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Post Info TOPIC: starting mavyret


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RE: starting mavyret
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That big first week is over. I understand any uncertainty that you could possibly have. During treatment I likely amplified any signal my body gave, was that a twinge? , am I experiencing liver pains? The incidence of these moments decreased after the first week so it was hard to say whether it was psychosomatic or not. In your case there are measurable findings and its not all in your head. You are going to be free of this thing very soon, Im pulling for you! Drink up!



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52 y/o male, Genotype 1B, F3, Dx - 1992, likely contracted virus 1977, Current Tx - 8 weeks Mavyret 07/23/2019. Tx - 1st time, Rebetron 6/2000-6/2001, 2nd time, Pegasys 11/2002-4/2003. VL - 636,000 AST - 49, ALT - 77

UND - 08/22/19!!!

SVR 12 - 12/17/2019, AST - 17, ALT - 14

 

 

 



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Week one behind me.

Seven to go.

Water...the magic elixir.

 

j



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Thanks I will.



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jammers, keep a log of your heart rate and either call the pharmacy or your doctor to ease your worries about it. That's why they get the big dollars $$$$$$$$$$$$$$$$$$$$$$ ....to answer our questions



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Gt:1a-36yrs .Started Intron-A in 96' for 2.5mo-VL still too high.taken off. Labs on 3.6.18:. A1 activity.  f3@60: fibrosur bloodtst. AFP=norm. enz=mostly norm.VL=3.9 million.sot=5.1.18>Harvoni>[8wks]: 4WEEKS=UND. Eot 6/25=L.J*13weeks=UND * 6 m =UND: CLUB ZERO.1yr.=0



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Jammers,

That's great that you are paying close attention to deviations from your norm. I'm not surprised that things are changing as you have some heavy duty anti virals running though your entire system. I agree, that you have to allow a period of adjustment. Still, keep paying attention and don't let that heart rate get too high without reporting it.  

It's pretty amazing that we have cures now that don't make you just plain sick, like the ones that Tig and others went through.  The sides back then caused some people to have to quit, and even worse, fail. My was no walk in the park as Ribaviren was included.  I was a mess and was rescued by Tig and others seeing me through. I think it's expected that your body is going to say, "Whoa! What the heck is this?" It will pay off, really.

Keep up the water. Eat well, and be patient.  It will all be over and gone soon. Stay in touch. I'm very interested in seeing how your journey continues.

 

Best wishes,

Ched



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GT2a, VL 681,500, Less than F1, Treatment Naive

12 wks Sovaldi/Ribavirin, SOT 2/25/16, EOT 5/17/16

UND at 2,4,8 and 12 wks during treatment but ribavirin crazy.

ALT/AST normal EOT

SVR12 8/13/2016!!!!!!!!!  I WON!!

EOT 6 Months 11/12/2016  CURED

 

Tig


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I found my heart rate greatly accelerated at times, but some of it I'm sure was stress related. Do you have a blood pressure cuff at home? It's good to have one for so many reasons. That's the thing to keep an eye on. I also suggest that you cut out any stimulants, coffee, chocolate (sorry), tea, etc. Anything with caffeine should be avoided or greatly reduced if you're experiencing higher than normal pulse rates. Try decaf for the time being.

Have you noticed any increased sweating? I did, terrible stuff! All medicine related. Certainly, if you're experiencing anything that is well above and beyond normal, for an extended period, call your doctor. If you have that blood pressure cuff, keep track of your vital signs for a couple of days, BP, Pulse and Respiration. I recommend doing it every 2-3 hours while you're awake and switch arms occasionally. If you end up calling the doctor, that will be a great help. It may also help you determine if there are lifestyle issues that may be causing it, other than the medication of course.

As I mentioned earlier, the first couple of weeks will be an adjustment period. You're going to experience some changes. As long as they aren't worrisome, don't worry about it. It's very likely just your metabolism adjusting to treatment and should level out fairly quickly. These are powerful medications and even though you're not going through a minefield of side effects, you'll still require time to adjust. They're in there doing some awesome Dragon Butt kicking! Exactly what is needed. smile



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Tig

64 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 6+ years!

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Is it normal to experience a higher than normal heart rate?

