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Post Info TOPIC: Mavyret and Me


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RE: Mavyret and Me
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EOT in 4 days HOOYAH!



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Male, 65, Dx 1990, GT 2a/2c. Pre-tx VL 11,500,000, ALT 10, AST 18, F3, 12.4 kPa. Rx: 12 weeks Epclusa, SOT 3/8/18, EOT 5/30/18. Week 2 VL 50, ALT 12, AST 21. Week 10 VL not detected, ALT 12, AST 18. EOT + 12 weeks: VL not detected, ALT 11, AST 19. EOT + 24 weeks VL not detected, ALT 9, AST 24.



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Iris,5-1,thanks for the get well wishes.I'm much better now.Lamassu,Canuck is this your way of telling me I need to start acting my age?Cause thats NEVER gonna happen.Seriously though,that is good advice and I should have known better.TX is kind of uncharted territory and I didn't know what to expect.My Doc never mentioned it.I had so many what-if's floating around in my brain,it just never occurred to me to get a flu shot.Hindsight really is 20/20.



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62 yo male GT 1b/2 ALT 60 AST 51 V/L 985,000 Fibro A2 F 3/4 began 12 wks Mavyret 9/13/2018

6 wk labs ALT 12 AST 18 V/L NOT DETECTED EOT 12/05/2018 NOT DETECTED



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I think that could be correct shemp, what you said, that just going through/being on tx, can put us at a disadvantage for a while. (Not the meds to blame exactly per say, but just all this stress of undergoing a bigtime treatment of our HCV, and our resources swinging widely within the pendulum of fighting for wellness, we need time to come back into balance). We arrive to treatment disadvantaged with this health burden and all that HCV can do to us, keeping our bodies very busy and taxed, we can already be in a depletion state, and maybe even more so we can arrive to EOT depleted. A lot of us have experienced some issues of this and that, some big, some minor, all bothersome and maybe curious or worrisome, unpleasant anyway after EOT! Succumbing to infections/cold/flus, skin things (sinus things such as 5 is going through right now), sometimes old complaints exacerbate - but we see people reporting that these maladies that are experienced while we are in hepc recovery, do stop occurring. Some people are more easily disadvantage than others, other get off much lighter with very few penalties. I too used to brag about NEVER or rarely getting flu or colds much, not like those poor folk who always seem to get them every year like clockwork or multiple times per year!, but as i aged and the longer I had unknowingly been packing this health robbing HCV around for decades, things were starting to catch up with me in the flu and cold karma dept., I started to get the odd cold and flu - so, lucky for me!, once i realized i had HCV, that was the good deciding factor for me to start getting immunized, for everything possible! And I will continue doing so, I certainly wish to avoid cold and flu if i can, prior, being so spoiled not having them. I was kinda a sickly kids with lots of other kinds of infections - kidneys, bronchitis, tonsillitis over and over again, thankfully i seemed to slowly outgrow those things in adulthood. So, in recent times I especially did not welcome any increasing bouts of colds and flu that I was starting to get! I will keep getting my flu shots - these last 3 years now I've gone every year for my a flu shot.

Some days feel very long don't they! - I bet your 5 days or so, before you sensed your flu starting to weaken, must have felt long and yuck! Yay for your immune system taking care of you, and for you, taking good care of you. : ) C. 



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HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 63 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



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oh no tig and shemp . i'm keeping my woes at bay with the antihistamine and ibuprophen and feeling thankful.

tig, did you get antibiotics yet? bronchitis gets better sooner with them, maybe only with them.

hang in there shemp, anitbiotics can't help your woes.

get well soon guys



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Gt:1a-36yrs .Started Intron-A in 96' for 2.5mo-VL still too high.taken off. Labs on 3.6.18:. A1 activity.  f3@60: fibrosur bloodtst. AFP=norm. enz=mostly norm.VL=3.9 million.sot=5.1.18>Harvoni>[8wks]: 4WEEKS=UND. Eot 6/25=L.July=norm liverpanel.13weeks=UND + 6 months =UND: CLUB ZERO



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Hey there Mr. Shemp, glad to hear you are feeling better. Seems really unfair to get so ill this close to the finish line. Best wishes!, Iris



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in the silence of the woods, you will not be alone- Chief Seattle

60 years on planet, Female, diagnosed 1978 as non-a non-b, VL 8mill+, Fibro f-1f-2, Genotype 1a, treatment naïve....UNTIL 7-01-18  !!!! started Harvoni 12 weeks. :)

4 weeks=UND, 8 weeks=UND, 12 weeks=UND (EOT= 09-23-2018)



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Shemp,

Thanks for the clarification. Glad you are feeling better. I think it is essential when you are over 60 to get a yearly flu shot before the end of October as advised by the CDC. Since I am 65 the shot is even free on Medicare. Cheap insurance against a miserable bout with the flu. Surprised the doc who is treating your Hep C did not insist on it.



