and bi's the next day and cycled, body is in shock, but a good shock..... all i know is, taking the Zepatier, I was doubtful that I could work out while taking the drug.

Slowly but surely I am bouncing back, reminds me a song that Robert Cray sang, " I'm finally bouncing back"! I blasted that song repeatedly after my divorce...... 6 years later I have bounced back from that too! This too Shall pass!

Once again, I'd like to thank all who gave me hope and inspiration.

John  


 That's good to hear.

I'm probably going to be starting Zepatier soon. I was going to ask how much if would effect work and exercise. Will it make you too weak to have a job where you're on your feet for 30 hours a week? I'm job hunting right now and I've been unemployed for a couple years. I thought having a job might take my mind off side effects if anything.



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60 year old male. Geno type Ib. Awaiting approval for treatment. Start Zepatier 10/13/2017- approved for 12 weeks. Fibrosis stage F3. Fibrosis score 0.65. AST- 34, ALT- 48. Hemotocrit- 51.0.

v/l - 2.34 million. Co2- 19.

Tig


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Glad to hear you're doing so well, John! Don't go pulling a muscle or popping a disk! Steady going my friend...  You'd be a great commercial ad for Zep smilesmile  Enjoy the victory!

 



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62 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 1-4 years!

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Its been almost a month now since the end of my 90 day cycle with Zepatier, it certainly did its job. Knocked the virus out in 30 days.... 90 day lab work great, although high Glucose showing..... the fatigue that I did feel, legs unstable, weak, and low energy has ceased. My legs are getting stronger, body beginning to bounce back, and the best yet is, I joined another gym now!

I love to work out, so I slowly grabbed the weights, ran a routine doing chest , triceps, one day, back and bi's the next day and cycled, body is in shock, but a good shock..... all i know is, taking the Zepatier, I was doubtful that I could work out while taking the drug.

Slowly but surely I am bouncing back, reminds me a song that Robert Cray sang, " I'm finally bouncing back"! I blasted that song repeatedly after my divorce...... 6 years later I have bounced back from that too! This too Shall pass!

Once again, I'd like to thank all who gave me hope and inspiration.

John  



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Male- 60yrs- GT-1-A, Pre-ALT-55-AST-33- VL-5mil+; 4wks=Undetected, ALT-27, AST-23



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Ah Jmiff, A lovely EOT UND and normal labs for you. Congrats. Especially sweet is that celebratory cake with the cherry on top (now that you have no funny blood sugars). Our zeppers are doing it mighty fine. I am hoping your sleeping gets a bit better. You can now rest easier with this most recent UND and lovely labs! C.

Image result for kids eating large cakes with cherry on top

 



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HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 63 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

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Another one bites the dust. That Merck combo is potent!!    Start the party.  RC



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YAHOO!! That's fantastic! Yes, HCV can affect your blood sugar. The Pancreas is involved in the Dragon's attack. I hope you have slayed two beasts with one arrow. How cool that would be for you. I think you've got a lot to be excited about and rightly so, you slayed the Dragon! I'm doing a happy dance for you, woohoo!!! Congrats!

Dead Dragon.png



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Tig

62 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 1-4 years!

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12 week blood work is still undetected as it has been since week 4 . All liver panel test are within normal ranges . My glucose prior to treatment was in the 130-140 range now that has also been normal since starting zepatier . Not sure if hep c causes elavated sugar levels but it did have me worried there for a while . Now i wait for my next test in 3 months!!

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Yes! The weird taste thing - I've been getting that too (I'm on week 6 of a 12 week Zepatier treatment) It's sort of metallic, comes and goes.Glad you mentioned this Jmiff, I thought it was just me! That and the weak and achy legs - they're about the only side effects I've noticed. Bit more tired than usual too.



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52 yo.Genotype 1a Dx 17/05/17 Infected 25-30 years Viral load at diagnosis 440,000 Fibroscan 6.2 kPa, ALT 29

27/7/17 commenced 12 weeks treatment with Zepatier 10/8/17 VL 110 after 2 weeks of treatment.

24/8/17 VL UND after 4 weeks of treatment.

17/10/17 EOT - UND!!

25/01/18 SVR12 - I am free!!!

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I'm unable to find any specific reference about Zepatier and dysgeusia. Aside from the first hand experiences from patients, like you and John, I have one impression regarding the topic. When I was on treatment, back when King George was ruling the Dragon empire, one of the drugs I took, Victrelis, caused the absolutely worst dysgeusia (altered taste). I noticed everything took on a horrid metallic taste. I took Peg Interferon and Ribavirin for 4 weeks, then they introduced the Victrelis for the remaining 24 weeks. It was after I started the Vic that the noticeable taste changes occurred.

You may wonder where I'm going with this, and here it is... While there is no mention of Zepatier causing this change in taste, consider this. Victrelis (now discontinued) was one of the two original NS3/4A protease inhibitors. Zepatier is a combination of two drugs, Elbasvir, a NS5A inhibitor and Grazoprevir (drum-roll) a NS3/4A protease inhibitor. Is there a connection between this drug class and dysgeusia? Perhaps...