I am usually in the 60-70 bpm but today after taking day four of the med, just relaxing my rate is around 90 bpm.

 

j



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Oh I am very familiar with the dry brush.

 

Thanks



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Good advice and info.

thanks

 



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Sorry bout spelling keyboard stuffed,

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D writer


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Hi everyone ,hope al BBH l going ok , Thankfully summer almost gone,the humidity here is high atm, hope this new coronavirus gets wiped out soon, went to supermarket yesterday people are already nearly in state of panic,buying up on toilet ect, I spoke with naturepath recently he told me that a lot of the pain issues we have Poste treatment might be caused by carting the virus around for so long, seems to make sense as a lot of people have similar symptoms neuropathic nerve bloating ect, I also had high VL which worried me about doing treatment, especially if they were doing damage ,at least getting rid of virus hopefully stops any more damage to our system, take care everyone.

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Tig


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We used to experience horrible itching with the old regimens. We would use a number of methods to combat it. An oatmeal bath often works wonders. I got permission to use Zyrtec (certrizine), which is a antihistamine. It was very effective and doesn’t cause drowsiness, like Benadryl does. There’s a number of over the counter lotions that help, too.

As Obs mentioned, most of the early reactions to these friendly, but powerful meds, will resolve on their own. It takes a week or two to adjust to the drug. Keep hydrating and getting the rest your body requires. The time will go by fast.



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Tig

64 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 6+ years!

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Great jammers, 

isnt it amazing that these new drugs are so *user friendly* compared to the misery so many suffered through with the interferon and ribivaron treatments of 5 years ago?  Im so happy for you that a mild and treatable headache is the main issue you are having... hopefully the itching will pass soon...I found most of my odd side effects only lasted  for a few days.  I was on an earlier DAA and ribivaron , the sides from  ribivaron were pretty awful.

The itching is one of the bodys mechanisms for removing waste...if it persists might I suggest you look into doing a dry brush massage... you can buy a body brush at any pharmacy (near the loofas) and google dry brush massage..



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61 y/o, Infected via transfusion Oct'83, GT-1a, F-4 cirrhotic,
tx Holkira pak/moderiba 12 weeks

4 years.... successful dragon slayer 



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hey jammers, sounds good so far........ maybe extra lotion for now?

happy trails

5



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Gt:1a-36yrs .Started Intron-A in 96' for 2.5mo-VL still too high.taken off. Labs on 3.6.18:. A1 activity.  f3@60: fibrosur bloodtst. AFP=norm. enz=mostly norm.VL=3.9 million.sot=5.1.18>Harvoni>[8wks]: 4WEEKS=UND. Eot 6/25=L.J*13weeks=UND * 6 m =UND: CLUB ZERO.1yr.=0



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Just popped Day 3.

Nothing much to report. No sides to speak of. Occasional mild headache, but i take a few aspirin and water and it's gone. Today though my skin itches a little, nothing major though.

 

Water water water.....

 

j



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Thank you.



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Yay jammers,

day one done.

I really like your painting...yummy colours. 



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61 y/o, Infected via transfusion Oct'83, GT-1a, F-4 cirrhotic,
tx Holkira pak/moderiba 12 weeks

4 years.... successful dragon slayer 



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Day one still in progress so far so good nothing to speak of besides a very mild headache waking up from a nap took two aspirins and some water and it vanished.

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You’re going to do great, Jamie! We’re here with our Pom Poms ready, woohoo!!



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Tig

64 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 6+ years!

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heeeeeeereeeee you go! let the healing begin , water water water..... and rest

 

5



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Gt:1a-36yrs .Started Intron-A in 96' for 2.5mo-VL still too high.taken off. Labs on 3.6.18:. A1 activity.  f3@60: fibrosur bloodtst. AFP=norm. enz=mostly norm.VL=3.9 million.sot=5.1.18>Harvoni>[8wks]: 4WEEKS=UND. Eot 6/25=L.J*13weeks=UND * 6 m =UND: CLUB ZERO.1yr.=0



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Home with first month supply.

 



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Yeah!! You got this   Before you know it, the dragon will be in the history books and out of your life, for good. Stay the course, never miss a dose and hydrate like the water will run out tomorrow. That's almost as important as the medication! It makes for great outcomes and no side effects.