-- Edited by lamassu on Saturday 1st of December 2018 06:01:44 PM

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Male, 65, Dx 1990, GT 2a/2c. Pre-tx VL 11,500,000, ALT 10, AST 18, F3, 12.4 kPa. Rx: 12 weeks Epclusa, SOT 3/8/18, EOT 5/30/18. Week 2 VL 50, ALT 12, AST 21. Week 10 VL not detected, ALT 12, AST 18. EOT + 12 weeks: VL not detected, ALT 11, AST 19. EOT + 24 weeks VL not detected, ALT 9, AST 24.



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Oh boy.  Sickly Season.  It can be so overwhelming.  Unfortunately, there is nothing to do but let it run it's course and give yourself enough time and rest.   I hope you have some remedies help to give it the boot.  

Shemp, this sounds awful.  I can't imagine getting the crud while on treatment. I hate that overmedicated feeling. It's like you can't find your own self in the midst of a thick fog. I felt lost and fearful that it was permanent.  Good to be wrong. I had a pretty quick return, especially at about 3 months, and let me tell you, finding your old self is a thrill! I'm glad you are so close to end and onto the next phase of natural recovery.

It's a funny thing, feeling like your'e whining when you know others have had it worse.  It helps me count my blessings, but everybody's own life is as real as it gets.  When you feel sh*tty, you feel sh*tty.  Just don't get stuck.  Another case of moving through it.

Besides, you've been plenty optimistic for others.

Tig and gang,  It's time to brush up those old party boots.  There's a happy dance coming up for Shemp.  Right??  



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GT2a, VL 681,500, Less than F1, Treatment Naive

12 wks Sovaldi/Ribavirin, SOT 2/25/16, EOT 5/17/16

UND at 2,4,8 and 12 wks during treatment but ribavirin crazy.

ALT/AST normal EOT

SVR12 8/13/2016!!!!!!!!!  I WON!!

EOT 6 Months 11/12/2016  CURED

 



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Thanks guys,Tig I feel for ya.You have to be careful that nasty bug can turn to pleurisy or pneumonia.There's a better way to get that six pack.Excercise,or just go to the 7-11.Seriously,if you can get a nebulizer and some albuterol it will help a bunch. My wife got that every winter,it ended her driving career.I can't remember the last time I had the flu but I know I haven't had a flu shot in about 15 years.I just don't usually get sick.Maybe the changes in my body because of TX.I dunno.Hoodies virtual chicken soup works wonders.



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62 yo male GT 1b/2 ALT 60 AST 51 V/L 985,000 Fibro A2 F 3/4 began 12 wks Mavyret 9/13/2018

6 wk labs ALT 12 AST 18 V/L NOT DETECTED EOT 12/05/2018 NOT DETECTED



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(((((((Tig))))))) that bronchitis sounds super rough. Please take good care and continue checking in. Have some virtual chicken soup and hugs from me!



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F, 51, GT3, HCV since 1989, no alcohol since 1999, Fibrosis score F0-1 (.36), VL 216,000, ALT 23, AST 26, Epclusa SOT 7/26/18 EOT 10/18/18. Thank you God. 



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Hi Shemp,

Did you just forget to get your flu shot or did you get the flu even with the vaccination? Glad to hear you are feeling better.



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Male, 65, Dx 1990, GT 2a/2c. Pre-tx VL 11,500,000, ALT 10, AST 18, F3, 12.4 kPa. Rx: 12 weeks Epclusa, SOT 3/8/18, EOT 5/30/18. Week 2 VL 50, ALT 12, AST 21. Week 10 VL not detected, ALT 12, AST 18. EOT + 12 weeks: VL not detected, ALT 11, AST 19. EOT + 24 weeks VL not detected, ALT 9, AST 24.

Tig


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Hi Shemp,

Glad to hear you’re past the worst of it. I on the other hand have what I believe is bronchitis. No fever, but awful trouble breathing, productive constant cough. So much so, I think I’m developing that abdominal 6 pack that has eluded me my entire life! I cough so much my ribs hurt. Sounds like we have a few people around here that have been afflicted by one thing or another. ‘‘Tis the season I guess, but that doesn’t make it any easier to tolerate. 

You‘re right about your meds clearing quickly. Within a week and you’ll be drug free. The time it takes you to get back to normal is purely subjective. Some feel different right away, but more often than not, you’ll adjust back to your normal slowly. Your system went through a thorough Dragon stomping cleanse. Even though you experienced little in the way of side effects, your system (internally) got creamed. It took time to ramp up and it’ll take time to smooth out. The things damaged by years of chronic infection and damage don’t repair overnight, but I assure you, they’re under repair now. Some things resolve completely, but others take time and some not completely. The good thing is, now you have everything going for you. A virus free body, a happy, healthier liver and the open road in front of you!

It’s gonna be a great new year



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Tig

62 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 1-4 years!