Be sure you tell your doctor about this. They need to know about these little nuances! My taste returned after stopping the drugs, so understanding it's temporary will hopefully make it a little more tolerable. It was hard to get used to it, but we'll always know what flavor an aluminum can is if someone asks!



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Tig

62 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 1-4 years!

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JMIFF, Yes, the weird taste in the mouth. Some of my real pleasures are a good Cuban Cigar, and I order them from Spain and they are shipped from Switzerland, but during my treatment, a cigar did not even taste good, so I saved a little money there. I cleared in 4 weeks with  Zepatier, and stopped my 90 day treatment on 8-2017. 

Taste came back for my cigars, legs that felt very weak, weak enough it was difficult walking across the street to my car, strength came back now, but thank God I never experienced any insomnia, I sleep like a baby but got up numerous times to pee. Yep, I drank a lot of water too.

Oh, well another chapter in our life gone, done..... now off to the next page of our life! Enjoy.

 

John 



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Well Jmiff,

A very, very happy EOT to you!!!!!!!!(tomorrow?) Celebrate with having that blood draw, and then do something special for yourself , you deserve it. A long haul, and finally, you are finshed now.

Congrats!

So, we already know how stellar your 4 weeks labs were with that beauty UND, and your ALT/AST's crashing from 99/46 to be in the 20's!! Like that didn't tell us how well this was all going to end. But we will relish right along with you in hearing those lovely numbers again with these labs too.

Please do let us know as soon as you know. 

I cannot speak to Zep trench mouth, I only knew vosevi breath. But seems to me we did have some talking here about taste distortion (dysgeusia/ageusia).

Sorry to hear the insomniac tendecies that stuck with you through treatment, did you ever try any of those "natural" remedies (if your doc had let you)?

I can wait to hear you are echoing that UND again. Are you feeling quite proud of yourself - you should be! EOT is a very good day. C.



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HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 63 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

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12 week blood draw is being done tomorrow . I was undetected at 4 weeks so im hoping for more good news . Has anyone else on Zepatier noticed weird taste in mouth ? Other than that and insomnia side affects have been well tolerated .

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Genotype1b . 2 million VL on june 5th now undetected july 6 th.


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John!,

Oh so lovely! Thought we might not get this info until the end of the month, so glad you got it and shared it with us now! 

What a long haul, but boy you sure did a good job of killin' it, right from the start and proven at week 4! Now, you thought just getting to EOT was sweet, more rewards to come, like re-confirming stellar results like these.

2 weeks free of those dang blister paks must feel like a reprieve, slowly and surely now, you will start reaping the benefits of ridding yourself of this health sucking virus. Celebrate every nuance you start to pick up on.

They are lovely numbers, to be VERY happy over. You dun it bro! Our zeppers are doin' it, doin' it! biggrin C.  



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HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 63 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



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SWEEEET numbers John! 



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Wendy 53 y/o, DX 1994, geno 1A F1

1999 TX 1 - Inter -non responder 2001 TX 2 - Peg + Riba - viral load tripled and taken off

T3:  Harvoni 12 weeks Sept. 19, 2015 ALT 41 AST 30 VL 541800 UND at EOT and SVR 24 ALT 18 AST 26 platelets 223

 



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Thanks TIG



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Tig


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Terrific news, John! Congratulations on your well earned victory. I'm happy to hear you're feeling better and I'm positive that you'll continue to notice more and more improvements. 

Keep hydrating, it helps your body flush out all of the toxins and keeps that happy liver smiling. John, you and your twin are Winners!!!

SVR12  



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62 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 1-4 years!

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Another fine VICTORY here in The Family. wink



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Harvoni TX 2 12 weeks. UND weeks 4, 12 and now EOT + 4 Weeks. SVR-12 09/29/16. All Glory, Honor and Thanks be to God.

"I go to war with the brothers I trust."



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Ladies and Gentlemen,

My lab results: This is great news to me. Treatment of Zepatier 90 days, after 30 non- detectable virus in my body, results below are after 90 days of treatment. Thank you my friends for your support and guidance through all of this. Yes, I am starting to feel better already, two weeks after stopping the medication.

 

 BUN 15 Creatinine, Serum 1.01 eGFR If NonAfricn Am 80 eGFR If Africn Am 93 BUN/Creatinine Ratio 15 Sodium, Serum 138 Potassium, Serum 4.8 Chloride, Serum 100 Carbon Dioxide, Total 22 Calcium, Serum 9.8 Protein, Total, Serum 7.4 Albumin, Serum 4.4 Globulin, Total 3.0 A/G Ratio 1.5 Bilirubin, Total 0.8 Alkaline Phosphatase, S 73

AST (SGOT) 17

ALT (SGPT) 13

HCV RT-PCR, Quant (Non-Graph)

FLAG

High Glucose, Serum 

Hepatitis C Quantitation
                     HCV Not Detected

 

 


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Christine, yes my legs too feel less shakey when I walk, slowly regaining my strength . TIG, Canuck, Wendy, words of wisdom in the process, grateful about the half life as well.

