Hep C Discussion Forum

Milliganus · Milliganus

Hi all, Is there anyway to know if you are getting the drug or just a placebo. I may get into a Merck trial with MK5172 & MK8742, no riba or INF. Getting a placebo would take me an additional 16 weeks before the real thing. Just curious if there's anything I can look for (if I get in of course). Finger...

Milliganus · Milliganus

Hi all, Been keeping my eye out and this trial looks like it will be coming up as a phase 3 multi-center trial soon. I'm hoping to jump on it if I can. It is going to be an 8 week or a 12 week randomized trial. No Riba or Inf. Any thoughts on SVR in trials only lasting 8 weeks? Phase II SVR results I've seen fo...

Mike716 · Mike716

Hi, Forum members. I hope everyone is enjoying the spring weather (if it's spring in your part of the world), and that you're having more luck than I am getting therapy. I just found out that the OPTIMIST trial (Sovaldi + Olysio for treatment-naive genotype 1) is no longer recruiting. I've been follo...

tgcd78 · tgcd78

Hello, I'm not sure if anyone cares but I thought I would update anyone who does. I have found it very useful, most times encouraging, to read about other peoples experiences. I am on day 11 of the Optimist Clinical trial. It involves taking Sofosbusvir and Simeprevir (Olyosio) 150 mg Once daily wit...

Milliganus · Milliganus

I'm thinking I've missed the boat to participate in a clinical trial for Gileads sofosbuvir & ledipasvir dual therapy. Does anyone know of any upcoming trials (U.S.) using these? I so want to get treated but I'm skeptical that my insurance will cover this combo due to price when they are approv...

Milliganus · Milliganus

Hi everybody, Just wondering if anyone knows of any upcoming trials? I've been watching Clinical Trials.gov waiting to jump on something. I'm doing pretty well, but the fatigue is getting me every day by mid-afternoon. We are in the Phoenix area for the winter and it's been very nice. Lots of sun...

Tig · Tig

A new phase III trial for HIV/HCV co infection, Ally 2, is currently being recruited. Bristol-Meyers Squibb is the sponsoring manufacturer. Check the included link for additional information. This information was provided by our member "Sara" and I want to thank her for bringing it to...

Milliganus · Milliganus

Called out to Scripps today and talked with them about the upcoming Janssen Optimist-1 clinical trial (NCT02114177). Sounds like they are going to accept me. It will start in May in California. We are currently in Colorado with a child with a broken arm. No problem to travel though. All of you ha...

Karen · Karen

For all who succeeded on the Gilead trial-they are offering a long term follow-up to continue to evaluate your response...started mine today!

Matt Chris · Matt Chris

Hey All This is Great article that Gilead and most of the Trials site Doctors have collaborated on that was released at the EASL Conference in London this week-end and also was released as a important article in The New England Journal of Medicine on Sat. Please follow this link to read http://www.nej...

Jayzcatt · Jayzcatt

Hi everyone my name is Janine I have hep c genotype 1a/1b I am awaiting news of when I will start my trial with sofosbuvir, has anyone out there got some advice anything really, I refused the interferon due to being told that it would more than likely not help me have just come from my specialist today he in...

balagan51 · balagan51

Meant tp post this on my Abbott thread apologies Just received a call from my coordinator...still UnDEtectABle at 10 weeks!!!! Going in for my 12 week labs on Monday HOPING for more good news HGB 14 Bili 1.2 Platelets Up to 120 ! sides: insomnia,transient anxiety Strained my neck & finally t...

Liamc · Liamc

Hi, has anyone heard of Abbvie trials for geno3a? Thanks in advance

findingthecure · findingthecure

Hi Everyone, It's been awhile since I've been on this forum. Life got very busy! I'm glad to announce that I achieved SVR on the Abbvie drugs and I'm still clear. I think we need to help those behind us as the latest results are very promising although I realize that not everyone was successful in beatin...

dragonfly · dragonfly

Can't even spell the name of the drug which I hope will save my life. At last the UK is doing widespread trials for geno3 - lobby your consultant. Dragonfly xxx

Millercollaborative · Millercollaborative

Hi folks, I started this trial about 9 weeks ago and end treatment at the end of this month. Is anyone else in this trial? Its very intensive in terms of clinic visits but seems to be having good results. Karen

Browneyedgirl · Browneyedgirl

New member and my first post. Gilead - LoneStar-3 Open Label Study of Sofosbuvir/Ledipasvir Combination with Ribavirin or GS-9669 250 mg or GS-9669 500 mg in Treatment Naïve or Treatment-Experienced Cirrhotic Subjects with Genotype 1 HCV. (Not posted on clinical trials.) Just started this...

