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Post Info TOPIC: Mavyret and Me


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RE: Mavyret and Me
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Champ,

Go with your instincts or best guesses (until you are otherwise self-enlightened) ... if you think (are convinced) the wakefulness coincides with and is directly related to the max. peak blood levels of Mav, then perhap you are right (despite any opinions to the contrary from anyone) - i think your theory on wakefulness might be a plausible possibility. (You said you take the Mav at bedtime and then, 5 or 6 hours later, when the max Mav level occurs, that is what is awakening you at about 5 AM?)

Had you noted this possible co-relation sooner in the treatment course, you might have had time to experiment with changing around the time of day dosing of the Mav (extremely slowly, with the OK and as advised by your doc) to be an hour earlier every day until you were taking your bedtime dose to be (say) a supper time dose, then (perhaps) the peak blood levels of Mav would have happened earlier, when you were under the heaviest influence of your nighttime sedation, perhaps then not waking? It may be pulling straws (or counting sheep may be more like it! heehee) but ... just thought I would throw my 2 cents into the lottery of dose timing , ... it's kind of late now to slowly shift the time of day dosing for your Mav to be earlier.

Like you said, being that you have had a hx of sleep trouble, perhaps no matter what time of day you took your Mav and when it peaked, you might have still experienced sleep difficulties at night, hard to say eh?

I know you will keep trying to do the best you can to treat your body well. Just keep trying to get as much quality rest, de-stress and relax time as you can, even if the normal sleep quota is not at all cooperating.  zzzz   ;o 



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 63 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



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Zolpidem makes me weird and groggy.  I'm glad it works for you, but more than 5 hours would be better.

Yeah, you're probably right.  The meds that are slaying dragons are bound to effect other areas, being so powerful. I'm glad you are able to take the good with the bad - no small feat. 

I like hearing your resolve, Champ/Shemp. 

Good to hear you got a good night's sleep. Wishing you many more.

 

P.S. Do you mean that cat that gets on top of your chest at dawn to ask for breakfast?  I love that guy, later on.

 



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GT2a, VL 681,500, Less than F1, Treatment Naive

12 wks Sovaldi/Ribavirin, SOT 2/25/16, EOT 5/17/16

UND at 2,4,8 and 12 wks during treatment but ribavirin crazy.

ALT/AST normal EOT

SVR12 8/13/2016!!!!!!!!!  I WON!!

EOT 6 Months 11/12/2016  CURED

 



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Thanks Cheddy,

I've had problems sleeping for years.Doc put me on generic Ambien it's called Zolpidem 10mg.No drug interaction I checked myself.I have no problem going to sleep but 5-6 hors later I'm wide awake.Not groggy,literally wide awake.I think it has to do with when my meds peak.Before I cleared the virus they were fighting.Now I guess they're kind of bored and they want me to wake up.Kinda like my cat.Had a good sleep finally last night and feel much better.27 more to go,no stopping me now.



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62 yo male GT 1b/2 ALT 60 AST 51 V/L 985,000 Fibro A2 F 3/4 began 12 wks Mavyret 9/13/2018

6 wk labs ALT 12 AST 18 V/L NOT DETECTED EOT 12/06/2018



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Dang it Shemp.  I'm so sorry this is happening to you  As Tig points out, it's a funny kind of normal to have these ups and downs. Thank goodness it's only 4 more weeks.  Unfortunately that feels like forever when we are in the middle of it. 

You've done so well on your treatment with food and water and a good attitude. Now we just have to figure out that sleep thing.  Sleep is medicine. I can't imagine being sleep deprived and making long drives.  No wonder you get worn out.  I don't know what your sleep meds were before but do they work now? Are they compatible with Tx?  Do they make you groggy the next day? Have you tried cal/mag?  That helps with body tired but doesn't always slow my curious mind down.  Lots of us have trouble with sleep so I hope more can chime in with what helps them.  

In the meantime, rest whenever you can, even if you don't sleep.  Find what keeps you calm.

Yeah, that Tig does run deep.  It is like the tide, coming in and going out. Just remember, you're not in a boat! That's a big honking truck your plowing through deep puddles, and you know how. 

