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Post Info TOPIC: ALL ABOARD THE VOSEVI TRAIN


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RE: ALL ABOARD THE VOSEVI TRAIN
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I know maybe for people in America it is more difficult to understand it but in Europe you can have what they offer in treatment regimes, it is not that it is "my insurance".



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2nd Vosevi12wks- SOT Sept 12,2018 to EOTDec 5, 2018. Pre-trtmnt - VL 1.4 mil, ALT 45, AST __, ALP 69, GGT 90. 2 week - VL 49, ALT 26, AST __, GGT 53. 4 week-VL <15, GGT42 other normal, 5week: ALT 17,AST 27, Bili 11.8, ALP 68,GGT 36,15X VL12., 6week ALT 19,AST 26,Bili 16,20,GGT35, VL<12,8W UND



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robertsamx wrote:

Mac, I believe its 8 weeks supression after you go und. No matter what you end up doing MAKE SURE its with your Drs blessings. Last time i checked with Jeff in Australia the vosevi was not available in generic form.  RC


Yes there is no generic Vosevi manufactured in countries like India where generic Epclusa is licensed and manufactured. What I find interesting is that Gilead does not appear to have any new HCV DAAs in the pipeline. That would probably mean they will not license a generic Vosevi for some time. 



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Male, 65, Dx 1990, GT 2a/2c. Pre-tx VL 11,500,000, ALT 10, AST 18, F3, 12.4 kPa. Rx: 12 weeks Epclusa, SOT 3/8/18, EOT 5/30/18. Week 2 VL 50, ALT 12, AST 21. Week 10 VL not detected, ALT 12, AST 18. EOT + 12 weeks: VL not detected, ALT 11, AST 19. EOT + 24 weeks VL not detected, ALT 9, AST 24.



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Mac, When my Dr ordered the extra 4 weeks of vosevi, my insurance turned it down saying it was off lable.   I appealed it and won.  Try to get the extra 4 weeks vosevi.  RC



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 M-61(3 Treatments)( SOF-RIBA 2014)(SOF-RIBA-PEG 2016)(HCC 2016) (LIVER TRANSPLANT 8-2017)(VOSEVI-RIBA 2017)   SVR-12. 3-13-18 https://aasldpubs.onlinelibrary.wiley.com/doi/pdf/10.1002/hep4.1280   



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epclusa only is available



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2nd Vosevi12wks- SOT Sept 12,2018 to EOTDec 5, 2018. Pre-trtmnt - VL 1.4 mil, ALT 45, AST __, ALP 69, GGT 90. 2 week - VL 49, ALT 26, AST __, GGT 53. 4 week-VL <15, GGT42 other normal, 5week: ALT 17,AST 27, Bili 11.8, ALP 68,GGT 36,15X VL12., 6week ALT 19,AST 26,Bili 16,20,GGT35, VL<12,8W UND



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Mac, I believe its 8 weeks supression after you go und. No matter what you end up doing MAKE SURE its with your Drs blessings. Last time i checked with Jeff in Australia the vosevi was not available in generic form.  RC



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 M-61(3 Treatments)( SOF-RIBA 2014)(SOF-RIBA-PEG 2016)(HCC 2016) (LIVER TRANSPLANT 8-2017)(VOSEVI-RIBA 2017)   SVR-12. 3-13-18 https://aasldpubs.onlinelibrary.wiley.com/doi/pdf/10.1002/hep4.1280   



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One thing here. I do not think NHS will prolongate my treatment. 

I will have to Buy one bottle of the Vosevi mySelf (very expensive but possible) or to order Epclusa from India. Epclusa is Vosevi Without Voxilalrevir. Does it make sense not to add Voxilaprevir or it is absolutely necessary? I have the officcial Doctor (so they want to test  me at week 8) and also another one i was on triala before. The second one says it is not a bad thing to make the treatment longer. 

RobertSamx- I remembered this what you said before- that it is important to suppress the virus for at least 4 weeks when it is a zero. This is why I started to worry - but it it wise to think of it.



-- Edited by mcmaklin on Monday 29th of October 2018 08:19:47 PM

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2nd Vosevi12wks- SOT Sept 12,2018 to EOTDec 5, 2018. Pre-trtmnt - VL 1.4 mil, ALT 45, AST __, ALP 69, GGT 90. 2 week - VL 49, ALT 26, AST __, GGT 53. 4 week-VL <15, GGT42 other normal, 5week: ALT 17,AST 27, Bili 11.8, ALP 68,GGT 36,15X VL12., 6week ALT 19,AST 26,Bili 16,20,GGT35, VL<12,8W UND



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HI ALL.    I wanted to chime in on mcmak and his progress.    Mac , I understand what it is like to have failed a couple treatments, so its no wonder your so worried about how yours is coming along. In my case i had failed 2 treatments so VOSEVI was about the only choice we had. it had just been FDA approved two weeks before my transplant.  Originally my R/X was 12 weeks Vosevi but by week 8 i was still detectable. My Dr called at week 8 and said he wanted to add ribavirin and also add 4 more weeks Vosevi extending my treatment to 16 weeks Vosevi .  So that I am clear, my treatment came out to be as follows

16 weeks VOSEVI, with riba added for the last 8 weeks.  I took riba the last half of my 16 week treatment.

It was very important that i was on treatment for at least 8 weeks undetectable,that 8 weeks und on treatment gave the R/X drugs time to mop things up . The addition of riba was our insurance that gave the VOSEVI the extra boost i needed.   I dont think the riba helped and i think the 16 weeks of Vosevi would have been all i needed but as you know after two failed treatments, you start grabbing anything to help.

Mac- In your case I dont think its a bad idea to get the extra 4 weeks of vosevi and extend your treatment to 16 weeks.       RC



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 M-61(3 Treatments)( SOF-RIBA 2014)(SOF-RIBA-PEG 2016)(HCC 2016) (LIVER TRANSPLANT 8-2017)(VOSEVI-RIBA 2017)   SVR-12. 3-13-18 https://aasldpubs.onlinelibrary.wiley.com/doi/pdf/10.1002/hep4.1280   



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i too thot mcmak was stopping tx and then getting other pills ; but then realized it was actually pills for a longer tx after eot in dec.

but with so many weeks to go you are doing a good job mcmak. keep up the good work.

we are cheering you on



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Gt:1a-36yrs .Started Intron-A in 96' for 2.5mo-VL still too high.taken off. Labs on 3.6.18:. A1 activity.  f3@60: fibrosur bloodtst. AFP=norm. enz=mostly norm.VL=3.9 million.sot=5.1.18>Harvoni>[8wks]: 4WEEKS=UND. Eot 6/25=Waiting for 3mo.VL.July=norm liverpanel.13weeks=UND



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This is one of those cases where I am glad I misunderstood! 