Jumpy · Jumpy

Hello, I am on the Sapphire Trial and after 3 months discovered I was on the placebo and am now into my fourth week of the real meds. Strangely enough I felt pretty appalling throughout the placebo - general malaise, aching body etc. Guess it was the virus. I am also getting side effects from the real meds...

Bob C · Bob C

I have 2 WK post EndTrial visit 2morrow. Tx SEs continue- stomach churning on laying down, all night, continues. Problem sleeping w stomach rumbling all night. BTW, anyone been hearing how the pre-SAPPHIRE, P2 (AVIATOR) are doing with SVR. Those trial folks s/b ~40 weeks.

newby4555 · newby4555

ok i try here, i am new, and genotype 1b, started the Abbott sapphire phase 3 5 days ago, wondering when side effects kick in lol that is about it

LC · LC

I am not only treatment naïve, I know nothing about clinical trials. Does anyone know if you have to live within a certain distance from where a trial is held? I am not seeing much in my area. Do you have to drive to the place the trial is being held each time they want to see you, or can they usually do yo...

bowens44 · bowens44

I haven't posted before but have been an occasional reader. A little background I have Hep C Genotype 1a. I believe I have had since the late 70s. First I was on the interferon ribavirin treatment. I had an initial large drop in viral load but it came back during treatment. I was taken of the meds. Next I...

Matt Chris · Matt Chris

Hey all We have an opportunity to give written input to the FDA regarding HCV treatment from the viewpoint of the patient in the future treatments with DAA's. This our chance to give real world input from our standpoint not just the drugs company's. If you ever wished or wanted them to consider your vie...

LUV2RYDE · LUV2RYDE

I just finished my Abbott trial on 6/26/13(last night I took meds) and was wondering how everyone is feeling off of the meds? My first day off meds I had to go in and turn in all empty med sleeves and bottle of riba and had a blood draw and EKG. But I noticed later that evening how friggen tired I was. I mean lik...

JLynch30 · JLynch30

Anyone know besides the clinical trials.gov where I can look for trials - I need one and I have tried everything and failed.

veronika · veronika

I finish the 42. day of treatment today, being on Malachit II study ( 12 weeks of Abbvie combination for previously non-responders). I got the UND result at week 2 and 4. However I don't have significant anemia I feel very tired by afternoon. Is it common side effect or I am to sensitive and looking my...

gerewolf · gerewolf

My wife, Julia, lives in New York/Pennsylvania. Does anybody know of any clinical trials with the new drugs she could get into? Thanks.

Terry · Terry

On Oct 3rd I took the last pills for the Turquoise II study with a 24 week duration. While the first few months were a breeze the last month the Ribavirin took hold and really worked over my anxiety level a lot. But I have now finished my part and have come a long way from the start of this program. At the sta...

lauralou57 · lauralou57

I just noticed this clinical trial in clinicaltrials.gov and I had not seen it before. It is using Gilead's sofosbuvir/ledipasvir and is for those with advanced liver disease or post-liver transplant. I thought I would post this as others might be interested. The link is below: http://clinicalt...

Lizard · Lizard

I was on a BMS trial for 24 weeks (the AI452-020 study) testing either Peg Interferon Alpha or Lambda, and either a protease or a polymerase inhibitor and Ribavirin. . I had to go off the trial in Dec 2011 (I started in July) due to another, unrelated, health issue. I was pretty tired in the beginning but...