At least here, you have the company of friends who know what it's like to go through this.  I wouldn't wish it on anybody else.

Please keep us up to date.  We'll be checking the tide charts.

Cheddy



__________________

GT2a, VL 681,500, Less than F1, Treatment Naive

12 wks Sovaldi/Ribavirin, SOT 2/25/16, EOT 5/17/16

UND at 2,4,8 and 12 wks during treatment but ribavirin crazy.

ALT/AST normal EOT

SVR12 8/13/2016!!!!!!!!!  I WON!!

EOT 6 Months 11/12/2016  CURED

 



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Hoodie,

Thanks for the kind words.Some days I don't feel like a champ but,this too shall pass.I never realized Tig was so deep.Words to live by.



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62 yo male GT 1b/2 ALT 60 AST 51 V/L 985,000 Fibro A2 F 3/4 began 12 wks Mavyret 9/13/2018

6 wk labs ALT 12 AST 18 V/L NOT DETECTED EOT 12/06/2018



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Hang in there champ! Im super proud of you and so happy that you joined us here with your marvelous wonderful attitude and your strength of character and fortitude. 

iPhone auto-corrected your name to champ and Im just gonna leave it because in this case it is fitting  

Tig I live this so much. The visual it evokes and the poetry of it, and also in a practical sense its true and right! 

High tide may swamp you, while low tide might allow you to walk across the bay.



__________________

F, 51, GT3, HCV since 1989, no alcohol since 1999, Fibrosis score F0-1 (.36), VL 216,000, ALT 23, AST 26, Epclusa SOT 7/26/18 EOT 10/18/18. Thank you God. 



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i kept working too shemp, but luckily i had a flexable schedule and sympathy from my coworkers.

you are amazing! driving up and down the east coast while on tx. wow

we'll all be thinking of you in prayer and thots.

5



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Gt:1a-36yrs .Started Intron-A in 96' for 2.5mo-VL still too high.taken off. Labs on 3.6.18:. A1 activity.  f3@60: fibrosur bloodtst. AFP=norm. enz=mostly norm.VL=3.9 million.sot=5.1.18>Harvoni>[8wks]: 4WEEKS=UND. Eot 6/25=Waiting for 3mo.VL.July=norm liverpanel.13weeks=UND



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Thanks for the support guys.27 days to go.Failure is not an option.I did notice once I cleared the virus there were some pretty dramatic changes.Most of them were good.I finally got more than 5 hours of sleep last night and I feel like a new boy.5-1 I wish I could take time off but,I own my truck,it's all on me.Heading north this weekend.I've got maybe two more trips before EOT.The things you do for money.



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62 yo male GT 1b/2 ALT 60 AST 51 V/L 985,000 Fibro A2 F 3/4 began 12 wks Mavyret 9/13/2018

6 wk labs ALT 12 AST 18 V/L NOT DETECTED EOT 12/06/2018



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Heya Shemp, 

youre almost on your last 4 weeks, eh? Sorry to hear the sides are coming back so much.

Thats a frustrating type of insomnia...my husband has had bouts like that...wide awake way too early for no good reason...I feel for you. He is like a zombie when that happens to him...

I have no helpful ideas, except perhaps magnesium...Thats good for the nervous system and helped me with my insomnia...although I got the kind that wont let me fall asleep in the first place.

You are a great dragon fighter and youve almost won. Try to take it easy



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60y/o, Infected via transfusion Oct'83, GT-1a, F-4 cirrhotic,
tx Holkira pak/moderiba 12 weeks

2.5years...post tx... successful dragon slayer 



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hang in there shemp; you can do this!

have you considered time off from work with sick leave, medical leave or fmla as needed?