Are you afraid that your insurance won't cover the prolonged course of treatment?

What does your doc have to say about it?



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F, 51, GT3, HCV since 1989, no alcohol since 1999, Fibrosis score F0-1 (.36), VL 216,000, ALT 23, AST 26, Epclusa SOT 7/26/18 EOT 10/18/18. Thank you God. 



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You misunderstood me- I wrote it not clear enough I am sorry. I will take all I need the Vosevi Till the end. I will not be taking more after I finish - I was thinking of adding other drugs after I finiish like an extra month 



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2nd Vosevi12wks- SOT Sept 12,2018 to EOTDec 5, 2018. Pre-trtmnt - VL 1.4 mil, ALT 45, AST __, ALP 69, GGT 90. 2 week - VL 49, ALT 26, AST __, GGT 53. 4 week-VL <15, GGT42 other normal, 5week: ALT 17,AST 27, Bili 11.8, ALP 68,GGT 36,15X VL12., 6week ALT 19,AST 26,Bili 16,20,GGT35, VL<12,8W UND



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 don't stop taking your pills

don't stop believing

 don't stop taking your pills

 



-- Edited by Hoodietree on Sunday 28th of October 2018 03:27:37 PM

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F, 51, GT3, HCV since 1989, no alcohol since 1999, Fibrosis score F0-1 (.36), VL 216,000, ALT 23, AST 26, Epclusa SOT 7/26/18 EOT 10/18/18. Thank you God. 



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mcmak, you have lots of weeks left for the vosevi to do it's job but i understand the idea of wanting to make sure. the doctors do know what they are doing now days.

your job is to follow this to the letter and find some ways to relax.

[2nd Vosevi12wks- SOT Sept 12,2018 to EOTDec ]



-- Edited by 5-1-18 on Sunday 28th of October 2018 08:17:00 AM

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Gt:1a-36yrs .Started Intron-A in 96' for 2.5mo-VL still too high.taken off. Labs on 3.6.18:. A1 activity.  f3@60: fibrosur bloodtst. AFP=norm. enz=mostly norm.VL=3.9 million.sot=5.1.18>Harvoni>[8wks]: 4WEEKS=UND. Eot 6/25=Waiting for 3mo.VL.July=norm liverpanel.13weeks=UND



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No, no. For now I am not going to be on treatment any longer.

I am only concidering, depending on what will happen. I will order Epclusa from India just in case. But I will not be taking any decision myself.



-- Edited by mcmaklin on Sunday 28th of October 2018 07:28:30 AM

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2nd Vosevi12wks- SOT Sept 12,2018 to EOTDec 5, 2018. Pre-trtmnt - VL 1.4 mil, ALT 45, AST __, ALP 69, GGT 90. 2 week - VL 49, ALT 26, AST __, GGT 53. 4 week-VL <15, GGT42 other normal, 5week: ALT 17,AST 27, Bili 11.8, ALP 68,GGT 36,15X VL12., 6week ALT 19,AST 26,Bili 16,20,GGT35, VL<12,8W UND



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mcmak, yep it's a scary deal to wonder if this time it will work.

i didn't do the full interferon tx's cos i was an early nonresponder so was spared. but i was still worried at test time becos of that one negative experience. but with these daa's they don't take us off cos they are created to cure what ails us.

what did you take before?

hang in there. we are all here cheering you on and thinking good thots towards your liver and your wellbeing.

how much longer will you be on tx? i forgotblankstare

5

 



-- Edited by 5-1-18 on Sunday 28th of October 2018 07:26:21 AM

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Gt:1a-36yrs .Started Intron-A in 96' for 2.5mo-VL still too high.taken off. Labs on 3.6.18:. A1 activity.  f3@60: fibrosur bloodtst. AFP=norm. enz=mostly norm.VL=3.9 million.sot=5.1.18>Harvoni>[8wks]: 4WEEKS=UND. Eot 6/25=Waiting for 3mo.VL.July=norm liverpanel.13weeks=UND



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thank you. I want to assure you that I am reading all posts carefully. I also was trying to find those people on the forum, that you mentioned. I had a problem of finding a person who was not und In week 6 and for genotype 1b.

Your knowledge is incredible. I assume it would be better to already have UND than <12 but this does not mean too much. I am ONLY considering - but I will see how it is going- to ask my doctor to make treatment longer with the Epclusa if things go too slow. And only because I would have to order it from India I need to prepare earlier but I am trying to thing a good way and I have a lot of Hope. 



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2nd Vosevi12wks- SOT Sept 12,2018 to EOTDec 5, 2018. Pre-trtmnt - VL 1.4 mil, ALT 45, AST __, ALP 69, GGT 90. 2 week - VL 49, ALT 26, AST __, GGT 53. 4 week-VL <15, GGT42 other normal, 5week: ALT 17,AST 27, Bili 11.8, ALP 68,GGT 36,15X VL12., 6week ALT 19,AST 26,Bili 16,20,GGT35, VL<12,8W UND



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Just more studies for you Mak,

 

Published in Gastroenterology

Journal Scan / Case Study · October 11, 2017

Clinical Cure of Hepatitis C Virus Is Possible Even With Detectable Viremia After Treatment Completion

 

 

TAKE-HOME MESSAGE

·         This small case series reported that 5 patients with a detectable hepatitis C virus level after completing treatment with direct-acting antivirals, 1 with detectable viral levels 4 weeks after completion of therapy, went on to have a sustained virologic response.

·         This case series highlights two important concepts for practitioners treating hepatitis C virus. The first is that a detectable virus level at the end of therapy does not mean that a patient will not achieve a sustained virologic response. The second is that clearance of the virus may take up to a month or longer in those patients with a detectable virus level at the end of therapy.

