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Post Info TOPIC: New to Mavyret


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RE: New to Mavyret
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Just took my first dose of Mavryet.... 15 minutes ago.  Praying for no or minimal side effects. Glad your journey is going well.  Hopefully soon we both can join the cured board



__________________

66 yr old female; polio survivor; hbv that wasnt treated but cleared; chronic hcv gt1a; diagnosed 2018 but likely infected during surgery as child; Metavir score F2-F3; mild to mod fibrosis; RNA 3,951,412; AST 40; ALT 47



Guru

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Hi MissusB,

I can answer you here a bit, but this is Stickers "On Treatment" thread - as a newcomer you can create a new thread that will be all your own (under "New Members".

We would have to know a bit more about your current Hep B status to be able to answer your question re: B reactivation.

HEY! THAT"S GREAT - I see you just (right this minute while I was writing) started a "newbie thread" all of your own - I'm hopping right over there, right now to say hi .  : )  C.



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 64 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



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I am prepaing to start Mavyret as soon as my shipment of meds arrive. Have chronic hep c and previous hep b.....both came as surprise to me when MD suggested testing due to being a baby boomer. Am a polio survivor and MS suspects contacted both viruses from surgeries in childhood. Excited for this treatment but also concerned due to potential for Hep b reactivation. Any advice? Plan on eating healthy and drinking lots of water.

__________________

66 yr old female; polio survivor; hbv that wasnt treated but cleared; chronic hcv gt1a; diagnosed 2018 but likely infected during surgery as child; Metavir score F2-F3; mild to mod fibrosis; RNA 3,951,412; AST 40; ALT 47



Moderator

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Greeting firends,

I sure am liking this thread. It's full of good stories, good support, good advice, good nature, tomfoolery, and CURES.  And yet, it's still a place where we can lay our burdens down as well as a place we can get our questions answered.

I'm happy to know the whole lot of you and I'm proud of our collective good work.  Gush.

Love,

Cheddy



__________________

GT2a, VL 681,500, Less than F1, Treatment Naive

12 wks Sovaldi/Ribavirin, SOT 2/25/16, EOT 5/17/16

UND at 2,4,8 and 12 wks during treatment but ribavirin crazy.

ALT/AST normal EOT

SVR12 8/13/2016!!!!!!!!!  I WON!!

EOT 6 Months 11/12/2016  CURED

 



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Hi Sticker-- 

A mantra indeed!   BTW -- even after completing treatment I continue to drink lots of water...many health and fitness folks say the best things to do first in the morning is drink 16 oz of water. I can get down about 12 oz  before a meditation and then I'm ready for a bit of coffee. For me one of the benefits of HCV treatment was learning to drink lots of water! Drink up or down..whatever works, just do it. 

 



__________________

 

New: Hepatomegaly 07/30/2019, AST 29 & ALT 15

Female,1a,F2 mod fibrosis,HCV 06/2017,SOT 08/04/2017, Harvoni

HCV VL 414,000, AST 54, ALT 74.  4 weeks AST 34 and ALT 31, SVR, Jan 2018. 

12 week EOT, AST 20 & ALT 23 and still VL UND.

Club Zero Member.

 



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Sticker, glad you're handling the Mav well. By the way tomfoolery is not only welcome, it's a requirement. 



__________________

62 yo male GT 1b/2 ALT 60 AST 51 V/L 985,000 Fibro A2 F 3/4 began 12 wks Mavyret 9/13/2018

6 wk labs ALT 12 AST 18 V/L NOT DETECTED EOT 12/05/2018 V/L NOT DETECTED

12 Wk post EOT ALT 11 AST 16 V/L NOT DETECTED  Thank you GOD

Take that stupid dragon

1/2/2020 SVR 12



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Tig,

Its me who enjoys reading your messages! You have managed to convey a sense of understanding and compassion without having to use too many words. I appreciate the efforts of you and all the members of this forum, who have been cured for some time but still share yourselves with people such as myself. You could have walked away.....but you didnt. That says quite a lot. Thanks 



__________________

52 y/o male, Genotype 1B, F3, Dx - 1992, likely contracted virus 1977, Current Tx - 8 weeks Mavyret 07/23/2019. Tx - 1st time, Rebetron 6/2000-6/2001, 2nd time, Pegasys 11/2002-4/2003. VL - 636,000 AST - 49, ALT - 77

UND - 08/22/19!!!