Topic		Started By	Replies	Views	Last Post
	Real or placebo? (Preview) Hi all, Is there anyway to know if you are getting the drug or just a placebo. I may get into a Merck trial with MK5172 & MK8742, no riba or INF. Getting a placebo would take me an additional 16 weeks before the real thing. Just curious if there's anything I can look for (if I get in of course). Finger...	Milliganus	8	1924	Jun 17, 2014 by Groupergetter
	Optimist-1 Janssen Sofosbusvir 400 mg and Simeprevir 150 mg upcoming trial (Preview) Hi all, Been keeping my eye out and this trial looks like it will be coming up as a phase 3 multi-center trial soon. I'm hoping to jump on it if I can. It is going to be an 8 week or a 12 week randomized trial. No Riba or Inf. Any thoughts on SVR in trials only lasting 8 weeks? Phase II SVR results I've seen fo...	Milliganus	11	2954	Jun 16, 2014 by Milliganus
	OPTIMIST trial: What happened with recruiting? (Preview) Hi, Forum members. I hope everyone is enjoying the spring weather (if it's spring in your part of the world), and that you're having more luck than I am getting therapy. I just found out that the OPTIMIST trial (Sovaldi + Olysio for treatment-naive genotype 1) is no longer recruiting. I've been follo...	Mike716	40	2773	Jun 14, 2014 by Beacon
	Optimist Trial - 11 days in (Preview) Hello, I'm not sure if anyone cares but I thought I would update anyone who does. I have found it very useful, most times encouraging, to read about other peoples experiences. I am on day 11 of the Optimist Clinical trial. It involves taking Sofosbusvir and Simeprevir (Olyosio) 150 mg Once daily wit...	tgcd78	1	1267	Jun 6, 2014 by Isiscat2011
	New upcoming trials? (Preview) I'm thinking I've missed the boat to participate in a clinical trial for Gileads sofosbuvir & ledipasvir dual therapy. Does anyone know of any upcoming trials (U.S.) using these? I so want to get treated but I'm skeptical that my insurance will cover this combo due to price when they are approv...	Milliganus	15	2898	Apr 28, 2014 by Tig
	New trials & checking in... (Preview) Hi everybody, Just wondering if anyone knows of any upcoming trials? I've been watching Clinical Trials.gov waiting to jump on something. I'm doing pretty well, but the fatigue is getting me every day by mid-afternoon. We are in the Phoenix area for the winter and it's been very nice. Lots of sun...	Milliganus	1	1323	Apr 27, 2014 by rundout
	Bristol-Myers Squibb Ally 2 Phase III : Recruiting now (Preview) A new phase III trial for HIV/HCV co infection, Ally 2, is currently being recruited. Bristol-Meyers Squibb is the sponsoring manufacturer. Check the included link for additional information. This information was provided by our member "Sara" and I want to thank her for bringing it to...	Tig	3	1413	Apr 26, 2014 by suziq
	Think I might have gotten a trial!!!!! Questions…. (Preview) Called out to Scripps today and talked with them about the upcoming Janssen Optimist-1 clinical trial (NCT02114177). Sounds like they are going to accept me. It will start in May in California. We are currently in Colorado with a child with a broken arm. No problem to travel though. All of you ha...	Milliganus	2	1963	Apr 23, 2014 by Milliganus
	Gilead-New Long Term Follow-up (Preview) For all who succeeded on the Gilead trial-they are offering a long term follow-up to continue to evaluate your response...started mine today!	Karen	2	1172	Apr 22, 2014 by Karen
	Ledipasvir and Sofosbuvir for Previously Treated HCV Genotype 1 Infection (Preview) Hey All This is Great article that Gilead and most of the Trials site Doctors have collaborated on that was released at the EASL Conference in London this week-end and also was released as a important article in The New England Journal of Medicine on Sat. Please follow this link to read http://www.nej...	Matt Chris	3	1638	Apr 13, 2014 by Matt Chris
	Trial for Sofosbuvir (Preview) Hi everyone my name is Janine I have hep c genotype 1a/1b I am awaiting news of when I will start my trial with sofosbuvir, has anyone out there got some advice anything really, I refused the interferon due to being told that it would more than likely not help me have just come from my specialist today he in...	Jayzcatt	4	1440	Mar 18, 2014 by Cinnamon Girl
	AlmosT Half way!!!! ( 1 2 ) (Preview) Meant tp post this on my Abbott thread apologies Just received a call from my coordinator...still UnDEtectABle at 10 weeks!!!! Going in for my 12 week labs on Monday HOPING for more good news HGB 14 Bili 1.2 Platelets Up to 120 ! sides: insomnia,transient anxiety Strained my neck & finally t...	balagan51	68	7876	Mar 2, 2014 by Cinnamon Girl
	Abbvie trials for 3a? (Preview) Hi, has anyone heard of Abbvie trials for geno3a? Thanks in advance	Liamc	4	1533	Feb 25, 2014 by Matt Chris
	Abbvie Treatment and SVR (Preview) Hi Everyone, It's been awhile since I've been on this forum. Life got very busy! I'm glad to announce that I achieved SVR on the Abbvie drugs and I'm still clear. I think we need to help those behind us as the latest results are very promising although I realize that not everyone was successful in beatin...	findingthecure	18	3028	Feb 4, 2014 by Matt Chris
	Sofosbuvir (Preview) Can't even spell the name of the drug which I hope will save my life. At last the UK is doing widespread trials for geno3 - lobby your consultant. Dragonfly xxx	dragonfly	30	6731	Jan 21, 2014 by Cinnamon Girl