Eric Kallwitz, MD

 

(Excerpt only) - for full info see Journal case study

 Gastroenterology

Written by Miguel Malespin MD

The presence of end-of-treatment viremia (EOT+) in patients treated with direct antiviral agents (DAA) can be stress-provoking to patients and providers alike. This case series further prompts the question of whether EOT+ is, in fact, a predictor of treatment failure with DAAs. Prior data obtained from 12 interferon-free clinical trials demonstrated that 55% of EOT+ patients went on to achieve a sustained viral response (SVR) 12.1 

Our group further evaluated EOT+/SVR12 in clinical practice and showed this phenomenon to occur in only 6% of HCV mono-infected patients treated with DAAs.2 Furthermore, 100% of EOT+ patients went on to reach SVR12, with EOT+/SVR12 occurring in only genotype 1a/b patients with advanced fibrosis/cirrhosis and by Abbott RealTime PCR assay (ART; Abbott Laboratories, Abbott Park, IL).2 Although there remains no consensus on why EOT+/SVR12 occurs, we can definitely conclude that EOT+ is not associated with treatment failure in patients treated with DAAs

References

1.     Harrington P, Deming D, Komatsu T, Naeger L. Hepatitis C virus RNA levels during interferon-free combination direct-acting antiviral treatment in registrational trials. Clin Infect Dis. 2015;61(4):666-667. https://academic.oup.com/cid/article-lookup/doi/10.1093/cid/civ402

2.     Malespin M, Benyashvili T, Uprichard SL, et al. Prevalence of end of treatment RNA-positive/sustained viral response in HCV patients treated with sofosbuvir combination therapies. Therap Adv Gastroenterol. 2017;10(1):68-73. http://journals.sagepub.com/doi/10.1177/1756283X16672392

 

__________________________________________________________________________________________________________________________________________________ 

 

HEPATITIS C TREATMENT

HCV viral load levels during treatment and speed of decline do not predict cure with interferon-free therapy

 

David Wyles presenting at CROI 2015.

Liz Highleyman

Produced in collaboration with hivandhepatitis.com

Published: 23 April 2015

(Excerpts only)

...  Conference on Retroviruses and Opportunistic Infections (CROI 2015) ...

...  Furthermore, even having low-level detectable HCV RNA at the end of treatment does not preclude a cure, the investigators for a related study concluded ...

 

Viral load monitoring

Sreetha Sidharthan and colleagues evaluated the ability of HCV RNA levels measured at week 4 and at the end of treatment to predict outcome among 37 people with HCV mono-infection who were part of the SYNERGY study and 50 people with HIV and HCV co-infection who were part of the ERADICATE study and who were treated with sofosbuvir/ledipasvir for 12 weeks (this analysis omitted SYNERGY participants who received one of the triple regimens for only 6 weeks). As noted above, SVR12 rates for this regimen were 100% in SYNERGY and 98% in ERADICATE.

Using the more sensitive Abbott assay with a quantification limit of 12 IU/ml, the majority of participants with HCV RNA >LLOQ, or below the LLOQ but still detectable, at week 4 went on to achieve SVR12. There were five people in SYNERGY and seven in ERADICATE who still had detectable HCV RNA at the end of treatment, and all achieved SVR12. The negative predictive value of week 4 viral load was less than 13%. Looking at people with HCV RNA >LLOQ at week 4 and at the end of treatment, a majority achieved SVR12 and the negative predictive value was >11%. Fewer people had HCV RNA >LLOQ or <LLOQ but detectable using the less sensitive Roche assay.

"Low negative predictive values of HCV RNA at week 4 underscore the importance of continued therapy for patients who fail to achieve undetectable levels of HCV RNA early on during treatment because the likelihood of achieving SVR12 is still high," the researchers concluded. "Contrary to past experience with interferon-containing treatments, the presence of detectable HCV RNA at EOT [end of treatment] is not predictive of relapse in these studies." ...

_________________________________________________________________________

 

Basic premises (and semantics) that need to be understood, about ... what constitutes SVR12 ... and it is NOT whether you are "UND", it is if your PCR shows that you are "below the lower limit of quantification" (below LLOQ) which for most of us, and the labs we go to, the LLOQ is often either <12 or <15 ...

Phase 3 Harvoni trials used this language ... Sustained virologic response (SVR) was the primary endpoint and was defined as HCV RNA less than LLOQ at 12 weeks after the cessation of treatment. Relapse was a secondary endpoint, which was defined as HCV RNA greater than or equal to LLOQ with 2 consecutive values or last available post-treatment measurement during the posttreatment period after achieving HCV RNA less than LLOQ at end of treatment."

 



-- Edited by Canuck on Sunday 28th of October 2018 04:38:38 AM

__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 63 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



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Oh my Mak! 

That is a tall research order you are asking for! ... that you want me to find you everybody who has ever been found to be <15 detected at EOT and gone on to be SVR12! (gee - and i thought it was hard enough or a lot of work just to look up some of the folks around here for you on this site who were also not UND by week 4, but went on to be perfectly cured! BTW- did you ever read that post, below, (where i found you some folk around here who were not UND at 4 weeks and were slow to go UND, but yet were cured??) - you rarely respond in depth to the posts we make to you, so i am not sure you have really read them, you often go on and skip ahead to another event.

So, further to showing you names of other people here who did not go UND at 4 weeks or who went UND slowly and still ended up being perfectly cured ... (see in my prior post to you) ...

Here is a post I copied from a nice lady called "Ella", she is from and on another website - she obviously reads studies about this topic of being detected at EOT too. She found one pretty good (related) study (337 people) but specifically a part of the study that spoke about only one person out of 18 who had been found detected at EOT who relapsed. 

Here is what Ella found and shared ...

 

Here's an interesting article from April 2017. It does not include Epclusa specifically (maybe not out then?), but I think it would apply to DAAs generally.


Virological and clinical significance of detectable HCV-RNA below limit of quantification at End-of-Treatment in patients treated with direct antiviral agents
http://livertree.easl.eu/easl/2017/international.liver.congress/168237/ubaldo.visco.comandini.virological.and.clinical.significance.of.detectable.html?f=m3t4035

337 patients enrolled in the study.
16 patients relapsed.
18 patients were detected, not quantifiable (DNQ) at end of treatment (EOT).
All patients DNQ at EOT or 4 weeks post were reanalyzed using an ultrasensitive HCV RNA test (US).
Out of 18 with detectable HCV-RNA with both tests at EOT or PTW4, only 1 experienced relapse
Out of 16 relapsers, only 2 showed DNQ at EOT (12.5%).

 

I have also found quite a few studies/articles which are ALL leaning to the premise that "detected <15" at EOT does not (cannot) predict/equate to failure. 