SVR 12 - 12/17/2019, AST - 17, ALT - 14

 

 

 



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Shemp,

You got me! I do like to tell some stories. This is testament to how comfortable I feel in this forum. I will try to spare you guys some of my tomfoolery! 



__________________

52 y/o male, Genotype 1B, F3, Dx - 1992, likely contracted virus 1977, Current Tx - 8 weeks Mavyret 07/23/2019. Tx - 1st time, Rebetron 6/2000-6/2001, 2nd time, Pegasys 11/2002-4/2003. VL - 636,000 AST - 49, ALT - 77

UND - 08/22/19!!!

SVR 12 - 12/17/2019, AST - 17, ALT - 14

 

 

 



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Thanks polosilver! I think your dad might have known my dad because his words to you are a familiar mantra. Also, I love your profile pic. That is totally me right now!



__________________

52 y/o male, Genotype 1B, F3, Dx - 1992, likely contracted virus 1977, Current Tx - 8 weeks Mavyret 07/23/2019. Tx - 1st time, Rebetron 6/2000-6/2001, 2nd time, Pegasys 11/2002-4/2003. VL - 636,000 AST - 49, ALT - 77

UND - 08/22/19!!!

SVR 12 - 12/17/2019, AST - 17, ALT - 14

 

 

 



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Hi Canuck! My mention of feeling medicated while taking Mavyret really only applies to the first day or two. It was sort of like when you suspect you might be coming down with the flu but youre not quite sure because you arent particularly sick yet and perhaps you will feel better in the morning. By the third dosage any such inklings had vanished, and I have felt fine since then. I never felt truly sick, I think that I mentally flirted with the idea that I could be. My doc stated that none of his patients reported any noticeable side effects, even those who were princesses. ( He may have been referring to me)  I thank you for the reminder about eating healthy. I do like junk food but seldom consume it. Part of that comes from working so closely with very conscientious firefighters, particularly when it comes to food. Gone are the days eating huge fat-laden meals at the station. Peer pressure is very effective among the guys. Everyone is involved with fitness (CrossFit, Mountain biking, weight training, etc.) to a certain degree. We often exercise together and dont want to sacrifice that benefit at the supper table. Its hard though, especially when a well-meaning citizen drops off baked goods at the station; we kindly thank them and try to leave most of it for the folks coming on duty the next morning. There really isnt too much ageism in the fire service. I have to meet the same physical requirements as the 24 y/o people. So far, so good. Im 52 now and hope to continue in my career til age 64 which will log me at 40 years on the job! 



__________________

52 y/o male, Genotype 1B, F3, Dx - 1992, likely contracted virus 1977, Current Tx - 8 weeks Mavyret 07/23/2019. Tx - 1st time, Rebetron 6/2000-6/2001, 2nd time, Pegasys 11/2002-4/2003. VL - 636,000 AST - 49, ALT - 77

UND - 08/22/19!!!

SVR 12 - 12/17/2019, AST - 17, ALT - 14

 

 

 



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Hey Iris, ignorance is exactly what it is. I don't handle grilling very well. That would have gone completely the other way for me.



__________________

62 yo male GT 1b/2 ALT 60 AST 51 V/L 985,000 Fibro A2 F 3/4 began 12 wks Mavyret 9/13/2018

6 wk labs ALT 12 AST 18 V/L NOT DETECTED EOT 12/05/2018 V/L NOT DETECTED

12 Wk post EOT ALT 11 AST 16 V/L NOT DETECTED  Thank you GOD

Take that stupid dragon

1/2/2020 SVR 12



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Sticker,I see there's a bit of a storyteller in you as well. Sometimes ya just can't help it. Glad you're doing well. Two more weeks until your first blood draw. Great. I was on 12 weeks of Mav so I didn't get mine until 6 weeks. But, I was undetected. I feel you will be as well. Rest when you can,drink.



