Hep C Discussion Forum

Members Login
Username 
 
Password 
    Remember Me  
Chatbox
Please log in to join the chat!
Hep C Discussion Forum -> Post Treatment -> AFP MARKER question
Post Info TOPIC: AFP MARKER question
Canuck


Guru

Status: Offline
Posts: 3249
Date:
RE: AFP MARKER question
Permalink  
 

Hey 5, 

Further to your original query here, about AFP's, which got us into the link below (showing Japan's use of AFP-L3's), see info in this post as well ... HCC Detection - Using AFP, AFP-L3 and DCP .

:  )  C.



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 64 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)
Canuck


Guru

Status: Offline
Posts: 3249
Date:
Permalink  
 

Hey RC,

What a treat! Nice to hear from you, and interesting that your AFP did not spike up too high - i had mistakenly thought you said one time it did jump up (quite a bit higher than that, in the hundreds?), but, i must not be recalling things well - not surprising for me tho LOL, given my mental prowess! Glad to hear you have some good summer plans. Many of us are doing that, getting better, feeling better, one step at a time. Good to know you heard from Boxers. Here's to a good summer for all of us!  : )  C. 



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 64 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)
robertsamx


Guru

Status: Offline
Posts: 915
Date:
Permalink  
 

Hi All. Its been a while.  I beleave my AFP only got as high as 24, I had 4 or 5 ablations and 1 tace procedure.  As Tig said my old liver was a tumor factory, as they ablated one a new one would pop up in different segment.They would do a follow up MRI 30 days after a ablation procedure to see if the ablated tumor was gone and see a new tumor someware else. This went on from May of 2016 tell I got the call August 13 2017 for Transplant.As I recall my tumor marker dident really spike, perhaps because the tumors were fairly small at 1 to 3 cm each episode. 

Its been 21 months since L/Transplant and its been a slow long tough at times recovery. With the foot surgery the year prior to transplant and then all the procedures on liver and throw  in 2 HCV R/X prior to L/T and one post L/T and well you all know the story. I got pretty weak on the post L/T treatment but it killed the virus thanks to VOSEVI RIBA cocktail. What a battle with the disease and insurance company to extend R/X out to 16 weeks. Upset stomach and lower GI issues are common now, and full/pressure feeling in gut is common. Numb at and below the  Transplant incision all the time- really weak abb muscles- I wont ever do a sit up again Lol !  All around and overall muscle weakness everywhere.  Recovery is taking some time but it is happening but at a slow rate. I have communicated with BOXERS over the last year and she is moving along ok. She has some issues like all of us L/T survivors.

Im looking forward to a nice summer where i can get out and get stronger!!  RC



__________________

 M-64) 3 Treatments)( SOF-RIBA 2014)(SOF-RIBA-PEG 2016)(HCC 2016) (LIVER TRANSPLANT 8-2017)(VOSEVI-RIBA 2017)   SVR-12. 3-13-18   
5-1-18


Guru

Status: Offline
Posts: 1302
Date:
Permalink  
 

i too love to hear the journeys.



__________________

Gt:1a-36yrs .Started Intron-A in 96' for 2.5mo-VL still too high.taken off. Labs on 3.6.18:. A1 activity.  f3@60: fibrosur bloodtst. AFP=norm. enz=mostly norm.VL=3.9 million.sot=5.1.18>Harvoni>[8wks]: 4WEEKS=UND. Eot 6/25=L.J*13weeks=UND * 6 m =UND: CLUB ZERO.1yr.=0
Canuck


Guru

Status: Offline
Posts: 3249
Date:
Permalink  
 

Ya, we would like to hear from RC and Boxers too, fer sure, but very happy you caught us up again SS!  I always want to hear more from you : )

Also, I am so glad you put that link there for us, I will get into that soon.

I recall RC shared with me one time that his AFP got pretty impressively increased as well during his tumour time. AFP's are good info to have.

C.

 



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 64 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)
Tig


Admin

Status: Offline
Posts: 9270
Date:
Permalink  
 

Thanks for sharing your journey, SS. All of the stories we have heard from our transplant group, have been both mind numbing and impressive. I appreciate yours!

It would be nice to hear from RC and Boxers >>>HINT<<<. Last I heard they were doing well. We like “well”...