The VL has to be done, and will be done again at EOT+12 weeks. And, lucky you, your doc will also be giving you another VL at 8 weeks and at EOT. So, even if the 8 week VL and the EOT VL shows detected at <15, this is still very good news - it is the same good news you have been receiving since you started the Vosevi, which is that you have had a very strong, good, early and robust response to the DAA and I am sure you will continue exactly this same way from now on - you have already succeeded in getting a lovely crashed VL and LFT's, and you have been getting yourself so many VL's done (overall, the private ones and the regular ones) they are ALL showing you that you are remaining/retaining/holding this crashed VL and LFT level. Achieving and holding these levels IS significant. The UND will come. smile 

Oh - and so, BTW, I don't really care if your lab says get another test with them OR at another lab - where you get it done likely doesn't matter much (although using the same lab, same equipment, same people is just better in theory and in practice) - the testing, via differing labs, would likely be reliable and very close to one another  anyway - the only dif being maybe whether their equipment goes down to >12 or >15, it is only that i thought it an odd comment for the lab to add to their report, that's all. It is likely some dumb "liability" cover-yer-butt sentence they add to a report. shrugs

You SIMPLY MUST discuss your failure fears with your hep doc - we cannot reassure you no matter what proof, evidence we find or say - as far as I am concerned your labs have already proven the Vosevi has whopped the poop out of your load, decimated your infection to smitherines, and that you will be UND and you will stay that way ... ASK YOUR DOC for his advice and opinion.

Later, C.

 



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 63 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



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Oh, I remember.  You are on your second treatment.  No wonder this comes up for you.  I have to say, I would probably be feeling the same. Still, I'm sincerely optimistic. Some people say that the early tests are just to see that you are taking your meds, not in fact because they think you will be cured early.  Hang in there, brother.  We are here to help you get through. 

Best to you.

 



__________________

GT2a, VL 681,500, Less than F1, Treatment Naive

12 wks Sovaldi/Ribavirin, SOT 2/25/16, EOT 5/17/16

UND at 2,4,8 and 12 wks during treatment but ribavirin crazy.

ALT/AST normal EOT

SVR12 8/13/2016!!!!!!!!!  I WON!!

EOT 6 Months 11/12/2016  CURED

 



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I hope to be UND soon - I will not be doing anything without doctors knowledge!



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2nd Vosevi12wks- SOT Sept 12,2018 to EOTDec 5, 2018. Pre-trtmnt - VL 1.4 mil, ALT 45, AST __, ALP 69, GGT 90. 2 week - VL 49, ALT 26, AST __, GGT 53. 4 week-VL <15, GGT42 other normal, 5week: ALT 17,AST 27, Bili 11.8, ALP 68,GGT 36,15X VL12., 6week ALT 19,AST 26,Bili 16,20,GGT35, VL<12,8W UND



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Stop it macmaklin!  You're going to be cured.

Please do so under medical care.  This is exact,  long term, and sophisticated science, so please don't self diagnose or self medicate.  I wan't you to get well and really don't think you should second guess it until after SRV12.  Although, EOT UND is a fantastic sign, the docs like to see that no stragglers found their way through after taking the meds.

There are very few cases UND at SVR12 these days.  Consider yourself a success rather than a failure.  

I don't mean to be harsh, just clear.  I do understand how worrisome this process can be and I'm sorry you have to got through it.  But, go through it anyway.  It's the way out.

Best to you, mcmaklin.

Cheddy



__________________

GT2a, VL 681,500, Less than F1, Treatment Naive

12 wks Sovaldi/Ribavirin, SOT 2/25/16, EOT 5/17/16

UND at 2,4,8 and 12 wks during treatment but ribavirin crazy.

ALT/AST normal EOT

SVR12 8/13/2016!!!!!!!!!  I WON!!

EOT 6 Months 11/12/2016  CURED

 



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hello, thank you - this was just recommandation to test the virus again in later time. I was talking to the person who operates machine for those tests. She told me that before if they write it is 12 it was just 12, if they write less it is less than 12 but when the machine shows UND they double check a curve again the next day.Maybe they wrote recommendation because I was talkin before they gave me those result I would not worry here. Another lab test not another laboratory.

if I cannot do things officially I am slowly thinking- I hope to be UND soon, if it will be a late UND I am thinking about buying myself Velpatasvir + sofosbuvir from India and make my treatment longer. 

how many cases there were who were not UND till the end of treatment and what would it mean? 



-- Edited by mcmaklin on Saturday 27th of October 2018 05:41:34 AM



-- Edited by mcmaklin on Saturday 27th of October 2018 05:42:26 AM



-- Edited by mcmaklin on Saturday 27th of October 2018 05:44:43 AM

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2nd Vosevi12wks- SOT Sept 12,2018 to EOTDec 5, 2018. Pre-trtmnt - VL 1.4 mil, ALT 45, AST __, ALP 69, GGT 90. 2 week - VL 49, ALT 26, AST __, GGT 53. 4 week-VL <15, GGT42 other normal, 5week: ALT 17,AST 27, Bili 11.8, ALP 68,GGT 36,15X VL12., 6week ALT 19,AST 26,Bili 16,20,GGT35, VL<12,8W UND



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Canuck, Might the mean another lab test and not another laboratory?

mcmaklin,  Those labs look pretty good to me.  Again, the purpose of these labs is to see if the treatment is working right now and to make sure you are going in the right direction. It does not tell you what it will say in the future.  EOT and SVR 12 results come later

Moving from 12,00 to <12 is does mean that it is going down. Again, you simply don't have all the information yet.  It's too early.  Take the encouragement. Make sure your medical team answers what they can, and keep asking questions.  You'll find lots of answers here.

Look up. Peace out. And wait.  Gruelling, isn't it?



__________________

GT2a, VL 681,500, Less than F1, Treatment Naive

12 wks Sovaldi/Ribavirin, SOT 2/25/16, EOT 5/17/16

UND at 2,4,8 and 12 wks during treatment but ribavirin crazy.

ALT/AST normal EOT

SVR12 8/13/2016!!!!!!!!!  I WON!!

EOT 6 Months 11/12/2016  CURED

 



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Ah, good. Thanks for doing that (writing it out "in full") ...

You wrote ... 

      "22 Oct 2018: HCV method PCR, quantitative  <12 IU/ml

     (found presence of target RNA sequencies of hepC virus. Range of method 12-100 000 000 IU/ml)

     Recommanded another lab from a different sample to confirm or exclude the presence of the virus" ...

 

The words (in red above,) "found presence", I would interpret "found presence" to mean the same as "Detected". Too low to measure/count any VL and this is why they would be saying "less than 12", but still, the evidence/presence of virus can still be detected.

I am guessing you are still not UND yet, going by this language in your report, but being detected into your 6th week is not critical - did you not read the posts we sent to you in the past 4 or 5 days about how people can remain detected long into their treatment and still end up perfectly cured?? You do not comment on this old post info to you.

