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Optimist-1 Janssen Sofosbusvir 400 mg and Simeprevir 150 mg upcoming trial
(Preview)
Hi all, Been keeping my eye out and this trial looks like it will be coming up as a phase 3 multi-center trial soon. I'm hoping to jump on it if I can. It is going to be an 8 week or a 12 week randomized trial. No Riba or Inf. Any thoughts on SVR in trials only lasting 8 weeks? Phase II SVR results I've seen fo...
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Milliganus
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11
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2583
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OPTIMIST trial: What happened with recruiting?
(Preview)
Hi, Forum members. I hope everyone is enjoying the spring weather (if it's spring in your part of the world), and that you're having more luck than I am getting therapy. I just found out that the OPTIMIST trial (Sovaldi + Olysio for treatment-naive genotype 1) is no longer recruiting. I've been follo...
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Mike716
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40
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2162
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Optimist Trial - 11 days in
(Preview)
Hello, I'm not sure if anyone cares but I thought I would update anyone who does. I have found it very useful, most times encouraging, to read about other peoples experiences. I am on day 11 of the Optimist Clinical trial. It involves taking Sofosbusvir and Simeprevir (Olyosio) 150 mg Once daily wit...
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tgcd78
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1
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912
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New upcoming trials?
(Preview)
I'm thinking I've missed the boat to participate in a clinical trial for Gileads sofosbuvir & ledipasvir dual therapy. Does anyone know of any upcoming trials (U.S.) using these? I so want to get treated but I'm skeptical that my insurance will cover this combo due to price when they are approv...
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Milliganus
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15
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2449
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New trials & checking in...
(Preview)
Hi everybody, Just wondering if anyone knows of any upcoming trials? I've been watching Clinical Trials.gov waiting to jump on something. I'm doing pretty well, but the fatigue is getting me every day by mid-afternoon. We are in the Phoenix area for the winter and it's been very nice. Lots of sun...
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Milliganus
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1
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1006
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Bristol-Myers Squibb Ally 2 Phase III : Recruiting now
(Preview)
A new phase III trial for HIV/HCV co infection, Ally 2, is currently being recruited. Bristol-Meyers Squibb is the sponsoring manufacturer. Check the included link for additional information. This information was provided by our member "Sara" and I want to thank her for bringing it to...
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Tig
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3
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1059
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Think I might have gotten a trial!!!!! Questions….
(Preview)
Called out to Scripps today and talked with them about the upcoming Janssen Optimist-1 clinical trial (NCT02114177). Sounds like they are going to accept me. It will start in May in California. We are currently in Colorado with a child with a broken arm. No problem to travel though. All of you ha...
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Milliganus
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2
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1312
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Gilead-New Long Term Follow-up
(Preview)
For all who succeeded on the Gilead trial-they are offering a long term follow-up to continue to evaluate your response...started mine today!
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Karen
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2
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849
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Ledipasvir and Sofosbuvir for Previously Treated HCV Genotype 1 Infection
(Preview)
Hey All This is Great article that Gilead and most of the Trials site Doctors have collaborated on that was released at the EASL Conference in London this week-end and also was released as a important article in The New England Journal of Medicine on Sat. Please follow this link to read http://www.nej...
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Matt Chris
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3
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1272
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Trial for Sofosbuvir
(Preview)
Hi everyone my name is Janine I have hep c genotype 1a/1b I am awaiting news of when I will start my trial with sofosbuvir, has anyone out there got some advice anything really, I refused the interferon due to being told that it would more than likely not help me have just come from my specialist today he in...
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Jayzcatt
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4
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1087
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AlmosT Half way!!!!
(
1 2
)
(Preview)
Meant tp post this on my Abbott thread apologies Just received a call from my coordinator...still UnDEtectABle at 10 weeks!!!! Going in for my 12 week labs on Monday HOPING for more good news HGB 14 Bili 1.2 Platelets Up to 120 ! sides: insomnia,transient anxiety Strained my neck & finally t...
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balagan51
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68
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6139
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Abbvie trials for 3a?
(Preview)
Hi, has anyone heard of Abbvie trials for geno3a? Thanks in advance
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Liamc
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4
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1121
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Abbvie Treatment and SVR
(Preview)
Hi Everyone, It's been awhile since I've been on this forum. Life got very busy! I'm glad to announce that I achieved SVR on the Abbvie drugs and I'm still clear. I think we need to help those behind us as the latest results are very promising although I realize that not everyone was successful in beatin...
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findingthecure
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18
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2108
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Sofosbuvir
(Preview)
Can't even spell the name of the drug which I hope will save my life. At last the UK is doing widespread trials for geno3 - lobby your consultant. Dragonfly xxx
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dragonfly
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30
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4608
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Bristol Myers 3 DAA clinical trial w/Daclatavir, Asunaprevir & BMS791325
(Preview)
Hi folks, I started this trial about 9 weeks ago and end treatment at the end of this month. Is anyone else in this trial? Its very intensive in terms of clinic visits but seems to be having good results. Karen
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Millercollaborative
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42
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6106
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LoneStar-3
(Preview)
New member and my first post. Gilead - LoneStar-3 Open Label Study of Sofosbuvir/Ledipasvir Combination with Ribavirin or GS-9669 250 mg or GS-9669 500 mg in Treatment Naïve or Treatment-Experienced Cirrhotic Subjects with Genotype 1 HCV. (Not posted on clinical trials.) Just started this...