Stay in touch and don't hesitate to ask questions when you have them. We're here to not only guide the way, but cheer you on to the last station - SVR-Ville wink



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Tig

64 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 6+ years!

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that's great jammers! getting on board the healing train to wellsville

5



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Gt:1a-36yrs .Started Intron-A in 96' for 2.5mo-VL still too high.taken off. Labs on 3.6.18:. A1 activity.  f3@60: fibrosur bloodtst. AFP=norm. enz=mostly norm.VL=3.9 million.sot=5.1.18>Harvoni>[8wks]: 4WEEKS=UND. Eot 6/25=L.J*13weeks=UND * 6 m =UND: CLUB ZERO.1yr.=0



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Thanks. That's my plan. Start tomorrow.



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Hey Jammers...I did Mavyret for 8 weeks.  Took mine at dinner time with food.  Drink LOTS of water.  I had zero side effects!  Hope your treatment was as easy as mine. 



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66 yr old female; polio survivor; hbv that wasnt treated but cleared; chronic hcv gt1a; diagnosed 2018 but likely infected during surgery as child; Metavir score F2-F3; mild to mod fibrosis; RNA 3,951,412; AST 40; ALT 47



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Thanks for the info.

i start on 2 march.



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yes. on 2 march.



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Yes observer said it is one of my paintings

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hey jammers, so you start in about 9 or 10 days?



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Gt:1a-36yrs .Started Intron-A in 96' for 2.5mo-VL still too high.taken off. Labs on 3.6.18:. A1 activity.  f3@60: fibrosur bloodtst. AFP=norm. enz=mostly norm.VL=3.9 million.sot=5.1.18>Harvoni>[8wks]: 4WEEKS=UND. Eot 6/25=L.J*13weeks=UND * 6 m =UND: CLUB ZERO.1yr.=0



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Jammer...Tig answered already but I have to let you know I really like your avatar picture...is it a drawing/painting that you did?



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61 y/o, Infected via transfusion Oct'83, GT-1a, F-4 cirrhotic,
tx Holkira pak/moderiba 12 weeks

4 years.... successful dragon slayer 

Tig


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Hey Jammer,

Yep, that’s right! It’s enough to make me want to run to the head (Navy) old habits die hard, lol! I recommend doing your best. If you can target 3-4 liters, 3 quarts, etc., and you aren’t experiencing any headaches (most common sfx from low water intake) then you’re fine. We have all recognized that as an indication to increase intake.

Best way, IMO, is to keep a refillable water bottle with you and sip all day. It makes it much easier. If you have trouble at night, needing to wake to go, cut back the intake a couple hours before bedtime. Keep the water with you at night and if you do wake up, take a sip. Just try and meet that requirement and you’ll be fine. 

How is your schedule coming? It will go by quickly, the preparation to launch is the longest, lol! I know you’re going to be successful. This stuff is a Dragon destroyer!



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Tig

64 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 6+ years!

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Gallon a day is what I have been hearing is how much water to drink on a daily basis. That's 8 16 ounce glasses in a 24 hour period. Does that sound about right?

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Welcome jammers,

Its great that you are getting rid of the hep. As the others said... water water water and of course listen to your body and if you have to...take it easy..

As for whens best to take it? Its really really important that you take it at the same time of day from start to finish so you will have to decide what works best for the compliance aspect of treatment.  As for the side effects affecting your ability to work... well.. we each are different - some have zero sides - some get tired..as long as you drink water you can usually stave off headache... 

let us know when you start

 

 

 



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61 y/o, Infected via transfusion Oct'83, GT-1a, F-4 cirrhotic,
tx Holkira pak/moderiba 12 weeks

4 years.... successful dragon slayer 



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We are still wondering what time of day is best to take the Mavyret. Morning. Bedtime. Food?

 



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GT2a, VL 681,500, Less than F1, Treatment Naive

12 wks Sovaldi/Ribavirin, SOT 2/25/16, EOT 5/17/16

UND at 2,4,8 and 12 wks during treatment but ribavirin crazy.

ALT/AST normal EOT

SVR12 8/13/2016!!!!!!!!!  I WON!!