That is an odd comment the lab added to your Oct 22 test - that you should go to another lab?? That's weird, I've never seen that written on a lab report before, and there are the spelling errors, unless those are just yours.

Your 8 week VL will soon be done. All still looks excellent. Nice crashed VL and LFT's. You are on target, even if you would wish to be UND earlier. C.

 

 



-- Edited by Canuck on Friday 26th of October 2018 11:12:08 PM

__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 63 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



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Additional labs are because I am doing it privately in a different EU country, not in English. I did it at week 5 and 6.  But they are of course up to highest standards.  So I can only translate it word by word. My next  official Labs are at week 8.

SO here it is:

15 Oct 2018: HCV method PCR, quantitative:  12,00 IU/ml

(found presence of target RNA sequencies of hepC virus. Range of method 12-100 000 000 IU/ml)

Made REAL-Time PCR method on m2000rt manufactured by Abbott.

Snesivity of the method around 95% in the range of method.

Made accroding do precedure IB/LAB/905 (vesrion V from 2016-10-21)

 

then

22 Oct 2018: HCV method PCR, quantitative  <12 IU/ml

(found presence of target RNA sequencies of hepC virus. Range of method 12-100 000 000 IU/ml)

Recommanded another lab from a different sample to confirm or exclude the presence of the virus

 

I am not saying what is my doctor saying because they do not say anything until my official 8 week labs



-- Edited by mcmaklin on Friday 26th of October 2018 08:50:03 AM

__________________

2nd Vosevi12wks- SOT Sept 12,2018 to EOTDec 5, 2018. Pre-trtmnt - VL 1.4 mil, ALT 45, AST __, ALP 69, GGT 90. 2 week - VL 49, ALT 26, AST __, GGT 53. 4 week-VL <15, GGT42 other normal, 5week: ALT 17,AST 27, Bili 11.8, ALP 68,GGT 36,15X VL12., 6week ALT 19,AST 26,Bili 16,20,GGT35, VL<12,8W UND



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Mac,

If you will please, (if you have the actual PCR lab report - in print - right there in front of you?) can you please type out (in full) what it says on your lab report "word for word" - and copy that to here so we can read the WHOLE of your lab report for ourselves with NO words left out. 

It is important to know these details, and, like we mentioned before, it is significant if the labs wording says "detected" or "not detected". 

Seeing the lab report in it's totality is better, so that we know that any important words are not being left out. C.

PS - I thought your next VL and LFT's was planned to be done at eight weeks? Why at 6 weeks? Without knowing exactly what "words" are on your VL report, I would only be guessing that this last lab was a similar result to the one you had last week. A VL number that is showing you have had a profoundly positive response to the Vosevi.



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 63 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



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Hello, I did another test this Monday 22 of Oct. Which is week 6. This Tuesday was a middle of my treatment. Is it normal?

Here are the results  <12 Iu/ml

Other results: 

phosphatase 65,

Bilirubin total 16,20

AST 26

ALT 19

GTP 35

 

By the way after taking Vitamin D level of vitamin was 16,20 ng/ml which is still low but better



__________________

2nd Vosevi12wks- SOT Sept 12,2018 to EOTDec 5, 2018. Pre-trtmnt - VL 1.4 mil, ALT 45, AST __, ALP 69, GGT 90. 2 week - VL 49, ALT 26, AST __, GGT 53. 4 week-VL <15, GGT42 other normal, 5week: ALT 17,AST 27, Bili 11.8, ALP 68,GGT 36,15X VL12., 6week ALT 19,AST 26,Bili 16,20,GGT35, VL<12,8W UND



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Sorry Mak, that this is so worrisome.  I understand.  It's quite difficult not to worry, but listen to the information below.  If and when you can stop the "what ifs" our minds seem to like to generate, you will have an easier time slugging through all of this.

There is room for great optimism.  We have cures these days!  Wow! That means you can get better all around with this virus out of your system  It seems like such a long haul, but you will be looking back on this.  It gets increasingly shorter looking at it in the rear view mirror.  

Try not to overthink it if you can.  You simply don't have enough information yet.  It's too early!!!  You'll see.

 



__________________

GT2a, VL 681,500, Less than F1, Treatment Naive

12 wks Sovaldi/Ribavirin, SOT 2/25/16, EOT 5/17/16

UND at 2,4,8 and 12 wks during treatment but ribavirin crazy.

ALT/AST normal EOT

SVR12 8/13/2016!!!!!!!!!  I WON!!

EOT 6 Months 11/12/2016  CURED

 



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Mak,

The other important bit to take note of is "early crashing", which is exactly just what you and me and everyone mostly do on these new DAA's.

Early crashing - a pronounced drop in LFT's and VL, often by week 4 of treatment - is a notable indicator of a successful/robust response to the DAA's, and you have already done this, shown a robust response. 

Less important is what particular day you go UND - that alone does not spell success. What is important about UND is that you sustain it, thus why SVR 12 is the official milestone.

It would be impossibly time-consuming for me to sift through every member hx to find you people who did not go UND exactly at 4 weeks! But they are there, and like I say, when you go UND is not critical, it is the sustaining of your UND (sustaining your virological response -  your SVR) is what most constitutes success

Tig has already mentioned to you someone who was detected at EOT and still became cured. RC was slow to become UND, I think he was not UND until his 9th week. "RainyJ" on Epclusa was detected at week 4, then was UND at week 5. "Lindsmatt52" on Epclusa was detected at week 4, became UND at week 8. "coolheat" on Harvoni was detected at EOT and then was UND at EOT+12 weeks. "Sydhanrhan" on sof/dac/riba was slow to go UND until week 9. And there ARE more folk than these. But, like I say the "particular day" you go UND is not as important as showing a good early robust response to the DAA's (as evidenced by early LFT and/or VL's drops).

You have already shown a very excellent robust successful response to Vosevi.

Which day you go UND is not as important as showing a good response to the DAA.

I know you won't stop worrying, but do try - focus on all the irrefutably positive signs you are showing! C.

PS - you never did say what your docs are saying to you, what they think or say to you, how they think you are doing?

 



-- Edited by Canuck on Monday 22nd of October 2018 12:26:59 AM

__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 63 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



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mc, that's why we are on the meds for 8-16 weeks, to catch the hiders who are trying to replicate... they don't stand a chance tho cos the daa's are like birthcontrol for the replicating the virus... they have lost the ability to produce more virus even if they did survive or showed up during early tx.