__________________

62 yo male GT 1b/2 ALT 60 AST 51 V/L 985,000 Fibro A2 F 3/4 began 12 wks Mavyret 9/13/2018

6 wk labs ALT 12 AST 18 V/L NOT DETECTED EOT 12/05/2018 V/L NOT DETECTED

12 Wk post EOT ALT 11 AST 16 V/L NOT DETECTED  Thank you GOD

Take that stupid dragon

1/2/2020 SVR 12



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Lamassu, like i said I've always been upfront with people and my blood. She chose the outcome. I chalked it up to you can't fix stupid.



__________________

62 yo male GT 1b/2 ALT 60 AST 51 V/L 985,000 Fibro A2 F 3/4 began 12 wks Mavyret 9/13/2018

6 wk labs ALT 12 AST 18 V/L NOT DETECTED EOT 12/05/2018 V/L NOT DETECTED

12 Wk post EOT ALT 11 AST 16 V/L NOT DETECTED  Thank you GOD

Take that stupid dragon

1/2/2020 SVR 12



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Hi Sticker,

Well, you're about 10 days into your Mav I guess, it won't be long now, and it will be 2 weeks done, then 4 weeks done, and then at the 4 week mark I think you said you were going to get your first blood draw done?

I hope you get some bouying early results at your 4 week mark (you may well)! Those lab "rewards" help spur one on through treatment. This time around is an entirely different drug treatment world than the last unsatisfactory drug attempt you had to go through. You are curing as we speak! Amazing nowadays, that we can be cured in just a mere 8 weeks.

I recall you said you love junk food - please do try to eat as healthily as you can, you are already doing so well in the knowledge/awareness/attitude, compliance, and water drinking areas, I just worry a tiny bit about your job/energy outputs and perhaps your busy lifestyle that could decrease the amount of good rest/sleep/time-off, and healthy food your body gets. Treat your precious body as good as you possibly can for the treatment duration (and beyond). Have you defined what it is you are feeling, as far as feeling "medicated" on the Mav?? Maybe we can come up with some helpful suggestions to counter specific things. Good diet, good rest (and water intake of course) can always helps (I think).

We are so looking forward to seeing you finally free from this virus! A soon day! : )  C.

 



__________________

HCV/HBV 1973. HBV resolved. HCV undiagnosed to 2015. 64 y.o. F. Canada.

GT3a, Fibroscan F3/12 kPa - F4/12.6 kPa, VL log 7.01 (10,182,417), steatosis, high iron load.

SOF/VEL with/without GS-9857 trial - NCT02639338.

SOT March 10 - EOT May 5, 2016 - SOF/VEL/VOX 8 week trial.

 

(SEE UPDATES IN BIO)



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We are survivors here! Amazed at the stories of how folks have been treated by so-called professionals. Glad we know how to take care of ourselves.

My dad had this saying that took various constructs over the years..for example:  When we would complain to him or someone would tell a dreadful story he would say, 'life, its just part of it' or 'shucks, that's rough, its just part of it'. I think it was another way of saying 'suck it up'. Sometimes it was funny and yet I appreciate we don't do that here all the time.

Sticker --- glad all is going well with your meds so far..be sure drink lots of water. I'm making a glass of water toast to you now! 

 

ps



__________________

 

New: Hepatomegaly 07/30/2019, AST 29 & ALT 15

Female,1a,F2 mod fibrosis,HCV 06/2017,SOT 08/04/2017, Harvoni

HCV VL 414,000, AST 54, ALT 74.  4 weeks AST 34 and ALT 31, SVR, Jan 2018. 

12 week EOT, AST 20 & ALT 23 and still VL UND.

Club Zero Member.

 



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@Iris, that is so incredibly uncool that a physician would behave in such a manner with you! Im glad you didnt go back! The contraction of this virus is entirely not relevant to treatment in my opinion. I am kind and respectful with doctors as well as being fully compliant with medical regime, if they cannot return that respect I will first demand it and if they cannot comply I will discharge myself from their service. At the end of the day, they are just people, not gods. disbelief



__________________

52 y/o male, Genotype 1B, F3, Dx - 1992, likely contracted virus 1977, Current Tx - 8 weeks Mavyret 07/23/2019. Tx - 1st time, Rebetron 6/2000-6/2001, 2nd time, Pegasys 11/2002-4/2003. VL - 636,000 AST - 49, ALT - 77

UND - 08/22/19!!!