5



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Gt:1a-36yrs .Started Intron-A in 96' for 2.5mo-VL still too high.taken off. Labs on 3.6.18:. A1 activity.  f3@60: fibrosur bloodtst. AFP=norm. enz=mostly norm.VL=3.9 million.sot=5.1.18>Harvoni>[8wks]: 4WEEKS=UND. Eot 6/25=Waiting for 3mo.VL.July=norm liverpanel.13weeks=UND

Tig


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Hey Shemp,

I can’t compare what I was on with your meds, but I did notice, as do most people on treatment in general, continual metabolic changes during treatment. There are so many things happening inside you right now, the ones you feel and the ones you don’t. Trust me on this though, they are BIG changes and your body tolerates some better than others. That doesn’t mean anything except the drugs are working. We used to consider the worse we felt, the better the results! Thank goodness we don’t measure treatment success on the degree of side effects. I suggest you look upon these waves of side effects as you would the tides. High tide may swamp you, while low tide might allow you to walk across the bay. Before you know it you’ll be cruising high and dry on that boat, above it all... Hang in there, Brother!



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Tig

62 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 1-4 years!

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The return of the sides,

Fellow warriors,I need some insight from those that have traveled this road before me.I just finished wk 8,4 more to go.The first few wks were an adjustment.Nausea, anxiety,insomnia.By wk 4 they seemed to level off and I was pretty much ok.Wk 6 came and I got great news from the lab,actually  had a few days where I hadn't felt that good in a long time.Wk7 was a slow roll downhill.Sides were coming back and I was just worn out.I had read on this forum that others had them return late in treatment as well.My biggest problem these day is sleep.My Doc had me on sleep meds before tx,but now it's just crazy.Now,I take my meds at night because of my work schedule.10:30 each night because my day is usually done by then.A little snack,meds bed.I'm up every day at 5 AM for no good reason.My eyes open and there is no hope of going back to sleep.I looked into Mavyret the other day and learned that it peaks 5 to 6 hrs.after you take it.Do you think that is what is waking me?I feel like the walking dead.My Doc and Abbvie are clueless. Any insight would be much appreciated.



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62 yo male GT 1b/2 ALT 60 AST 51 V/L 985,000 Fibro A2 F 3/4 began 12 wks Mavyret 9/13/2018

6 wk labs ALT 12 AST 18 V/L NOT DETECTED EOT 12/06/2018



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Hey thanks Canuck,I don't know how you got that recording of my wife.Maybe thats why I can't sleep



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62 yo male GT 1b/2 ALT 60 AST 51 V/L 985,000 Fibro A2 F 3/4 began 12 wks Mavyret 9/13/2018

6 wk labs ALT 12 AST 18 V/L NOT DETECTED EOT 12/06/2018



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Aw, lovely for you Shemp, your first UND!, just one of many more, you will be UND now for the rest of your life. Good-bye virus, finally! So nice for you to have this first UND under your belt, makes all the past strife and hard work and unpleasantness a bit easier to take, seeing some tangible results. And just look at those really nice, teeny, tiny LFT's - wowie, so nice and low now compared to before! It's a lovely crash!

You look great Shemp!, even if you feel like you have been dragged backwards through a rosebush. Your attitude, strength, LFT's and UND and sense of direction is very, very good. You will get to where you want to go. Soon you will be finished!! 

Are you home for a while now, to rest up and maybe celebrate just a bit?

In honour of the great occasion of your first UND I highly recommend some nice long deep healing sleeps and/or as many impromptu naps as you can manage to fit it - maybe just the relief of reaching this first UND milestone will help you sleep a tad better tonight. Hope so. wink C.

Here ya go Shemp, this one's jes fer you - sleep tight. https://www.youtube.com/watch?v=wwxre4eFbb4



-- Edited by Canuck on Saturday 3rd of November 2018 03:19:09 AM



-- Edited by Canuck on Saturday 3rd of November 2018 03:40:13 AM

__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 63 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



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Shemp wrote:

Thanks Cheddy,

1979 was when I got it .I was diagnosed in 2000.They offered me clinical trials but I couldn't get myself to commit to experiments.Really glad I waited,hope my liver forgives me.


 really it's better that you waited for these new daa's cos they were created specifically for hcv

your whole body and mind thanks you for waiting



__________________

Gt:1a-36yrs .Started Intron-A in 96' for 2.5mo-VL still too high.taken off. Labs on 3.6.18:. A1 activity.  f3@60: fibrosur bloodtst. AFP=norm. enz=mostly norm.VL=3.9 million.sot=5.1.18>Harvoni>[8wks]: 4WEEKS=UND. Eot 6/25=Waiting for 3mo.VL.July=norm liverpanel.13weeks=UND



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Thanks Cheddy,

1979 was when I got it .I was diagnosed in 2000.They offered me clinical trials but I couldn't get myself to commit to experiments.Really glad I waited,hope my liver forgives me.