 



-- Edited by 5-1-18 on Sunday 21st of October 2018 06:11:19 AM

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Gt:1a-36yrs .Started Intron-A in 96' for 2.5mo-VL still too high.taken off. Labs on 3.6.18:. A1 activity.  f3@60: fibrosur bloodtst. AFP=norm. enz=mostly norm.VL=3.9 million.sot=5.1.18>Harvoni>[8wks]: 4WEEKS=UND. Eot 6/25=Waiting for 3mo.VL.July=norm liverpanel.13weeks=UND



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Thank you, just one think - i read many bios here of people taking Harvoni or Epclusa. Where there anyone who was not UND at week 4 and 5?



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2nd Vosevi12wks- SOT Sept 12,2018 to EOTDec 5, 2018. Pre-trtmnt - VL 1.4 mil, ALT 45, AST __, ALP 69, GGT 90. 2 week - VL 49, ALT 26, AST __, GGT 53. 4 week-VL <15, GGT42 other normal, 5week: ALT 17,AST 27, Bili 11.8, ALP 68,GGT 36,15X VL12., 6week ALT 19,AST 26,Bili 16,20,GGT35, VL<12,8W UND



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Mak,

The most important part of this to understand  - is whether you are "detected" or "undetected". Don't worry - you will soon be "undetected". 

All of your labs (from ALTs to VLs) are indicating you are responding beautifully to the Vosevi. Just wait - it will not be long before you are undetected.

Your "Abbott" PCR was only telling you they detected their lowest level (12 IU), similar to the other test (maybe a Roche-Tagman PCR) which was also telling you they could only detect their lowest level (less than 15). 2 different testing systems you have had done, one operates by only being able to go as low as 12 in detection, and the other operates by only being able to go as low as 15 IU.

Undetected is undetected, and it would not matter which test system you have it done by next (by the one with 15 as their lower limit, or the one using 12 as their lower limit ...  by either system ... UN-detected will be UN-detected. C.

 



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 63 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



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Thank you for all your heart. My question: why they have told me it was 12 Units not just impossible to count and less than 12? So were they able to count exactly 12 units? And before they told me it is was less then 15 and they were not able to count. Is it just the same?



-- Edited by mcmaklin on Saturday 20th of October 2018 11:59:58 AM

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2nd Vosevi12wks- SOT Sept 12,2018 to EOTDec 5, 2018. Pre-trtmnt - VL 1.4 mil, ALT 45, AST __, ALP 69, GGT 90. 2 week - VL 49, ALT 26, AST __, GGT 53. 4 week-VL <15, GGT42 other normal, 5week: ALT 17,AST 27, Bili 11.8, ALP 68,GGT 36,15X VL12., 6week ALT 19,AST 26,Bili 16,20,GGT35, VL<12,8W UND



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Mak,

Regarding whether you are <15 or 12 (at either lab) ... this was what I had said to you about it earlier ....

One lab says <15, the other similarly says 12 detected - I am not surprised at this similarity between the two results, given that both these VL tests were done so close together.  15 may be the lowest level of detection (at the first lab) using their particular PCR equipment, and 12 may happen to be the lowest level of detection (at the other lab you used), because of the particular type of PCR equip they happen to use.

Because you have failed a prior treatment you are pre-primed with "fear of failure", thus no matter how pleased we are and no matter how pleased your docs must be with your very obvious stellar response to the Vosevi, you will likely continue to struggle with this fear. Accept it that you will just naturally have this fear, fears cannot always be conquered for convenience, or to help yourself get through things more easily. Often we just have to bite the bullet and do only what we are capable of doing, mustering all the courage and hope we can - I think you are doing a VERY good job in holding up - you are trying very hard, to be accurate and to comply with every nuance of your treatment, and you are going to succeed (this time)! You will have to just take our word for it, that we feel so confident FOR YOU, maybe a little of our sureness has rubbed off on you just a tiny bit - i think you are truly waaaaaay more hopeful than you are fearful. There is nothing to fear really (except for the fear itself), what you are doing right now (going through everything you are going through, good and bad) is an extremely positive and hopeful act, we cannot ask anything more of you and nor can you ask more of yourself - you ARE performing the ultimate act of positive action here - be proud of this work and struggle you are going through.

You had already clarified, quite a while back, that your doc had already planned on doing (additionally) an 8 week VL?, as well as a EOT VL? - so that will be a lot of VL's you will have had done through treatment!

Becoming und at 2 weeks, or 4 weeks or at 2 months is good, but it is not counting as an official cure, just very good news - like Tig points out, your "sustained" virological response is what officially counts ... your SVR12 (your und 12 weeks after treatment has finished is what counts). I suspect you would STILL worry about failure all throughout treatment until you see your und at SVR12! 

I hope you do not have to wait that long to be be feeling more confident that things ARE (indeed) going well! C.



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 63 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



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I am taking only D3 with K2 as I was indeed low on D vitamin. I will take for a week and test. I have asked my other doctor as I am not  that close from home, I have asked the one from clinical trials and on my previous treatment. Also I noticed that there ar no interactions between those vitamins and my drugs In the hepc interactions chart
by the way the one from Abott m200rt machine -counted 12 IU (the range of the method is 12-100 000 000 IU/ml)
Tig wrote:

You can still be <15 IU/ml and be detected. I know it's odd, but the PCR has a lowest level of quantification of 15. If there is still a few stragglers around, the test isn't sensitive enough to quantify them, but will still pick up the few stragglers remaining and categorize it as "<15 IU/ml - Detected" That's not uncommon, especially when they do the viral load early on. Many doctors don't test the viral load until the end of treatment, some even wait until EOT +12.

Mak, don't worry about it. Your viral load dropped to almost nothing and did it fast. You're responding exactly as you should be. I'm sure by now, you're undetected, considering how close the last test results were. You don't need to do these weekly or biweekly viral loads, they can be deceiving. You're doing fine. Wait until the end of treatment and 12 weeks after that. The EOT + 12 is the money shot, all the rest are just to confirm something is happening and it is. You don't need to be taking a bunch of supplements during treatment either. Some of them aren't recommended, so be sure you get permission from your doctor before taking anything while on treatment. If they said to take a bunch of vitamins, then follow their instructions. Don't just add stuff without checking first.

You're doing fine, don't overthink all of this.


 



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2nd Vosevi12wks- SOT Sept 12,2018 to EOTDec 5, 2018. Pre-trtmnt - VL 1.4 mil, ALT 45, AST __, ALP 69, GGT 90. 2 week - VL 49, ALT 26, AST __, GGT 53. 4 week-VL <15, GGT42 other normal, 5week: ALT 17,AST 27, Bili 11.8, ALP 68,GGT 36,15X VL12., 6week ALT 19,AST 26,Bili 16,20,GGT35, VL<12,8W UND



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I have 50 more pills to take  since Monday.