SVR 12 - 12/17/2019, AST - 17, ALT - 14

 

 

 



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Lol Shemp!! I would have loved the expression on her face had you chosen to tell her that! Youre a kind person for sparing her! We have no choice but to accept ownership of the virus so I think that ANY story you decide to tell is up to you! I have burn scars covering 46% of my body and the scars are quite visible on my legs. A young lady on the beach in Florida was staring and eventually asked me if I had survived a shark attack! I thought for a second and said, yes, yes I did survive a shark attack which is more than I can say for the shark! Im a stinker! 



__________________

52 y/o male, Genotype 1B, F3, Dx - 1992, likely contracted virus 1977, Current Tx - 8 weeks Mavyret 07/23/2019. Tx - 1st time, Rebetron 6/2000-6/2001, 2nd time, Pegasys 11/2002-4/2003. VL - 636,000 AST - 49, ALT - 77

UND - 08/22/19!!!

SVR 12 - 12/17/2019, AST - 17, ALT - 14

 

 

 



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Shemp that dental hygienist who refused to treat you broke the law and you could sue for discrimination or get her boss in very hot water. All health professionals have followed universal precautions guidelines (sterilization, gloves and masks) since 1988 over thirty years ago. A healthcare provider can not refuse to treat a patient because of their HCV or HIV status period. You would not want to be treated in an office like that anyways. My dentist and hygienist know my HCV status and do not have a problem at all.



__________________

Male, 67, Dx 1990, GT 2a/2c. Pre-tx VL 11,500,000, ALT 10, AST 18, F3, 12.4 kPa. Rx: 12 weeks Epclusa, SOT 3/8/18, EOT 5/30/18. Week 2 VL 50, ALT 12, AST 21. EOT + 12 weeks: VL not detected, ALT 11, AST 19. EOT + 24 weeks VL not detected, ALT 9, AST 24. 8/15/19 F2 8.8 kPa.



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Hey, good to hear you are tolerating the meds well, I think your statement about them being kinder to the virus may be more like it is kinder to our bodies, those who underwent the old therapies we super humans! and actually one of the reasons I waited, don't think I would have been a good candidate considering the depressive part of the side effects disbelief  Keep on slaying Stickie!!

@ Shemp, it never ceases to amaze me the ignorance of folks, I mean why on earth would a dentist care where you got this? Criminy! it doesn't change the precautions they must follow. Seriously, the bulk of us do not know how we got this. I also had a Dr. grill me about how I got this, I told him I suspected it was my tattoo, he wasn't buying it, I left in tears and I never went back there again.

BB, Iris



__________________

in the silence of the woods, you will not be alone- Chief Seattle

60 years on planet, Female, diagnosed 1978 as non-a non-b, VL 8mill+, Fibro f-1f-2, Genotype 1a, treatment naïve....UNTIL 7-01-18  !!!! started Harvoni 12 weeks. :)

4 weeks=UND, 8 weeks=UND, 12 weeks=UND (EOT= 09-23-2018)

Tig


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Hey Michael,

I enjoy reading your messages. They are full of the experiences we have all lived with and are packed with wisdom. Your ability to see the whole picture and share it with meaning and understanding, helps everyone reading it. Your story is exactly what those following you need to understand. It helps us Veterans as well. People need to know the experiences we have all had and how we dealt with them. Keep up the positive message, we all benefit from it!

I‘m glad you’re doing well, but also know these treatments still affect you mentally and physically. The first few weeks of any treatment is full of adjustments and peculiar feelings. That’s completely normal, not particularly enjoyable, but tolerable. Your commitment to wellness will pay off. Stay the course, hydrate and success will be yours...



__________________

Tig

67yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 9+ years!