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Glad youre over the flu Shemp.  In my experience you can expect to feel better in a few weeks after EOT. Sorry I know that seems like a long my time. Maybe youll feel better sooner though especially in contrast to the sickness of the flu. Hugs and best wishes



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F, 51, GT3, HCV since 1989, no alcohol since 1999, Fibrosis score F0-1 (.36), VL 216,000, ALT 23, AST 26, Epclusa SOT 7/26/18 EOT 10/18/18. Thank you God. 



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I think I'm finally over the flu,thank God.My wife didn't come down with it(a miracle).It's really wiped me out.5 days till EOT.Right now I feel very tired and really,really medicated.I guess 11 weeks of super meds will do that.I'm hoping after I'm done with the meds the super medicated feeling will end.If I have my info right it should take 4-5 days for my system to clear the meds.I wonder what that will feel like?I really should stop whining,when I think about Tig and others that have gone through the stone age TX.my road has been a blessing.Just wanted to update and thank you all for your help and support.



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62 yo male GT 1b/2 ALT 60 AST 51 V/L 985,000 Fibro A2 F 3/4 began 12 wks Mavyret 9/13/2018

6 wk labs ALT 12 AST 18 V/L NOT DETECTED EOT 12/05/2018 NOT DETECTED



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Thanks 5-1,feelin a bit better today.I hope I my wife doesn't come down with it.I've been telling her to stay away from me.In a nice way(of course)



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62 yo male GT 1b/2 ALT 60 AST 51 V/L 985,000 Fibro A2 F 3/4 began 12 wks Mavyret 9/13/2018

6 wk labs ALT 12 AST 18 V/L NOT DETECTED EOT 12/05/2018 NOT DETECTED



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shemp, i'm so glad you are on the mend from the flu. 

i'm happy to say i have been able to donate twice and will continue weekly donations for a while.

i hope you feel well soon.



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Gt:1a-36yrs .Started Intron-A in 96' for 2.5mo-VL still too high.taken off. Labs on 3.6.18:. A1 activity.  f3@60: fibrosur bloodtst. AFP=norm. enz=mostly norm.VL=3.9 million.sot=5.1.18>Harvoni>[8wks]: 4WEEKS=UND. Eot 6/25=L.July=norm liverpanel.13weeks=UND + 6 months =UND: CLUB ZERO



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Thanks for the love guys.The sides from TX make you feel like crap but having the flu on top of that brings it to a whole new level.Fever hit 102 last evening and finally broke thank God,Feeling better today but very drained.Maybe it was Hoodies virtual chicken soup.I'd like to ask anybody who can help Ziggy and the people of the Cal.fires,please do so.I can relate having lived through many devastating hurricanes in FL.This is just the start of a long uphill battle for them.PLEASE help if you can.



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62 yo male GT 1b/2 ALT 60 AST 51 V/L 985,000 Fibro A2 F 3/4 began 12 wks Mavyret 9/13/2018

6 wk labs ALT 12 AST 18 V/L NOT DETECTED EOT 12/05/2018 NOT DETECTED



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ew. flu's. yuck. Really too bad. ya, the epsom salts bath sounds therapeutic, maybe. Water, in all forms, from immersions to heat paks to drinkable, you think would be helpful. Here's to short lived afflictions, I hope mighty short. C.



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HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 63 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

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get well soon shemp and tig. take it easy and hydrate... smart water is easy

 



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Gt:1a-36yrs .Started Intron-A in 96' for 2.5mo-VL still too high.taken off. Labs on 3.6.18:. A1 activity.  f3@60: fibrosur bloodtst. AFP=norm. enz=mostly norm.VL=3.9 million.sot=5.1.18>Harvoni>[8wks]: 4WEEKS=UND. Eot 6/25=L.July=norm liverpanel.13weeks=UND + 6 months =UND: CLUB ZERO



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Hope you feel better soon Shemp.

Agree with Iris and everyone else, good call on nixing the abx. Curious if you got a flu shot this year, just as a data point. We can still catch random flu strains, right, even after getting that precautionary shot.  no sense borrowing trouble but of course I always worry. 

Will have to keep Iriss recipe handy just in case

Let us know how youre doing, k? Check back in so we can give you hair pats and virtual chicken soup



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F, 51, GT3, HCV since 1989, no alcohol since 1999, Fibrosis score F0-1 (.36), VL 216,000, ALT 23, AST 26, Epclusa SOT 7/26/18 EOT 10/18/18. Thank you God. 

Tig


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Hey Shemp,

I agree, give the antibiotics a pass. Iris is right, taking them for the wrong reason will cause all kinds of hate and discontent within your system! I have been down with a nasty chest cold all week, so I can relate to the feeling you’re having. I don’t get sick very often, but when I do, I don’t screw around! I hope you’re feeling better soon, Brother...



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Tig

62 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 1-4 years!

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Thanks Cheddy,I didn't even want to think FLU.But I can't ignore the symptoms.I do have a nurse advocate from Abbvie.Guess I give her a ring.



