Hep C Discussion Forum

tkflex36 · tkflex36

I have been looking at getting into a trial of this sort, the lady in charge of the trials for University of Penn hospital in Philadelphia has been in contact with me over the past week and has all my info. She thinks they may be an immediate opening, if not one is starting within the next month. I always vie...

lilbit · lilbit

I have just started a new study called Topazii and am on week 2. Has anyone one gone through earlier phases of this study>

hippiechick · hippiechick

I started my Abbvie Topaz clinical trial on July 14, had my two weeks checkup on July 29 and on July 31 was told my VL was down from 4 million+ to undetectable (<15) My ALT went from 180 to 20 and my AST from 170 to 30. I was so happy I cried. Just had to share!

scotu · scotu

Haven't posted in a while... was kinda of scolded by trial coordinator for posting/sharing too much. Coming to the end of 48 weeks of Sofosbuvir (400mg x 1 a day) and Ribavirin (200mg 3 x am, 3 x pm). 9 days left. Undetectable from day 3 on. This stuff works for me. Sad to hear it now costs a grand a pill. S...

JudeMzr · JudeMzr

Comment removed at member`s request. -- Edited by Cinnamon Girl on Monday 29th of December 2014 11:23:23 PM

Liamc · Liamc

Was told today the news , walked out of the hospital crossed the road sat down in the park and cried and cried, after 30 years the uninvited visitor has finally left. Thankyou all for your encouragement and wisdom. . My bloods Bilirubin 9 Alt 26 Ast 29 ALP 56 Are these numbers below of any concern? heamogl...

Liamc · Liamc

hi, Just finished my 3 rd week on the trials, I was not going to accept the trial but have bit the bullet and am going for it. My VL went from 1,700,000 to 110 in the first week and my alt and ast are normal for the first time in 20 years. I am starting to feel tired and having shortness of breath. Just wondering i...

dragonfly · dragonfly

After 8 weeks EOT still free of virus - I wish the same to everyone and will continue to campaign that everyone gets this treatment. I know that I still have a bit of a way to go 40 years or so of having this but we have a lovely home and life so really I can't complain. All the best. Nxxx

Donna165 · Donna165

Is anyone starting the new Hep C drugs in clinical trials?

Karen · Karen

The call came today to start pre-screening (March 26) for the open-label study to investigate the efficacy and safety of Sofosbuvir/GS-5885 Fixed-Dose Combination ± Ribavirin for 12 and 24 weeks in treatment-naive subjects with chronic genotype 1 HCV infection. I am wondering if there are ques...

dragonfly · dragonfly

Well, I've finished and have been undetectable since week 2. My ALT went down to 30. I am told that if those of us on Daclatsvir relapse after 12 weeks of treatment we get the 24 course. I am hoping that this will not be necessary. I'm also hoping to reduce my Child-Pugh score which is 7-9. To everyone...

LC · LC

I went for my 4 week labs and found out I'm undetected!! I'm very happy tonight!

Liamc · Liamc

I have just been screened for the phase 3 sofosbuvir/gs5816 for 12 weeks or sofos and riba for 24 weeks for geno 3. i will know in the next 2 weeks when my blood work is back if I am accepted or not. i was told be the doctor that gilead does not want our viral load disclosed until 12 weeks into the trial, does an...

LC · LC

I was just wondering if they all did that or what? It was a nice surprise that they would actually pay me to go there. On top of free very expensive medication. I wonder if it is for some legal reason, like they are worried we might try to come back on them if all doesn't go well?

frannie58 · frannie58

Is anyone else here on or has been on the Ledipisvir trail? I am on the Led/sofo trial without riba for 12 weeks..5 days in. Im looking for info please on how you felt on it..side effects. I have headaches, a bit dizzy. I feel like I am here but not here...feel weird...does this make sense? Thank you for a...

suziq · suziq

Hi. I'm into my 10th week of the latest Merck Study with MK-5172 and MK-8742, now called the C-Worthy trial. Is anyone else here doing that trial??? Or did the same trial earlier this year?? I was <25 weeks 1 and 2 and UND weeks 4 and 8. I am on the arm for cirrhosis with ribavirin. I would love to hea...