__________________

Tig

67yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

Hep C FAQ   Lab Ref. Ranges  HCV Resistance

Signature Line Set Up/Abbreviations   Payment Assistance

 
5-1-18


Guru

Status: Offline
Posts: 1302
Date:
Permalink  
 

we get the afp 2x a year over here at my house, both being f3'rs.



__________________

Gt:1a-36yrs .Started Intron-A in 96' for 2.5mo-VL still too high.taken off. Labs on 3.6.18:. A1 activity.  f3@60: fibrosur bloodtst. AFP=norm. enz=mostly norm.VL=3.9 million.sot=5.1.18>Harvoni>[8wks]: 4WEEKS=UND. Eot 6/25=L.J*13weeks=UND * 6 m =UND: CLUB ZERO.1yr.=0
sailing shoes


Veteran Member

Status: Offline
Posts: 57
Date:
Permalink  
 

Link:

burdenofgeniusfilm.com

__________________

70 YO M, Dx 1999, 1a, cirrhosis; Pegasys/Riba Neupogen Aranesp in 2001, partial responder; PegIntron Riba 2002, partial; Phase 2 Clinical Trial Pegasys/Valopocitabine 2004, relapse at EOT; Sovaldi/Olysio 2014, SVR; HCC 2015, TACE 2016, Transplant 2016
sailing shoes


Veteran Member

Status: Offline
Posts: 57
Date:
Permalink  
 

Hi Iris, Canuck - I saw everything through a cirrhotic lens - I only know the damage caused by the virus left a cirrhotic liver susceptible to cancer, specifically, HCC, so I asked to test for AFP every time there was a blood draw. I don't know about low fibro livers. But an annual AFP can't hurt.

Tig - my tumor was located at the junction of the portal vein and the vena cava. It could not be removed surgically. It was only 1.6 cm when first found. That was enough to bring my case to the Tumor Board for transplant list consideration, but it needs to be 2.0 or more to count toward the MELD exemption points - 22 points are awarded for a tumor over 2.0 cm. I was listed with my itty-bitty tumor, but my MELD was too low to qualify for an actual liver. My tumor grew quickly, it measured 2.4 two months later. We applied for the points and then I had a TACE procedure to slow the growth rate or even kill the tumor. Six months later I got the points.  I now had MELD 34, and one month after that I got "the call". I only had the one TACE.

BTW, we just saw a most remarkable documentary film called "Burden of Genius". It's the story of Dr Starzl and his development of liver transplants and anti-rejection meds. Not a dry eye in the house. We saw it on a 70 ft by 38 ft screen in HD. If you get a chance ....

So, anybody know how Boxers and RC are doing?

/



__________________

70 YO M, Dx 1999, 1a, cirrhosis; Pegasys/Riba Neupogen Aranesp in 2001, partial responder; PegIntron Riba 2002, partial; Phase 2 Clinical Trial Pegasys/Valopocitabine 2004, relapse at EOT; Sovaldi/Olysio 2014, SVR; HCC 2015, TACE 2016, Transplant 2016
Iris Dragonfly


Guru

Status: Offline
Posts: 1166
Date:
Permalink  
 

I asked my hepatologist to add that to the next test. ..she had done it before. But because she said my fibroo score was low, I didn't need to add that test anymore. I haven't been diagnosed with cirrhosis so she said it was unnecessary. Hope she's right. My last test was very low like a 7.

Bb, Iris



__________________

in the silence of the woods, you will not be alone- Chief Seattle

60 years on planet, Female, diagnosed 1978 as non-a non-b, VL 8mill+, Fibro f-1f-2, Genotype 1a, treatment naïve....UNTIL 7-01-18  !!!! started Harvoni 12 weeks. :)

4 weeks=UND, 8 weeks=UND, 12 weeks=UND (EOT= 09-23-2018)
Canuck


Guru

Status: Offline
Posts: 3249
Date:
Permalink  
 

Hey SS,

Nice to see ya!

Ya, I love the AFP test and all the various following testing that should be done.

MY, what a long road you have walked.

How are things? We've been wondering how all our TP folk are doing. : )  C.



