Does anyone know if a move from 1.11 to 1.22 INR means anything serious? Everything else is perfectly normal and Alk Phos, AST, and ALT are all mid-range normal. But, it's always been below 1.20 previously.
I went for an ultrasound today and it appears that I have lost the fluid from my abdomen. I know that my bilirubin level is down so I'm hoping that I have made the step back from decomensated to compensated. I know I have gone down a stage on the Child-Pugh level anyway. So far, so good!
Pharmacokinetics - of HarvoniSometimes described as what the body does to a drug, refers to the movement of drug into, through, and out of the body the time course of its absorption, bioavailability, distribution to tissues, and metabolism.Why it can be important. Working in harmony with the HC...
Hi all, The March issue of the HCV Advocate newsletter is available.It's disappointing that the FDA will not be giving out any more Priority Reviews to HCV treatments. What about the Geno 3's?Also it's good to see that patients with a SVR can expect a 'normal' life span. Cheers.http://www.hcvadvo...
had 12wk blood test results. virus undetected.am so pleased.been a long time with virus 25 yrs.found out i had it in 2007.but i had not felt well for quite a few yrs before i was diagnosed.had type 1b.was put on 48 wks of interferon ribavirin.but was taken off after 12 wks as i was inteferon intolerant.s...
I have been on 300mg Zantac for my heartburn since two days after I stopped Harvoni. I am still suffering here. Sleeping very well, better than ever. Achy still but different than before treatment. It's better for sure than it was. My foot issues if you all recall that... are gone! Whew that was...
Hi Everyone, After a 10 week battle with my insurance company I was finally approved for 8-weeks of Harvoni. The 8-week duration is because my viral load was under 6 million. For anyone getting ready to take the medicine, I have found it to be a breeze so far. No side effects at all. I'm having good gy...
It would be quite naive to believe that the hep c virus is the only biological function to use the NS3/4A and NS5B pathways. In fact, I will postulate that billions of biological processes use these pathways. When they are inhibited with drugs such as Olysio and Sofosbuvir, the body must immediately...
The FDA intends to rescind the breakthrough designation of Merck's new investigational drugs. It does state their purchase of Idenix Pharmaceuticals and their plan to ramp up investigational studies later this year.This may be an excellent chance for all interested. Keep your eye open for tria...
First pill of 12 week treatment last Friday. No major side effects, sleep a bit restless the first night, second pretty good. looking forward to ridding my body of this virus
Hi All, Just a bit of history so you understand my question. About 10 years ago, I began to notice the skin on my feet, ankles and calves beginning to turn dark. It stopped at my knees. I saw my GP at the time and asked her about it and she immediately said I was developing venous insufficiency. I was 48 at the...
Hello everyone,Just thought I'd post an update on how my treatment went. I started treatment (interferon + ribavirin) on June 3rd, 2014, and finished a 24 week course on November 17th, 2014. My initial VL was 469,838. I am also co-infected with HBV. After 12 weeks on tx, I was undetected, and I was also...
Hi all. My second post. Went to the doctors for my report on pre blood work and MRI. Apparently and amazingly I am now geno 1a from 1b 10 yrs ago. Since 2009 my viral load has stayed at a low 225,000. (Thank-you supplements). Now.....Doc had no explanation how I switched geno's. No new testing practice...
Hey all, Just received my 16 week lab results and am a little concerned. I called the doctor, but am not expecting a call back until tomorrow..wondering if anyone has insight as to theses values? Alk Phos Oct. 9: 214 Nov 21: 181 Dec 5 : 159 Jan 2: 174 ...
wellll.s*** where to start its 1030pm 3-4-15 i just got done reading posts everything from new people who have arrived here yes i see that you guys greet every new person :) which more then i do :) applauds you on your kindness.... Mallani Dog story was cute at the beach.... i hear you can relapse o...
The subject of of long term side effects after treatment has recently been raised by many people and really does need to be addressed. According to some recent studies, this is more widespread than we have been led to believe. One of the main issues is that the choice to do treatment should be based on &q...
Hello everyone. Just wanted to give you a quick update on what has been happening to my husband Angelo. After several MRI HCC was proven. 3 tumors were found, 5cm, 1.5 cm 2cm. the whole team of doctors decided that the best course of action would be to do RADIOEMBOLIZATION. On feb. 12 they did a map...
I believe I carried hep c geno type 1 for 30 years. I never had any ill effects from the desease. I completed 6 months of Sovaldi and Ribivirin 30 weeks ago. I had a pretty rough time with it especially at the end. I was successful in killing the virus. I had expectations of "bouncing back' to my old sel...
This site is a great discovery today. I am getting ready to try to beat this HCV for the 3rd time. So glad to have found this site. Looking forward to learning and sharing here. Take Care, OOTB
This digital copy of the February 2015 Federal Practitioner was sent to me and since it has open access online, I selected an article some may find interesting. The entire publication is informative. I point out the charts and graphs particularly. They provide an easy reference/comparison to the o...
In draft guidance published today healthcare guidance body NICE (The National Institute for Health and Care Excellence) has recommended ledipasvir-sofosbuvir (Harvoni) as a treatment option for some adults with genotype 1 or 4 chronic hepatitis C.This is draft guidance; NICE has not yet issue...
I haven't been visiting the forum much the past week or so. So first of all, hope all is well with everyone & more of you are able to get Harvoni or one of the other "no-sides" drugs. It's been one month now & I haven't gotten my blood-work results back yet but everything has been going...
When I found out I had HepC in 2004 I had been going to doctors for around 2 yrs. complaining of symptoms that no one could put a name to. I was given handfuls of anti-depressant scripts because of course; "it was all in my head". I was given pain meds basically to shut me up seems that's what doc...
My platelets have been between 195-224 over the last three years ( pre tx 224 ) - Today after 2 weeks tx 184 - Any ideas? Other CBC with diff all ok. Waiting for AST/ALT Bili results later today. thanks
I'm just starting treatment on 3/5/2014 and would like to share my progress, if anyone is interested. I had a lung tumor when I was 10 and got several blood transfusions. And also the virus. I was first diagnosed in 2005 during a full physical exam. At the time, the doctor said that I could wait for treat...
MUMBAI Mon Mar 2, 2015 2:22pm IST (Reuters) - Natco Pharma Ltd said on Monday it has agreed a deal with Gilead Sciences Inc to supply generic copies of the U.S. drugmaker's chronic hepatitis C medicines, including $1,000-a-pill drug Sovaldi, in 91 developing nations. Drugs under the deal with Natco...
Healthcare guidance body NICE has today published final guidance recommending sofosbuvir (Sovaldi, Gilead Sciences) and simeprevir (Olysio, Janssen) as treatment options for some people with chronic hepatitis C.Sofosbuvir has a marketing authorisation in the UK for use in combination with...
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