Terry · Terry

I haven't post on here in quite some time but still come to read the many stories that new people are posting. I can remember the start of my journey here and the state I was in and the fear we all have when we have be given the news about HCV. The great people on this site did their best to alleviate my fears and...

Milliganus · Milliganus

Going into the trial center today for my last pill. This is the Merck C-Edge 1 pill, 2 drug combo. I have to say the whole thing has been a breeze with almost no side effects. I should know in a couple of weeks my VL. Cautiously optimistic.

Rockyfeller · Rockyfeller

I finished up my clinical trial with sofosbuvir/ledispavir on March 4, got my 4 week results today and was undetected. I won't start celebrating yet, but I didn't make it this far after the first try, so I'm optimistic. I retired 1 month into the treatment. I had been going to the health club infreque...

HR · HR

Hello everyone, I have been reading these forums for a while now and decided to join and share my experiences as I hopefully pass the screening on Thursday for the ION-3 trial. ION-3 3 arm- open label 8 weeks of Sof/Led 8 weeks of Sof/Led + Rib 12 week of Sof/Led Hopefully all goes well as they've had my me...

blipette1209 · blipette1209

I posted this in the chat box, but doing it here to as I see where in the past I have posted stuff and it went to wrong locations. Anywhoo, I wanna keep up on the one shot cure trials, anyone know where to go online to be able to do that??? Thanks

User Friendly Clinical Trial Reference · Isiscat2011

Some of you are probably already aware of this but I just stumbled upon a site that lists clinical trials in a much more user friendly way than clinicaltrials.gov. It lists clinical trials by the name of the pharma co. Just click on the applicable link and you are there: http://hcvadvocate.blogsp...

Milliganus · Milliganus

Hi all, I'm a little over 2 weeks on the Merck 1 pill combo phase 3 trial. The coordinator thinks I'm not on the placebo as my labs have been responding. I haven't had any side effects other than a strange headache the 1st week which is now gone. I have however had a LOT more energy than I can remember in qu...

Milliganus · Milliganus

Went to the trial center to check in. Been on the Merck combo for 15 days. Since it's a blinded study I didn't know if I've been on placebo or real thing. Trial coordinator is pretty sure it's the real thing since my liver enzymes have dropped by about 50%. They've never been very high anyway, but I che...

robdbird · robdbird

Hi all new to the board, diagnosed with HCV 1a 2010 while doing routine blood work for hormone therapy, apparently have had it since the 70s and not sure how I got it but was doing a lot of partying back then. Anyways my original dr had me slated for clinical trial with bocevir and interferon but I didn't qu...

Terry · Terry

Well I have not posted for some time as I waited for the results from my 24 week tests. I just gave blood for my second to last test and received the 24 week ones and everything seemed really good. BUT the part that had me concerned was the fact that I also had a Fibro Scan done and my results from that were no...

lauralou57 · lauralou57

I just started this trial and I have been taking the medication for one week. The medication is daclatasvir (NS5A inhibitor) 30 mg, asunaprevir (NS3 inhibitor) 30 mg and BMS-791325 (NS5B inhibitor) 75 mg all in one tablet taken twice a day. So far I feel no side effects. In addition, I FEEL BETTER. For e...

suziq · suziq

Hi All,Got this email from my trial coordinator this morning. Good news for one who HAD Hep C and has type 2 diabetes. I'll post my lab flow sheet when I get it. Merck is great !! I am SO grateful for having the opportunity to participate in their trial. Reached my goal of SVR before my 80th birthday in...