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62 yo male GT 1b/2 ALT 60 AST 51 V/L 985,000 Fibro A2 F 3/4 began 12 wks Mavyret 9/13/2018

6 wk labs ALT 12 AST 18 V/L NOT DETECTED EOT 12/06/2018



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Nice numbers, Shemp!  

40 years! Talk about waiting.  It must have been a shock when you even found out that you could be treated at all.

Really good news and good work, Shemp. Gear down and coast on down that hill..



__________________

GT2a, VL 681,500, Less than F1, Treatment Naive

12 wks Sovaldi/Ribavirin, SOT 2/25/16, EOT 5/17/16

UND at 2,4,8 and 12 wks during treatment but ribavirin crazy.

ALT/AST normal EOT

SVR12 8/13/2016!!!!!!!!!  I WON!!

EOT 6 Months 11/12/2016  CURED

 



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Thank you Iris,the good part about my Doc is I can steer him pretty easily.He doesn't object to my requests.5 more weeks till EOT and it's getting easier.This is a good day.



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62 yo male GT 1b/2 ALT 60 AST 51 V/L 985,000 Fibro A2 F 3/4 began 12 wks Mavyret 9/13/2018

6 wk labs ALT 12 AST 18 V/L NOT DETECTED EOT 12/06/2018



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    sweet music! CONGRATULATIONS Shemp, very glad for you!!!

Weirdness with the dr. thank goodness he was wrong.

Onward! 

Bb, Iris



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in the silence of the woods, you will not be alone- Chief Seattle

59 years on planet, Female, diagnosed 1978 as non-a non-b, VL 8mill+, Fibro f-1f-2, Genotype 1a, treatment naïve....UNTIL 7-01-18  !!!! started Harvoni 12 weeks. :)

4 weeks=UND, 8 weeks=UND, 12 weeks=UND (EOT= 09-23-2018)

Tig


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Anytime my friend! Here you go I just asked it if you’re on your way to SVR. The answer is clear!

 



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Tig

62 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 1-4 years!

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Thanks Tig,5.It's really is a feeling I'm still trying to get a grip on.Tig ,do you think I can borrow that magic 8 ball?There's this powerball thing I've been working on.It might help.



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62 yo male GT 1b/2 ALT 60 AST 51 V/L 985,000 Fibro A2 F 3/4 began 12 wks Mavyret 9/13/2018

6 wk labs ALT 12 AST 18 V/L NOT DETECTED EOT 12/06/2018

Tig


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Congrats, Shemp!! I knew it, my Magic 8 Ball told me so. I love that thing, it has never been wrong. Those are some mighty good numbers and of course that last little thing, “Undetected”, is the HCV Holy Grail! I’m glad you’re not on the road right now, you would’ve had to pull over or wreck, lol!

I’m thrilled to hear your great news, Brother. It’s all worth it!  

F358D600-4B94-413E-8DD1-9D55F9A995A1.jpeg



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Tig

62 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 1-4 years!

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shemp :w00t. , isn't it the best feeling ever??????????????

and yes... laugh and cry. it is that good!



-- Edited by 5-1-18 on Friday 2nd of November 2018 07:20:33 AM

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Gt:1a-36yrs .Started Intron-A in 96' for 2.5mo-VL still too high.taken off. Labs on 3.6.18:. A1 activity.  f3@60: fibrosur bloodtst. AFP=norm. enz=mostly norm.VL=3.9 million.sot=5.1.18>Harvoni>[8wks]: 4WEEKS=UND. Eot 6/25=Waiting for 3mo.VL.July=norm liverpanel.13weeks=UND



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I got Hep C via transfusion in 1979 after a car accident left me bleeding out of pretty much everywhere.40 years I've lived with the beast.But today the results are in.