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62 yo male GT 1b/2 ALT 60 AST 51 V/L 985,000 Fibro A2 F 3/4 began 12 wks Mavyret 9/13/2018

6 wk labs ALT 12 AST 18 V/L NOT DETECTED EOT 12/05/2018 NOT DETECTED



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Oh no.  The worst day.  Well, it does sound like you are describing flu symptoms - fatigue, achy bones, even the teeth.  I had something similar while in NYC.  It was quick, except the fatigue.

I agree completely with Iris' comments below.  Antibiotics are for infections, not viral illness, and you need a full run when you do take them.  Otherwise the infectious bacteria can become resistant.  Her recipe sounds like a really good idea.  Personally, I would take ibuprofen, too.

Beyond that, I don't know what the specific drug interactions with treatment (say Theraflu or the like), and specifically the interactions with Mavyret.  Do they have a number you can call?

Well, Shemp, you're near the end. I was hoping you would skate through, but your whole body is getting hit with a powerful treatment ingested specifically for the liver.

Ray of sunshine: less than 2 weeks to go! Then the next level of healing begins.  It's not for the faint of heart, is it?  I just crawled over the finish line.  Then I saw the entire sun.

Hang in there  - and REST!  I  recommend old movies or audio books for distraction.  An epson salt bath might be nice, too.

 

Note: when I go into a clinic or even on an airplane, I use the hand sanitizer around my nostrils in addition to my hands. 



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GT2a, VL 681,500, Less than F1, Treatment Naive

12 wks Sovaldi/Ribavirin, SOT 2/25/16, EOT 5/17/16

UND at 2,4,8 and 12 wks during treatment but ribavirin crazy.

ALT/AST normal EOT

SVR12 8/13/2016!!!!!!!!!  I WON!!

EOT 6 Months 11/12/2016  CURED

 



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Thanks Iris,I really didn't think antibiotics was the way to go.You know how it is when you're feeling bad.just looking for a ray of sunshine.



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62 yo male GT 1b/2 ALT 60 AST 51 V/L 985,000 Fibro A2 F 3/4 began 12 wks Mavyret 9/13/2018

6 wk labs ALT 12 AST 18 V/L NOT DETECTED EOT 12/05/2018 NOT DETECTED



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Ikes!!!, do not take the amoxicillin! Antibiotics are only for infections and the full course must be taken when prescribed.  If you have leftovers someone did not take all of their Rx as prescribed. Taking antibiotics when not needed creates resistance to them.

You likely did pick up a bug at the dr. I cannot say for sure what kinds of over the counter cold meds are ok. But I'll tell you what I took a few times to nip an oncoming cold in the butt while I was on treatment, or even after one is ill... take a glass of water and put 1 tablespoon of honey, 1 tbs. lemon or lime (fresh squeeze), 1 tbs. cider vinegar, a pinch of salt, and generous (as much as you can stand) cayenne pepper and ginger. (I used powedered) stir well, and down the hatch!

Hope you feeling better soon! And thanks for the B-day wish, bb, Iris



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in the silence of the woods, you will not be alone- Chief Seattle

60 years on planet, Female, diagnosed 1978 as non-a non-b, VL 8mill+, Fibro f-1f-2, Genotype 1a, treatment naïve....UNTIL 7-01-18  !!!! started Harvoni 12 weeks. :)

4 weeks=UND, 8 weeks=UND, 12 weeks=UND (EOT= 09-23-2018)



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Happy birthday to all,and a belated happy thanksgiving.I was really out of it yesterday,worst day I've had in 10wks.I don't know how much of may be sides related.or if I'm coming down with something.I did go to my Docs office Monday.I don't like dr's offices(too many sick people).Since them it's been a slow slide downhill.Very fatigued,every bone in my body hurts,my teeth hurt and I have a low grade fever past 2 nights.If I am coming down with something,I don't know if I can take anything for it.I have some amoxicillin,and there are no drug interactions I can find,but do I really want to do that?I'm hoping this very learned group can shed some light on being sick while in TX.I have 13 days to go and am determined to see this through to the end.Any insight would be great.



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62 yo male GT 1b/2 ALT 60 AST 51 V/L 985,000 Fibro A2 F 3/4 began 12 wks Mavyret 9/13/2018

6 wk labs ALT 12 AST 18 V/L NOT DETECTED EOT 12/05/2018 NOT DETECTED



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Shemp wrote:

Had my follow up Doc app.today and he didn't tell me anything I didn't already know.Enzyme levels good, and undetected.He doesn't want to do bloods at EOT because he says the new DAA's are so effective it's not necessary.Mid March will be 12 wks after EOT so i'll just have to wait till then.17 days to go.


 they did that to me too. tested UND at 4 weeks then told to wait till the 3 months eot. it was still UND, so i think they are finding new standards for testing.