Milliganus · Milliganus

Got the call today to start meds next Thursday on the Merck 5172/8742 combo. Its a 12 week, 1 pill day, double blinded placebo trial. Of course I'm hoping I'm in the 75% not on placebo, but even if I'm not, I still get the real thing after 18 weeks. Excited to finally have a hope of being free of this crap....

rundout · rundout

I was set up for the Sobosovir / peg /rib by my liver Dr and found the Idenix trial ... I dont know if this is a very small trial or just not being done by a big co but I very seldom see anything about it. I am Starting my 5 th week of the Helix 2 trial because of the weather I didnt get blood results past day7 til...

Topic		Started By	Replies	Views	Last Post
	Anyone on trials for solvaldi and gs-5816? (Preview) I have been looking at getting into a trial of this sort, the lady in charge of the trials for University of Penn hospital in Philadelphia has been in contact with me over the past week and has all my info. She thinks they may be an immediate opening, if not one is starting within the next month. I always vie...	tkflex36	2	4755	Apr 4, 2015 by Tig
	AbbVie combo TopazII with Ribo ( 1 2 ) (Preview) I have just started a new study called Topazii and am on week 2. Has anyone one gone through earlier phases of this study>	lilbit	77	18486	Mar 2, 2015 by Tig
	Undetectable after 2 weeks (Preview) I started my Abbvie Topaz clinical trial on July 14, had my two weeks checkup on July 29 and on July 31 was told my VL was down from 4 million+ to undetectable (<15) My ALT went from 180 to 20 and my AST from 170 to 30. I was so happy I cried. Just had to share!	hippiechick	26	7130	Jan 17, 2015 by Cinnamon Girl
	Fight the Good Fight - Sofosbuvir Working for Me, now for SVR. (Preview) Haven't posted in a while... was kinda of scolded by trial coordinator for posting/sharing too much. Coming to the end of 48 weeks of Sofosbuvir (400mg x 1 a day) and Ribavirin (200mg 3 x am, 3 x pm). 9 days left. Undetectable from day 3 on. This stuff works for me. Sad to hear it now costs a grand a pill. S...	scotu	23	4270	Jan 10, 2015 by sandyw
	Merck MK-5172 / Mk-8742 clinical trial ( 1 2 ) (closed) (Preview) Comment removed at member`s request. -- Edited by Cinnamon Girl on Monday 29th of December 2014 11:23:23 PM	JudeMzr	58	14236	Dec 30, 2014 by Cinnamon Girl
	Undetectable after 4-6 weeks (Preview) Was told today the news , walked out of the hospital crossed the road sat down in the park and cried and cried, after 30 years the uninvited visitor has finally left. Thankyou all for your encouragement and wisdom. . My bloods Bilirubin 9 Alt 26 Ast 29 ALP 56 Are these numbers below of any concern? heamogl...	Liamc	8	2855	Dec 24, 2014 by Liamc
	anyone on the 24 weeks Solvaldi/ riba trials for geno3s.? (Preview) hi, Just finished my 3 rd week on the trials, I was not going to accept the trial but have bit the bullet and am going for it. My VL went from 1,700,000 to 110 in the first week and my alt and ast are normal for the first time in 20 years. I am starting to feel tired and having shortness of breath. Just wondering i...	Liamc	20	4348	Dec 14, 2014 by Zlikster
	After 8 weeks (Preview) After 8 weeks EOT still free of virus - I wish the same to everyone and will continue to campaign that everyone gets this treatment. I know that I still have a bit of a way to go 40 years or so of having this but we have a lovely home and life so really I can't complain. All the best. Nxxx	dragonfly	3	1634	Dec 9, 2014 by Cinnamon Girl
	Starting clinicals Dec. 3rd...what can I expect from side effects? (Preview) Is anyone starting the new Hep C drugs in clinical trials?	Donna165	1	1629	Nov 26, 2014 by LC
	A journey through the twists and turns of Sofosbuvir/GS-5885 Fixed-Dose Combination ± Ribavirin ( 1 2 3 4 ) (Preview) The call came today to start pre-screening (March 26) for the open-label study to investigate the efficacy and safety of Sofosbuvir/GS-5885 Fixed-Dose Combination ± Ribavirin for 12 and 24 weeks in treatment-naive subjects with chronic genotype 1 HCV infection. I am wondering if there are ques...	Karen	168	22709	Nov 23, 2014 by angelseven