 

ALT   12

AST   18

HCV RNA Quantitative    NOT DETECTED

I don't know whether to laugh or cry.I do know in this case Shakespeare is wrong.Parting is not sweet sorrow.And I hope the door hit ya really hard on the way out.Thank you all for your help and support.You have become part of my new life.That won't change.

 



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62 yo male GT 1b/2 ALT 60 AST 51 V/L 985,000 Fibro A2 F 3/4 began 12 wks Mavyret 9/13/2018

6 wk labs ALT 12 AST 18 V/L NOT DETECTED EOT 12/06/2018



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Canuck,

The reason my Doc gave me for doing bloods at 6 weeks was he put me on treatment for 12 weeks instead of 8.Guess he figured it was half way.As far as being sleep deprived goes,I don't sleep well to begin with.Mavyret seems to make it worse.5 1/2 or 6 hours is about the best I can do.Once I begin to wake up it's over,there's no going back to sleep.I did use the Ativan once in a while for stressful situations,like driving in New York city.It helped .I see I just got an e-mail from my lab.I'll keep you posted.



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62 yo male GT 1b/2 ALT 60 AST 51 V/L 985,000 Fibro A2 F 3/4 began 12 wks Mavyret 9/13/2018

6 wk labs ALT 12 AST 18 V/L NOT DETECTED EOT 12/06/2018



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Aw, that's a bugger, when yer waitin', and ya think "yay the labs have arrived" and then .... nope! (worse yet, add in a negative false-alarm, and then  it's ... just go back to waitin!). I always hated these waiting parts.

I thought it was a little funny that your doc was going to do your first on-treatment labs at week 6 (versus at week 4) but, that doesn't matter so much, weirder still was that he was only going to do a VL? at the 6 week mark, and he was not planning on doing LFT's at the same time? confuse, so, I think that was very good on your part to to expressly request that he also do the LFT's.

Your LFT's should have been back by now (I think), these VL's seem to be returning more and more quickly nowadays, but generally the LFT's have always seemed to arrive back the quickest, and usually surface within days and often arrive back before the VL's return. 

Shouldn't be much longer though before you get some good news coming back to you.

So you said you were sleep-deprived .... cuzzzzz... why?, insomnia?, worried/waiting for results?, just wired for no good reason?, how did it work out BTW using the ativan - did you have to avail yourself upon it very many times to relax?? Did you take the ativan like a "sleeping pill", or, how did you end up best utilizing it.

I recall how I agonized over getting my lab results back in a timely fashion, even some of the very first assessment ones, not just the on-treatment or post-treatment ones. One time the lab completely missed taking a sample and I was going crazy waiting for the results to return (I actually had to figure that one out for them!), another time the staff (for the longest time) just did not know where or how to look to find the results that were there! (argh!), another time ... bloods drawn in one part of my Province (in one health jurisdiction) never routinely get forwarded out to a different doc, if that doc is in another part of the Province (in a different health jurisdiction) - a specific request has to be made or else the info will never travel! Another time, for the life of me I could NOT understand why my first VL and GT came back missing the GT, I had been fretting over what the load would be - dreamt about it, a nightmare that it was one million!, results came in ... 10 million, bugger, and no GT!, man ... I was  frustrated, I kept going back to reception and asking and asking for "when does the GT part arrive?", "nope, nothing has come in today" she kept saying, "nope, not today either" she would report ... while i waited for the non-returning GT to return, I kept studying the big dismal-looking 10 million VL number on the page over and over, sigh!, funny though, when i noticed ...  way, way far away from every other typed word on the page, separated away from the main body of info on the page, standing alone, all by itself, were 2 keystrokes .... no heading, no capitalization, no explanation - just this way-up-in-the-corner (in a vast sea of otherwise white mostly blank paper), a tiny  "3a". Duh, and boo.

You can look forward to good news, right shortly, it makes the wait all the more rewarding.

Are you off work for a while now?? Can you stay home and rest up a bit, or, after you get your good news are you going to go out again? How are you physically feeling now? I am really hoping the last half of your mav is going to go faster and easier for you.  smile C.