Hep C FAQ   Lab Ref. Ranges  HCV Resistance

Signature Line Set Up/Abbreviations   Payment Assistance

 



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Hey Sticker, glad you're coping well. Feeling medicated goes with the territory. They told me Mavyret has a short half life, but it still builds up in your system. That judgement thing always amazed me. I was always up front with people who might come in contact with my blood. A dental hygienist once told me she would not touch me until I told her how I got the virus.I thought about telling her the Texas chainsaw massacre was real and I was there, but in the end I told her have a nice day and left. I've told people that I hit the unlucky lottery, and they just stare at me puzzled. Who cares how you got it.What's important is getting rid of it. Really happy you're on your way. Stay strong, Drink, Rest.



__________________

62 yo male GT 1b/2 ALT 60 AST 51 V/L 985,000 Fibro A2 F 3/4 began 12 wks Mavyret 9/13/2018

6 wk labs ALT 12 AST 18 V/L NOT DETECTED EOT 12/05/2018 V/L NOT DETECTED

12 Wk post EOT ALT 11 AST 16 V/L NOT DETECTED  Thank you GOD

Take that stupid dragon

1/2/2020 SVR 12



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sticker, you are allowed to complain to us when you need to. we went thru it and yes keeping a good attitude helps so much, but it's also good to know someone has felt things you might be feeling.

i had a bit of depression when i first started feeling tired or weird becos i didn't want to have any side effects.

i hope it's easy for you tho.



__________________

Gt:1a-36yrs .Started Intron-A in 96' for 2.5mo-VL still too high.taken off. Labs on 3.6.18:. A1 activity.  f3@60: fibrosur bloodtst. AFP=norm. enz=mostly norm.VL=3.9 million.sot=5.1.18>Harvoni>[8wks]: 4WEEKS=UND. Eot 6/25=L.J*13weeks=UND * 6 m =UND: CLUB ZERO.1yr.=0



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Thanks guys! I have finished week one of TX. Its not too bad but I can definitely tell that I am taking medicine, my body has noticed. Im not complaining though, if anything, I am enormously grateful that the side effects are so minimal thus far. Week two, here I come! It is heartening to read everybodys signature line and learn of their fight with HepC. You know, its not like we tell everyone we meet that we have this virus. I especially love when I am judged by someone assuming that I contracted it through my own negligent behavior. Like it really matters how a person contracted the virus. Its ironic that there is growth to be found in dealing with this virus. I am more understanding, sympathetic, less judgmental, still  deeply flawed though. Its probably also a function of age, hopefully I will grow to become more wise. Since turning 50 a few years back I was struck with how much time has passed and hopefully much more still to pass. I have much to learn yet from those more experienced but have gathered enough moss to realize it. Will check back in soon. Much love to you all.



__________________

52 y/o male, Genotype 1B, F3, Dx - 1992, likely contracted virus 1977, Current Tx - 8 weeks Mavyret 07/23/2019. Tx - 1st time, Rebetron 6/2000-6/2001, 2nd time, Pegasys 11/2002-4/2003. VL - 636,000 AST - 49, ALT - 77

UND - 08/22/19!!!

SVR 12 - 12/17/2019, AST - 17, ALT - 14

 

 

 



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Hey Sticker, Happy to see you're finally on your way.Won't be long till that dragon is in the rear view. Treatment is a waiting game. Wait for approval, wait for drugs, wait for blood work, wait for SVR. But, in the end it will all be worth it.Glad to see you're coping well with the TX. Stay strong but, rest.



__________________

62 yo male GT 1b/2 ALT 60 AST 51 V/L 985,000 Fibro A2 F 3/4 began 12 wks Mavyret 9/13/2018

6 wk labs ALT 12 AST 18 V/L NOT DETECTED EOT 12/05/2018 V/L NOT DETECTED

12 Wk post EOT ALT 11 AST 16 V/L NOT DETECTED  Thank you GOD

Take that stupid dragon

1/2/2020 SVR 12



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Yay Sticker.... our poster boy of dragon fighting.