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Gt:1a-36yrs .Started Intron-A in 96' for 2.5mo-VL still too high.taken off. Labs on 3.6.18:. A1 activity.  f3@60: fibrosur bloodtst. AFP=norm. enz=mostly norm.VL=3.9 million.sot=5.1.18>Harvoni>[8wks]: 4WEEKS=UND. Eot 6/25=L.July=norm liverpanel.13weeks=UND + 6 months =UND: CLUB ZERO



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Yuck.  I hate waiting, but I see his point.  The space between EOT and SVR12 can leave you hanging.  For some people it's an anxious time.  However, I am pleased to hear that we have reached a point in time where DAAs are are becoming so reliable that a doctor can feel that confident.  Personally, I would insist on the test as kind of a chill pill.  One day, we will panic no more - sigh. 

Yeah NYC is overfilled maze.  No way I would drive there and I'm glad to be in the peace and quiet of my own home.

Thanks for sharing your love story.  35 years of friendship is a remarkable thing.

Get some rest, pal.



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GT2a, VL 681,500, Less than F1, Treatment Naive

12 wks Sovaldi/Ribavirin, SOT 2/25/16, EOT 5/17/16

UND at 2,4,8 and 12 wks during treatment but ribavirin crazy.

ALT/AST normal EOT

SVR12 8/13/2016!!!!!!!!!  I WON!!

EOT 6 Months 11/12/2016  CURED

 



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Had my follow up Doc app.today and he didn't tell me anything I didn't already know.Enzyme levels good, and undetected.He doesn't want to do bloods at EOT because he says the new DAA's are so effective it's not necessary.Mid March will be 12 wks after EOT so i'll just have to wait till then.17 days to go.



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62 yo male GT 1b/2 ALT 60 AST 51 V/L 985,000 Fibro A2 F 3/4 began 12 wks Mavyret 9/13/2018

6 wk labs ALT 12 AST 18 V/L NOT DETECTED EOT 12/05/2018 NOT DETECTED



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Thanks for the warm welcome back.The truth is she doesn't push me at all.The honey -do list is more of a things I've been meaning to do list.She was my co-driver for 12 years,and understands that my life on the road isn't exactly(as seen on tv).When you spend 24/7 in a confined space that doesn't stop for 3 days except for fuel,you better be really good friends.Been that way for 35 years we've been together.So get that image of a cruel woman with a whip out of your heads.Hmmm.I won't go there.So this week no schedule, no hurry,no worries.



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62 yo male GT 1b/2 ALT 60 AST 51 V/L 985,000 Fibro A2 F 3/4 began 12 wks Mavyret 9/13/2018

6 wk labs ALT 12 AST 18 V/L NOT DETECTED EOT 12/05/2018 NOT DETECTED



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Welcome back Shemp! Glad you and your wife are on such good terms that the honey do list is something you like to do or at least arent complaining about too terribly much. Thats really nice



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F, 51, GT3, HCV since 1989, no alcohol since 1999, Fibrosis score F0-1 (.36), VL 216,000, ALT 23, AST 26, Epclusa SOT 7/26/18 EOT 10/18/18. Thank you God. 



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welcome back shemp. i'm so glad to hear you had 6 good days and only the one bad....... and that you drove thru tx like a champ

i hope you have some time off before your next trip and can just relax a bit



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Gt:1a-36yrs .Started Intron-A in 96' for 2.5mo-VL still too high.taken off. Labs on 3.6.18:. A1 activity.  f3@60: fibrosur bloodtst. AFP=norm. enz=mostly norm.VL=3.9 million.sot=5.1.18>Harvoni>[8wks]: 4WEEKS=UND. Eot 6/25=L.July=norm liverpanel.13weeks=UND + 6 months =UND: CLUB ZERO



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Jes splain to her, that we all keep pushing you and saying to you, that you simply must keep trying to pace yourself, get decent stress-free rest periods (during work and at home) that allow you best to cure/ heal, and deal with the viral war and aftermath you are going through, and to retain some reserve for yourself (physically and psychologically). She should understand, just explain it to her, your temporary needs. She wants you to be well too, it will not be must longer that you will be under the demanding/duressing effects of this cure, and not too much longer after that, that you will be in a recovery period. You should be the priority right now, as much as possible (not things, duties and obligations), this process of getting rid of the hepc will not last forever, this is temporary, after recovery you will have the rest of your healthier life to catch up on what needs to get done. Keep trying to conserve, pace and treat yourself as well as you possibly can. 

Your comment about it being cold/rainy, and that influencing you to not want to drink water on days like those? ... if I heat my water (on cold rainy days), it being hot/warm, I found that I welcome the water more that way - soothing, warming. smile C.



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 63 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)

Tig


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Enjoy your week off, Shemp! Sounds like you need a rest, but I’m not sure a honey-do list that long will allow it. At least all that work will be on your time and schedule, not dispatch. Momma might drive you harder though, ha, ha! I know you’ll prevail

PS: Coffee counts as water, just control the caffeine. Actually, coffee is extremely beneficial to the liver! 



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Tig

62 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 1-4 years!