 

 



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 63 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



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Tig.

Ya we can go with that.And snowbirds are migrating back.I noticed a lot more volume at the lab.But,for that one fleeting moment I was whistling zip a dee doo da from my,well you get it.So far it's been the high point of my day.I'm guessing a couple more days.



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62 yo male GT 1b/2 ALT 60 AST 51 V/L 985,000 Fibro A2 F 3/4 began 12 wks Mavyret 9/13/2018

6 wk labs ALT 12 AST 18 V/L NOT DETECTED EOT 12/06/2018

Tig


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Hey Shemp,

Funny, but not funny! I can feel your pain and aggravation. That seems a cruel way to start someone’s day. Is this the first time you used their portal? Could be it was the first message notifying you the portal access was now active and listed your previous results. Let’s go with that! I know your coming results will be far better than the pre treatment numbers. It shouldn’t take more than 3-5 days to get them back. Stand by....



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Tig

62 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 1-4 years!

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Picture this if you will.It's 5 am.A man sits in front of his laptop.The pale light illuminates his bloodshot,sleep deprived eyes.It's the only light in the house.He checks his e-mail.There is one from his lab saying the results of his bloodwork are in.What sort of magic is this, he wonders.He only had blood drawn 3 days ago.Could it be that the lab people were this efficient?He logs into his lab account.It says results from tests on 10/29.Oh happy day.He begins to read.ALT high AST high Fibroscore unchanged V/L unchanged.(deflating balloon sound here) Heeey... wait a minute.He scrolls back up to the top of the page and finds..... the date of the test is actually before TX.Way to go lab.They sent the same results from 2 months ago.Oh well,he did have that Christmas morning feel,if only for a moment.He'll keep you posted.Thanks for letting me vent.



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62 yo male GT 1b/2 ALT 60 AST 51 V/L 985,000 Fibro A2 F 3/4 began 12 wks Mavyret 9/13/2018

6 wk labs ALT 12 AST 18 V/L NOT DETECTED EOT 12/06/2018



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Thanks Tig,

GREAT to have ya back.



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62 yo male GT 1b/2 ALT 60 AST 51 V/L 985,000 Fibro A2 F 3/4 began 12 wks Mavyret 9/13/2018

6 wk labs ALT 12 AST 18 V/L NOT DETECTED EOT 12/06/2018

Tig


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Hey Shemp,

I just got back, too. I‘m glad to be back... What a trip! More info on that later. I’ve got some catching up to do around here. 

I know you’ll be pleased with the blood test results. They always show significant improvements and that alone is a great morale booster. Stand by to crest that hill and hit the Jake! (Just to let them hear you coming, ha!) The ride down is a lot easier to your finish line.



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Tig

62 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 1-4 years!

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  World travels?... that must be some truck wink biggrin

better days! yeah! keep on trucking!

bb, Iris

 



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in the silence of the woods, you will not be alone- Chief Seattle

59 years on planet, Female, diagnosed 1978 as non-a non-b, VL 8mill+, Fibro f-1f-2, Genotype 1a, treatment naïve....UNTIL 7-01-18  !!!! started Harvoni 12 weeks. :)

4 weeks=UND, 8 weeks=UND, 12 weeks=UND (EOT= 09-23-2018)



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 Thanks for checking in Shemp, good to hear from you! glad you're feeling better  



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F, 51, GT3, HCV since 1989, no alcohol since 1999, Fibrosis score F0-1 (.36), VL 216,000, ALT 23, AST 26, Epclusa SOT 7/26/18 EOT 10/18/18. Thank you God. 



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welcome back shemp, so glad you are having more good days than bad



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Gt:1a-36yrs .Started Intron-A in 96' for 2.5mo-VL still too high.taken off. Labs on 3.6.18:. A1 activity.  f3@60: fibrosur bloodtst. AFP=norm. enz=mostly norm.VL=3.9 million.sot=5.1.18>Harvoni>[8wks]: 4WEEKS=UND. Eot 6/25=Waiting for 3mo.VL.July=norm liverpanel.13weeks=UND



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Hi y'all

Just got back home from my world travels last night.I have my 6 weeks bloods today.It seems to be getting easier but I still have an off day now and then.I'll keep you posted.