Getting exercise is a good idea, just listen to your body and make sure youre not overdoing it and are staying balanced...your body is full time fighting and destroying that nasty virus so...rest and good diet are equally important 

In British Columbia...some of  local drug stores are offering HCV tests so people who are unknowingly infected can get on treatment. Now that the new treatments  have such wonderful success rates...hopefully someday HCV can be eradicated 



__________________

61 y/o, Infected via transfusion Oct'83, GT-1a, F-4 cirrhotic,
tx Holkira pak/moderiba 12 weeks

4 years.... successful dragon slayer 



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yes, i got a short trial of interferon .. that is some harsh medicine! i was glad and sad when they took me off due to low response

and for sure, one of the hardest things about the new daa tx is waiting for the home delivery , the days leading up to it and making sure to be awake and attentive . talk about anxiety.

i'm so glad you are doing as well as you are sticker , and that you are on it with the water



__________________

Gt:1a-36yrs .Started Intron-A in 96' for 2.5mo-VL still too high.taken off. Labs on 3.6.18:. A1 activity.  f3@60: fibrosur bloodtst. AFP=norm. enz=mostly norm.VL=3.9 million.sot=5.1.18>Harvoni>[8wks]: 4WEEKS=UND. Eot 6/25=L.J*13weeks=UND * 6 m =UND: CLUB ZERO.1yr.=0



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Well said Mike. I have been following your journey and enjoy reading your posts. The 'pay it forward' concept is not lost on you and reflects well on the warrior you are. Rock steady my friend.

 



__________________

60 yo (2013), genotype 2b, started 28 week tx Sept.14, 2013. Triple Therapy (ribavirin, victrelis, peginterferon), VL 235k prior to tx, UND right through. EOT March 29, 2014. EOT24 Sept. 15, 2014 and EOT + ONE YEAR April 1, 2015 UND.... SVR!

 



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Anyone new to this forum that is starting Mavyret, do not sweat it!! I have been posting in the new arrivals section of the forum; just getting acquainted with everyone. I began Mavyret on 23 July, 2019. I am almost a week into the treatment regimen and coping really well. I felt it worthwhile to post about my process in getting here so that anyone navigating into the unknown might have some clue about getting and starting meds. I discovered that this doesnt happen quickly in the way that it would with other prescriptions. Approvals and negotiations have to occur between the insurer and the specialty pharmacy all of which take a little bit of time. Next, you have to be home to accept the package delivery from FedEx because they are not leaving such a high valuation package just sitting on your front porch. My first 4 weeks of Mavyret came with a price tag of around $14,000. 

Now, the medicine. I was treated years ago with a 12 month course of Rebetron (interferon/ribavirin), many in this forum are familiar with that poisondoh. This was followed with Pegasys (pegylated interferon/ribavirin), it sucked slightly less than the first course of treatment, lasting only 6 months. During this time there were also liver biopsies doneI say all of this simply to point out that the trauma is over, the new meds are infinitely more kind to the organism overall. 

Pay attention to the repeated advice given here in the forum about water intake. I believed everything I have read here and have taken it as the gospel, and the gospel is: Water, you will drink enough of it to feel like you are walking on water! The literature included with Mavyret also states that patients should drink 2-4 liters of water daily. 

I am additionally trying to get regular exercise. I dont know how much that helps with treatment, but it makes my brain feel better. In my case, hard exercise; the kind where all you think about the whole time is how bad you want to quit, seems to help my mind throughout the day. This statement does not mean I am some fitness junkie. Im just a regular dude with a poor diet ( I love to eat garbage!) 

I am hopeful and I am thinking positively, the depression associated with previous HepC treatments hasnt shown up with the Mavyret. If it does, I will share that in the forum. HepCfriends has been a comfort to me and I hope that it is a comfort for anyone coming here too! Thank you all so very much, I cannot express how much it means to me to know you are out there! 



__________________

52 y/o male, Genotype 1B, F3, Dx - 1992, likely contracted virus 1977, Current Tx - 8 weeks Mavyret 07/23/2019. Tx - 1st time, Rebetron 6/2000-6/2001, 2nd time, Pegasys 11/2002-4/2003. VL - 636,000 AST - 49, ALT - 77

UND - 08/22/19!!!

SVR 12 - 12/17/2019, AST - 17, ALT - 14

 

 

 

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