EOT 6 Months 11/12/2016  CURED

 

Tig


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Hey Jamie,

Welcome to the club! You’re starting one of the most successful protocols known to man or beast. I can tell you that I know of no one that has failed this treatment. It’s that good!

As far as side effects, they are minimal, if any. Do your part and hydrate like a thirsty Camel, eat properly and get the rest you need, not what you’re used to. Try and get 7-8 hours of good sleep while you’re going through this. The first couple of weeks may impart some weird feelings, that’s normal, but they shouldn’t be anything you can’t handle at home or work. There might be so muscle aches and pains, but extra water should relieve those quickly. Water is the magic elixir!

We have a lot of info here on Mavyret, as well as personal stories from your fellow Warriors. Spend a minute or two and read this monograph on Mav, it will give you some professional insight into the drug action. MAVYRET

If you have any questions, don’t hesitate to ask. I know you’ll do great!



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Tig

64 yo GT1A - 5 Mil - A2/F3 - (1996) Intron A - Non Responder, (2013) Peg/Riba/Vic SOT:05/23/13 EOT:12/04/13 SVR 6+ years!

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Hi!, and welcome to the forum! yep, good support here. will be following your journey.

bb, Iris



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in the silence of the woods, you will not be alone- Chief Seattle

60 years on planet, Female, diagnosed 1978 as non-a non-b, VL 8mill+, Fibro f-1f-2, Genotype 1a, treatment naïve....UNTIL 7-01-18  !!!! started Harvoni 12 weeks. :)

4 weeks=UND, 8 weeks=UND, 12 weeks=UND (EOT= 09-23-2018)



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Thank you Guru I always tell my doctors the best way to find out how treatment is going to go or a surgery is to hear it from people who have gone through it. I spent a long time helping manage Colon cancer forums so the messages and information people got in there was invaluable and many times saved their lives.

 



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Thanks and hello. My colon doctors got me used to drinking massive amounts of water so I will give it my best.



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welcome jammers,

yep, all the new DAA drugs are so good that not many ppl show up here now days; but i found it a great idea to get the support and info that the good ppl of this forum provided for me during tx.

lots of water and rest and do what you can.....cross those bridges when you come to them; expect good news



-- Edited by 5-1-18 on Thursday 13th of February 2020 02:22:53 AM

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Gt:1a-36yrs .Started Intron-A in 96' for 2.5mo-VL still too high.taken off. Labs on 3.6.18:. A1 activity.  f3@60: fibrosur bloodtst. AFP=norm. enz=mostly norm.VL=3.9 million.sot=5.1.18>Harvoni>[8wks]: 4WEEKS=UND. Eot 6/25=L.J*13weeks=UND * 6 m =UND: CLUB ZERO.1yr.=0



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Welcome, Jammers.  Unfortunately, I don't know enough about Mavyret in particular to answer your question, but I'm sure someone will get back to you on this. I do know that the new meds for hepC are wildly successful and with far less side effects than earlier medications. 

It's great that your viral load is low and that your liver has put up with this.  Getting rid of the virus is a really smart move. You don't need the virus replicating unchecked.

One thing you will hear from all of us here is that you need to drink loads of water. Yep - a gallon a day. It really helps to reduce any side effects and keeps your system flushed.  It's hard to get used to drink that much, but it's worth it. Dehydration is a big no-no.

I wish you the best on your journey and I am happy you are taking it. Be sure to let us know how it's going.  We learn a lot from each other.

Best to you,

Cheddy



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GT2a, VL 681,500, Less than F1, Treatment Naive

12 wks Sovaldi/Ribavirin, SOT 2/25/16, EOT 5/17/16

UND at 2,4,8 and 12 wks during treatment but ribavirin crazy.

ALT/AST normal EOT

SVR12 8/13/2016!!!!!!!!!  I WON!!

EOT 6 Months 11/12/2016  CURED

 



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hello

I have had hepc for a very long time. Since my military service.

I am told my liver is surprisingly in great shape with a viral load of 400,000.

I have agreed to start mavyret on 2 march.

My main concern, needing to keep working a schedule of 0800-1300, what is the best time to take this so that one might experience the side effects less at work, if that is even possible?

This looks like a great place to be and give and get support.

 

Thank you in advance

jammers



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