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Post Info TOPIC: New Cures, Incredible!!


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RE: New Cures, Incredible!!
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Hi Alan,

What a blast from the past! It's hard to believe I finished my 48 weeks of Victrelis triple therapy 6 years ago.

You were a great support for me during treatment.

All the best mate. Cheers.



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Geno 1b, IL28B CT,  x3 prior relapser,  ex-cirrhotic, 75 yo, did 48 weeks with Victrelis/Peg./Riba.  VL 1.28m at start, UNDET. at 8 ,12 ,16 ,24 ,30  and 48 weeks.  EOT 15 Feb 2013 , UNDET. at EOT + 28 weeks. SVR!  Still Undet. at EOT +5 years

Malcolm



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Hi there Alan, it`s been a while, hasn`t it!  smile

Good to hear from you with your update, sounds like you`re dong very well post SVR. 

Yes, the new generation of HCV treatment drugs are absolutely mindblowing!  You certainly did it the hard way with the Incivek triple, physically and mentally.  I thought myself lucky to `only` have to do 24 weeks of Peg Int + Riba...as if that wasn`t bad enough!  But we did what we had to do, and thankfully no-one has to endure such dreadful ordeals these days.

Thanks for stopping by... stay well... smile  Jill

 

 

 



__________________

Jill 

(69 yo, lives in UK)

Was Gen 3a, 

24wks Peg Ifn/Riba, Sep 2010 - Mch 2011

UND @ Wk.4, UND @ EOT, 

SVR Nov 2011 --> Still UND @ EOT + 4 yrs.

 

 



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News,  

I second that thank you for running that research gamut.

The new treatments do work well and they are already better than when I was treated a couple of years ago. I didn't have it as bad as you pioneers did at all, even though I did get Ribavirin.  That stuff made me intolerant, and reactive, and bleak.  I certainly wasn't excited about life and was no fun at all. Still,  I did get through it (with the much needed help of these fine friends!) and came out the other side feeling better and brighter than I had in a long time, a lot tougher, too. It's like getting your life back, isn't it?  I have no left over maladies to report.

So you are seven years out now. It's unfortunate that you still have some sides, but you have good labs and ultrasounds, and that's terrific.

Thanks for stopping in.  I think it helps us all get some perspective on how times have changed.  And it gives everybody hope and a push to get treated.

All the best news, News.



__________________

GT2a, VL 681,500, Less than F1, Treatment Naive

12 wks Sovaldi/Ribavirin, SOT 2/25/16, EOT 5/17/16

UND at 2,4,8 and 12 wks during treatment but ribavirin crazy.

ALT/AST normal EOT

SVR12 8/13/2016!!!!!!!!!  I WON!!

EOT 6 Months 11/12/2016  CURED

 



Guru

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Hey, nice you replied right away!

I have to thank you so very much for going through that gruelling time and treatment, without you, (all of you poor tough souls who had NO choice but to bravely do these early treatments), the rest of us would not be where we are today - in a far kinder, better treatment place. You all were (for many years) the real pioneers of finding effective HCV treatment. We newbies who have now come along in your wake are grateful for the better path you beat down for us.

Now, when I speak of a kinder, better treatment place of today, that is not to say your cruel old drugs did not do right by you in giving you your SVR, but that is ALL I will ever say that was ANY possible good of having to endure the physical/and mental torture served up in those drugs you were forced to do. What made it really killer insulting is that you had to pay like that - so unjust! Having to pay big time bucks for that WAS so wrong on top of all else!

On the other hand, we always have to keep in mind, that had you waited, who knows what horrid thing(s) could have had a good head start, before you ended up cured by some other kinder, less lethal-feeling drug regime at a later date. 

Odd, ditto for me on itchy scalp/some hair loss/and dry skin! But not the "backside" issue. And certainly maybe not to the degrees you may have been bothered. But I do wonder why these plaguing oddities, itchy scalp, etc. occur. How bad IS yer backside, still, BTW, if i can be so nosey!? I will have to do some reading an check out your Fscores and LFT's etc, have your bili's been normal? You say only once your LFT's have migrated upward? - how high did they go?

The newest doubles and triples (like Mav and Vosevi) have proven extremely effective, I highly doubt we will EVER have to go back to the exact kind of wicked triples you had to do. 

I am glad you are seeing to it that you are being followed, that your bloods and U/S's show good. I am happy for your cure. : ) C.

 

 

 



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 63 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



Guru

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I have done OK. Still have trouble with itchy scalp and hair loss, dry skin, and the damage to my backside will never heal. Also very brittle fingernails. Have to file them constantly. But I have never worried about the virus since SVR, and have not engaged in any activity that might reinfect me. Liver enzymes climbed briefly last year, but went back down. Ultrasound exams always look good. So the job was done in 12 weeks of Interferon/Incivek/Ribovirin and 8 more weeks without Incivek. I just hope these new treatments work well. I don't want anyone to have to go back to what I did. $27k per month for drugs that made you wish for death just seemed wrong somehow. Alan

__________________

Geno 1A  Started Pegasys/Ribavirin/Incivek Nov. 20, 2011 .  Completed July 28, 2012 (36 weeks). For a treatment history, see:  https://jshare.johnshopkins.edu/xythoswfs/webview/_xy-9921874_1

SVR on January 14, 2013!!



Guru

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Hi news,

Glad to share the good news of this post with you. Your 2013 treatment was before my time here, but I think I do recall you from some of the older posts. It's so nice for all of us, new and past, to be able to keep meeting up here. 

You and so many others (just a few years back) certainly had hard-won cures on the old hard-to-endure drug regimes. The newest blockbusters Mav and Vosevi are like such wonderful xmas gifts for so many of us now. Yes, such a difference, between going through the old treatments and these new ones nowadays. 

We have had quite a few here on the site do Mav this year, although at 12 week courses, not many doing the short regime yet. Some have been doing the short courses of Harvoni for a while now tho in certain cases.

It IS so wonderful about the new treatments that are finally in use now. 

Glad to see your post here - fill us in on how you have been doing - we'd be all ears. smile C.



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 63 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



Guru

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I am seeing TV ads for something called Mavyret (I believe) that promises a cure in 8 weeks, for any strain, and no other drugs required. Quite an improvement over my 2011 treatment consisting of Ribovirin, pegylated intergeron b, and Incivek, the big purple pill that made me want to die. What a difference a few years makes. Alan

__________________

Geno 1A  Started Pegasys/Ribavirin/Incivek Nov. 20, 2011 .  Completed July 28, 2012 (36 weeks). For a treatment history, see:  https://jshare.johnshopkins.edu/xythoswfs/webview/_xy-9921874_1

SVR on January 14, 2013!!

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