	EOT (Preview) Well, I've finished and have been undetectable since week 2. My ALT went down to 30. I am told that if those of us on Daclatsvir relapse after 12 weeks of treatment we get the 24 course. I am hoping that this will not be necessary. I'm also hoping to reduce my Child-Pugh score which is 7-9. To everyone...	dragonfly	13	3648	Nov 15, 2014 by Brian1412
	Another undetected at 2 weeks on Abbvie trial!!! (Preview) I went for my 4 week labs and found out I'm undetected!! I'm very happy tonight!	LC	16	3410	Nov 7, 2014 by LC
	Just finished screening. (Preview) I have just been screened for the phase 3 sofosbuvir/gs5816 for 12 weeks or sofos and riba for 24 weeks for geno 3. i will know in the next 2 weeks when my blood work is back if I am accepted or not. i was told be the doctor that gilead does not want our viral load disclosed until 12 weeks into the trial, does an...	Liamc	8	2141	Nov 5, 2014 by Liamc
	Do all clinical trials pay you to participate? (Preview) I was just wondering if they all did that or what? It was a nice surprise that they would actually pay me to go there. On top of free very expensive medication. I wonder if it is for some legal reason, like they are worried we might try to come back on them if all doesn't go well?	LC	17	2650	Oct 22, 2014 by lilbit
	Is anyone else in the Ledipisvir trial...I am on it now (Preview) Is anyone else here on or has been on the Ledipisvir trail? I am on the Led/sofo trial without riba for 12 weeks..5 days in. Im looking for info please on how you felt on it..side effects. I have headaches, a bit dizzy. I feel like I am here but not here...feel weird...does this make sense? Thank you for a...	frannie58	24	3213	Oct 12, 2014 by Beacon
	Merck Trial with MK-5172 and MK-8742 ( 1 2 ) (Preview) Hi. I'm into my 10th week of the latest Merck Study with MK-5172 and MK-8742, now called the C-Worthy trial. Is anyone else here doing that trial??? Or did the same trial earlier this year?? I was <25 weeks 1 and 2 and UND weeks 4 and 8. I am on the arm for cirrhosis with ribavirin. I would love to hea...	suziq	92	15321	Oct 9, 2014 by suziq
	You have to believe (Preview) I haven't post on here in quite some time but still come to read the many stories that new people are posting. I can remember the start of my journey here and the state I was in and the fear we all have when we have be given the news about HCV. The great people on this site did their best to alleviate my fears and...	Terry	8	2005	Oct 4, 2014 by Matt Chris
	Last pill today!! (Preview) Going into the trial center today for my last pill. This is the Merck C-Edge 1 pill, 2 drug combo. I have to say the whole thing has been a breeze with almost no side effects. I should know in a couple of weeks my VL. Cautiously optimistic.	Milliganus	21	2110	Oct 3, 2014 by suziq
	Fingers crossed, 4 week undetected (Preview) I finished up my clinical trial with sofosbuvir/ledispavir on March 4, got my 4 week results today and was undetected. I won't start celebrating yet, but I didn't make it this far after the first try, so I'm optimistic. I retired 1 month into the treatment. I had been going to the health club infreque...	Rockyfeller	32	5209	Aug 28, 2014 by Paul B
	ION-3 trial ( 1 2 3 4 5 … 11 ) (Preview) Hello everyone, I have been reading these forums for a while now and decided to join and share my experiences as I hopefully pass the screening on Thursday for the ION-3 trial. ION-3 3 arm- open label 8 weeks of Sof/Led 8 weeks of Sof/Led + Rib 12 week of Sof/Led Hopefully all goes well as they've had my me...	HR	533	42300	Aug 21, 2014 by Tig