	Bristol Myers 3 DAA clinical trial w/Daclatavir, Asunaprevir & BMS791325 (Preview) Hi folks, I started this trial about 9 weeks ago and end treatment at the end of this month. Is anyone else in this trial? Its very intensive in terms of clinic visits but seems to be having good results. Karen	Millercollaborative	42	6731	Dec 22, 2013 by suziq
	LoneStar-3 (Preview) New member and my first post. Gilead - LoneStar-3 Open Label Study of Sofosbuvir/Ledipasvir Combination with Ribavirin or GS-9669 250 mg or GS-9669 500 mg in Treatment Naïve or Treatment-Experienced Cirrhotic Subjects with Genotype 1 HCV. (Not posted on clinical trials.) Just started this...	Browneyedgirl	23	2858	Dec 22, 2013 by suziq
	Sapphire Trial ( 1 2 ) (Preview) Hello, I am on the Sapphire Trial and after 3 months discovered I was on the placebo and am now into my fourth week of the real meds. Strangely enough I felt pretty appalling throughout the placebo - general malaise, aching body etc. Guess it was the virus. I am also getting side effects from the real meds...	Jumpy	50	6146	Dec 12, 2013 by Jumpy
	Abbott/Abbvie SAPPHIRE I, completed 4/4/13. UNDETECTED- Post Tx news?? (Preview) I have 2 WK post EndTrial visit 2morrow. Tx SEs continue- stomach churning on laying down, all night, continues. Problem sleeping w stomach rumbling all night. BTW, anyone been hearing how the pre-SAPPHIRE, P2 (AVIATOR) are doing with SVR. Those trial folks s/b ~40 weeks.	Bob C	2	1875	Dec 9, 2013 by Tig
	Abbott Sapphire phase 3 (Preview) ok i try here, i am new, and genotype 1b, started the Abbott sapphire phase 3 5 days ago, wondering when side effects kick in lol that is about it	newby4555	17	3117	Dec 9, 2013 by Biggyb
	Is distance a big issue in clinical trials? (Preview) I am not only treatment naïve, I know nothing about clinical trials. Does anyone know if you have to live within a certain distance from where a trial is held? I am not seeing much in my area. Do you have to drive to the place the trial is being held each time they want to see you, or can they usually do yo...	LC	6	1942	Dec 6, 2013 by LC
	Week 4 of Gilead Sofosbuvir/GS-5885 trial with ribaviran (Preview) I haven't posted before but have been an occasional reader. A little background I have Hep C Genotype 1a. I believe I have had since the late 70s. First I was on the interferon ribavirin treatment. I had an initial large drop in viral load but it came back during treatment. I was taken of the meds. Next I...	bowens44	25	4225	Dec 5, 2013 by mallani
	Forums Opportunity to give input to FDA HCV Treatment Guidelines (Preview) Hey all We have an opportunity to give written input to the FDA regarding HCV treatment from the viewpoint of the patient in the future treatments with DAA's. This our chance to give real world input from our standpoint not just the drugs company's. If you ever wished or wanted them to consider your vie...	Matt Chris	0	1294	Nov 28, 2013 by Matt Chris
	Life after Abbott trial diary (Preview) I just finished my Abbott trial on 6/26/13(last night I took meds) and was wondering how everyone is feeling off of the meds? My first day off meds I had to go in and turn in all empty med sleeves and bottle of riba and had a blood draw and EKG. But I noticed later that evening how friggen tired I was. I mean lik...	LUV2RYDE	19	2669	Nov 16, 2013 by LUV2RYDE
	Need a trial (Preview) Anyone know besides the clinical trials.gov where I can look for trials - I need one and I have tried everything and failed.	JLynch30	0	1206	Nov 12, 2013 by JLynch30
	Side effect (Preview) I finish the 42. day of treatment today, being on Malachit II study ( 12 weeks of Abbvie combination for previously non-responders). I got the UND result at week 2 and 4. However I don't have significant anemia I feel very tired by afternoon. Is it common side effect or I am to sensitive and looking my...	veronika	14	2109	Nov 8, 2013 by Biggyb
	Clinical trials in NY (Preview) My wife, Julia, lives in New York/Pennsylvania. Does anybody know of any clinical trials with the new drugs she could get into? Thanks.	gerewolf	0	1221	Oct 21, 2013 by gerewolf
	Treatment Completed !! (Preview) On Oct 3rd I took the last pills for the Turquoise II study with a 24 week duration. While the first few months were a breeze the last month the Ribavirin took hold and really worked over my anxiety level a lot. But I have now finished my part and have come a long way from the start of this program. At the sta...	Terry	13	1609	Oct 8, 2013 by Terry
	New Gilead Clinical Trial With Sofosbuvir/Ledipasvir For Those With Advanced Liver Disease Or Post-Liver Transplant (Preview) I just noticed this clinical trial in clinicaltrials.gov and I had not seen it before. It is using Gilead's sofosbuvir/ledipasvir and is for those with advanced liver disease or post-liver transplant. I thought I would post this as others might be interested. The link is below: http://clinicalt...	lauralou57	6	2476	Sep 29, 2013 by lauralou57
	Unblinded (Preview) I was on a BMS trial for 24 weeks (the AI452-020 study) testing either Peg Interferon Alpha or Lambda, and either a protease or a polymerase inhibitor and Ribavirin. . I had to go off the trial in Dec 2011 (I started in July) due to another, unrelated, health issue. I was pretty tired in the beginning but...	Lizard	2	1287	Sep 25, 2013 by Lizard
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