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Browneyedgirl
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23
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2421
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Sapphire Trial
(
1 2
)
(Preview)
Hello, I am on the Sapphire Trial and after 3 months discovered I was on the placebo and am now into my fourth week of the real meds. Strangely enough I felt pretty appalling throughout the placebo - general malaise, aching body etc. Guess it was the virus. I am also getting side effects from the real meds...
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Jumpy
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50
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5065
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Abbott/Abbvie SAPPHIRE I, completed 4/4/13. UNDETECTED- Post Tx news??
(Preview)
I have 2 WK post EndTrial visit 2morrow. Tx SEs continue- stomach churning on laying down, all night, continues. Problem sleeping w stomach rumbling all night. BTW, anyone been hearing how the pre-SAPPHIRE, P2 (AVIATOR) are doing with SVR. Those trial folks s/b ~40 weeks.
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Bob C
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2
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1502
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Abbott Sapphire phase 3
(Preview)
ok i try here, i am new, and genotype 1b, started the Abbott sapphire phase 3 5 days ago, wondering when side effects kick in lol that is about it
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newby4555
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17
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2710
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Is distance a big issue in clinical trials?
(Preview)
I am not only treatment naïve, I know nothing about clinical trials. Does anyone know if you have to live within a certain distance from where a trial is held? I am not seeing much in my area. Do you have to drive to the place the trial is being held each time they want to see you, or can they usually do yo...
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LC
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6
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1566
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Week 4 of Gilead Sofosbuvir/GS-5885 trial with ribaviran
(Preview)
I haven't posted before but have been an occasional reader. A little background I have Hep C Genotype 1a. I believe I have had since the late 70s. First I was on the interferon ribavirin treatment. I had an initial large drop in viral load but it came back during treatment. I was taken of the meds. Next I...
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bowens44
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25
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3115
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Forums Opportunity to give input to FDA HCV Treatment Guidelines
(Preview)
Hey all We have an opportunity to give written input to the FDA regarding HCV treatment from the viewpoint of the patient in the future treatments with DAA's. This our chance to give real world input from our standpoint not just the drugs company's. If you ever wished or wanted them to consider your vie...
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Matt Chris
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0
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953
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Life after Abbott trial diary
(Preview)
I just finished my Abbott trial on 6/26/13(last night I took meds) and was wondering how everyone is feeling off of the meds? My first day off meds I had to go in and turn in all empty med sleeves and bottle of riba and had a blood draw and EKG. But I noticed later that evening how friggen tired I was. I mean lik...
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LUV2RYDE
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19
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2327
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Need a trial
(Preview)
Anyone know besides the clinical trials.gov where I can look for trials - I need one and I have tried everything and failed.
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JLynch30
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0
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868
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Side effect
(Preview)
I finish the 42. day of treatment today, being on Malachit II study ( 12 weeks of Abbvie combination for previously non-responders). I got the UND result at week 2 and 4. However I don't have significant anemia I feel very tired by afternoon. Is it common side effect or I am to sensitive and looking my...
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veronika
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14
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1747
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Clinical trials in NY
(Preview)
My wife, Julia, lives in New York/Pennsylvania. Does anybody know of any clinical trials with the new drugs she could get into? Thanks.
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gerewolf
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0
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897
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Treatment Completed !!
(Preview)
On Oct 3rd I took the last pills for the Turquoise II study with a 24 week duration. While the first few months were a breeze the last month the Ribavirin took hold and really worked over my anxiety level a lot. But I have now finished my part and have come a long way from the start of this program. At the sta...
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Terry
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13
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1240
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TURQUOISE II AbbVIE TRIAL.
(Preview)
Hi all, I beleive may be I can share my new experience with you. I have the feeling that may be AbbVie Turquoise II is not totally going the same way in the US and here in Europe ? For example, I saw a message here from some one on Turquoise II who had placebo the first 12 weeks. Well, here, this can't happen bec...
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ios9
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40
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3805
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New Gilead Clinical Trial With Sofosbuvir/Ledipasvir For Those With Advanced Liver Disease Or Post-Liver Transplant
(Preview)
I just noticed this clinical trial in clinicaltrials.gov and I had not seen it before. It is using Gilead's sofosbuvir/ledipasvir and is for those with advanced liver disease or post-liver transplant. I thought I would post this as others might be interested. The link is below: http://clinicalt...
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lauralou57
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6
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2107
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Unblinded
(Preview)
I was on a BMS trial for 24 weeks (the AI452-020 study) testing either Peg Interferon Alpha or Lambda, and either a protease or a polymerase inhibitor and Ribavirin. . I had to go off the trial in Dec 2011 (I started in July) due to another, unrelated, health issue. I was pretty tired in the beginning but...
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Lizard
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2
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978
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