Well I'm headed into the city now, putting on my happy face and going to meet some clients at a trade show, happy, happy! Fake it until you make is words that ring out loud to me on a daily basis. Thank God, I say it all the time, people who lived like I used to shouldnt be here, so I am grateful to have been given another chance at life.

I go see my Doctor on the 30th, for results, I fear not.

John



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All I could envision/hear is when someone is getting defib'd and the doc says CLEAR. So for the Zep twins; you are CLEAR!



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Wendy 53 y/o, DX 1994, geno 1A F1

1999 TX 1 - Inter -non responder 2001 TX 2 - Peg + Riba - viral load tripled and taken off

T3:  Harvoni 12 weeks Sept. 19, 2015 ALT 41 AST 30 VL 541800 UND at EOT and SVR 24 ALT 18 AST 26 platelets 223

 

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This is the official statement on Zepatier half life/elimination. You'll be clear in just a few days at most.

Elimination

The geometric mean apparent terminal half-life for elbasvir (50 mg) and grazoprevir (100 mg) is approximately 24 and 31 hours, respectively, in HCV-infected subjects.

Metabolism

Elbasvir and grazoprevir are partially eliminated by oxidative metabolism, primarily by CYP3A. No circulating metabolites of either elbasvir or grazoprevir were detected in human plasma.

Excretion

The primary route of elimination of elbasvir and grazoprevir is through feces with almost all (greater than 90%) of radiolabeled dose recovered in feces compared to less than 1% in urine.



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62 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 1-4 years!

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John, I've had the same question. I'd like to know if my system is clear of the blessed Zepatier. 

Thank goodness for Canuck's gentle technical wisdom and Wendy's cheerleading.

My legs don't shake with weakness so much when I use the stairs this week. Also I'm sleeping a couple extra hours each night! Hallelujah!! My muscles are thoroughly decondioned but I'm hopefulthat there are stronger days ahead.

The main thing is that we beat that mutha to a pulp!

Twins forever,

Christine



-- Edited by MyMallards on Sunday 13th of August 2017 01:52:34 AM

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58 yo with GT1b for 32 years post blood transfusion after first childbirth, F3/9.6 kPa, VL 890K,Treatment naive, Liver enzymes ALT 33, AST 39, Cryoglobulinemia and pos Rheumatoid factor, Started 12 week Zepatier on 5/2/17. 4 week: VL Undetected!  ALT 15, AST 25. 

 

 



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John,

Yes, keep flushing. biggrin

It's hard to answer your question - about how long the drugs remain in you. (But, if you really mean ... how long will it take for me to feel better? ... that's a whole dif ques. and that's even harder to anwser)!

Technically, "laboratorial-ly" (if that is a word), all those pharma people have seemingly tested a million guinea pigs to know exactly how long it takes various bodies to absorb their drugs (to reach peak blood concentrations) and the "ebb" of them, on a daily basis, but there is more to it than just the in's and out's - one can accumulate not enough or too much - that is another factor - generally we absorb an effective amount, period, mg's. carefully designed "just so" to meet that purpose, thus all that importance heaped on the avoidance of the contra-indicated drugs/foods that are know to contribute to screwing up the absorption, one way or another (seen in the Zep mongraph). Peak absorption levels (in the monogrph) 3-6 hours i think?

With your finishing, the drugs have already stopped gojng in, there should be a rapid and steady decline (first day and days), your liver and kidneys have been doing the same job with these drugs since day one, and continue to excrete the vestiges of your last days metabolised dose no differently - I would hazard a guess that a lab would be hard pressed to "easily" find any circulating drug in your blood even days after finishing. Perhaps you will start to feel some discernable "improvements" in the next couple weeks

It took me a fair while to start to glean any feeling of "being better" after I stopped my meds, but it came! -  some things right away, other very slow, in dribs and drabs, little things which snuck up on me to where I suddenly realized - hey, I don't have this or that anymore! A year later I am still improving in VERY important ways - my labs and tests prove it!

We had one fellow (for a while) here, on 24 weeks of sof/dac, he was having a bit of a hard time on it, it got harder as he went along, he and his doc(s) finally deduced he was just unluckily having a diet very high in an inhibitor which caused him to easily accumulate/potentiate some of his drugs - he got a nice super-saturating dose with the long course of his drugs - super-cured!,  but wiser for the lesson was he and his doc. He started to improve within weeks after finishing. Not suggesting anything like that to you, mind you, just pointing that out everyone is dif for dif reasons.

In the monograph, starting around P. 15, see "Elimination" and "Geriatrics", also around P. 16, see "Renal Implications", "Hepatic Implications" and "Drug Interaction Studies", but they will not really give you the direct answer you seek about how long the drugs take to be "gone" from your body, nor will it tell you "how long" it may be before you start feeling better. 

Prescribing Information - Merck.com

Be patient, you are cured, recovery takes some time. My technical "cirrhosis", started a downward morph into pleasingly simple fibrosis levels in not too long, and, within one year my fibroscan shows a normal liver! You will bounce back from this war you've just been through. biggrin C.

  



-- Edited by Canuck on Sunday 13th of August 2017 02:47:55 AM

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HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 63 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

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