-- Edited by mcmaklin on Wednesday 17th of October 2018 03:37:53 PM

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2nd Vosevi12wks- SOT Sept 12,2018 to EOTDec 5, 2018. Pre-trtmnt - VL 1.4 mil, ALT 45, AST __, ALP 69, GGT 90. 2 week - VL 49, ALT 26, AST __, GGT 53. 4 week-VL <15, GGT42 other normal, 5week: ALT 17,AST 27, Bili 11.8, ALP 68,GGT 36,15X VL12., 6week ALT 19,AST 26,Bili 16,20,GGT35, VL<12,8W UND

Tig


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You can still be <15 IU/ml and be detected. I know it's odd, but the PCR has a lowest level of quantification of 15. If there is still a few stragglers around, the test isn't sensitive enough to quantify them, but will still pick up the few stragglers remaining and categorize it as "<15 IU/ml - Detected" That's not uncommon, especially when they do the viral load early on. Many doctors don't test the viral load until the end of treatment, some even wait until EOT +12.

Mak, don't worry about it. Your viral load dropped to almost nothing and did it fast. You're responding exactly as you should be. I'm sure by now, you're undetected, considering how close the last test results were. You don't need to do these weekly or biweekly viral loads, they can be deceiving. You're doing fine. Wait until the end of treatment and 12 weeks after that. The EOT + 12 is the money shot, all the rest are just to confirm something is happening and it is. You don't need to be taking a bunch of supplements during treatment either. Some of them aren't recommended, so be sure you get permission from your doctor before taking anything while on treatment. If they said to take a bunch of vitamins, then follow their instructions. Don't just add stuff without checking first.

You're doing fine, don't overthink all of this.



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Tig

62 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 1-4 years!

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Huh? Do you have another bottle/pack coming?  If you have 28 more, you are definitely early.

I thought <15 is considered undetected.  Tig? Canuk? Even if you are undetected "early" treatment continues to flush out any hiders, or replicators trying to sneak through.  We're not taking any chance.  We're kicking dragon butt!

Call your doctor. Find out your actual treatment time.  

And, enjoy your good looking labs.



__________________

GT2a, VL 681,500, Less than F1, Treatment Naive

12 wks Sovaldi/Ribavirin, SOT 2/25/16, EOT 5/17/16

UND at 2,4,8 and 12 wks during treatment but ribavirin crazy.

ALT/AST normal EOT

SVR12 8/13/2016!!!!!!!!!  I WON!!

EOT 6 Months 11/12/2016  CURED

 



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Is it all Normal? 34 day which is almost 5 weeks and still virus is there But on so low level? When it usually disappears? I am so worried.

I started to take D3 + K2 vitamin to boost my immune system a bit as it was low in those vitamins 



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2nd Vosevi12wks- SOT Sept 12,2018 to EOTDec 5, 2018. Pre-trtmnt - VL 1.4 mil, ALT 45, AST __, ALP 69, GGT 90. 2 week - VL 49, ALT 26, AST __, GGT 53. 4 week-VL <15, GGT42 other normal, 5week: ALT 17,AST 27, Bili 11.8, ALP 68,GGT 36,15X VL12., 6week ALT 19,AST 26,Bili 16,20,GGT35, VL<12,8W UND

Tig


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mcmaklin wrote:

in fact there are 28 pills only in the box. So the treatment is not 12 weeks


 Three bottles or packs of 28 pills, 4 weeks X 3? That equals 12 weeks on my calendar! wink



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Tig

62 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 1-4 years!

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You, should be very happy you are showing such wonderful looking labs and VL's, early. 

 Is it early?



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2nd Vosevi12wks- SOT Sept 12,2018 to EOTDec 5, 2018. Pre-trtmnt - VL 1.4 mil, ALT 45, AST __, ALP 69, GGT 90. 2 week - VL 49, ALT 26, AST __, GGT 53. 4 week-VL <15, GGT42 other normal, 5week: ALT 17,AST 27, Bili 11.8, ALP 68,GGT 36,15X VL12., 6week ALT 19,AST 26,Bili 16,20,GGT35, VL<12,8W UND



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in fact there are 28 pills only in the box. So the treatment is not 12 weeks



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2nd Vosevi12wks- SOT Sept 12,2018 to EOTDec 5, 2018. Pre-trtmnt - VL 1.4 mil, ALT 45, AST __, ALP 69, GGT 90. 2 week - VL 49, ALT 26, AST __, GGT 53. 4 week-VL <15, GGT42 other normal, 5week: ALT 17,AST 27, Bili 11.8, ALP 68,GGT 36,15X VL12., 6week ALT 19,AST 26,Bili 16,20,GGT35, VL<12,8W UND



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The 2 VL's you had done (only about a week apart!) one slightly shy of (early of) 4 weeks and then again the next one, not a week later, just barely starting into your 5 week!, are bound to show about the same result - which (as we can see) they do!

They are showing you that you have the tiniest of a VL, one that can hardly be detected, and is proof that you are being cured as we speak! Proof not only by your VL response but by how all your labs have responded.

You have had an astoundingly strong, successful and early response to the Vosevi.

These 2 VL's (taken too close together) wouldn't tell you much more than you already knew from last week!

One lab says <15, the other similarly says 12 detected - I am not surprised at this similarity between the two results, given that both these VL tests were done so close together.

15 may be the lowest level of detection (at the first lab) using their particular PCR equipment, and 12 may happen to be the lowest level of detection (at the other lab you used), because of the particular type of PCR equip they happen to use.

You, should be very happy you are showing such wonderful looking labs and VL's, early. 

Nice new sig line BTW - I hope you saved your old sig line to put in your bio info for hx. wink C.



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 63 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



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How should it be?

Message from 15 of Oct. 

Virus detected method real-time PCR using m2000rt Abott. Sensitivity of method 95% in the range of method. Result: 12IU/ml

In the results from 8th of Oct it was not possible to count which was <15 iu/ml 

 

Is it normal? Why it is not going down? 