	How to get updated on trials status (Preview) I posted this in the chat box, but doing it here to as I see where in the past I have posted stuff and it went to wrong locations. Anywhoo, I wanna keep up on the one shot cure trials, anyone know where to go online to be able to do that??? Thanks	blipette1209	5	1603	Aug 10, 2014 by Isiscat2011
	User Friendly Clinical Trial Reference (Preview) Some of you are probably already aware of this but I just stumbled upon a site that lists clinical trials in a much more user friendly way than clinicaltrials.gov. It lists clinical trials by the name of the pharma co. Just click on the applicable link and you are there: http://hcvadvocate.blogsp...	Isiscat2011	0	1638	Aug 1, 2014 by Isiscat2011
	2 weeks in and what's going on??? (Preview) Hi all, I'm a little over 2 weeks on the Merck 1 pill combo phase 3 trial. The coordinator thinks I'm not on the placebo as my labs have been responding. I haven't had any side effects other than a strange headache the 1st week which is now gone. I have however had a LOT more energy than I can remember in qu...	Milliganus	3	1587	Jul 27, 2014 by Milliganus
	1st labs are in.... (Preview) Went to the trial center to check in. Been on the Merck combo for 15 days. Since it's a blinded study I didn't know if I've been on placebo or real thing. Trial coordinator is pretty sure it's the real thing since my liver enzymes have dropped by about 50%. They've never been very high anyway, but I che...	Milliganus	1	1267	Jul 25, 2014 by jimbob
	Abbvie Malachite clinical trial (Preview) Hi all new to the board, diagnosed with HCV 1a 2010 while doing routine blood work for hormone therapy, apparently have had it since the 70s and not sure how I got it but was doing a lot of partying back then. Anyways my original dr had me slated for clinical trial with bocevir and interferon but I didn't qu...	robdbird	38	7280	Jul 21, 2014 by hippiechick
	24 weeks completed and still SVR (Preview) Well I have not posted for some time as I waited for the results from my 24 week tests. I just gave blood for my second to last test and received the 24 week ones and everything seemed really good. BUT the part that had me concerned was the fact that I also had a Fibro Scan done and my results from that were no...	Terry	41	4646	Jul 17, 2014 by Terry
	New Bristol-Byers Squibb Clinical Trial NCT01979939 With Daclatasvir 30 mg, Asunaprevir 30 mg and BMS-791325 75 mg ( 1 2 ) (Preview) I just started this trial and I have been taking the medication for one week. The medication is daclatasvir (NS5A inhibitor) 30 mg, asunaprevir (NS3 inhibitor) 30 mg and BMS-791325 (NS5B inhibitor) 75 mg all in one tablet taken twice a day. So far I feel no side effects. In addition, I FEEL BETTER. For e...	lauralou57	94	7448	Jul 16, 2014 by Matt Chris
	24 Weeks EOT Merck Trial C-Worthy SVR (Preview) Hi All,Got this email from my trial coordinator this morning. Good news for one who HAD Hep C and has type 2 diabetes. I'll post my lab flow sheet when I get it. Merck is great !! I am SO grateful for having the opportunity to participate in their trial. Reached my goal of SVR before my 80th birthday in...	suziq	10	1806	Jul 7, 2014 by Matt Chris
	Starting trial next week!!! (Preview) Got the call today to start meds next Thursday on the Merck 5172/8742 combo. Its a 12 week, 1 pill day, double blinded placebo trial. Of course I'm hoping I'm in the 75% not on placebo, but even if I'm not, I still get the real thing after 18 weeks. Excited to finally have a hope of being free of this crap....	Milliganus	5	1376	Jul 2, 2014 by jimbob
	Helix 2 trial by Idenix (Preview) I was set up for the Sobosovir / peg /rib by my liver Dr and found the Idenix trial ... I dont know if this is a very small trial or just not being done by a big co but I very seldom see anything about it. I am Starting my 5 th week of the Helix 2 trial because of the weather I didnt get blood results past day7 til...	rundout	15	2344	Jun 19, 2014 by rundout
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