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Thanks Cheddy,It was pretty much the week from hell workwise.7 days 2900 miles. Left the house last Sat.night.3deliveries in NJ Mon.3 in CT Tues.Back in NJ Wed.to reload and back to FL for Fri.Healthwise it was really good.6 good days 1 bad.I'm starting to sleep better.As of today I have 19 days to go.I have a DR app.Mon to tell me what I already know.Who knows maybe he'll tell me something I don't know.Pretty sure the bad day I had was because it was cold and raining and I didn't feel like drinking water.Anyway,thats past and I'm taking off next week.I have a honeydo list as long as my leg.Been putting things off for the last 2 months.Sorry to hear you're in NYC in the snow.I left the northeast just as it was coming in.The city is brutal when it's 85 and sunny,cold and snow puts it over the top.Try to enjoy!!



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62 yo male GT 1b/2 ALT 60 AST 51 V/L 985,000 Fibro A2 F 3/4 began 12 wks Mavyret 9/13/2018

6 wk labs ALT 12 AST 18 V/L NOT DETECTED EOT 12/05/2018 NOT DETECTED



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Welcome back, Shemp.  How was the drive this time?  I hope you can rest now that you are home.

Any better luck with the sleeping? Do you have another drive lined up? Am I right that you have less than 3 weeks to go? I make it sound like a short time, but I remember that it feels like FOREVER when you are struggling to get through the fatigue. I couldn't even climb the stairs on Sovaldi/Ribavirin, but you have done as well as can be expected, working and all. I trust you will enjoy many improvements after treatment. It feels fantastic just to be my old self.

I'm on the road, too.  I was hiking in Zion National Park just over a week ago and am slogging in snow this week in NYC.  I'm here for a family wedding.  Then, at last, some down time at home.  And no holiday stress for this girl. Nope, not doing it.

Let us know how you are doing.  It nice having you around.

Cheddy



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GT2a, VL 681,500, Less than F1, Treatment Naive

12 wks Sovaldi/Ribavirin, SOT 2/25/16, EOT 5/17/16

UND at 2,4,8 and 12 wks during treatment but ribavirin crazy.

ALT/AST normal EOT

SVR12 8/13/2016!!!!!!!!!  I WON!!

EOT 6 Months 11/12/2016  CURED

 



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Champ,

Go with your instincts or best guesses (until you are otherwise self-enlightened) ... if you think (are convinced) the wakefulness coincides with and is directly related to the max. peak blood levels of Mav, then perhap you are right (despite any opinions to the contrary from anyone) - i think your theory on wakefulness might be a plausible possibility. (You said you take the Mav at bedtime and then, 5 or 6 hours later, when the max Mav level occurs, that is what is awakening you at about 5 AM?)

Had you noted this possible co-relation sooner in the treatment course, you might have had time to experiment with changing around the time of day dosing of the Mav (extremely slowly, with the OK and as advised by your doc) to be an hour earlier every day until you were taking your bedtime dose to be (say) a supper time dose, then (perhaps) the peak blood levels of Mav would have happened earlier, when you were under the heaviest influence of your nighttime sedation, perhaps then not waking? It may be pulling straws (or counting sheep may be more like it! heehee) but ... just thought I would throw my 2 cents into the lottery of dose timing , ... it's kind of late now to slowly shift the time of day dosing for your Mav to be earlier.

Like you said, being that you have had a hx of sleep trouble, perhaps no matter what time of day you took your Mav and when it peaked, you might have still experienced sleep difficulties at night, hard to say eh?

I know you will keep trying to do the best you can to treat your body well. Just keep trying to get as much quality rest, de-stress and relax time as you can, even if the normal sleep quota is not at all cooperating.  zzzz   ;o 



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 63 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



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Zolpidem makes me weird and groggy.  I'm glad it works for you, but more than 5 hours would be better.

Yeah, you're probably right.  The meds that are slaying dragons are bound to effect other areas, being so powerful. I'm glad you are able to take the good with the bad - no small feat. 

I like hearing your resolve, Champ/Shemp. 

Good to hear you got a good night's sleep. Wishing you many more.

 

P.S. Do you mean that cat that gets on top of your chest at dawn to ask for breakfast?  I love that guy, later on.

 



__________________

GT2a, VL 681,500, Less than F1, Treatment Naive

12 wks Sovaldi/Ribavirin, SOT 2/25/16, EOT 5/17/16

UND at 2,4,8 and 12 wks during treatment but ribavirin crazy.

ALT/AST normal EOT

SVR12 8/13/2016!!!!!!!!!  I WON!!

EOT 6 Months 11/12/2016  CURED

 



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Thanks Cheddy,

I've had problems sleeping for years.Doc put me on generic Ambien it's called Zolpidem 10mg.No drug interaction I checked myself.I have no problem going to sleep but 5-6 hors later I'm wide awake.Not groggy,literally wide awake.I think it has to do with when my meds peak.Before I cleared the virus they were fighting.Now I guess they're kind of bored and they want me to wake up.Kinda like my cat.Had a good sleep finally last night and feel much better.27 more to go,no stopping me now.