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62 yo male GT 1b/2 ALT 60 AST 51 V/L 985,000 Fibro A2 F 3/4 began 12 wks Mavyret 9/13/2018

6 wk labs ALT 12 AST 18 V/L NOT DETECTED EOT 12/06/2018



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Oh lucky you Shemp, not that we want you to need them....so still opt for you to go to a fine dining place with Tig biggrin

I had to take my pills every 12 hours so no Tums for me for 3 months.... but...hcvfree makes it  worth it. smile



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60y/o, Infected via transfusion Oct'83, GT-1a, F-4 cirrhotic,
tx Holkira pak/moderiba 12 weeks

2.5years...post tx... successful dragon slayer 



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Iris,

There are plenty pf women your age driving trucks.My wife was my co-driver for 12 years.She's 4'11 100 lbs and she could truck with the best of them.Go for it.



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62 yo male GT 1b/2 ALT 60 AST 51 V/L 985,000 Fibro A2 F 3/4 began 12 wks Mavyret 9/13/2018

6 wk labs ALT 12 AST 18 V/L NOT DETECTED EOT 12/06/2018



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Nothing wrong with Dairy Queen.  I love the kale and artichoke shakes.  'Glad your packing fresh food.

Best.



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GT2a, VL 681,500, Less than F1, Treatment Naive

12 wks Sovaldi/Ribavirin, SOT 2/25/16, EOT 5/17/16

UND at 2,4,8 and 12 wks during treatment but ribavirin crazy.

ALT/AST normal EOT

SVR12 8/13/2016!!!!!!!!!  I WON!!

EOT 6 Months 11/12/2016  CURED

 



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Canuck,

My sides seem to be getting better.Just finished my last delivery in Boston so I can put my feet up for a day or two.The world won't end if I hang up the keys for a while longer.There will just be a few less cars in my driveway.I appreciate your concern.



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62 yo male GT 1b/2 ALT 60 AST 51 V/L 985,000 Fibro A2 F 3/4 began 12 wks Mavyret 9/13/2018

6 wk labs ALT 12 AST 18 V/L NOT DETECTED EOT 12/06/2018



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Hey Observer,

My Doc says I can take tums or prilosec as long as it's 12 hours after my meds.Guess I need to dust of the crystal ball.



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62 yo male GT 1b/2 ALT 60 AST 51 V/L 985,000 Fibro A2 F 3/4 began 12 wks Mavyret 9/13/2018

6 wk labs ALT 12 AST 18 V/L NOT DETECTED EOT 12/06/2018



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Tig,

If you're going to Atlanta,there's a great BBQ joint on Marrietta St. just down from the CNN building.Check it out



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62 yo male GT 1b/2 ALT 60 AST 51 V/L 985,000 Fibro A2 F 3/4 began 12 wks Mavyret 9/13/2018

6 wk labs ALT 12 AST 18 V/L NOT DETECTED EOT 12/06/2018



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Hoodie, 

you're always such an inspiration.Sometimes I feel like Mel Gibson in the Road Warrior.Glad you're feeling better though.Happy EOT !!!



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62 yo male GT 1b/2 ALT 60 AST 51 V/L 985,000 Fibro A2 F 3/4 began 12 wks Mavyret 9/13/2018

6 wk labs ALT 12 AST 18 V/L NOT DETECTED EOT 12/06/2018



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Cheddy,

I did stock the fridge in my truck with lot of fruits and veggies.And plenty of water.Whats wrong with Dairy Queen?



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62 yo male GT 1b/2 ALT 60 AST 51 V/L 985,000 Fibro A2 F 3/4 began 12 wks Mavyret 9/13/2018

6 wk labs ALT 12 AST 18 V/L NOT DETECTED EOT 12/06/2018



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5-1,

Great to hear from you to.I trust all is going well.