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2nd Vosevi12wks- SOT Sept 12,2018 to EOTDec 5, 2018. Pre-trtmnt - VL 1.4 mil, ALT 45, AST __, ALP 69, GGT 90. 2 week - VL 49, ALT 26, AST __, GGT 53. 4 week-VL <15, GGT42 other normal, 5week: ALT 17,AST 27, Bili 11.8, ALP 68,GGT 36,15X VL12., 6week ALT 19,AST 26,Bili 16,20,GGT35, VL<12,8W UND

Tig


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Hi Mak,

HBV & HCV are known causes of lowered Vitamin D levels. Often it’s due to the inability of the liver to process and absorb it properly. Research shows that SVR may correct that, but your intake (diet) and sun exposure has to be adequate. If you’re not getting enough, you can’t expect things to just automatically correct themselves. Diet and supplementation can turn it around fairly easily. You want to provide yourself the recommended intake and D3 seems to be the easiest to process. Are you taking a daily multi vitamin? That may be enough. Drink milk and get some sun. Sun exposure helps greatly.

Here‘s an article that will help:

Dietary supplements

In supplements and fortified foods, vitamin D is available in two forms, D2 (ergocalciferol) and D3 (cholecalciferol) that differ chemically only in their side-chain structure. Vitamin D2 is manufactured by the UV irradiation of ergosterol in yeast, and vitamin D3 is manufactured by the irradiation of 7-dehydrocholesterol from lanolin and the chemical conversion of cholesterol [6]. The two forms have traditionally been regarded as equivalent based on their ability to cure rickets and, indeed, most steps involved in the metabolism and actions of vitamin D2 and vitamin D3 are identical. Both forms (as well as vitamin D in foods and from cutaneous synthesis) effectively raise serum 25(OH)D levels [2]. Firm conclusions about any different effects of these two forms of vitamin D cannot be drawn. However, it appears that at nutritional doses vitamins D2 and D3 are equivalent, but at high doses vitamin D2 is less potent.

Vitamin D Info



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Tig

62 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 1-4 years!

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Thank You. 

I did this privately in a different Place- I am curious about my viral count. 

Another thing - I am low on D vitamin. What can I take safely?

Too low would be <10 ng/ml

not enough is 10-30

Enough is 30-100

I have: 14

shall I take D3 vitamin ? And how much?

 

 

 

https://www.wjgnet.com/1007-9327/full/v24/i4/445.htm



-- Edited by mcmaklin on Tuesday 16th of October 2018 05:34:52 AM

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2nd Vosevi12wks- SOT Sept 12,2018 to EOTDec 5, 2018. Pre-trtmnt - VL 1.4 mil, ALT 45, AST __, ALP 69, GGT 90. 2 week - VL 49, ALT 26, AST __, GGT 53. 4 week-VL <15, GGT42 other normal, 5week: ALT 17,AST 27, Bili 11.8, ALP 68,GGT 36,15X VL12., 6week ALT 19,AST 26,Bili 16,20,GGT35, VL<12,8W UND



Guru

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Great numbers Mak! biggrin 

Everything is working as it should be.

I am bumping your "suggested" signature line up here: and I've added your latest figures ... I'm still hoping you can use this sig. line ...

M, GT1b, TT, F1 ... Viekira/Exviera failed 2016 ...  2nd treatment - Vosevi 12 weeks - SOT Sept 12?, 2018 to EOT Dec 5, 2018. Pre-treatment - VL 1.2 mil, ALT 45, AST __, ALP 69, GGT 90. 2 week labs - VL 49, ALT 26, AST __, GGT 53. 4 weeks labs - VL <15, ALT 17, AST 27, Bili 11.8,  ALP 68, GGT 36 ...

Nice BTW, that you found your 4 week AST!

I am wondering something though (if i have your Sep 12 SOT date right, and your other blood draw dates correct), then ... you had your 2 week blood draw aprox Sep 26, and your 4 week blood drawn aprox. Oct 10 (or very near Oct 10), so ... why would you be saying today (Oct 16) that you are going to have more bloods drawn privately today (when you have just had your 4 week bloods drawn near Oct 10 and we even have your current 4 week a PCR VL and your LFT result back here)? confuse

But very good news and numbers for you Mak - congrats on a very good start! This is going to go as it is supposed to. biggrin How are you feeling? C.

 



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HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 63 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)

Tig


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Hey Mak,

I replied on the Harvoni thread, so here’s a copy of my reply. Your results are good.

 

Depending on the lab providing your results, they may not use the term of Zero viral load. What determines an "Undetected" result, the test will show a "<15 IU/ml" AND it will say "Undetected". It sounds to me like your results at week 4 are "<15 IU/ml - Detected". That's not uncommon at all and is nothing to be concerned about. Your numbers are going in the right direction and having the viral load unquantifiable, is good news. Next time, the results will likely be "Undetected".

The Vitamin D testing is up to you. It should have no bearing on your treatment or the results. Some people get their vitamin levels tested when determining anemia. If that's a problem for you or you're simply curious, go ahead.

 

 



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Tig

62 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 1-4 years!

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I did my test privately today. The viral count PCR test will be available in 2,3 days.

For now from today:

AST is 27   

ALT is 17

Bilirubin is 11,80qmol/l

Phosphatase is 68

GGTP is 36

 

All normal 

 



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2nd Vosevi12wks- SOT Sept 12,2018 to EOTDec 5, 2018. Pre-trtmnt - VL 1.4 mil, ALT 45, AST __, ALP 69, GGT 90. 2 week - VL 49, ALT 26, AST __, GGT 53. 4 week-VL <15, GGT42 other normal, 5week: ALT 17,AST 27, Bili 11.8, ALP 68,GGT 36,15X VL12., 6week ALT 19,AST 26,Bili 16,20,GGT35, VL<12,8W UND



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it is good news Mak you're doing great! Keep it up!! Hang in there you're headed for a cure for sure!!



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F, 51, GT3, HCV since 1989, no alcohol since 1999, Fibrosis score F0-1 (.36), VL 216,000, ALT 23, AST 26, Epclusa SOT 7/26/18 EOT 10/18/18. Thank you God. 



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Hello,

Please advice me if it is OK.

Pre treatment: 1.44 million iu/ml
2 weeks: 49 iu/ml
4 weeks: <15 iu/ml

It is still detected but below number that they can measure it accurately.

They wrote me that there will never be ZERO on the blood report. Anything below 15, its cannot be measurable. It was 2 weeks without 1 day.

 

2. Shall I measure the level of D vitamin???

 



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2nd Vosevi12wks- SOT Sept 12,2018 to EOTDec 5, 2018. Pre-trtmnt - VL 1.4 mil, ALT 45, AST __, ALP 69, GGT 90. 2 week - VL 49, ALT 26, AST __, GGT 53. 4 week-VL <15, GGT42 other normal, 5week: ALT 17,AST 27, Bili 11.8, ALP 68,GGT 36,15X VL12., 6week ALT 19,AST 26,Bili 16,20,GGT35, VL<12,8W UND

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