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 64 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)
Tig


Admin

Status: Offline
Posts: 9270
Date:
Permalink  
 

Hey SS,

Good to hear from you, Bro! I hope life is treating you right. I don‘t remember talking about that timeline with you before. I remember the transplant discussion, but reading your last, your escalation to the actual transplant was fast! Do you recall the location of the tumor? I remember our moderator, RC, he was ate up with tumors and what they removed or ablated, seemed to grow back faster than light speed. 



__________________

Tig

67yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

Hep C FAQ   Lab Ref. Ranges  HCV Resistance

Signature Line Set Up/Abbreviations   Payment Assistance

 
sailing shoes


Veteran Member

Status: Offline
Posts: 57
Date:
Permalink  
 

When I finally cleared the virus, I checked AFP with every blood test. I was cirrhotic.  18 months after SVR, the AFP jumped from it's normal 6 to 167. Two days later a MRI found a itty-bitty HCC tumor, and 5 weeks after that I was on the transplant list. 9 months later I had a new liver.
I still check AFP every year. Worked for me.



__________________

70 YO M, Dx 1999, 1a, cirrhosis; Pegasys/Riba Neupogen Aranesp in 2001, partial responder; PegIntron Riba 2002, partial; Phase 2 Clinical Trial Pegasys/Valopocitabine 2004, relapse at EOT; Sovaldi/Olysio 2014, SVR; HCC 2015, TACE 2016, Transplant 2016
5-1-18


Guru

Status: Offline
Posts: 1302
Date:
Permalink  
 

thnx canuck,  that's interesting. i will read that tomorrow. bed early today, go to ent on 5/1/19

hope she can clear my ears , then home to eat filet and cake , 



__________________

Gt:1a-36yrs .Started Intron-A in 96' for 2.5mo-VL still too high.taken off. Labs on 3.6.18:. A1 activity.  f3@60: fibrosur bloodtst. AFP=norm. enz=mostly norm.VL=3.9 million.sot=5.1.18>Harvoni>[8wks]: 4WEEKS=UND. Eot 6/25=L.J*13weeks=UND * 6 m =UND: CLUB ZERO.1yr.=0
Canuck


Guru

Status: Offline
Posts: 3249
Date:
Permalink  
 

Mornin' 5,

AFP can be found elevated in newborns, sometimes in expectant Mom's. Elevations can also be found in people with liver damage (like if you have chronic hep or cirrhosis) your AFP might also get/be chronically elevated in those cases. 

Might see high or sudden spikes/elevations (or maybe not) in certain Ca's (liver/testicles/ovaries). AFP elevations might be seen in other Ca's ... stomache, colon, breast, lymphoma, but maybe not. It can be a very useful but not necessarily foolproof telling tool. 

 

https://labtestsonline.org/tests/alpha-fetoprotein-afp-tumor-marker#no-back    See this link (if it opens) and read the "Common Questions" - ie "How the AFP Test is Used". And beyond "How it is used" there is some good info to read in there if you click on and read all the bits that open up on the subject of AFP there (Japan, etc.).  : ) 



-- Edited by Canuck on Wednesday 1st of May 2019 03:55:13 AM



-- Edited by Canuck on Wednesday 1st of May 2019 04:06:20 AM

__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 64 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)
5-1-18


Guru

Status: Offline
Posts: 1302
Date:
Permalink  
 

hi everyone. 

I was wondering if the AFP tumor marker we get every 6 months can find all tumors, or just in the liver?

just wondering



__________________

Gt:1a-36yrs .Started Intron-A in 96' for 2.5mo-VL still too high.taken off. Labs on 3.6.18:. A1 activity.  f3@60: fibrosur bloodtst. AFP=norm. enz=mostly norm.VL=3.9 million.sot=5.1.18>Harvoni>[8wks]: 4WEEKS=UND. Eot 6/25=L.J*13weeks=UND * 6 m =UND: CLUB ZERO.1yr.=0
Page 1 of 1  sorted by
 
Quick Reply

Please log in to post quick replies.
Hep C Discussion Forum -> Post Treatment -> AFP MARKER question
Legal Disclaimer:

THIS FORUM, IT'S OWNERS, ADMINISTRATORS, MODERATORS AND MEMBERS DO NOT AT ANY TIME GIVE MEDICAL ADVICE AND IN ALL CASES REFER ANYONE HERE TO SEEK APPROPRIATE MEDICAL ADVICE FROM THEIR DOCTOR.