__________________

62 yo male GT 1b/2 ALT 60 AST 51 V/L 985,000 Fibro A2 F 3/4 began 12 wks Mavyret 9/13/2018

6 wk labs ALT 12 AST 18 V/L NOT DETECTED EOT 12/05/2018 NOT DETECTED



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Dang it Shemp.  I'm so sorry this is happening to you  As Tig points out, it's a funny kind of normal to have these ups and downs. Thank goodness it's only 4 more weeks.  Unfortunately that feels like forever when we are in the middle of it. 

You've done so well on your treatment with food and water and a good attitude. Now we just have to figure out that sleep thing.  Sleep is medicine. I can't imagine being sleep deprived and making long drives.  No wonder you get worn out.  I don't know what your sleep meds were before but do they work now? Are they compatible with Tx?  Do they make you groggy the next day? Have you tried cal/mag?  That helps with body tired but doesn't always slow my curious mind down.  Lots of us have trouble with sleep so I hope more can chime in with what helps them.  

In the meantime, rest whenever you can, even if you don't sleep.  Find what keeps you calm.

Yeah, that Tig does run deep.  It is like the tide, coming in and going out. Just remember, you're not in a boat! That's a big honking truck your plowing through deep puddles, and you know how. 

At least here, you have the company of friends who know what it's like to go through this.  I wouldn't wish it on anybody else.

Please keep us up to date.  We'll be checking the tide charts.

Cheddy



__________________

GT2a, VL 681,500, Less than F1, Treatment Naive

12 wks Sovaldi/Ribavirin, SOT 2/25/16, EOT 5/17/16

UND at 2,4,8 and 12 wks during treatment but ribavirin crazy.

ALT/AST normal EOT

SVR12 8/13/2016!!!!!!!!!  I WON!!

EOT 6 Months 11/12/2016  CURED

 



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Hoodie,

Thanks for the kind words.Some days I don't feel like a champ but,this too shall pass.I never realized Tig was so deep.Words to live by.



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62 yo male GT 1b/2 ALT 60 AST 51 V/L 985,000 Fibro A2 F 3/4 began 12 wks Mavyret 9/13/2018

6 wk labs ALT 12 AST 18 V/L NOT DETECTED EOT 12/05/2018 NOT DETECTED



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Hang in there champ! Im super proud of you and so happy that you joined us here with your marvelous wonderful attitude and your strength of character and fortitude. 

iPhone auto-corrected your name to champ and Im just gonna leave it because in this case it is fitting  

Tig I live this so much. The visual it evokes and the poetry of it, and also in a practical sense its true and right! 

High tide may swamp you, while low tide might allow you to walk across the bay.



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F, 51, GT3, HCV since 1989, no alcohol since 1999, Fibrosis score F0-1 (.36), VL 216,000, ALT 23, AST 26, Epclusa SOT 7/26/18 EOT 10/18/18. Thank you God. 



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i kept working too shemp, but luckily i had a flexable schedule and sympathy from my coworkers.

you are amazing! driving up and down the east coast while on tx. wow

we'll all be thinking of you in prayer and thots.

5



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Gt:1a-36yrs .Started Intron-A in 96' for 2.5mo-VL still too high.taken off. Labs on 3.6.18:. A1 activity.  f3@60: fibrosur bloodtst. AFP=norm. enz=mostly norm.VL=3.9 million.sot=5.1.18>Harvoni>[8wks]: 4WEEKS=UND. Eot 6/25=L.July=norm liverpanel.13weeks=UND + 6 months =UND: CLUB ZERO



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Thanks for the support guys.27 days to go.Failure is not an option.I did notice once I cleared the virus there were some pretty dramatic changes.Most of them were good.I finally got more than 5 hours of sleep last night and I feel like a new boy.5-1 I wish I could take time off but,I own my truck,it's all on me.Heading north this weekend.I've got maybe two more trips before EOT.The things you do for money.



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62 yo male GT 1b/2 ALT 60 AST 51 V/L 985,000 Fibro A2 F 3/4 began 12 wks Mavyret 9/13/2018

6 wk labs ALT 12 AST 18 V/L NOT DETECTED EOT 12/05/2018 NOT DETECTED



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Heya Shemp, 

youre almost on your last 4 weeks, eh? Sorry to hear the sides are coming back so much.

Thats a frustrating type of insomnia...my husband has had bouts like that...wide awake way too early for no good reason...I feel for you. He is like a zombie when that happens to him...

I have no helpful ideas, except perhaps magnesium...Thats good for the nervous system and helped me with my insomnia...although I got the kind that wont let me fall asleep in the first place.

You are a great dragon fighter and youve almost won. Try to take it easy



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61 y/o, Infected via transfusion Oct'83, GT-1a, F-4 cirrhotic,
tx Holkira pak/moderiba 12 weeks

3 years...post tx... successful dragon slayer 



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hang in there shemp; you can do this!

have you considered time off from work with sick leave, medical leave or fmla as needed?