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62 yo male GT 1b/2 ALT 60 AST 51 V/L 985,000 Fibro A2 F 3/4 began 12 wks Mavyret 9/13/2018

6 wk labs ALT 12 AST 18 V/L NOT DETECTED EOT 12/06/2018



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I always wanted to be a truck driver, there was a school of trucking when I was around 17-18 advertised on the tv all the time but my parents said girls don't drive trucks and wouldn't pay for the school. It still is a fancy of mine but how may 60 year old women are just starting out on that sort of work?? 

Anyway, wanted to send you my best, glad to hear you are feeling a bit better Next time you are at the junction of  CA. hwy 395 and 58, try the Roadhouse at Kramer junction, my Grandmother would always get some pie she said it was the best.

BB, Iris



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in the silence of the woods, you will not be alone- Chief Seattle

59 years on planet, Female, diagnosed 1978 as non-a non-b, VL 8mill+, Fibro f-1f-2, Genotype 1a, treatment naïve....UNTIL 7-01-18  !!!! started Harvoni 12 weeks. :)

4 weeks=UND, 8 weeks=UND, 12 weeks=UND (EOT= 09-23-2018)

Tig


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You make a valid point, Obs! Guess that means we’ll be eating in the finest of restaurants. After all, we wouldn’t want to risk Shemp’s treatment with ill advised indigestion mishaps! I guess waiting four hours after eating to take a rescue antacid would be kind of painful. Ha, ha! Looks like you get to pick the place, Shemp. Make it a good one!



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Tig

62 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 1-4 years!

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Ummmmm...Tig 

i dont think Shemp can share Tums with you while hes on treatment. (unless theyve changed the rules) wink

Shemp, it must be really hard to eat healthy on the road, but hopefully with 25 years of driving you must know a few good places to get a decent dinner smile

Take care

 

 



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60y/o, Infected via transfusion Oct'83, GT-1a, F-4 cirrhotic,
tx Holkira pak/moderiba 12 weeks

2.5years...post tx... successful dragon slayer 



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Shemp,

Don't believe everything we say!

Speaking of less-than-ideal eateries, I have found (most of the time) I have actually enjoyed hospital food! OH dear, now what on earth could THAT tell ya! other than I am a terrible cook! I hope Tig's rig has a CB in it, then you can give him a handle like Big-Tums-Buddy and tell him where to go (heehee), I guess you always have to pack some of your own foods when you are trucking eh?  

Now about sides, according to most people, it's only the first couple/few weeks that most people have trouble with sides or getting used to DAA's. According to Hoodie and lamassu it is actually only the last couple weeks you don't notice sides, ha!, and for me ... I noticed nothing very pleasant for 12 weeks! - I just got into a routine with it and rolled with it's punches. You can do the same, keep making modifications as required, no matter how it keeps rolling out for you - you have some options you can turn to - EOT is not that many weeks away. At that milestone, you will have less and less need to have to make any modification, to have things cramp your normal style and routines. It will NOT be the end of the world if you hang up the keys again for a while. C.

 

 



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HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 63 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)

Tig


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NEW JERSEY?? That has to be stressing just crossing the state line, lol! Sounds like you had to take the scenic route to get there and then some. I’m heading into Atlanta tomorrow morning and picking up a Class A bus for a drive through GA, NC, WV and TN. Maybe we’ll run into each other at some gut bomb joint along the way! We can share some Tums together...

Slow and steady is the key. Don’t let them run you ragged. Take every chance you get to put your feet up for a few minutes. I hope you get some rest tonight and a decent meal. Be careful out there, Brother!



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Tig

62 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 1-4 years!

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Great to hear from you Shemp!  Keep on trucking road warrior  I started feeling much much better at the 10 week mark and I just read a post from a guy named lamasu who said the same thing. We were told when we first start taking these meds that the first couple weeks can be a rough period of adjustment. For some of us that first couple weeks is prolonged for about 10 weeks, but I did eventually start feeling better and I trust you will too. Hang in there!



-- Edited by Hoodietree on Thursday 18th of October 2018 10:30:00 AM

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F, 51, GT3, HCV since 1989, no alcohol since 1999, Fibrosis score F0-1 (.36), VL 216,000, ALT 23, AST 26, Epclusa SOT 7/26/18 EOT 10/18/18. Thank you God. 

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