5



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Gt:1a-36yrs .Started Intron-A in 96' for 2.5mo-VL still too high.taken off. Labs on 3.6.18:. A1 activity.  f3@60: fibrosur bloodtst. AFP=norm. enz=mostly norm.VL=3.9 million.sot=5.1.18>Harvoni>[8wks]: 4WEEKS=UND. Eot 6/25=L.July=norm liverpanel.13weeks=UND + 6 months =UND: CLUB ZERO

Tig


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Hey Shemp,

I can’t compare what I was on with your meds, but I did notice, as do most people on treatment in general, continual metabolic changes during treatment. There are so many things happening inside you right now, the ones you feel and the ones you don’t. Trust me on this though, they are BIG changes and your body tolerates some better than others. That doesn’t mean anything except the drugs are working. We used to consider the worse we felt, the better the results! Thank goodness we don’t measure treatment success on the degree of side effects. I suggest you look upon these waves of side effects as you would the tides. High tide may swamp you, while low tide might allow you to walk across the bay. Before you know it you’ll be cruising high and dry on that boat, above it all... Hang in there, Brother!



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Tig

62 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 1-4 years!

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The return of the sides,

Fellow warriors,I need some insight from those that have traveled this road before me.I just finished wk 8,4 more to go.The first few wks were an adjustment.Nausea, anxiety,insomnia.By wk 4 they seemed to level off and I was pretty much ok.Wk 6 came and I got great news from the lab,actually  had a few days where I hadn't felt that good in a long time.Wk7 was a slow roll downhill.Sides were coming back and I was just worn out.I had read on this forum that others had them return late in treatment as well.My biggest problem these day is sleep.My Doc had me on sleep meds before tx,but now it's just crazy.Now,I take my meds at night because of my work schedule.10:30 each night because my day is usually done by then.A little snack,meds bed.I'm up every day at 5 AM for no good reason.My eyes open and there is no hope of going back to sleep.I looked into Mavyret the other day and learned that it peaks 5 to 6 hrs.after you take it.Do you think that is what is waking me?I feel like the walking dead.My Doc and Abbvie are clueless. Any insight would be much appreciated.



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62 yo male GT 1b/2 ALT 60 AST 51 V/L 985,000 Fibro A2 F 3/4 began 12 wks Mavyret 9/13/2018

6 wk labs ALT 12 AST 18 V/L NOT DETECTED EOT 12/05/2018 NOT DETECTED



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Hey thanks Canuck,I don't know how you got that recording of my wife.Maybe thats why I can't sleep



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62 yo male GT 1b/2 ALT 60 AST 51 V/L 985,000 Fibro A2 F 3/4 began 12 wks Mavyret 9/13/2018

6 wk labs ALT 12 AST 18 V/L NOT DETECTED EOT 12/05/2018 NOT DETECTED



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Aw, lovely for you Shemp, your first UND!, just one of many more, you will be UND now for the rest of your life. Good-bye virus, finally! So nice for you to have this first UND under your belt, makes all the past strife and hard work and unpleasantness a bit easier to take, seeing some tangible results. And just look at those really nice, teeny, tiny LFT's - wowie, so nice and low now compared to before! It's a lovely crash!

You look great Shemp!, even if you feel like you have been dragged backwards through a rosebush. Your attitude, strength, LFT's and UND and sense of direction is very, very good. You will get to where you want to go. Soon you will be finished!! 

Are you home for a while now, to rest up and maybe celebrate just a bit?

In honour of the great occasion of your first UND I highly recommend some nice long deep healing sleeps and/or as many impromptu naps as you can manage to fit it - maybe just the relief of reaching this first UND milestone will help you sleep a tad better tonight. Hope so. wink C.

Here ya go Shemp, this one's jes fer you - sleep tight. https://www.youtube.com/watch?v=wwxre4eFbb4



-- Edited by Canuck on Saturday 3rd of November 2018 03:19:09 AM



-- Edited by Canuck on Saturday 3rd of November 2018 03:40:13 AM

__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 63 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



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Shemp wrote:

Thanks Cheddy,

1979 was when I got it .I was diagnosed in 2000.They offered me clinical trials but I couldn't get myself to commit to experiments.Really glad I waited,hope my liver forgives me.


 really it's better that you waited for these new daa's cos they were created specifically for hcv

your whole body and mind thanks you for waiting



__________________

Gt:1a-36yrs .Started Intron-A in 96' for 2.5mo-VL still too high.taken off. Labs on 3.6.18:. A1 activity.  f3@60: fibrosur bloodtst. AFP=norm. enz=mostly norm.VL=3.9 million.sot=5.1.18>Harvoni>[8wks]: 4WEEKS=UND. Eot 6/25=L.July=norm liverpanel.13weeks=UND + 6 months =UND: CLUB ZERO

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